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| 1 | Psychosocial and spiritual needs of patients with chronic diseases: validation of the Chinese version of the Spiritual Needs Questionnaire显示文摘OBJECTIVE: Even in secular societies, a small portion of patients find their spirituality to help cope with illness. But for the majority of patients, psychosocial and spiritual needs are neither addressed nor even considered a relevant factor by health care professionals. To measure such specific needs, the Spiritual Needs Questionnaire (SpNQ) was developed. The aim of this study was to validate the Chinese version of the SpNQ (SpNQ-Ch) and thus to measure psychosocial and spiritual needs of Chinese patients. METHODS: This was a cross-sectional study among 168 patients with chronic diseases who were recruited in the Changhai Hospital of Traditional Chinese Medicine, Shanghai, China using standardized questionnaires. We performed reliability and factor analyses, as well as analyses of variance, first order correlations and regression analyses. RESULTS: The 17-item SpNQ-Ch had a similar factorial structure as the original version with two main and three minor factors which accounted for 64% of variance, and internal consistency estimates (Cronbach's α) ranging from 0.51 to 0.81. Included were the 4-item scale Inner Peace Needs, the 5-item scale Giving/Generativity Needs, the 5-item scale Religious Needs (with 2 sub-constructs, Praying and Sources), and a 3-item scale Reflection/Release Needs. In Chinese patients with cancer (63%), pain affections (10%), or other chronic conditions (23%), the needs for Giving/Generativity (which refer to categories of Connectedness and Meaning) and Inner Peace Needs scored highest, while Religious Needs and the Reflection/Release Needs scored lower. CONCLUSION: The SpNQ-Ch is congruent with its primary version, and can be used in future studies with the mostly nonreligious patients from China. First findings indicate specific psychosocial and spiritual needs which should be addressed by health care professionals to support patients in their struggle with chronic illness in terms of psycho-emotional stabilization, finding hope and meaning, and thus achieving peaceful states of mind despite chronic illness. | Arndt Büssing Xiao-feng Zhai Wen-bo Peng Chang-quan Ling | 2013 | Journal of Integrative Medicine2013，11，2： | 13 |
| 2 | Interpretation of illness in patients with chronic diseases from Shanghai and their associations with life satisfaction, escape from illness, and ability to reflect the implications of illness显示文摘OBJECTIVE: The aim of this study is to analyze how patients with chronic diseases from Shanghai interpret their disease, and how these interpretations infl uence patients' life satisfaction, intention to escape from their illness and their ability to refl ect on the implications of their illness.METHODS: A cross-sectional study enrolling 142 patients(mean age(50 ± 16) years; 63% men, 37% women) with chronic diseases(60% cancer) was recruited in the Changhai Hospital of Traditional Chinese Medicine, Shanghai, China and surveyed using standardized questionnaires.RESULTS: Patients with chronic diseases from Shanghai interpreted their illness mostly as an Adverse Interruption of Life(55%), as a Threat/Enemy(50%), but also as a Challenge(49%), and only rarely as a Call for Help(18%) or as a Punishment(13%). Particularly fatalistic negative(i.e., Threat/Enemy, Adverse Interruption of Life) and strategy-associated disease interpretations(i.e., Relieving Break, Call for Help) were moderately associated with patients' intention to escape from illness. In contrast, positive interpretations(i.e., something of Value, Challenge) and also the guilt-associated negative interpretation Failure were moderately related with patients' ability to refl ect on their illness. However, life satisfaction was weakly associated only with the view that illness might be a Challenge. Interestingly, 58% of those who would see their illness as an Adverse Interruption(AI+) could see it also as a Challenge(Ch+). Detailed analyses showed that AI+Ch+ patients differ from their AI+Ch- counterparts signifi cantly with respect to their ability to refl ect life and implications of illness(F=9.1; P=0.004).CONCLUSION: The observed interpretations of illness, particularly the negative perceptions, could be used as indicators that patients require further psychological assistance to cope with their burden. Helping AI+ patients see their illness also as a Challenge, and thus develop a higher Refl ection on Life Concerns, would be greatly benefi cial, and encourages further research. | Arndt Büssing Ariane von Bergh Xiao-feng Zhai Chang-quan Ling | 2014 | Journal of Integrative Medicine2014，12，5： | 4 |
| 3 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 4 | Type I,but not Type Ⅱ,interferon is critical in liver injury induced after ischemia and reperfusion显示文摘 | Zhai Y Qiao B Gao F | 2008 | Hepatology2008，47，： | 1 |
| 5 | Immunocytochemistry of renal membrane proteins on epoxy sections显示文摘 | Zhai X Y Kristoffersen I B Christensen E I | 2007 | Kidney Int2007，72，6： | 1 |
| 6 | Distribution, degradation and dynamics of dissolved organic carbon and its major compound classes in the Pearl River estuary, China显示文摘 | HE B Y DAI M H ZHAI W D | 2010 | Marine Chemistry2010，119，14： | 1 |
| 7 | Tanshinone HA protects rat primary hepatoeytes against carbon tetrachloride toxicity via inhibiting mitochondriapermeability transition 显示文摘 | Zhu B Zhai Q Yu B | 2010 | Pharm Biol2010，48，5： | 1 |
| 8 | 查看详情显示文摘 | Zhai X H Zhao Y B | | 0，，： | 1 |
| 9 | Disturbance attenuation properties of time-controlled switched systems显示文摘 | Zhai G Hu B Yasuda K Michel A-N | 2001 | Journal of the Franklin Institute2001，338，7： | 1 |
| 10 | Disturbance attenuation properties of time-controlled switched systems显示文摘 | ZHAI Guisheng HU B YASUDA K | 2001 | J Franklin Inst2001，338，7： | 1 |
| 11 | Ultraviolet degradation of methyltins: Elucidating the mechanism by identification of a detected new intermediary product and investigating the kinetics at various environmental conditions 显示文摘 | Zhai G S Liu J F He B | 2008 | Chemosphere2008，72，3： | 1 |
| 12 | Temperature measurement and distribution inside planar SOFC stacks显示文摘 | Guan W B Zhai H J Jin L | 2012 | Fuel Cells2012，12，1： | 1 |
| 13 | Effect of detail design on fatigue performance of fastener hole 显示文摘 | Liu J Xu H L Zhai FI B | 2010 | Materials and Design2010，31，2： | 1 |
| 14 | A modified ultrasonic linear motor显示文摘 | Zhai B Lim S P Lee K H | | 0，，03： | 1 |
| 15 | On-orbit capture with flexible tether-net system 显示文摘 | Zhai G Qiu Y Liang B | 2009 | Acta Astronautica2009，65，56： | 1 |
| 16 | Three-Dimensional Reconstruction of the Mouse Nephron显示文摘 | Xiao-Yue Zhai Jesper ST Henrik B | 2006 | Journal of the American Society of Nephrology2006，，： | 1 |
| 17 | Humanin peptide suppressesapoptosis by interfering with Bax activation 显示文摘 | Guo B Zhai D Cabezas E | 2003 | Nature2003，423，6938： | 1 |
| 18 | Petrogenesis of the Ultrahigh-pressure rocks and their country rocks at Shuanghe in Dabieshan, central China显示文摘 | Zhai M Carswell D A | 1995 | European Journal of Mineralogy1995，7，： | 1 |
| 19 | Europ Polym J显示文摘 | Xu W B Liang G D Zhai H B Tang S P Hang G P Pan W P | 2003 | 39:1 4672003，39，： | 1 |
| 20 | Distribution, degradation and dynamics of dissolved organic carbon and its major compound clas-ses in the Pearl River estuary, China 显示文摘 | He B Y Dai M H Zhai WD | 2010 | Marine Chemistry2010，119，14： | 1 |
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