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| 1 | The clinicopathological and prognostic significance of PD-L1 expression in pancreatic cancer:A meta-analysis显示文摘Background: Immunotherapy has shown promise against solid tumors. However, the clinical significance of programmed cell death 1(PD-1) and programmed cell death ligand 1(PD-L1) in pancreatic ductal adenocarcinoma(PDAC) remains unclear. This meta-analysis aimed to analyze the prognostic effect of PD-L1 in PDAC.Data sources: Electronic search of the Pub Med, Cochrane Library and Web of Science was performed until December 2016. Through database searches, we identified articles describing the relationship between PD-L1 status and PDAC patient prognosis. Meta-analysis was performed to investigate the relationship between PD-1 and overall survival(OS).Results: Nine studies with 989 PDAC patients were included for PD-L1 expression analysis. And 5 studies with 688 PDAC patients were included in the prognostic analysis. The PD-L1 positive rate measured by immunohistochemistry(IHC) was higher than that measured by polymerase chain reaction(PCR)(P < 0.001). PDAC patients with high expression levels of PD-L1 had significantly reduced OS(HR = 2.34;95% CI: 1.78–3.08). Subgroup analysis showed that the prognostic effect of PD-L1 levels was similar between the IHC and PCR methods. The PD-L1 positive rate was associated with PDAC T stages; the PD-L1 positive rate in the T3–4 group was higher than that in the T1-2 group(OR = 0.37; P = 0.001).Conclusions: High PD-L1 expression levels predicted a poor prognosis in PDAC patients. Thus, PD-L1 status helps determine treatment in PDAC patients. | He-Li Gaoa Liang Liua Zi-Hao Qi Hua-Xiang Xu Wen-Quan Wang Chun-Tao Wu Shi-Rong Zhang Jin-Zhi Xu Quan-Xing Ni Xian-Jun Yua | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，2： | 13 |
| 2 | Comparative pharmacokinetics of chlorogenic acid after oral administration in rats显示文摘The present study was aimed at the comparison of the pharmacokinetics of pure chlorogenic acid and extract of Solanum lyratum Thunb.The animals were allocated to two groups,and were administered chlorogenic acid or extract of S.lyratum Thunb.at a dose of 50.0 mg/kg orally.Blood samples were collected up to 8 h post-dosing.Plasma chlorogenic acid analyses were performed using an HPLC method with UV detector.The pharmacokinetic parameters were evaluated using non-compartmental assessment.Significant differences existed in the two groups for AUC 0 t,AUC 0 N and CLz/F.The reliable HPLC method was successfully applied to the determination of chlorogenic acid in rat plasma at dosage of 50.0 mg/kg. | Wei Qi Ting Zhao Wen-Wen Yang Guang-Hou Wang Hua Yua Hai-Xiao Zhao Chen Yang Li-Xin Suna | 2011 | Journal of Pharmaceutical Analysis2011，1，4： | 6 |
| 3 | The Treatment of Mid-shaft Clavicle Fractures显示文摘 | Qing-Hua Sang Zhi-Gang Gou Hua-Yong Zheng Jing-Tao Yua Jian-Wen Zhao Hong-Ying He Chuang Liu Zhi Liu | 2015 | Chinese Medical Journal2015，，21： | 5 |
| 4 | Structural Design and Application of Azo-based Supramolecular Polymer Systems显示文摘This article presents a brief overview of recent advances in azo-containing supramolecular systems.In literature,it has been shown that azo supramolecular polymers and their composite materials exhibit fast and intelligent responses to various external stimuli,such as temperature,pH change,redox reagents,ligands,coupling reagents,etc.In applications,these systems are widely used for molecular motors,shape memory,liquid crystal,solar thermal energy storage,signal transmission,intelligent encryption,and other purposes.Furthermore,these systems can function as key components for device upgrade processing.However,the design and rules of azo supramolecular polymers are still not supported by an exact theory.Information about the relationship between the spatial structure and behavior is lacking,and new supramolecular materials cannot be designed by adding functional moieties to known azo polymers.Based on the current research status,this review mainly summarizes the structural design principles as well as structures and applications of known azo supramolecules;meanwhile,it highlights the emerging development fields,recent advances,and prospects in fabricating sei住assembling intelligent supramolecular systems with azo supramolecular polymers as responsive units.The goal of this review is to bring new inspiration to researchers who want to optimize the chemical structure,steric conformation,electrostatic environment,and specific molecular functionalization. | Hui-Tao Yua Jun-Wen Tang Yi-Yu Feng Wei Feng | 2019 | Chinese Journal of Polymer Science2019，37，12： | 4 |
| 5 | Interactions of pyrogallol red with proteins and the determination of proteins by resonance light-scattering | Hu Xiaoli, female, 35 years old, instructor. * Supported by the National Natural Science Foundation of China (NSFC) and the Municipal Science Foundation of Chongqing for Young and Middle Scientists (No: 97-4729). Hu Xiaoli, Feng Ping, Li Yua | 1998 | 西南师范大学学报(自然科学版)1998，23，5： | 3 |
| 6 | Multi-scale synergic optimization strategy for dielectric energy storage ceramics显示文摘Dielectric capacitors,serving as the indispensable components in advanced high-power energy storage devices,have attracted ever-increasing attention with the rapid development of science and technology.Among various dielectric capacitors,ceramic capacitors with perovskite structures show unique advantages in actual application,e.g.,excellent adaptability in high-temperature environments.And the optimization of their energy storage performance has become a hot research topic recently.This review presents the basic principles of energy storage in dielectric ceramics and introduces multi-scale synergic optimization strategies according to the key factors for superior energy storage performance.By summarizing the common points in numerous works,several universal modification strategies are reviewed,and future research on fatigue fracture of ceramic capacitors under multi-field including but not limited to force,electric,and thermal coupling conditions is also anticipated. | Xuhui Fan Jing Wang Hao Yua Zehan Zheng Ji Zhang Kongjun Zhu | 2023 | Journal of Advanced Ceramics2023，12，4： | 2 |
| 7 | Preparative separation and purification of deoxyschizandrin from Schisandrae Sphenantherae Fructus by high-speed counter-current chromatography显示文摘A high-speed counter-current chromatography(HSCCC)method was successfully developed for the preparative separation and purification of deoxyschizandrin from Schisandrae Sphenantherae Fructus in one step.The purity of deoxyschizandrin was 98.5%,and the structure was identified by MS,UV and NMR.This method was simple,fast,convenient and appropriate to prepare pure compound as reference substances for related research on Schisandrae Sphenantherae Fructus. | Xin-Ying Li Mei Yang Jie-Yun Huang Xiao-Xue Yua Min-Qian Zhao Zhi-Kun Liang Zhi-Sheng Xie Xin-Jun Xu | 2013 | Journal of Pharmaceutical Analysis2013，3，6： | 2 |
| 8 | Synthesis of the ABC skeleton of the aglycon of Echinoside A显示文摘Echinoside A is a triterpene saponin isolated from the sea cucumber Actinopyga echinites(JAEGER), which displays potent antitumor activities in vitro and in vivo. Here, we report the synthesis of the ABC-fused ring skeleton of the aglycon of Echinoside A, with the enantiomerically pure(+)-Wieland–Miescher ketone being used as starting material and a Robinson annulation as the key reaction. | Jun Yu Biao Yua | 2015 | Chinese Chemical Letters2015，26，11： | 2 |
| 9 | Blockchain-based continuous data integrity checking protocol with zero-knowledge privacy protection显示文摘The cloud computing technology has emerged,developed,and matured in recent years,consequently commercializing remote outsourcing storage services.An increasing number of companies and individuals have chosen the cloud to store their data.However,accidents,such as cloud server downtime,cloud data loss,and accidental deletion,are serious issues for some applications that need to run around the clock.For some mission and business-critical applications,the continuous availability of outsourcing storage services is also necessary to protect users'outsourced data during downtime.Nevertheless,ensuring the continuous availability of data in public cloud data integrity auditing protocols leads to data privacy issues because auditors can obtain the data content of users by a sufficient number of storage proofs.Therefore,protecting data privacy is a burning issue.In addition,existing data integrity auditing schemes that rely on semi-trusted third-party auditors have several security problems,including single points of failure and performance bottlenecks.To deal with these issues,we propose herein a blockchain-based continuous data integrity checking protocol with zero-knowledge privacy protection.We realize a concrete construction by using a verifiable delay function with high efficiency and proof of retrievability,and prove the security of the proposal in a random oracle model.The proposed construction supports dynamic updates for the outsourced data.We also design smart contracts to ensure fairness among the parties involved.Finally,we implement the protocols,and the experimental results demonstrate the efficiency of the proposed protocol. | Yiting Huang Yong Yua Huilin Li Yannan Li Aikui Tian | 2022 | Digital Communications and Networks2022，8，5： | 2 |
| 10 | Investigation of the interaction between HIV-1 DNA and cyclic peptides by electrospray ionization mass spectrometry显示文摘在 HIV-1 DNA 和五周期的肽之间的相互作用(CP1– CP5 ) 用电镀物品被调查祈祷电离团 spectrometry (ESIMS ) 。它揭示了那 CP1 [c (Ala-Tyr-Leu-Ala-Gly )] 并且 CP4 [c (Pro-D-Tyr-Leu-D-Ala-Gly )] 在五周期的肽之中与双 DNA 有更高有约束力的亲密关系。 | Yi Quan Liu Hui Hui Li Yun Hua Ye Gu Yua | 2009 | Chinese Chemical Letters2009，20，3： | 2 |
| 11 | Human health risk assessment of chlorinated disinfection by-products in drinking water using a probabilistic approach显示文摘 | Hamidina N Yua Q J Connellb D W | | 0，，13： | 1 |
| 12 | Simultaneous nitrification, denitrificaiton, and biological phosphorus removal in a lab scale sequencing batch reactor 显示文摘 | Zeng R Lemaire R Yua Z | 2003 | Journal of Biotechnology2003，84，： | 1 |
| 13 | The identificE,tion and assess- ment of ecological risks for land consolidation based on the an- ticipation of ecosystem stabilization: a case study in Hubei Province China显示文摘 | Guangming Yua Jing Feng | 2010 | Land Use Policy2010，，27： | 1 |
| 14 | Neutron diffraction residual strain measurements in post-treated thermal spray cermet eoatings显示文摘 | AHMEDA R YUA H STOICAA V | 2008 | Materials Science and Engineering A2008，498，： | 1 |
| 15 | Development and evaluation of penciclovir-loaded solid lipid nanoparticles for topical de- livery显示文摘 | Lv QZ Yua AH Yd YW | 2009 | Int J Pharm2009，372，12： | 1 |
| 16 | Electrochemical preparation of NiA1 intermetallic compound from solid oxides in molten CaCl2 and its corrosion behaviors in NaC1 aqueous solution 显示文摘 | Huayi Yina Tang Yua Diyong Tanga | 2012 | Materials Chemistry and Physics2012，133，： | 1 |
| 17 | Analyzing Netizens 'View and Reply Behaviors on the Forum显示文摘 | Jiefei Yua Yanqing Hua Min Yub | 2010 | Physica A2010，，389： | 1 |
| 18 | High concentrationpowdered activated carbon-membrane bioreactor(PAC-MBR)forslightly polluted surface water treatment at low temperature显示文摘 | Cong Ma Shuili Yua Wenxin Shi | 2012 | Bioresource Technology2012，113，： | 1 |
| 19 | Control of grain size, shape and quality by OsSPL16 in rice显示文摘 | Wang S K Wu K Yua Q B Liu X Y Liu Z B Lin X Y Zeng R Z Zhu H T Dong G J Qian Q Zhang G Q Fu X D | 2012 | Nature Genetics2012，44，8： | 1 |
| 20 | Formulation design of microemulsion for dermal delivery of penciclovir 显示文摘 | Zhua W W Yua A H | 2008 | International Journal of Pharma ceutics2008，360，2： | 1 |
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