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| 1 | Upregulation of vimentin and aberrant expression of E-cadherin /beta-catenin complex in oral squamous cell carcinomas:correlation with the clinicopathological features and patient outcome显示文摘Oral squamous cell carcinoma is a challenging oncology problem.A reliable biomarker for metastasis or high-risk prognosis in oral cancer patients remains undefined.Using quantitative immunohistochemistry,we examined the expression of vimentin,E-cadherin,and beta-catenin in 83 oral squamous cell carcinoma patients,and the relationships between the expression of these markers and specific clinicopathological features were analysed.The high expression of vimentin was observed in 23 of 43(53%) tumours from patients who eventually developed a recurrent tumour and was associated with recurrence and death(P < 0.001 and < 0.001,respectively).The decreased expression of E-cadherin was observed in 36 of 43(84%) tumours from patients who eventually developed a recurrent tumour and was also associated with recurrence and death(P < 0.001 and < 0.001,respectively).Although no correlation between beta-catenin expression in whole-tumour sections and clinicopathological features was observed,decreased beta-catenin expression at the tumour invasive front was closely associated with recurrence and death(P=0.002 and 0.002,respectively).The expression of vimentin and that of E-cadherin were associated with survival and were independent prognostic factors in univariate and multivariate analyses.Our data show that the overexpression of vimentin was closely associated with recurrence and death in oral squamous cell carcinoma patients.The combination of the upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complexes at the tumour invasive front may provide a useful prognostic marker in oral squamous cell carcinoma. | Liu,LK Jiang,XY Zhou,XX Wang,DM Song,XL Jiang,HB Nanjing Med Univ,Coll Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing Med Univ,Inst Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing Med Univ,Coll Stomatol,Dept Oral & Maxillofacial Surg,Nanjing 210029,Jiangsu,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 25 |
| 2 | Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3显示文摘AIM: To investigate the inhibitory role and the underlying mechanisms of sorafenib on signal transducer and activator of transcription 3 (STAT3) activity in hepatocellular carcinoma (HCC).METHODS: Human and rat HCC cell lines were treated with sorafenib. Proliferation and STAT3 dephosphorylation were assessed. Potential molecular mechanisms of STAT3 pathway inhibition by sorafenib were evaluated. In vivo antitumor action and STAT3 inhibition were investigated in an immunocompetent orthotopic rat HCC model.RESULTS: Sorafenib decreased STAT3 phosphorylationat the tyrosine and serine residues (Y705 and S727), but did not affect Janus kinase 2 (JAK2) and phosphatase shatterproof 2 (SHP2), which is associated with growth inhibition in HCC cells. Dephosphorylation of S727 was associated with attenuated extracellular signal-regulated kinase (ERK) phosphorylation, similar to the effects of a mitogen-activated protein kinase (MEK) inhibitor U0126, suggesting that sorafenib induced S727 dephosphorylation by inhibiting MEK/ERK signaling. Meanwhile, sorafenib could also inhibit Akt phosphorylation, and both the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 and Akt knockdown resulted in Y705 dephosphorylation, indicating that Y705 dephosphorylation by sorafenib was mediated by inhibiting the PI3K/Akt pathway. Finally, in the rat HCC model, sorafenib signifi cantly inhibited STAT3 activity, reducing tumor growth and metastasis.CONCLUSION: Sorafenib inhibits growth and metastasis of HCC in part by blocking the MEK/ERK/STAT3 and PI3K/Akt/STAT3 signaling pathways, but independent of JAK2 and SHP2 activation. | Fang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian ZhouFang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian Zhou, Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Shanghai 200032, China Author contributions: Gu FM, Li QL and Gao Q contributed equally to this work Gu FM and Li QL performed the experi- ments and interpretation of the data and statistical analysis Zhou J and Gao Q contributed to the conception and design of the study Gu FM, Gao Q, Li QL and Zhou J wrote the manuscript Jiang JH, Huang XY, Pan JF and Fan J made substantial contri- bution to the design and conception of the study and interpreta- tion of data all authors read and approved the f inal manuscript. | 2011 | World Journal of Gastroenterology2011，17，34： | 18 |
| 3 | 12-Deoxyphorbol Esters from Euphorbia Fischeriana显示文摘12-DeoxyphorbolEstersfromEuphorbiaFischerianaWenZiLIU;XiaoYunWU;GenJinYANG;QingGaoMA;TianXiZHOU;XiCanTANGandGuoWeiQIN(Departm... | Liu, WZ Wu, XY Yang, GJ Ma, QG Zhou, TX Tang, XC Qin, GW | 1996 | Chinese Chemical Letters1996，7，10： | 7 |
| 4 | Application study of quick cogni- tive screening test in identifying mild cognitive impairment显示文摘 | Guo QH Cao XY Zhou Y | 2010 | Neurosei Bu112010，26，1： | 1 |
| 5 | Continuous-time mean portfolio selection: a stochastic LQ framework显示文摘 | Zhou XY Li D | 2000 | Applied Mathematical&Optimization2000，42，： | 1 |
| 6 | Ku affects the ATM- dependent S phase checkpoint following ionizing radiation显示文摘 | Zhou XY Wang X Wang H | 2002 | Oncogene2002，21，41： | 1 |
| 7 | Acid-induced unfolding mechanism of recombinant human endostatin 显示文摘 | Li B Wu XY Zhou H | 2004 | Biochemistry2004，43，9： | 1 |
| 8 | Predictive role of GSTs on the prognosis of breast cancer patients with neoadjuvant chemotherapy 显示文摘 | Bai YL Zhou B Jing XY | 2012 | Asian Pac J Cancer Prev2012，13，10： | 1 |
| 9 | Expression of interleukin-17 and itsclinical significance in gastric cancer patients显示文摘 | Meng XY Zhou CH Ma J | 2012 | Med Oncol2012，29，5： | 1 |
| 10 | BML - 111, a lipoxin receptor agonist, protected carbon tetrachloride - induced hepatic fibrosis in rats显示文摘 | Zhou XY Yu ZJ Yan D | 2013 | Inflammation2013，36，5： | 1 |
| 11 | Low-dose mife-pristone increases uterine natural killer cell cytotoxicity and perforin expression during the receptive phase显示文摘 | Zhou F Chen XY Zhuang YL | 2011 | Fertility and Sterility2011，96，3： | 1 |
| 12 | Cortisol and cytokines inchronic and treatment-resistant patients with schizophrenia :association with psychopatholc^y and response to antipsychotics显示文摘 | Zhang XY Zhou DF Cao LY | 2005 | Neuropsychopharmacology2005，30，8： | 1 |
| 13 | Blockade of CD86 signaling facilitates a Th2 bias at the maternal-fetal interface and expands peripheral CD4+CD25+regulatory T cells to rescue abortion-prone fetuses显示文摘 | Zhu XY Zhou YH Wang MY | 2005 | Biol Reprod2005，72，2： | 1 |
| 14 | Sonographic and Doppler imaging in the diagnosis and treatment of gestational trophoblastic disease : a 12-year experience 显示文摘 | Zhou Q Lei XY Xie Q | 2005 | J Ultrasound Med2005，24，1： | 1 |
| 15 | Neuroprotectlve effects of mi- croRNA-210 on hypoxic-isehe mic encephalopathy 显示文摘 | Qiu J Zhou XY Zhou XG | 2013 | Biomed Res Int2013，，35： | 1 |
| 16 | Oxidized low density lipoprotein decreases macrophage expression of scavenger receptor B-I显示文摘 | Han J Nicholson AC Zhou XY | 2001 | J Biol Chem2001，276，16： | 1 |
| 17 | Hemodynamic responses dur-ing induction : comparison of Marsh and Schnider pharmacokineticmodels 显示文摘 | Yang XY Zhou ZB Yang | 2015 | Int J Clin Pharmacol Ther2015，53，1： | 1 |
| 18 | Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross- linking显示文摘 | Issa R Zhou XY Christothea M | 2004 | Gastroenterology2004，126，7： | 1 |
| 19 | Role of the 20-hydroxyl group in camptothecin binding by the topoisomerase I-DNA binary complex显示文摘 | Wang XY Zhou X Hecht SM | 1999 | Biochemistry1999，38，14： | 1 |
| 20 | Corneal nerve morphology and sensitivity changes after ultratolet A/riboflavin treatment显示文摘 | Xia Y Chai XY Zhou CQ Ren QS | | 0，，04： | 1 |
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