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| 1 | 代谢健康的肥胖和腹型肥胖与高血压风险增加相关显示文摘代谢健康型肥胖是指具有正常代谢特征的肥胖人群。研究者在中国农村地区队列研究(the rural Chinese cohort study)的成年人中,探究了代谢健康型肥胖与高血压风险的关系。这项前瞻性队列研究纳入中国成人9137名,在基线时(2007-2008年)无高血压、2型糖尿病或血脂异常,在2013-2014年进行随访。 | 周卫(译) 袁源(审校) Zhao Y Qin P Sun HH Liu Y Liu D Zhou Q Guo C Li Q Tian G Wu X Hu D Sun X Zhang M | 2020 | 中华高血压杂志2020，28，9： | 7 |
| 2 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 3 | Establishment and Applications of Epstein-Barr Virus-based Episomal Vectors in Human Embryonic Stem Cells显示文摘 | Ren C Zhao M Yang X Li D Jiang X Wang L Shan W Yang H Zhou L Zhou W Zhang H | 2006 | 中国生物学文摘2006，20，7： | 4 |
| 4 | 查看详情显示文摘 | Zhao C T Hou J N Zhang X Zhu W.Xu M | | 高分子科学(英文版)0，，： | 2 |
| 5 | Ferroelectric, Piezoelectric and Pyroelectric Properties of Sr1+ xBi4- x- Ti4- xTaxO Ceramics (x=0- 1) 显示文摘 | Zhao M L Wang C L Zhong W L | 2002 | Jpn J Appl Phys2002，41，： | 2 |
| 6 | Morphology and orientation evolution of Cu_(6)Sn_(5)grains on(001)Cu and(011)Cu single crystal substrates under temperature gradient显示文摘The morphology and orientation evolution of Cu_(6)Sn_(5)grains formed on(001)Cu and(011)Cu single crystal substrates under temperature gradient(TG)were investigated.The initial orientated prism-type Cu_(6)Sn_(5)grains transformed to non-orientated scallop-type after isothermal reflow.However,the Cu_(6)Sn_(5)grains with strong texture were revealed on cold end single crystal Cu substrates by imposing TG.The Cu_(6)Sn_(5)grains on(001)Cu grew along their c-axis parallel to the substrate and finally merged into one grain to form a fully IMC joint,while those on(011)Cu presented a strong texture and merged into a few dominant Cu_(6)Sn_(5)grains showing about 30°angle with the substrate.The merging between neighboring Cu_(6)Sn_(5)grain pair was attributed to the rapid grain growth and grain boundary migration.Accordingly,a model was put forward to describe the merging process.The different morphology and orientation evolutions of the Cu_(6)Sn_(5)grains on single crystal and polycrystal Cu substrates were revealed based on crystallographic relationship and Cu flux.The method for controlling the morphology and orientation of Cu_(6)Sn_(5)grains is really benefitial to solve the reliability problems caused by anisotropy in 3 D packaging. | Yuanyuan Qiao Xiaoying Liu Ning Zhao Lawrence C M Wu Chunying Liu Haitao Ma | 2021 | Journal of Materials Science & Technology2021，，36： | 2 |
| 7 | Automotive spark-ignited direct-injection gasoline engines显示文摘 | Zhao F Lai M C Harrington D L | 1999 | Progress in Energy and Combustion Science1999，25，： | 1 |
| 8 | Determination of glycyrrhetic acid in human plasma by HPLC-MS method and investigation of its pharmacokinetics 显示文摘 | Zhao W J Wang B J Wei C M | 2008 | J Clin Pharm Ther2008，33，： | 1 |
| 9 | Cytotoxic Acylated Triterpene Saponins from the husks of Xanthoceras sorbifolia显示文摘 | Chan P K Zhao M Che C T | 2008 | J Nat Prod2008，71，： | 1 |
| 10 | Biological properties of the chitosan -gelatin sponge wound dressing 显示文摘 | DENG C M HE L Z ZHAO M | 2007 | Carbohydr Polym2007，69，3： | 1 |
| 11 | The dynamically coursing processes of the microstructures in the nondendritic AlSi7Mg alloy remelted in the semi-solid state 显示文摘 | Mao W M Cui C L Zhao A M | 2000 | Trans Nonferrous Met Soc China2000，10，1： | 1 |
| 12 | Adenosine attenuates reperfusion-induced apoptotic cell death by modulating expression of Bcl-2 and Baxproteins显示文摘 | Zhao Z Q Budde J M Morris C | 2001 | J Mol Cell Cardiol2001，33，1： | 1 |
| 13 | Silkworm,Bombyx mori larvae expressed the spider silk protein through a novel Bac-to-Bac/BmNPV baculovirus显示文摘 | Miao Y G Zhao A C Nakagaki M | 2006 | J Appl Entomology2006，130，5： | 1 |
| 14 | New kinematic structures for 2-,3-,4-,and 5-DOF parallel manipulator designs显示文摘 | Gao F Li W M Zhao X C | 2002 | Mechanism and Machine Theory2002，37，11： | 1 |
| 15 | Two new oleanane saponins from Anemone flaccida显示文摘 | Zhao L Chen W M Fang Q C | 1991 | Planta Med1991，57，： | 1 |
| 16 | Inhibition of myocardial apoptosis reduces infarct size and improves regional contractile dysfunction during reperfusion 显示文摘 | Zhao Z Q Morris C D Budde J M | 2003 | Cardiovas Res2003，59，： | 1 |
| 17 | Intracontinental deform- ation in a frontier of super-convergence: A perspective on the tectonic milieu of the South China Block显示文摘 | Li S Z Santosh M Zhao G C | 2012 | Journal of Asian Earth Sciences2012，49，： | 1 |
| 18 | Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia 显示文摘 | Chao MP Alizadeh AA Tang C Jan M Weissman-Tsukamoto R Zhao F | 2011 | Cancer Res2011，71，4： | 1 |
| 19 | Fibers Coated with Molecularly Imprinted Polymers for Solid-Phase Microextraction 显示文摘 | Yang L Q Zhao X M Crescenzi C | 2007 | Analytical Chemistry2007，79，： | 1 |
| 20 | Anal Chim Acta显示文摘 | Cao D S Hu Q N Xu Q S Yang Y N Zhao J C Lu H M Zhang L X Liang Y Z | 2011 | 692(1-2):502011，692，12： | 1 |
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