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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Human mesenchymal stem cells overexpressing pigment epitheliumderived factor inhibit hepatocellular carcinoma in nude mice(摘要)显示文摘 | Gao, Y Yao, A Zhang, W Lu, S Yu, Y Deng, L Yin, A Xia, Y Sun, B Wang, X | 2010 | 南京医科大学学报(自然科学版)2010，30，8： | 25 |
| 3 | The precipitation strengthening behavior of Cu-rich phase in Nb contained advanced Fe-Cr-Ni type austenitic heat resistant steel for USC power plant application | Cheng-yu Chi a, Hong-yao Yu b, Jian-xin Dong b, Wen-qing Liu c, Shi-chang Cheng d, Zheng-dong Liu d, Xi-shan Xie b a School of Metallurgical and Ecological Engineering, University of Science & Technology Beijing, Beijing 100083, China b School of Materials Science and Engineering, University of Science & Technology Beijing, Beijing 100083, China c Instrumental Analysis & Research Center, Shanghai University, Shanghai 200444, China d Central Iron and Steel Research Institute, Beijing 100081, China | 2012 | Progress in Natural Science:Materials International2012，22，3： | 20 |
| 4 | Genes associated with testicular germ cell tumors and testicular dysgenesis in patients with testicular microlithiasis显示文摘阴囊的 microlithiasis (TM ) 是阴囊的 dysgenesis 症候群(TDS ) 的症状之一。TM 作为阴囊的细菌房间肿瘤(TGCT ) 的一个增进知识的标记特别地有趣。工具包 ligand 基因( KITLG ), BCL2 对手/杀手 1 ( BAK1 ),并且表明对手 4 的 sprouty RTK ( SPRY4 ),基因与 TGCT 的高风险被联系骨头形态基因的蛋白质 7 基因( BMP7 ),转变生长因素贝它受体 3 基因( TGFBR3 ),并且 homeobox D 簇基因( HOXD )与 TDS 有关。使用的聚合酶链反应限制碎片长度多型性( PCR-RFLP )分析,我们为 KITLG 调查了等位基因和遗传型频率( rs995030 , rs1508595 ), SPRY4 ( rs4624820 , rs6897876 ), BAK1 ( rs210138 ), BMP7 ( rs388286 ), TGFBR3 ( rs12082710 ),并且在 142 个 TGCT 病人, 137 个 TM 病人,和 153 个肥沃的人(控制组)的 HOXD ( rs17198432 )。我们在 TM 在 KITLG GG_rs995030 遗传型发现了重要差别(P = 0.01 ) 并且 TGCT 病人(P = 0.0005 ) 与控制相比。我们也揭示了在 KITLG_rs1508595 和 TM 之间的强壮的协会(G 等位基因, P = 0.003;GG 遗传型, P = 0.01 ) 并且在 KITLG_rs1508595 和 TGCT 之间(G 等位基因, P = 0.0001;GG 遗传型, P = 0.0007 ) 。而且,在在 TGCT 组和控制之间的 BMP7_rs388286 有重要差别(T 等位基因, P = 0.00004;TT 遗传型, P = 0.00006 ) 并且在 TM 组和控制之间(T 等位基因, P = 0.04 ) 。HOXD 也与 TGCT 表明了一个强壮的协会(rs17198432 A 等位基因, P = 0.0001;AA 遗传型, P = 0.001 ) 。而且,重要差别在 BAK1_rs210138 G 等位基因在 TGCT 组和控制之间被发现(P = 0.03 ) 并且 GG 遗传型(P = 0.01 ) 。KITLG 和 BMP7 基因,与 TGCT 的发展联系了,可能也与 TM 有关。在摘要, KITLG GG_rs995030, GG_rs1508595, BMP7 TT_rs388286, HOXD AA_rs17198432,和 BAK1 GG_rs210138,遗传型与 TGCT 开发的高风险被联系。 | Ilya S Dantsev Evgeniy V Ivkin Aleksey A Tryakin Dmitriy N Godlevski Oleg Yu Latyshev Victoriya V Rudenko Dmitry S Mikhaylenko Vyacheslav B Chernykh Elena A Volodko Aleksey B Okulov Oleg B Loran Marina V Nemtsova | 2018 | Asian Journal of Andrology2018，20，6： | 4 |
| 5 | ^(99m)Tc-AMD3100:A novel potential receptor-targeting radiopharmaceutical for tumor imaging显示文摘The chemokine CXCR4 receptor is over-expressed in a wide variety of tumors.In this study,AMD3100,which was a prototype non-peptide antagonist of CXCR4 receptor,was labeled with ^(99m)Tc.^(99m)Tc-AMD3100 was verified by thin layer radio chromatography(TLRC).The tumor-localizing properties of ^(99m)Tc-AMD3100 were evaluated and proved in mice bearing Hep-G2 tumor xenograft.^(99m)Tc-AMD3100 was a promising,novel receptor-specific radiopharmaceutical with potential application in the imaging of human tumors. | Jin Ming Zhang~(a,),Jia He Tian~a,Tian Ran Li~a, Hai Yu Guo~a,Li Shen~b a Department of Nuclear Medicine,The PLA General Hospital,Beijing,100853,China b Peking University Health Science Center,Beijing,100191,China | 2010 | Chinese Chemical Letters2010，21，4： | 3 |
| 6 | Lymph node ratio and preoperative CA 19-9 levels predict overall survival and recurrence-free survival in patients with resected pancreatic adenocarcinoma显示文摘AIM:Clinicopathologic factors predicting overall survival (OS) would help identify a subset to benefit from adjuvant therapy. METHODS: One hundred and sixty-nine patients patients from 1984 to 2009 with curative resections for pancreatic adenocarcinoma were included. Tumors were staged by American Joint Committee on Cancer 7th edition criteria. Univariate and multivariable analyses were performed using Kaplan-Meier methodology or Cox proportional hazard models. Log-rank tests were performed. Statistical inferences were assessed by two-sided 5% significance level. RESULTS: Median age was 67.1 (57.2-73.0) years with equal gender distribution. Tumors were in the head (89.3%) or body/tail (10.7%). On univariate analysis, adjuvant therapy, lymph node (LN) ratio, histologic grade, negative margin status, absence of peripancreatic extension, and T stage were associated with improved OS. Adjuvant therapy, LN ratio, histologic grade, number of nodes examined, negative LN status, and absence of peripancreatic extension were associated with improved recurrence-free survival (RFS). On multivariable analysis, LN ratio and carbohydrate antigen (CA) 19-9 levels were associated with OS. LN ratio was associated with RFS. CONCLUSION: The LN ratio and CA 19-9 levels are independent prognostic factors following curative resections of pancreatic cancer. | Sabrina C Wentz Zhi-Guo Zhao Yu Shyr Chan-Juan Shi Kay Washington Nipun B Merchant Fen Xia A Bapsi Chakravarthy | 2012 | World Journal of Gastrointestinal Oncology2012，4，10： | 3 |
| 7 | Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas显示文摘Pancreatic cancer is one of the deadliest cancers with a very poor prognosis. Recently, there has been a significant increase in research directed towards identifying potential biomarkers that can be used to diagnose and provide prognostic information for pancreatic cancer. These markers can be used clinically to optimize and personalize therapy for individual patients. In this review, we focused on 3 biomarkers involved in the DNA damage response pathway and the necroptosis pathway: Chromodomainhelicase-DNA binding protein 5, chromodomain-helicaseDNA binding protein 7, and mixed lineage kinase domain-like protein. The aim of this article is to review present literature provided for these biomarkers and current studies in which their effectiveness as prognostic biomarkers are analyzed in order to determine their future use as biomarkers in clinical medicine. Based on the data presented, these biomarkers warrant further investigation,and should be validated in future studies. | Crystal S Seldon Lauren E Colbert William A Hall Sarah B Fisher David S Yu Jerome C Landry | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 8 | Laboratory diffractometer-based XAFS spectrometer显示文摘 | Shuvaev A T Helmer B Yu Lyubeznova T A | 1999 | J Synchrotron Rad1999，6，： | 2 |
| 9 | 高功率重频电化学HF激光器(英文)显示文摘研制了高功率、高重频非链式HF激光器,并研究了脉冲模式和重频模式下在SF6的混合气中增加电极边缘电场强度而不使用其它措施即可实现自持体引发放电的可能性,得到了重复频率为20 Hz,脉冲能量为67 J,转换效率为3%的激光输出。 | BULAEV V D GUSEV V S FIRSOV K N KAZANTSEV S Yu KONONOV I G LYSENKO S L MOROSOV Yu B POZNYSHEV A N | 2011 | 中国光学2011，4，1： | 2 |
| 10 | 基于XeF(C-A)放大器的混合(固态/气态)超高功率飞秒激光系统(英文)显示文摘提出了基于前端发生器和终端放大器,使用光泵浦XeF(C-A)激活介质的太瓦级混合激光器(THL-100)系统。前端发生器由长532 nm的连续激光泵浦的钛宝石飞秒脉冲振荡器,脉冲展宽机构,532 nm的脉冲激光泵浦的再生多通道放大器,衍射光栅压缩器和二次谐波发生器(KDP)组成。其光束输出参数为:脉冲持续时间50 fs,二次谐波(475 nm)辐射能量5 mJ。前端发生器以10 Hz的单脉冲模式工作。XeF(C-A)放大器由双高压脉冲发生器(线性变压器),爆炸式阴极发射真空二极管,电子束注入系统,充满Xe的气室转换器和激光单元组成。高压发生器包括12个变压器,每个变压器有8个电容(40 nF)和火花隙,电容可以充电至100 kV。真空二极管中的电子束参数为:总电流300 kA,峰值电压550kV,脉冲持续时间约150 ns。穿透金属箔片到达Xe转换器的6个100 cm×12 cm电子束的总能量为67 kJ。激光系统通过泵浦能量的级联处理导致Xe2*的快速形成,并在(172±5)nm连续辐射。真空紫外辐射通过CaF2窗口辐射到含有XeF2蒸汽和氮气缓冲气体的激光单元中,使XeF2光解,形成XeF*准分子。由真空紫外辐射泵浦的放大器激活介质长110 cm,直径为24 cm。文中通过数值模拟给出了输出参数和第一实验结果,根据XeF(C-A)放大器参数模型和增益测量结果,得到的输出能量高达23 J,这意味着50 fs脉冲的峰值功率高达4060 TW。 | LOSEV V ALEKSEEV S IVANOV N KOVALCHUK B MIKHEEVL MESYATS G PANCHENKO Yu PUCHIKIN A RATAKHIN N YASTREMSKY A | 2011 | 光学精密工程2011，19，2： | 2 |
| 11 | Porosity calculations of multi-component mixtures of spherical particles 显示文摘 | YU A B STANDISH N | 1987 | Powder Technol1987，52，： | 2 |
| 12 | Fine mapping of a C-terminal linear epitope highly conserved among the major envelope gly coprotein E2 (gpS1 to gp54) of different pestiviruses显示文摘 | Yu M Wang L F Shiell B J Morrissy C J Westbury H A | 1996 | Virology1996，222，： | 1 |
| 13 | Modeling Discontinuous Liquid Flow in a Blast Furnace显示文摘 | Wang G X Chew S J Yu A B | 1997 | Metallurgical and Materials Transactions1997，28，2： | 1 |
| 14 | Formation condi- tions and regularities of the distribution of large and superlarge baux- ite deposits显示文摘 | Bogatyrev B A Zhukov V V Tsekhovsky Yu G | 2009 | Lithology and Mineral Resources2009，44，2： | 1 |
| 15 | Assessment of model formulations in the discrete particle simulation of gas-solid flow 显示文摘 | Feng Y Q Yu A B | 2004 | Industrial & Engineering Chemistry Research2004，43，26： | 1 |
| 16 | DEM simulation of particle flow on a multi-deck banana screen显示文摘 | DONG K J YU A B BRAKE I | 2009 | Minerals Engineering2009，22，： | 1 |
| 17 | DEM study of the transverse mixing of wet particles in rotating drums显示文摘 | LIU P Y YANG R Y YU A B | 2013 | Chemical Engineering Science2013，86，： | 1 |
| 18 | Automatic text location in images and video frames显示文摘 | JAIN A K YU B | 1998 | Pattern Recognition1998，31，12： | 1 |
| 19 | Numerical simulation of the gasparticle flow in a fluidized bed by combining discrete particle method with computational fluid dynamics 显示文摘 | XU B H YU A B | 1997 | Chemical Engineering Science1997，52，： | 1 |
| 20 | Efficient inverted solar cells using TiO, nanotube arrays 显示文摘 | YU B Y TSAI A TSAI S P | 2008 | Nanotechnology2008，19，25： | 1 |
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