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| 1 | VDR基因敲除鼠一氧化氮合酶和内皮素-1基因的表达显示文摘目的探讨维生素D受体(VDR)基因敲除鼠血压变化以及与血压水平密切相关的内皮型一氧化氮合酶、内皮素-1基因在主动脉的表达情况,了解维生素D、维生素D受体与血压的联系及可能机制。方法小鼠血压采用动脉血管插管法直接测定,主动脉内皮型一氧化氮合酶、内皮素-1基因表达采用实时定量聚合酶链式反应检测。结果内皮型一氧化氮合酶、内皮素-1基因均能在野生型正常鼠及维生素D受体基因敲除鼠主动脉表达。与野生型正常鼠比较,纯合子维生素D受体基因敲除鼠收缩压、舒张压明显升高,主动脉内皮型一氧化氮合酶基因表达明显下调,内皮素-1基因表达明显上调(P均<0.05),杂合子维生素D受体基因敲除鼠收缩压、舒张压及主动脉内皮型一氧化氮合酶、内皮素-1基因表达则无明显改变(P均>0.05)。相关性研究发现主动脉内皮型一氧化氮合酶基因表达水平与收缩压、舒张压水平呈负相关,与收缩压、舒张压水平呈正相关(P均<0.05)。结论纯合子维生素D受体基因敲除鼠存在与血压密切相关的主动脉内皮型一氧化氮合酶、内皮素-1基因表达水平明显异常。 | 向伟 蒋湘玲 符生苗 Wei Zheng Uskokovic M Jian Kong YC Li | 2005 | 中国热带医学2005，5，5： | 7 |
| 2 | Effects of Heat Treatment on the Transformation Temperature and the Microstructure of Ni-Ti-Nb Shape Memory Alloy显示文摘The effects of heat treatment on the phase transformation temperature and the microstructure of Ni-Ti-Nb alloy have been investigated by means of R-T method, TEM and EPMA. With the increase of annealing temperature, cooling rate and ageing temperature, the Ms temperature increases. TEM observations show no new precipitated phase was found in the B2 parent phase after heat treatment, but EPMA shows the content of Ni (or Ni/Ti ratio) in the B2 matrix changed. The main reason for the change of transformation temperature lies in the change of the matrix composition (or Ni/Ti ratio) with the variation of heat treatment procedure. | Zheng, YF Cai, W Wang, YQ Luo, YC Zhao, LC | 1998 | Journal of Materials Science & Technology1998，14，1： | 4 |
| 3 | Tympanometry assessment of 61 inbred strains of mice显示文摘 | Zheng QY Tong YC Alagramam KN | 2007 | Hear Res2007，231，： | 1 |
| 4 | Human infection with Candidatus Rickettsia tarasevichiae 显示文摘 | Jia N Zheng YC Jiang JF | 2013 | N Engl J Med2013，369，12： | 1 |
| 5 | Clinical value of signal transducers and activators of transcription 3 ( STAT3 ) gene expression in human os- t eosareoma 显示文摘 | Wang YC Zheng LH Ma BA | 2011 | Acta Histochem2011，113，4： | 1 |
| 6 | Altered gene expression profile in the kidney of vitamin D receptor knockout mice 显示文摘 | Li X Zheng W Li YC | 2003 | J Cell Bio- ehem2003，89，： | 1 |
| 7 | WEGO:a tool for plotting GO annotations显示文摘 | Yu J Yc J Fang L Zheng H | 2006 | Nucleic Acids Res2006，34，： | 1 |
| 8 | Genetic diversity of Magnaporthe grisea in China as revealed by DNA fingerprint haplotypes and pathotypes显示文摘 | CHEN QH WANG YC ZHENG XB | 2006 | Phytopathology2006，154，： | 1 |
| 9 | Traditional Chinese medicine combined with warm acupuncture treatment of 50cases with chronic pelvic inflammatory disease显示文摘 | HUANG YC ZHENG M LI YM | 2011 | Joumal of China Traditional Chinese Medicain Information2011，3，15： | 1 |
| 10 | Cloning and expression of bo- vine sodium/glucose cotransporters显示文摘 | Zhao FQ Zheng YC Wall EH | 2005 | J Dairy Sci2005，88，1： | 1 |
| 11 | Phenolic compounds and analog as superoxide anion scavenges and antioxidant显示文摘 | Zhou YC Zheng RL | 1991 | Biochem Pharmacol1991，42，： | 1 |
| 12 | Epidemiological, clinical, and labo- ratoly characteristics of~ cases of 'Babesia venatorum' infection in China: a descriptive study显示文摘 | Jiang JF Zheng YC Jiang RR | 2015 | Lancet Infect Dis2015，15，2： | 1 |
| 13 | Laparoscopic management of severe acute pancreatitis 显示文摘 | Zhou ZG Zheng YC Shu Y | 2003 | Pancreas2003，27，3： | 1 |
| 14 | Is acupuncture a placebo therapy? 显示文摘 | Zheng YC Yuan 'IF Liu T | 2014 | Complement Ther Med2014，22，4： | 1 |
| 15 | In vitro antitumor activity of silybin nanosuspension in PC-3 cells 显示文摘 | Zheng DD Wang YC Zhang DR | 2011 | Cancer Lett2011，307，2： | 1 |
| 16 | Actinoplanes utahensis ZJB-08196 fed-batch fermentation at elevated osmolality for enhancing acarbose production 显示文摘 | Wang YJ Liu LL Wang YS Xue YP Zheng YG Shen YC | 2012 | Bioresource Technol2012，103，1： | 1 |
| 17 | Distribution and patterns of lymph nodes metastases and micrometastases in the mesorectum of rectal cancer显示文摘 | Zheng YC Zhou ZG Li L | 2007 | J Surg Oncol2007，96，3： | 1 |
| 18 | A model to determine 3-monthmortality risk in patients with acute-on-chronic hepatitis B liverfailure显示文摘 | Zheng MH Shi KQ Fan YC | 2011 | Clin Gastroenterol Hepatol2011，9，6： | 1 |
| 19 | Autofluorescence of epithelial tissue: single-photon versus two-photon excitation 显示文摘 | Zheng W Wu YC Li D | 2008 | J Biomed Opt2008，13，05： | 1 |
| 20 | Triazoie-dithioearbamate based selective lysine specific demethylase I(LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration 显示文摘 | Zheng YC Duan YC Ma JL | 2013 | J Med Chem2013，56，21： | 1 |
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