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| 1 | Molecular therapy for hepatic injury and fibrosis:Where are we?显示文摘肝的纤维变性是弯屈的愈合的回答,包含发炎和纤维发生的小径。响应各种各样的侮辱,例如酒精,局部缺血,病毒的代理人,和药或肝毒素, hepatocyte 损坏将在肝由 Kupffer 房间和另外的房间类型引起 cytokines 和另外的可溶的因素的版本。这些因素导致肝的星形细胞的激活,它综合大量细胞外的矩阵部件。与长期的损害和纤维变性,肝建筑学和新陈代谢被破坏,最后作为肝硬化和它的复杂并发症表明。除了消除病原学,例如抗病毒的治疗和药理学干预,新奇策略正在被开发直接在细胞的潜水艇和分子的层次探讨肝的损害和纤维变性,这令人鼓舞。与在理解这些机制和小径的改进,在损害给步调音,发信号,激活,和基因表示被分子的形式和分子的其它或基因治疗途径正在指向。这篇文章打算为肝的损害和纤维变性以分子的治疗的当前的地位提供更改并且我们多远从这些新治疗学的形式的临床的利用。 | Colette C Prosser Roy D Yen Jan Wu | 2006 | World Journal of Gastroenterology2006，12，4： | 41 |
| 2 | Numerical Analysis of Deteriorated Sub-sea Pipelines under Environmental Loads显示文摘The significant point is the bidirectional interaction technique in FSI analysis while investigating subsea corrosion effect. By this way, pipe environment is accurately modelled and fluid effects are also considered. The effect of external corrosion defects on structural behaviour of a pipeline is studied by creating a nonlinear numerical model based on the finite element method according to ABAQUS analysis program. Corrosion losses of sections are obtained from experimental results and applied to the model. Numerical model is formed by a span of sub-sea pipeline that is subjected to environmental loads. Seismic and wind-generated irregular wave loads are considered as environmental loads. Irregular wave is represented with equivalent eight regular waves via FFT. The pipe is modelled according to two different types which are non-corroded(intact) and corroded(deteriorated) to demonstrate corrosion effects on it. The visible type of corrosion in marine environment is named ‘pitting' corrosion, in which the material loss is locally interpenetrated over the surface. By considering this situation, the corroded and non-corroded pipes are modelled as 3D solid elements. The main point is revealing how the subsea corrosion affects the structural behaviour of pipelines on the basis of implementation of experimental results to a model structure due to changes of stresses and displacement. | GüCüYEN Engin | 2015 | Chinese Journal of Mechanical Engineering2015，28，6： | 7 |
| 3 | PTEN,a putative protein tyrosine phosphatase gene mutated in human brain,breast,and prostate cancer显示文摘 | Li J Yen C Liaw D | | 0，，： | 4 |
| 4 | 纳米碳化钒强化TWIP钢加工硬化机制研究显示文摘弥散分布的纳米碳化钒颗粒能明显提高TWIP钢的屈服强度,但同时将在一定程度上降低加工硬化率。采用一个修正的物理模型来研究纳米碳化钒颗粒对一种实验室等级的FeMnC奥氏体TWIP钢加工硬化率的影响。试验发现在塑性变形过程中弥散分布的纳米碳化钒颗粒会加快位错累积速率,但也会降低孪晶形成速率。与不含析出相的TWIP钢相比,在小应变时含纳米碳化钒颗粒的TWIP钢加工硬化率较高,但随着应变量的增加其硬化率减小的速度高于不含析出相的TWIP钢,因此在高应变条件下含纳米碳化钒颗粒的TWIP显示出较低的钢加工硬化率。 | Liang ZY Huang M X Yen H W Scott C P 魏世同(翻译) | 2014 | 钢铁钒钛2014，35，1： | 3 |
| 5 | Adult metaplastic hutch diverticulum with robotic-assisted diverticulectomy and reconstruction:A case report显示文摘BACKGROUND Hutch diverticulum arises from the compromised muscular development at the ureteral orifice.It is a congenital disease and extremely rare in adult,only accounting for about 3%occurrence worldwide.It can be either symptomatic or asymptomatic,and relies on image tools for diagnosis and preoperative planning.Indications for surgery are dependent on the complications from the diverticulum.Metaplasia is about 10%among those with hutch diverticulum,and it still has chances turning into malignancy,especially urothelial cell carcinoma.CASE SUMMARY A 27-year-old man was presented with frequently recurrent urinary tract infection for one year,and had suffered from intermittent right flank pain for 3 mo.No past medical histories were recorded before.No obvious abnormalities on laboratory data and urine examination were found.Under ultrasound,right hydronephrosis was seen and an anatomical abnormality was observed on intravenous pyelography.Further computed tomography urogram showed one diverticulum seated at superolateral side of right ureteral orifice.Cystoscopy was done and biopsy results showed focal metaplasia.After discussing with him,roboticassisted diverticulectomy with reconstruction was performed.Right hydronephrosis was greatly improved after surgery.He has completed his 1.5-year follow-ups,and no malignancies were seen from urine cytology and image of intravenous pyelography.CONCLUSION Robotic-assisted diverticulectomy and reconstruction to hutch diverticulum is a safe and efficient operation,providing several advantages over open and laparoscopic ones. | Che H Yang Yi S Lin Yen C Ou Wei C Weng Li H Huang Chin H Lu Chao Y Hsu Min C Tung | 2020 | World Journal of Clinical Cases2020，8，20： | 2 |
| 6 | Association of the Pro12Ala variant in the peroxisome proliferator activated receptor γ gene with obesity in two Caucasian populations显示文摘 | Beamer B Yen C Andersen R | 1998 | Diabetes1998，47，： | 2 |
| 7 | Ultrasonic tissue characterization evaluates myocardial viability and ischemia in patients with coronary artery disease显示文摘 | LIN L C YEN R F HWANG J J | 2000 | Ultrasound Med Biol2000，26，5： | 2 |
| 8 | Assessment of menopause-induced myocardial changes by integrated backscatter during inotropic stimulation and atropine injection显示文摘 | HO Y L LIN L C YEN M L | 2002 | Ultrasound Med Biol2002，28，7： | 2 |
| 9 | House of quality:a fuzzy logic-based requirements analysis显示文摘 | TEMPONI C YEN J TIAO W A | 1999 | European Journal of Operational Research1999，117，2： | 1 |
| 10 | Information Technology and Supply Chain Collaboration : Moderating Effects of Existing Relationships between Partners 显示文摘 | Chae B S Yen H J R Sheu C | 2005 | IEEE Transactions on Engineering Management2005，52，4： | 1 |
| 11 | Design of a multimode QC-LDPC decoder based on shift-routing network显示文摘 | Liu C Lin C Yen S | 2009 | IEEE Trans on Cir- cuits Syst II Exp Briefs2009，56，9： | 1 |
| 12 | The development of regulations for food nanotechnology显示文摘 | CHAU C F WU S H YEN G C | 2007 | Trends in Food Science & Technology2007，18，5： | 1 |
| 13 | Detection of fecal shed- ding of rotavirus vaccine in infants following their first dose of pentavalent rotavirus vaccine 显示文摘 | YEN C JAKOB K ESONA MD | 2011 | Vaccine2011，29，24： | 1 |
| 14 | Flow behavior of high strength high-performance concrete 显示文摘 | YEN T TANG C W CHANG C S CHEN K H | 1999 | Cement and Concrete Composites1999，21，： | 1 |
| 15 | Campadson of antimutagenic effect of various tea extract (green, oolong, pouching, and black tea)显示文摘 | YEN G C CHEN H Y | 2000 | Food Protect2000，57，： | 1 |
| 16 | Effect of honey on naringin absorption from a decoction of the pericarps of Citrus grandis显示文摘 | Hou Y C Hsiu S L Yen H F | 2000 | Planta Med2000，66，5： | 1 |
| 17 | The process of electrochemical deposited hydroxyapatite coatings on biomedical titanium at room temperature显示文摘 | KUO M C YEN S K | 2002 | Mater Sci Eng2002，20，： | 1 |
| 18 | PTEN,a putative protein tyrosine phosphatase gene mutated in human brain,breast,and prostate cancer显示文摘 | Li J Yen C Liaw D | 1997 | Science1997，275，25： | 1 |
| 19 | Relationship between antioxidant activity and maturity of peanut hulls显示文摘 | Yen G C Duh P D Tsai C L | 1993 | Agric Food Chem1993，41，： | 1 |
| 20 | Enterprise application integration in the electronic commerce world显示文摘 | NAVEEN Erasala YEN DAVID C RAJKUMAR T M | 2003 | Computer Standards & Interfaces2003，25，： | 1 |
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