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| 1 | Extensive translation of circular RNAs driven by N6-methyladenosine显示文摘广泛的 pre-mRNA 拼接背在人的 transcriptome 产生众多的圆形的 RNA (circRNAs ) 。然而,这些 circRNAs 的生物功能仍然保持大部分不清楚。这里,我们报导那 N 6-methyladenosine (m 6 一) , RNA 的最丰富的基础修正,在人的房间从 circRNAs 支持蛋白质翻译的有效开始。我们发现那一致 m 6 A 主题在 circRNAs 和单个 m 6 一个地点是足够的驾驶翻译开始。这 m 6A 驱动的翻译要求开始因素 eIF4G2 和 m 6 读者 YTHDF3,并且被 methyltransferase METTL3/14 提高,在热吃惊之上由 demethylase FTO,和 upregulated 禁止了。通过介绍的 polysome 的进一步的分析,计算预言和集体 spectrometry 揭示那 m 6 circRNAs 的 A 驱动的翻译是普遍的,与有翻译潜力的几百内长的 circRNAs。我们的学习扩展人的 transcriptome 的编码风景,并且在对环境应力的细胞的回答建议导出 circRNA 的蛋白质的一个角色。 | Yun Yang Xiaojuan Fan Miaowei Mao Xiaowei Song Ping Wu6,7 Yang Zhang Yongfeng Jin Yi Yang Ling-Ling Chen Yang Wang Catherine CL Wong Xinshu Xiao Zefeng Wang | 2017 | Cell Research2017，27，5： | 246 |
| 2 | The Tea Tree Genome Provides Insights into Tea Flavor and Independent Evolution of Caffeine Biosynthesis显示文摘茶是世界有巨大的经济、药用、文化的重要性的最旧、很流行的包含咖啡因的饮料。这里,我们在场第一个高质量的核苷酸序列充满重复(80.9%) ,栽培的茶树山茶 sinensis 的 3.02-Gb 染色体。我们证明茶树的一种非常地大的染色体尺寸从一些 LTR retrotransposon 家庭的慢、稳定、长期的扩大被结果。除了一个最近的整个染色体的复制事件,基因的系特定的扩大把新陈代谢的生合成与 flavonoid 联系了被发现,它提高 catechin 生产,萜烯酶激活,和应力公差,为茶风味和改编的重要特征。我们相对可可子和咖啡表明一个独立人士和茶咖啡因合成小径的快速的进化。在 25 山茶种类之中的比较研究表明那更高的表情大多数 flavonoid- 和咖啡因铺平 -- 然而并非 theanine 相关的基因贡献 catechins 和咖啡因的增加的生产并且因此提高处理茶的适用性和茶质量。这些新奇调查结果为进一步的 metabolomic 和典型生合成小径的功能的 genomic 精炼铺平道路并且将帮助开发将最后满足并且吸引世界范围的更多的茶喝酒者的茶风味的一个更多样化的集合。 | En-Hua Xia Hai-Bin Zhang Jun Sheng Kui Li Qun-Jie Zhang Changhoon Kim Yun Zhang Yuan Liu Ting Zhu Wei Li Hui Huang Yan Tong Hong Nan Cong Shi Chao Shi Jian-Jun Jiang Shu-Yan Mao Jun-Ying Jiao Dan Zhang Yuan Zhao You-Jie Zhao Li-Ping Zhang Yun-Long Liu Ben-Ying Liu Yue Yu Sheng-Fu Shao De-Jiang Ni Evan E. Eichler Li-Zhi Gao | 2017 | Molecular Plant2017，10，6： | 113 |
| 3 | Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients显示文摘Background:A patient’s infectivity is determined by the presence of the virus in different body fluids,secretions,and excreta.The persistence and clearance of viral RNA from different specimens of patients with 2019 novel coronavirus disease(COVID-19)remain unclear.This study analyzed the clearance time and factors influencing 2019 novel coronavirus(2019-nCoV)RNA in different samples from patients with COVID-19,providing further evidence to improve the management of patients during convalescence.Methods:The clinical data and laboratory test results of convalescent patients with COVID-19 who were admitted to from January 20,2020 to February 10,2020 were collected retrospectively.The reverse transcription polymerase chain reaction(RT-PCR)results for patients’oropharyngeal swab,stool,urine,and serum samples were collected and analyzed.Convalescent patients refer to recovered non-febrile patients without respiratory symptoms who had two successive(minimum 24 h sampling interval)negative RT-PCR results for viral RNA from oropharyngeal swabs.The effects of cluster of differentiation 4(CD4)+T lymphocytes,inflammatory indicators,and glucocorticoid treatment on viral nucleic acid clearance were analyzed.Results:In the 292 confirmed cases,66 patients recovered after treatment and were included in our study.In total,28(42.4%)women and 38 men(57.6%)with a median age of 44.0(34.0-62.0)years were analyzed.After in-hospital treatment,patients’inflammatory indicators decreased with improved clinical condition.The median time from the onset of symptoms to first negative RT-PCR results for oropharyngeal swabs in convalescent patients was 9.5(6.0-11.0)days.By February 10,2020,11 convalescent patients(16.7%)still tested positive for viral RNA from stool specimens and the other 55 patients’stool specimens were negative for 2019-nCoV following a median duration of 11.0(9.0-16.0)days after symptom onset.Among these 55 patients,43 had a longer duration until stool specimens were negative for viral RNA than for throat swabs,with a median delay of 2.0(1.0-4.0)days.Results for only four(6.9%)urine samples were positive for viral nucleic acid out of 58 cases;viral RNA was still present in three patients’urine specimens after throat swabs were negative.Using a multiple linear regression model(F=2.669,P=0.044,and adjusted R2=0.122),the analysis showed that the CD4+T lymphocyte count may help predict the duration of viral RNA detection in patients’stools(t=-2.699,P=0.010).The duration of viral RNA detection from oropharyngeal swabs and fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group(15 days vs.8.0 days,respectively;t=2.550,P=0.013)and the duration of viral RNA detection in fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group(20 days vs.11 days,respectively;t=4.631,P<0.001).There was no statistically significant difference in inflammatory indicators between patients with positive fecal viral RNA test results and those with negative results(P>0.05).Conclusions:In brief,as the clearance of viral RNA in patients’stools was delayed compared to that in oropharyngeal swabs,it is important to identify viral RNA in feces during convalescence.Because of the delayed clearance of viral RNA in the glucocorticoid treatment group,glucocorticoids are not recommended in the treatment of COVID-19,especially for mild disease.The duration of RNA detection may relate to host cell immunity. | Yun Ling Shui-Bao Xu Yi-Xiao Lin Di Tian Zhao-Qin Zhu Fa-Hui Dai Fan Wu Zhi-Gang Song Wei Huang Jun Chen Bi-Jie Hu Sheng Wang En-Qiang Mao Lei Zhu Wen-Hong Zhang Hong-Zhou Lu | 2020 | Chinese Medical Journal2020，，9： | 58 |
| 4 | The Chromosome-Based Rubber Tree Genome Provides New Insights into Spurge Genome Evolution and Rubber Biosynthesis显示文摘The rubber tree,Hevea brasiliensis,produces natural rubber that serves as an essential industrial raw material.Here,we present a high-quality reference genome for a rubber tree cultivar GT1 using single-molecule real-time sequencing(SMRT)and Hi-C technologies to anchor the~1.47-Gb genome assembly into 18 pseudochromosomes.The chromosome-based genome analysis enabled us to establish a model of spurge chromosome evolution,since the common paleopolyploid event occurred before the split of Hevea and Manihot.We show recent and rapid bursts of the three Hevea-specific LTR-retrotransposon families during the last 10 million years,leading to the massive expansion by~65.88%(~970 Mbp)of the whole rubber tree genome since the divergence from Manihot.We identify large-scale expansion of genes associated with whole rubber biosynthesis processes,such as basal metabolic processes,ethylene biosynthesis,and the activation of polysaccharide and glycoprotein lectin,which are important properties for latex production.A map of genomic variation between the cultivated and wild rubber trees was obtained,which contains~15.7 million high-quality single-nucleotide polymorphisms.We identified hundreds of candidate domestication genes with drastically lowered genomic diversity in the cultivated but not wild rubber trees despite a relatively short domestication history of rubber tree,some of which are involved in rubber biosynthesis.This genome assembly represents key resources for future rubber tree research and breeding,providing novel targets for improving plant biotic and abiotic tolerance and rubber production. | Jin Liu Cong Shi Cheng-Cheng Shi Wei Li Qun-Jie Zhang Yun Zhang Kui Li Hui-Fang Lu Chao Shi Si-Tao Zhu Zai-Yun Xiao Hong Nan Yao Yue Xun-Ge Zhu Yu Wu Xiao-Ning Hong Guang-Yi Fan Yan Tong Dan Zhang Chang-Li Mao Yun-Long Liu Shi-Jie Hao Wei-Qing Liu Mei-Qi Lv Hai-Bin Zhang Yuan Liu Ge-Ran Hu-tang Jin-Peng Wang Jia-Hao Wang Ying-Huai Sun Shu-Bang Ni Wen-Bin Chen Xing-Cai Zhang Yuan-Nian Jiao Evan E.Eichler Guo-Hua Li Xin Liu Li-Zhi Gao | 2020 | Molecular Plant2020，13，2： | 15 |
| 5 | Effect of Rapid Eye Movement Sleep Behavior Disorder on Obstructive Sleep Apnea Severity and Cognition of Parkinson's Disease Patients显示文摘 | Jun-Ying Huang Jin-Ru Zhang Yun Shen Hui-Jun Zhang Yu-Lan Cao Cheng-Jie Mao Ya-Ping Yang Jing Chen Chun-Feng Liu Jie Li | 2018 | Chinese Medical Journal2018，，8： | 12 |
| 6 | Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus显示文摘分泌蛋白质的刺猬(Hh ) 家庭为在脊椎动物和无脊椎动物的开发是必要的。作为主要 morphogens 之一在后生动物的开发期间,分级的 Hh 信号通过它的细胞质的尾巴的微分 phosphorylation 是越过由 Smoothened (Smo ) 的血浆膜的 transduced,导致小径激活和目标基因的微分表达式。然而,怎么 Smo transduces 经由建筑群糟糕仍然是的 Costal2 (Cos2 )/Fused (Fu ) 的分级的 Hh 信号理解。这里我们在场对由翻译 Smo phosphorylation 信息到 Fu dimerization 和肘脉 interruptus (Ci ) 的一个 Hh 坡度的房间反应的一个模型原子本地化信息。我们的调查结果建议 Smo 的 phosphorylated C 终点招募 Cos2/Fu 建筑群到通过在 Smo 和 Cos2 之间的相互作用的膜,它进一步导致 Fu dimerization。使聚合成二聚物的 Fu 是 phosphorylated 和 transduces 由 phosphorylating Cos2 和 Fu (苏(fu )) 的 Suppressor 的 Hh 信号。我们进一步证明这个过程支持全身的 Ci (Ci155 ) 和 Cos2 或苏(fu ) 的分离,并且导致 Ci155 的 translocation 进原子核,激活目标基因的表示。 | Yanyan Zhang Feifei Mao Yi Lu Wenqing Wu Lei Zhang Yun Zhao | 2011 | Cell Research2011，21，10： | 12 |
| 7 | Rapid Eye Movement Sleep Behavior Disorder Symptoms Correlate with Domains of Cognitive Impairment in Parkinson's Disease显示文摘 | Jin-Ru Zhang Jing Chen Zi-Jiao Yang Hui-Jun Zhang Yun-Ting Fu Yun Shen Pei-Cheng He Cheng-Jie Mao Chun-Feng Liu | 2016 | Chinese Medical Journal2016，，4： | 11 |
| 8 | Electroacupuncture regulates glucose-inhibited neurons in treatment of simple obesity显示文摘The glucose-inhibited neurons present in the lateral hypothalamic area are regarded as glucose detectors. This structure is involved in the regulation of food intake through extracellular blood glucose concentrations, and plays a crucial role in obesity onset. In the present study, obesity models established with high fat feeding were treated with electroacupuncture at Zusanli (ST36)/ Inner Court (ST44) on the left side and Tianshu (ST25) bilaterally. We found that electroacupuncture could effectively reduce body weight and the fat-weight ratio, and decrease serum leptin, resistin, tumor necrosis factor alpha, and neuropeptide Y levels, while increase serum adiponectin and cholecystokinin-8 levels. This treatment altered the electrical activity of glucose-inhibited neurons in the lateral hypothalamic area, with electroacupuncture at Zusanli/ Inner Court exerting an inhibitory effect, while electroacupuncture at bilateral Tianshu exerting an excitatory effect. These data suggest that electroacupuncture at the lower limbs and abdominal cavity is an effective means for regulating the activity of glucose-inhibited neurons in the lateral hypothalamic area and for improving the secretory function of adipose tissue. | Zhi Yu Youbing Xia Chuanhui Ju Qinghua Shao Zhen Mao Yun Gu Bin Xu | 2013 | Neural Regeneration Research2013，8，9： | 11 |
| 9 | Effect of graphene nanoplatelets(GNPs)addition on strength and ductility of magnesium-titanium alloys显示文摘Effect of graphene nanoplatelets(GNPs)addition on mechanical properties of magnesium–10wt%Titanium(Mg–10Ti)alloy is investigated in current work.The Mg-(10Ti+0.18GNPs)composite was synthesized using the semi powder metallurgy method followed by hot extrusion.Microstructural characterization results revealed the uniform distribution of reinforcement(Ti+GNPs)particles in the matrix,therefore(Ti+GNPs)particles act as an effective reinforcing filler to prevent the deformation.Room temperature tensile results showed that the addition of Ti+GNPs to monolithic Mg lead to increase in 0.2%yield strength(0.2%YS),ultimate tensile strength(UTS),and failure strain.Scanning Electron Microscopy(SEM),Energy-Dispersive X-ray Spectroscopy(EDS)and X-Ray Diffraction(XRD)were used to investigate the surface morphology,elemental dispersion and phase analysis,respectively. | Muhammad Rashad Fusheng Pan Aitao Tang Yun Lu Muhammad Asif Shahid Hussain Jia She Jun Gou Jianjun Mao | 2013 | Journal of Magnesium and Alloys2013，1，3： | 10 |
| 10 | Large-scale real-world radio signal recognition with deep learning显示文摘In the past ten years, many high-quality datasets have been released to support the rapid development of deep learning in the fields of computer vision, voice, and natural language processing. Nowadays, deep learning has become a key research component of the Sixth-Generation wireless systems(6G) with numerous regulatory and defense applications. In order to facilitate the application of deep learning in radio signal recognition, in this work, a large-scale real-world radio signal dataset is created based on a special aeronautical monitoring system-Automatic Dependent Surveillance-Broadcast(ADS-B). This paper makes two main contributions. First, an automatic data collection and labeling system is designed to capture over-the-air ADS-B signals in the open and real-world scenario without human participation. Through data cleaning and sorting, a high-quality dataset of ADS-B signals is created for radio signal recognition. Second, we conduct an in-depth study on the performance of deep learning models using the new dataset, as well as comparison with a recognition benchmark using machine learning and deep learning methods.Finally, we conclude this paper with a discussion of open problems in this area. | Ya TU Yun LIN Haoran ZHA Ju ZHANG Yu WANG Guan GUI Shiwen MAO | 2022 | Chinese Journal of Aeronautics2022，35，9： | 9 |
| 11 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 12 | Comparison of persistent submacular fluid in different preoperative macular status after vitrectomy for rhegmatogenous retinal detachment显示文摘AIM: To compare the incidence of persistent submacular fluid(SMF) and visual outcome after pars plana vitrectomy(PPV) for rhegmatogenous retinal detachment(RRD) in different preoperative macular status according to optical coherence tomography(OCT).METHODS: A non-randomized, retrospective review was performed for patients who underwent successful PPV for RRD. OCT exams were taken preoperatively and 1 mo after surgery, until SMF disappeared. According to the preoperative macular status on OCT, patients were divided into two groups: macula-off RRD(Group A) and maculaon RRD(Group B). In Group A, there were two subgroups: macula partly detached(Group A1) and macula totally detached(Group A2). The main outcome measures were the presence of SMF on OCT 1 mo after surgery, and the preoperative and postoperative best corrected visual acuities(BCVA), among the different groups and depending on the presence or absence of persistent SMF.RESULTS: A total of 139 eyes of 139 patients were included in the study. Persistent SMF at 1 mo after surgery was 15.8%(22/139), all occurring in Group A(22/101); Group B had no SMF at 1 mo after surgery(0/38, P=0.002). The incidence of persistent SMF at 1 mo after surgery in Group A1 was 50%(14/28), and in Group A2 was 11.0%(8/73, P<0.001). Significant differences were shown between the presence and absence of persistent SMF on foveolaoff RRD, the preoperative BCVA, the 1 mo postoperative BCVA, and the degree of the BCVA improvement from 1 mo postoperatively to the final follow-up(P<0.05). However, there were no significant differences in the final BCVA(P>0.05).CONCLUSION: Persistent SMF after PPV for retinal detachment is associated with preoperative macular status. Macula-uninvolving RRD shows no persistent SMF after PPV. Macular partly detached RRD has a higher incidence of SMF than macula totally detached RRD after PPV. The persistence of SMF may be responsible for the delayed visual recovery, whereas there were no significant differences in the final visual acuity. | Jian-Bo Mao Jing-Jing Lin Xue-Ting Yu Dan Cheng Yi-Qi Chen Ji-Wei Tao Han-Fei Wu Lu Jiang Yun Zhang Li-Jun Shen | 2018 | International Journal of Ophthalmology(English edition)2018，11，11： | 7 |
| 13 | Tonic Electromyogram Density in Multiple System Atrophy with Predominant Parkinsonism and Parkinson's Disease显示文摘 | Yi Wang Yun Shen Kang-Ping Xiong Pei-Cheng He Cheng-Jie Mao Jie Li Fu-Yu Wang Ya-Li Wang Jun-Ying Huang Chun-Feng Liu | 2017 | Chinese Medical Journal2017，，6： | 7 |
| 14 | PREPARATION STUDY OF SEMI-SOLID 60Si2Mn SPRING STEEL SLURRY显示文摘The nondendritic semi-solid slurry preparation of 60Si2Mn spring steel is studied in this paper. The experiments show that when stirred for 2 minutes under the test condition, the semi-solid slurry with 50%-60% fraction solid phase and spherical primary austenite in the size of 100-300μm can be obtained and is easy to be discharged from the little bottom hole of the stirring chamber. The more homogeneous temperature field and solute distribution of the 60Si2Mn spring steel melt appear because of the electromagnetic stirring, which restrains the formation of large primary austenitic dendrites and create a base to form spheroidized structure. The stronger temperature fluctuation in the melt with many rosette primary austenites caused by stirring and the remelting of the secondary arm roots in the same time are the most important reasons for deposition of spheroidized primary austenites. | W.M. Mao, A.M. Zhao, D. Yun, L.P. Zhang and X.Y. ZhongUniversity of Science & Technology Beijing, Beijing 100083, China | 2003 | Acta Metallurgica Sinica(English Letters)2003，16，6： | 6 |
| 15 | Semi-solid slurry preparation and rolling of 1Cr18Ni9Ti stainless steel显示文摘The preparation and rolling of the semi-solid slurry 1Crl8Ni9Ti stainless steel were researched. The experimental results show that when stirred for 2-3 min under the given test condition, the semi-solid slurry with about 50%-60% (volume fraction) solid and the spherical primary austenitic grains in the size of 100-200 μm can be obtained, and it is easy to be discharged from the bottom little hole of the stirring chamber. The semi-solid slurry of 1Crl8Ni9Ti stainless steel can be rolled into the given plate successfully.However, the solid phase and liquid phase are easily separated in the rolling process, so that the solid primary austenitic grains are concentrated in the center and the liquid phase is near the edge of the rolled plate. The strengths of the plate rolled in the semi-solid state are higher than that of the traditionally repeated hot-rolled plate of 1Cr18Ni9Ti stainless steel. | Weimin Mao, Aimin Zhao, Dong Yun, Leping Zhang, and Xueyou ZhongMaterials Science and Engineering School, University of Science and Technology Beijing, Beijing 100083, China | 2003 | Journal of University of Science and Technology Beijing2003，10，6： | 6 |
| 16 | Neuronal Death Mechanisms and Therapeutic Strategy in Ischemic Stroke显示文摘Ischemic stroke caused by intracranial vascular occlusion has become increasingly prevalent with considerable mortality and disability,which gravely burdens the global economy.Current relatively effective clinical treatments are limited to intravenous alteplase and thrombectomy.Even so,patients still benefit little due to the short therapeutic window and the risk of ischemia/reperfusion injury.It is therefore urgent to figure out the neuronal death mechanisms following ischemic stroke in order to develop new neuroprotective strategies.Regarding the pathogenesis,multiple pathological events trigger the activation of cell death pathways.Particular attention should be devoted to excitotoxicity,oxidative stress,and inflammatory responses.Thus,in this article,we first review the principal mechanisms underlying neuronal death mediated by these significant events,such as intrinsic and extrinsic apoptosis,ferroptosis,parthanatos,pyroptosis,necroptosis,and autophagic cell death.Then,we further discuss the possibility of interventions targeting these pathological events and summarize the present pharmacological achievements. | Rui Mao Ningning Zong Yujie Hu Ying Chen Yun Xu | 2022 | Neuroscience Bulletin2022，38，10： | 6 |
| 17 | Effect of intravitreal conbercept treatment before vitrectomy in proliferative diabetic retinopathy显示文摘● AIM: To evaluate the safety and efficacy of intravitreal conbercept(IVC) injections as pretreatment for pars plana vitrectomy(PPV) in severe proliferative diabetic retinopathy(PDR).● METHODS: This was a retrospective chart review of all patients who underwent PPV for PDR from January 2014 to October 2016. Patients who underwent IVC injection before PPV were assigned to the IVC group; the others were assigned to the control group. The IVC was performed 3-7 d before surgery in the IVC group. All the eyes in the two groups were operated by the same doctor to complete the vitrectomy. Intraoperative complications and the changes in best-corrected visual acuity(BCVA) before and after surgery were compared between the two groups.● RESULTS: A total of 68 eyes of 63 patients(22 eyes in the IVC group and 46 eyes in the control group) were examined. The risk of intraoperative bleeding was lower in the IVC group(2/22) than in the control group(25/46, P=0.000). Furthermore, the use of endodiathermy was significantly lower in the IVC group(1/22) than in the control group(12/46, P=0.047). The surgical time in the IVC group(112.64±34.52 min) was significantly shorter than in the control group(132.85±40.04 min, P<0.05). Compared to the BCVA before surgery, the mean BCVA was significantly improved after surgery for both groups(P<0.05).● CONCLUSION: PPV is an effective treatment and can improve vision in patients with PDR. Preoperative intravitreal injection of conbercept could reduce the chances of intraoperative bleeding and the use of endodiathermy and shorten the operative time, which are beneficial in the management of PDR. | Jian-Bo Mao Han-Fei Wu Yi-Qi Chen Shi-Xin Zhao Ji-Wei Tao Yun Zhang Bin Zheng Lin Wang Li-Jun Shen | 2018 | International Journal of Ophthalmology(English edition)2018，11，7： | 6 |
| 18 | Higher-Ordered Actin Structures Remodeled by Arabidopsis ACTIN-DEPOLYMERIZING FACTOR5 Are Important for Pollen Germination and Pollen Tube Growth显示文摘肌动朊细胞骨架的动力学为花粉萌芽和花粉试管生长是必要的。使解聚肌动朊的因素(ADF ) 典型地由切断 / 使解聚肌动朊细丝贡献肌动朊周转。最近,我们证明 Arabidopsis 亚纲 III ADF (ADF5 和 ADF9 ) 从保存 F-actin-depolymerizing 功能发展了 F-actin-bundling 功能。然而,很少对生理的功能,进化意义,和这些 neofunctionalized ADF 的肌动朊捆绑机制被知道。这里,我们报导 ? 引起的 ADF5 功能的那损失推迟了花粉萌芽,延迟的花粉试管生长,并且增加对由影响肌动朊捆的产生和维护的 latrunculin B (LatB ) 处理敏感。在生活房间的肌动朊细丝动力学的检查表明捆绑频率显著地在 adf5 花粉试管被减少,与它的生物化学的功能一致。进一步生物化学、基因的互补分析 ? 两个都表明了那 N-? 并且 ADF5 的 C 终端肌动朊绑定域为它的生理、生物化学的函数被要求。有趣地,当两个是不正常的肌动朊捆绑 ADF, ADF5,然而并非 ADF9 时,在成熟花粉起一个重要作用生理的活动。一起拿,我们的结果建议 ADF5 发展了捆绑肌动朊细丝的功能并且在花粉萌芽和花粉试管生长期间在肌动朊捆的形成,组织,和维护起一个重要作用。 | Jingen Zhu Qiong Nan Tao Qin Dong Qian Tonglin Mao Shunjie Yuan Xiaorong Wu Yue Niu Qifeng Bai Lizhe An Yun Xiang | 2017 | Molecular Plant2017，10，8： | 6 |
| 19 | Large numbersLarge numbers of new bacterial taxa found by Yunnan Institute of Microbiology显示文摘Extreme environments, primeval forest, sea sediments and plants in China yielded members of a new suborder, Jiangellineae, a new family Sinobacteraceae, and 23 new genera of actinomycetes and other bacteria. Three suggestions were made for further discoveries of new actinomycetes. First, natural habitats such as old growth forests, and extreme environments, should be given sampling priority; second, culturing procedures need to be constantly improved to mimic natural habitats; third, less than 98.5% similarity of 16S rRNA sequence to that of a known species could be used as an indicator of a new species. | JIANG Yi CAO YanRu ZHAO LiXing TANG ShuKun WANG Yun LI WenJun XU Ping LOU Kai MAO PeiHong XU LiHua | 2011 | Chinese Science Bulletin2011，56，8： | 5 |
| 20 | Genetic and Antibiotic Resistance Characteristics ofCampylobacterjejuni Isolated from Diarrheal Patients,Poultry and Cattle in Shenzhen显示文摘Objective To investigate genetic and antibiotic resistance characteristics of Campylobacter jejuni(C. jejuni) isolated from Shenzhen. Methods Multilocs sequence typing and agar dilution methods were used to define the genotype and antibiotic resistance of C. jejuni, respectively. Results In total, 126 C. jejuni strains were isolated. The prevalence of C. jejuni was 5.3% in diarrheal patients. The prevalence in poultry meat(36.5%) was higher than that in cattle meat(1.1%). However, the prevalence in poultry cloacal swabs(27.0%) was lower than that in cattle stool(57.3%). Sixty-two sequence types were obtained, among which 27 of the STs and 10 alleles were previously unreported. The most frequently observed clonal complexes were ST-21(11.9%), ST-22(10.3%), and ST-403(7.1%). ST-21, ST-45, ST-354, ST-403, and ST-443 complexes overlapped between isolates from patients and cattle, whereas ST-45 and ST-574 complexes overlapped between isolates from patients and poultry. All C. jejuni were resistant to at least one antibiotic. The highest resistance rate was toward ciprofloxacin(89.7%), followed by tetracycline(74.6%), and nalidixic acid(69.0%). Conclusion This is the first report of the genotypes and antibiotic resistance of C. jejuni in Shenzhen. Overlapping clonal complexes were found between isolates from patients and cattle, and between patients and poultry. | JU Chang Yan ZHANG Mao Jun MA Yan Ping LU Jing Rang YU Mu Hua CHEN Hui LIU Chu Yun GU Yi Xin FU Yan Yan DUAN Yong Xiang | 2018 | Biomedical and Environmental Sciences2018，31，8： | 5 |
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