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| 1 | Expression of perforin and granzyme B mRNA in judgement of immunosuppressive effect in rat liver transplantation显示文摘AIM To explore the expression of perform andgranzyme B genes mRNA to judge the effect ofimmunosuppression in acute rejection of livertransplantation.METHODS The expression of perform andgranzyme B genes mRNA was examined byreverse transcriptase-polymerase chain reaction(RT--PCR) in hamster to rat liver grafts under theimmunosuppression of cyclosporine or/andsplenectomy. Histological findings were studiedcomparatively.RESULTS Cyclosporine could obviouslydecrease the cellular infiltration, and completelyrepress the expression of mRNA for perform andgranzyme B, but could not change severehepatocyte necrosis and hemorrhage.SPlenectomy could significantly lightenhepatocyte necrosis, and completely eliminatehemorrhage, but not atfect the cellularinfiltration and the expression of perform andgranzyme B genes mRNA. Cyclosporine orsplenectomy alone could not prolong theSurvival time, however, their combination couldcompletely repress the rejection of liver grafts.The survival time of animals were significantlyprolonged (37.1 days ). The architecture ofhepatic lobules was preserved. There was slightcellular infiltration in the portal tracts and noexpression of perform and granzyme B genesmRNA could be seen in three weeks aftertransplantation.CONCLUSION Perform and granzyme B genesare valuable in judging the effect ofimmunosuppression in liver transplantation. | Zhang SG Wu MC Tan JW Chen H Yang JM Qian QJ | 1999 | World Journal of Gastroenterology1999，5，3： | 15 |
| 2 | Intraspinal transplantation of CD34+ human umbilical cord blood cells after spinal cord hemisection injury improves functional recovery in adult rats显示文摘 | Zhao,ZM Li,HJ Liu,HY Lu,SH Yang,RC Zhang,QJ Han,ZC | 2005 | 中国生物学文摘2005，19，3： | 2 |
| 3 | Structural elucidation of a neutral fucogalactan from the mycelium of Coprinus comatus显示文摘 | FAN JM ZHANG JS TANG QJ | 2006 | Carbohydr Res2006，341，9： | 1 |
| 4 | Presence and integration of HBV-DNA in mouse oocytes显示文摘 | Huang TH Zhang QJ Xie QD | 2005 | World J Gastroenterol2005，11，： | 1 |
| 5 | Differential gene expression in vascular smooth muscle cells in primary atherosclerosis and In stent stenosis in humans显示文摘 | Goddard M Shanahan C | 2002 | Arterioscler Thromb Vasc2002，22，： | 1 |
| 6 | Friction and wear characteristics of lead and its compounds filled PTFE composites under oil lubricated conditions 显示文摘 | ZHANG Z Z XUE QJ LIU W M | 1998 | Tribology International1998，31，7： | 1 |
| 7 | The selective 5-HT1Areceptor antagonist WAY-100635 inhibits neuronal activity of the ventromedial prefrontal cortex in a rodent model of Parkinsons disease显示文摘 | CAO J LIU J ZHANG QJ | 2007 | Neurosci Bull2007，23，： | 1 |
| 8 | NANOG changes in mouse kidneys with age显示文摘 | Yan QJ Chen XM Zhang YM | 2005 | Rejuvenation Res2005，8，4： | 1 |
| 9 | Pool Analysis of the Performance of Liquid-Based Cytology in Population-based Cervical Cancer Screening Studies in China 显示文摘 | Pan QJ Hu SY Zhang X | 2013 | Cancer Cytopathol2013，121，9： | 1 |
| 10 | The pyramidal neurons in the medial prefrontal cortex show decreased response to 5-hydroxytryptamine-3 receptor stimulation in a rodent model of Parkinsons disease显示文摘 | ZHANG QJ LI LB LIU J | 2011 | Brain Res2011，1384，： | 1 |
| 11 | Unilateral lesion of the nigrostriatal pathway induces an increase of neuronal firing of the midbrain raphe nuclei 5-HT neurons and a decrease of their response to5-HT(1A)receptor stimulation in the rat显示文摘 | WANG S ZHANG QJ LIU J | 2009 | Neuroscience2009，159，2： | 1 |
| 12 | Firing activity of locus coeruleus noradrenergic neurons increases in a rodent model of Parkinsonism显示文摘 | WANG T ZHANG QJ LIU J | 2009 | Neuroscience2009，25，1： | 1 |
| 13 | Upregulated p27kip1 can downregulate survivin expression and inhibit telomerase activity in gastric carcinoma cells显示文摘 | Zhang W Tong Qj Wu Oo | 2009 | Cancer Invest2009，27，9： | 1 |
| 14 | Endotheliumspecific overexpression of class Ⅲ deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E deficient mice显示文摘 | Zhang QJ Wang Z Chen HZ | 2008 | Cardiovasc Res2008，80，2： | 1 |
| 15 | Mild hypothermia therapy re-duces blood glucose and lactate and improves neurologic out-comes in patients with severe traumatic brain injury 显示文摘 | Zhao QJ Zhang XG Wang LX | 2011 | J CritCare2011，26，3： | 1 |
| 16 | In vivo effect of 5-HT7receptor agonist on pyramidal neurons in medial frontal cortex of normal and 6-hydroxydopamine-lesioned rats:an electrophysiological study显示文摘 | FAN LL ZHANG QJ LIU J | 1999 | Neuroscience1999，190，： | 1 |
| 17 | In vivo effect of 5-HT7 receptor agonist on pyramidal neurons in medial frontal cortex of normal and 6-hydroxydopamine-lesioned rats : an electrophysiological study 显示文摘 | Fan LL Zhang QJ Liu J | 2011 | Neuroscience2011，190，5： | 1 |
| 18 | PLK1 is transcriptionallyactivated by NF-kB during cell detachment and enhancesanoikis resistance through inhibiting j3-catenin degradationin esophageal squamous cell carcinoma 显示文摘 | Lin DC Zhang Y Pan QJ | 2011 | Clin CancerRes2011，17，13： | 1 |
| 19 | Association between the polymorphisms in intercellular adhesion molecule-1 and the risk of coronary atherosclerosis:A case-controlled study显示文摘 | YANG M FU ZK ZHANG QJ | 2014 | PLoS One2014，9，10： | 1 |
| 20 | 46, XX incomplete 17 alphahydroxylase/17, 20-lyase deficiency显示文摘 | Tian QJ Zhang YW Lu ZL | 2008 | Gynecol Endocrinol2008，24，7： | 1 |
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