2篇
您的检索式：作者名="Yu, Haiguo"
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| 1 | Development and Application of On-line Wind Power Risk Assessment System显示文摘Because of the large-scale integration of wind power,the dynamic characteristics of power system have many uncertain effects.Based on deterministic analysis methods,traditional on-line security assessment system cannot quantitatively estimate the actual operating conditions of the power system for only considering the most serious and credible accidents.Therefore,the risk theory is introduced into an on-line security assessment system and then an on-line risk assessment system for wind power is designed and implemented by combining with the dynamic security assessment system.Based on multiple data integration,the wind power disturbance probability is available and the security assessment of the power grid can obtain security indices in different aspects.The operating risk index is an expectation of severity,computed by summing up all the products of the result probability and its severity.Analysis results are reported to the dispatchers in on-line environment,while the comprehensive weak links are automatically provided to the power dispatching center.The risk assessment system in operation can verify the reasonableness of the system. | Su, Feng Zhou, Xiaoxin Yu, Haiguo Xian, Wenjun Lü, Ying Ren, Lingyu | 2012 | 电力系统自动化2012，36，8： | 0 |
| 2 | A novel silicone derivative of natural osalmid(DCZ0858)induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma via the JAK2/STAT3 pathway显示文摘Diffuse large B-cell lymphoma(DLBCL)is a highly heterogeneous malignant tumor characterized by diffuse growth.DCZ0858 is a novel small molecule with excellent antitumor effects in DLBCL.This study explored in depth the inhibitory effect of DCZ0858 on DLBCL cell lines.Cell Counting Kit-8(CCK-8)and plate colony formation assays were used to evaluate cell proliferation levels.Flow cytometry was employed to analyze apoptosis and the cell cycle,and western blotting was used to quantify the expression of cell cycle regulators.The results indicated that DCZ0858 inhibited cell growth in a concentration-dependent and time-dependent manner while inducing no significant toxicity in normal cells.Moreover,DCZ0858 initiated cell apoptosis via both internal and external apoptotic pathways.DCZ0858 also induced cell cycle arrest in the G0/G1 phase,thereby controlling cell proliferation.Further investigation of the molecular mechanism showed that the JAK2/STAT3 pathway was involved in the DCZ0858-mediated antitumor effects and that JAK2 was the key target for DCZ0858 treatment.Knockdown of JAK2 partly weakened the DCZ0858-mediated antitumor effect in DLBCL cells,while JAK2 overexpression strengthened the effect of DCZ0858 in DLBCL cells.Moreover,a similar antitumor effect was observed for DCZ0858 and the JAK2 inhibitor ruxolitinib,and combining the two could significantly enhance cancer-suppressive signaling.Tumor xenograft models showed that DCZ0858 inhibited tumor growth in vivo and had low toxicity in important organs,findings that were consistent with the in vitro data.In summary,DCZ0858 is a promising drug for the treatment of DLBCL. | Kang Lu Bo Li Hui Zhang Zhijian Xu Dongliang Song Lu Gao Haiguo Sun Liping Li Yingcong Wang Qilin Feng Gege Chen Liangning Hu Rong Wei Yongsheng Xie Dandan Yu Xiaosong Wu Weiliang Zhu Jumei Shi | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
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