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| 1 | Treatment with NADPH oxidase inhibitor apocynin alleviates diabetic neuropathic pain in rats显示文摘Increased reactive oxygen species by the activation of NADPH oxidase(NOX) contributes to the development of diabetic complications.Apocynin,a NOX inhibitor,increases sciatic nerve conductance and blood flow in diabetic rats.We investigated potential protective effect of apocynin in rat diabetic neuropathy and its precise mechanism of action at molecular level.Rat models of streptozotocin-induced diabetes were treated with apocynin(30 and 100 mg/kg per day,intragastrically) for 4 weeks.Mechanical hyperalgesia and allodynia were determined weekly using analgesimeter and dynamic plantar aesthesiometer.Western blot analysis and histochemistry/immunohistochemistry were performed in the lumbar spinal cord and sciatic nerve respectively.Streptozotocin injection reduced pain threshold in analgesimeter,but not in aesthesiometer.Apocynin treatment increased pain threshold dose-dependently.Western blot analysis showed an increase in catalase and NOX-p47 phox protein expression in the spinal cord.However,protein expressions of neuronal and inducible nitric oxide synthase(n NOS,i NOS),superoxide dismutase,glutathion peroxidase,nitrotyrosine,tumor necrosis factor-α,interleukin-6,interleukin-1β,aldose reductase,cyclooxygenase-2 or MAC-1(marker for increased microgliosis) in the spinal cord remained unchanged.Western blot analysis results also demonstrated that apocynin decreased NOX-p47 phox expression at both doses and catalase expression at 100 mg/kg per day.Histochemistry of diabetic sciatic nerve revealed marked degeneration.n NOS and i NOS immunoreactivities were increased,while S-100 immunoreactivity(Schwann cell marker) was decreased in sciatic nerve.Apocynin treatment reversed these changes dose-dependently.In conclusion,decreased pain threshold of diabetic rats was accompanied by increased NOX and catalase expression in the spinal cord and increased degeneration in the sciatic nerve characterized by increased NOS expression and Schwann cell loss.Apocynin treatment attenuates neuropathic pain by decelerating the increased oxidative stress-mediated pathogenesis in diabetic rats. | Murat Olukman Aytül onal Fatma Gül celenk Yigit Uyankgil Türker cavusoglu Neslihan Düzenli Sibel ülker | 2018 | Neural Regeneration Research2018，13，9： | 4 |
| 2 | Spring-dashpot models for the Dynamics of radially rotating beam with impact显示文摘 | Ulsoy A G Scott R A | 1990 | Journal of Sound and Vibration1990，142，3： | 1 |
| 3 | Further hemolytic disease of the newborn caused by anti-M 显示文摘 | Kanra T Erdem G Tekinalp G Gurgey A Yigit S Dogru D | 1996 | Am J Hematol1996，53，4： | 1 |
| 4 | Dynamics of a radially rotating beam with impact, Part 1 : Theoretical and computational model 显示文摘 | Yigit A S Ulsoy A G Scott R A | 1990 | Journal of Vibration and Acoustics1990，112，： | 1 |
| 5 | Effects of various back- wash scenarios on membrane fouling in a membrane bioreactor 显示文摘 | Yigit N O Civelekoglu G Harman I | 2009 | Desalination2009，237，123： | 1 |
| 6 | Dynamics of a radially rotating beam with impact,part 1:theoretical and computational model显示文摘 | Yigit A S Ulsoy A G Scott R A | 1990 | J of Vibration and Acoustics1990，112，： | 1 |
| 7 | Dynamics of a radially rotating beam with impact,part 2:experimental and simulation results显示文摘 | Yigit A S Ulsoy A G Scott R A | 1990 | J of Vibration and Acoustics1990，112，： | 1 |
| 8 | Ovarian cancer creates a suppressive microenvironment to escape immune elimination显示文摘 | YIGIT R MASSUGER L F FIGDOR C G | 2010 | Gynecol Oncol2010，117，2： | 1 |
| 9 | Endothelin 1 concentrationgs in infants with meconium stained amniotic fluid显示文摘 | Yigit S Tekinalp G Oran O | 2002 | Arch Dis Child Fetal Neonatal Ed2002，87，3： | 1 |
| 10 | Novelcarbapenem-hydrolyzing beta-lactamase, KPC-1, from acarbapenem-resistant strain of Klebsiella pneumoniae显示文摘 | Yigit H Queenan A M Anderson G J | 2001 | Antimicrob Agents Chemother2001，45，4： | 1 |
| 11 | Dynamics of a radially rotating beam with impact, part 1 : Theoretical and computational model 显示文摘 | Yigit A S Ulsoy A G Scott R A | 1990 | J of Vibration and Acoustics1990，112，： | 1 |
| 12 | Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae 显示文摘 | Yigit H Queenan A M Anderson G J | 2001 | Antimicrob Agents chemother2001，45，4： | 1 |
| 13 | Dynamics of a radially rotating beam with impact, part 2 : Experimental and simulation results 显示文摘 | Yigit A S Ulsoy A G Scott R A | 1990 | J of Vibration and Acoustics1990，112，： | 1 |
| 14 | Ovarian cancer creates a suppressive microenvironment to escape immune elimination显示文摘 | Yigit R Massuger L F Figdor C G | 2010 | Gynecol Oncol2010，117，2： | 1 |
| 15 | Stone disease in kidney transplantation显示文摘 | Yigit B Aydin C Altaca G | 2004 | Transplant Proc2004，36，1： | 1 |
| 16 | Spring-dashpot models for the dynamics of a radially rotating beam with impact显示文摘 | Yigit A S Ulsoy A G Scott R A | 1990 | J Sound and Vibration1990，142，3： | 1 |
| 17 | Novel earbapen- em-hydrolyzing beta-lactamase, KPC-l,from a earbapenem-re- sistant strain of Klebsiella pneumoniae显示文摘 | Yigit H Queenan A M Anderson G J | 2001 | Antimicrob Agents Chemother2001，45，4： | 1 |
| 18 | Flexural motion of a rotating beam attached to a rigid body显示文摘 | SCOTT R A ULSOY A G | 1988 | Journal of Sound and Vibration1988，121，： | 1 |
| 19 | Spring-dashpot models for the dynamics of a radially rotating beam with impact显示文摘 | Yigit A S Ulsoy A G Scott R A | 1990 | Journal of Sound and Vibration1990，142，3： | 1 |
| 20 | Ovarian cancer creates a suppressive microenvironment to escape immune elimination显示文摘 | Yigit R Massuger L F Figdor C G | 2010 | Gynecol Oncol2010，117，2： | 1 |
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