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| 1 | Microsatellite analysis of genetic diversity and population structure of Chinese mitten crab (Eriocheir sinensis)显示文摘中国露指手套螃蟹(Eriocheir sinensis ) 在中国比 Eriocheir 的任何另外的种类作为食物来源有更高商业的价值。为了评估细菌原生质资源并且在不同的水系统,二张股票和二张耕作人口描绘基因差异和螃蟹的人口结构,与在公共场合可得到的 25 多态的 microsallite loci 被估计 GenBank。基本统计证明一般水准观察了杂合现象(惊讶) 在人口之中从 0.5789 ~ 0.6824 。然而,使近交的显著存在和异质接合体缺乏被观察。到分析人口结构,配对系数从露指手套螃蟹人口的分向仅仅 10.3% 可变性解释了的明智的 FST,留下的可变性在潜水艇人口以内源自分。尽管四张人口有细微区别,不同突变而产生之遗传的频率导致了不同人口结构。二张股票和股票耕作人口一起被聚类到 Yangtze 螃蟹的种系发生的分支,与 95% 的一个近似会员。而,另一张耕作人口单身地被聚类到 Liaohe 螃蟹的种系发生的分支,与 97.1% 的一个会员。为单个混合的测试证明那只 Yangtze 螃蟹可能从另外的水系统与个人一起被污染了。在人口之间的基因关系也支持了尽管有一样的种类的起源,那只 Yangtze 螃蟹和 Liaohe 螃蟹有不同基因库的结论。 | Yumei Chang Liqun Liang Haitao Ma Jianguo He Xiaowen Sun | 2008 | Journal of Genetics and Genomics2008，35，3： | 29 |
| 2 | Characteristics of change in water quality along reclaimed water intake area of the Chaobai River in Beijing, China显示文摘To reveal the basic characteristics and controlling factors of water quality change in the project Wenyu to Chaobai reclaimed water diversion, the water quality in the study area was monitored for one year at seven monitoring sites. Inverse geochemical models of the statistical groups were developed using PHREEQC to elucidate the hydrochemistry characteristics of reclaimed water and the factors. The monitoring results indicated that nitrogen and phosphorus contents were significantly reduced along the river mainly caused by seasonal and location variation. The pH ranged from 7.44 to 9.81. Photosynthesis of algae and denitrification in anaerobic microenvironment ultimately led to a sudden p H increase after the Jian River and the Chaobai River confluence. Mg^(2+)and SO_4^(2-) levels dropped obviously in the summer and increased in winter seasons after intersection. Na+and Cl-are relatively stable, and marked drop in the concentration only after the two rivers meet. And there is a decrease of Ca^(2+) and HCO^(3-) and increase in CO_3^(2-) during monitoring period. As a whole, the primary ions and nutrient components, including nitrogen and phosphorus, had high levels in winter. Algae's photosynthesis and respiration were observed to have an impact on the river water quality; there was precipitation–dissolution of minerals and denitrification from upstream to downstream. Inverse geochemical PHREEQC modeling confirmed that there was precipitation of aragonite or calcite, and gypsum or anhydrite in summer, and dissolution in winter; as well as precipitation of dolomite in winter, and cationic exchange and denitrification along the river. | Lei Yang Jiangtao He Yumei Liu Jian Wang Lie Jiang Guangcai Wang | 2016 | Journal of Environmental Sciences2016，28，12： | 14 |
| 3 | Optimized clinical practice for superaged patients with hip fracture:significance of damage control and enhanced recovery program显示文摘With the advent of global aging,the incidence,mortality,and medical costs of hip fracture among aged patients are increasing annually.The number of controlled clinical studies and health economics analyses that conform to evidence-based medicine principles is growing day by day.However,unfortunately,no specific recommendations regarding the procedures for the treatment of hip fracture are available.Meanwhile,the existence of both traditional treatment systems and new treatment theories means that most doctors confront difficult choices in their daily practice.These factors make the therapeutic approach for aged patients,especially among superaged patients with hip fracture,extremely challenging.This study focuses on superaged patients(>80 years as defined by the World Health Organization)with hip fracture and includes their preoperative pathological condition;therapeutic decision-making in terms of the benefit and risk ratio,damage control theory,and enhanced recovery after surgery were also investigated.These patients were discussed specifically by combining the current treatment strategies from several experts and the results of a meta-analysis published recently.The study presents some new ideas and approaches currently recognized in the field,such as preoperative assessment,surgical planning,safety consideration,complication intervention,and enhanced recovery implementation,and further presents some clear interpretations regarding misunderstandings in clinical practice.Finally,optimized treatment according to damage control principles and enhanced recovery after surgery during the perioperative period among superaged hip fracture patients is defined. | Zaiyang Liu Jun Zhang Kaiqi He Yumei Zhang Yuan Zhang | 2019 | Burns & Trauma2019，7，1： | 9 |
| 4 | Human telomeric proteins occupy selective interstitial sites显示文摘人的 telomeres 被在六核心 telomeric 蛋白质 RAP1, TRF1, TRF2, TIN2, TPP1,和 POT1 附近装配的蛋白质建筑群绑并且保护。telomeres 上的这些蛋白质的功能广泛地被学习了。最近,增加证据在 telomeres 外面为这些蛋白质建议了可能的角色。然而,不在经典中(extra-telomeric ) 人的 telomeric 蛋白质遗体的功能糟糕理解。到这个目的,我们系统地沿着人的染色体调查了 telomeric 蛋白质的有约束力的地点,由执行为 RAP1 和 TRF2 的整个染色体的染色质 immunoprecipitation (薄片) 。(ChIP-seq ) 薄片定序表明 RAP1 和 TRF2 能在空隙的地点的一个小数字上被发现,包括对基因近似的区域。一些这些有约束力的地点包含短 telomere 重复,建议蛋白质能直接绑在空隙的地点的那 telomeric。有趣地,仅仅可得到的空隙的 telomere 的小部分包含重复的区域被 RAP1 和 TRF2 占据。宫外地表示的 TRF2 能占据另外的空隙的 telomere 重复地点,建议蛋白质集中可以支配到空隙的地点的 telomeric 蛋白质的选择指向。由 RNA 干扰减少 RAP1 和 TRF2 表示导致了指向 RAP1 、指向 TRF2 的基因的改变的抄写。我们的结果显示人的 telomeric 蛋白质能占据一小部分空隙的地点并且调整基因抄写。 | Dong Yang Yuanyan Xiong Hyeung Kim Quanyuan He Yumei Li Rui Chen Zhou Songyang | 2011 | Cell Research2011，21，7： | 7 |
| 5 | Nanoporous titanium implant surface promotes osteogenesis by suppressing osteoclastogenesis via integrin β1/FAKpY397/MAPK pathway显示文摘Macrophages and osteoclasts are both derived from monocyte/macrophage lineage,which plays as the osteoclastic part of bone metabolism.Although they are regulated by bone implant surface nanoarchitecture and involved in osseointegration,the beneath mechanism has not been simultaneously analyzed in a given surface model and their communication with osteoblasts is also blurring.Here,the effect of implant surface topography on monocyte/macrophage lineage osteoclastogenesis and the subsequent effect on osteogenesis are systematically investigated.The nanoporous surface is fabricated on titanium implant by etching and anodizing to get the nanotubes structure.The early bone formation around implant is significantly accelerated by the nanoporous surface in vivo.Meanwhile,the macrophage recruitment and osteoclast formation are increased and decreased respectively.Mechanistically,the integrin mediated FAK phosphorylation and its downstream MAPK pathway(p-p38)are significantly downregulated by the nanoporous surface,which account for the inhibition of osteoclastogenesis.In addition,the nanoporous surface can alleviate the inhibition of osteoclasts on osteogenesis by changing the secretion of clastokines,and accelerate bone regeneration by macrophage cytokine profiles.In conclusion,these data indicate that physical topography of implant surface is a critical factor modulating monocyte/macrophage lineage commitment,which provides theoretical guidance and mechanism basis for promoting osseointegration by coupling the osteogenesis and osteoclastogenesis. | Yide He Zhe Li Xin Ding Boya Xu Jinjin Wang Yi Li Fanghao Chen Fanhui Meng Wen Song Yumei Zhang | 2022 | Bioactive Materials2022，7，2： | 4 |
| 6 | Growing vertical aligned mesoporous silica thin film on nanoporous substrate for enhanced degradation,drug delivery and bioactivity显示文摘Mesoporous silica thin film has been widely used in various fields,particularly the medical implant coating for drug delivery.However,some drawbacks remain with the films produced by traditional method(evaporation-induced self-assembly,EISA),such as the poor permeability caused by their horizontal aligned mesochannels.In this study,the vertical aligned mesoporous silica thin film(VMSTF)is uniformly grown alongside the walls of titania nanotubes array via a biphase stratification growth method,resulting in a hierarchical two-layered nanotubular structure.Due to the exposure of opened mesopores,VMSTF exhibits more appealing performances,including rapid degradation,efficient small-molecular drug(dexamethasone)loading and release,enhanced early adhesion and osteogenic differentiation of MC3T3-E1 cells.This is the first time successfully depositing VMSTF on nanoporous substrate and our findings suggest that the VMSTF may be a promising candidate for bone implant surface coating to obtain bioactive performances. | Zhe Li Yide He Lasse Hyldgaard Klausen Ning Yan Jing Liu Fanghao Chen Wen Song Mingdong Dong Yumei Zhang | 2021 | Bioactive Materials2021，6，5： | 4 |
| 7 | Pathogenesis and multidisciplinary management of medication-related osteonecrosis of the jaw显示文摘Medication-related osteonecrosis of the jaw(MRONJ)is a serious side effect of bone-modifying agents and inhibits angiogenesis agents.Although the pathogenesis of MRONJ is not entirely clear,multiple factors may be involved in specific microenvironments.The TGF-β1 signalling pathway may have a key role in the development of MRONJ.According to the clinical stage,multiple variables should be considered when selecting the most appropriate treatment.Therefore,the prevention and management of treatment of MRONJ should be conducted in patient-centred multidisciplinary team collaborative networks with oncologists,dentists and dental specialists.This would comprise a closed responsibility treatment loop with all benefits directed to the patient.Thus,in the present review,we aimed to summarise the pathogenesis,risk factors,imaging features,clinical staging,therapeutic methods,prevention and treatment strategies associated with MRONJ,which may provide a reference that can inform preventive strategies and improve the quality of life for patients in the future. | Lina He Xiangyu Sun Zhijie Liu Yanfen Qiu Yumei Niu | 2020 | International Journal of Oral Science2020，12，3： | 4 |
| 8 | Interference of CsGPA1,theα-submit of G protein,reduces drought tolerance in cucumber seedlings显示文摘The G proteinα-subunit,GPA1,is an integral component of several signaling pathways in plants,including response to abiotic stress.However,the molecular mechanism behind these processes remains largely unknown in the cucumber plant(Cucumis sativus L.).In order to further understand the role of CsGPA1 in cucumber under drought stress,changes in plant growth,physiological parameters,and gene expression of CsAQPs were all measured under water stress induced by polyethylene glycol(PEG)using wild type(WT)and CsGPA1-interference(RNAi)cucumber seedlings.Our results demonstrated that the RNAi plants had lower drought tolerance,displaying seriously withered leaves,lower relative growth rate,lower root-shoot ratio,and lower root activity under drought stress compared to WT plants.Physiological studies indicated that the suppression of CsGPA1 weakened drought stress tolerance due to higherwater loss rate in the leaves,higher levels of hydrogen peroxide(H2O2),increased malondialdehyde(MDA)content,lower free proline content,lower soluble sugar content,lower soluble protein content,and decreased antioxidant enzyme activities.qRT-PCR analysis demonstrated that the interference of CsGPA1 up-regulated the expression of most AQP genes(except for CsPIP2;3 in leaves)and down-regulated the expression of CsPIP1;2,CsPIP1;4,CsPIP2;1,and CsPIP2;4 in roots under drought stress when compared to WT plants.Our results demonstrated that CsGPA1 could function as a positive regulator in drought stress response by decreasing the accumulation of reactive oxygen species(ROS),improving permeable potentials,and reducing water loss in cucumber plants. | Yumei Liu Qinghua Du Longqiang Bai Mintao Sun Yansu Li Chaoxing He Jun Wang Xianchang Yu Yan Yan | 2021 | Horticultural Plant Journal2021，7，3： | 3 |
| 9 | Design and im- plementation of mine-map management information system based on B/S model显示文摘 | He Hujun Yan Yumei Li Wanling | 2012 | Applied Mechanics and Materials2012，，12： | 1 |
| 10 | Evolution of microbial community diversity and enzymatic activity during composting显示文摘 | Yumei He Kaizhi Xie Peizhi Xu Xu Huang Wenjie Gu Fabao Zhang Shuanhu Tang | 2012 | Research in Microbiology2012，，： | 1 |
| 11 | Miscibility,morpholo-gy,thermal,and mechanical properties of a DGEBA based epoxyresin toughened with a liquid rubber显示文摘 | Thomas R Ding Yumei He Yuelong | 2008 | Polymer2008，49，1： | 1 |
| 12 | Abrasion Resistance of Thermoplastic Polyurethane materials Blended with Eth- ylene-propylene-diene Monomer Rubber 显示文摘 | Tan Jing Ding Yumei He Xutao | 2008 | Journal of Applied Polymer Science2008，110，3： | 1 |
| 13 | Miscibility, morphology, thermal and mechanical properties of a DGEBA based epoxy resin toughened with a liquid rubber 显示文摘 | RAJU THOMAS DING YUMEI HE YUELONG | 2008 | Polymer2008，49，27： | 1 |
| 14 | A new approach for inversion of receiver function for crustal structure in the depth domain显示文摘A method for reconstructing crustal velocity structure using the optimization of stacking receiver function amplitude in the depth domain,named common conversion amplitude(CCA)inversion,is presented.The conversion amplitude in the depth domain,which represents the impedance change in the medium,is obtained by assigning the receiver function amplitude to the corresponding conversion position where the P-to-S conversion occurred.Utilizing the conversion amplitude variation with depth as an optimization objective,imposing reliable prior constraints on the structural model frame and velocity range,and adopting a stepwise search inversion technique,this method efficiently weakens the tendency of easily falling into the local extremum in conventional receiver function inversion.Synthetic tests show that the CCA inversion can reconstruct complex crustal velocity structures well and is especially suitable for revealing crustal evolution by estimating diverse velocity distributions.Its performance in reconstructing crustal structure is superior to that of the conventional receiver function imaging method. | TianYu Zheng YuMei He Yue Zhu | 2022 | Earth and Planetary Physics2022，6，1： | 1 |
| 15 | In situ and one-step synthesis of hydrophobic zinc borate nanoplatelets显示文摘 | Tian Yumei He Yi Yu Lianxiang | 2008 | Colloids and Surfaces A: Physicochem Eng Aspects2008，312，2： | 1 |
| 16 | Partial delamination of the organo-montmorillonite with surfactant containing hydroxyl groups in maleated poly(propylene carbonate)显示文摘 | Zhihao Zhang Qiang Shi Juan Peng Jianbin Song Qingyong Chen Junliang Yang Yumei Gong Ronghua Ji Xiaofeng He Joong-Hee Lee | 2006 | Polymer2006，，26： | 1 |
| 17 | Miscibility, morphology, thermal, and mechanical properties of a DGEBA based epoxy resin toughened with a liquid rubber显示文摘 | Thomas R Yumei D He Y L | 2008 | Polymer2008，49，1： | 1 |
| 18 | Neural network retrieval of ocean surface parameters from SSM/Ⅰ data 显示文摘 | Lei Meng Yijun He Yumei Wu Jinnan Chen | 2007 | Monthly Weather Review2007，，135： | 1 |
| 19 | A genome wide association study between copy number variation (CNV) and human height in Chinese population显示文摘Copy number variation (CNV) is a type of genetic variation which may have important roles in phenotypic variability and disease susceptibility. To hunt for genetic variants underlying human height variation, we performed a genome wide CNV association study for human height in 618 Chinese unrelated subjects using Affymetrix 500K array set. After adjusting for age and sex, we found that four CNVs at 6p21.3, 8p23.3-23.2, 9p23 and 16p12.1 were associated with human height (with borderline significant p value: 0.013, 0.011, 0.024, 0.049; respectively). However, after multiple tests correction, none of them was associated with human height. We observed that the gain of copy number (more than 2 copies) at 8p23.3-23.2 was associated with lower height (normal copy number vs. gain of copy number: 161.2 cm vs. 153.7 cm, p = 0.011), which accounted for 0.9% of height variation. Loss of copy number (less than 2 copies) at 6p21.3 was associated with 0.8% lower height (loss of copy number vs. normal copy number: 154.5 cm vs. 161.1 cm, p = 0.013). Since no important genes influencing height located in CNVs at loci of 8p23.3-23.2 and 6p21.3, the two CNVs may cause the structural rear- rangements of neighbored important candidate genes, thus regulates the variation of height. Our results expand our knowledge of the genetic factors underlying height variation and the biological regulation of human height. | Xi Li Lijun Tan Xiaogang Liu Shufeng Lei Tielin Yang Xiangding Chen Fang Zhang Yue Fang Yan Guo Liang Zhang Han Yan Feng Pan Zhixin Zhang Yumei Peng Qi Zhou Lina He Xuezhen Zhu Jing Cheng Lishu Zhang Yaozhong Liu Qing Tian Hongwen Deng | 2010 | Journal of Genetics and Genomics2010，37，12： | 1 |
| 20 | A study of wavelet entropy theory and its application in power system显示文摘 | He Zhengyou Cai Yumei Qian Qingquan | 2004 | IEEE Robotic and Automation Society IEEE Industrial Electronics Society2004，2004，： | 1 |
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