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| 1 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 2 | Diterpenoid Alkaloids from Aconitum Pendulum显示文摘A new diterpenoid 12 -epiacetyldehydrolucidusculline (1) and a new norditerpenoid alkaloid 2-hydroxydeoxyaconitine (2) were isolated from the roots of Aconitum pendulum, together with eight known alkaloids aconitine (3), deoxyaconitine (4), 3-acetylaconitine (5), 12-epiacetyldehydronapelline (6), dehydrolucidusculline (7), dehydronapelline (8), 12 -epidehydrnapelline (9), and noeline (10). The structures of the new alkaloids (1-2) were determined on the basis of spectral method. | Zhang, SM Tan, LQ Ou, QY | 1997 | Chinese Chemical Letters1997，8，11： | 5 |
| 3 | Discovery of virus pathogen from soft-shelled turtle Trionyx sinesis显示文摘THE soft-shelled turtle Trionyx sinesis, because of its nutritional and medicinal values, | Zhang, QY Li, ZQ Jiang, YL Liang, SC Gui, JF | 1997 | Chinese Science Bulletin1997，42，6： | 3 |
| 4 | Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer显示文摘 | Zhang XM Miao XP Liang G Hao BT Wang YG Tan W Li Y Guo YL He FC Wei QY Lin DX | 2006 | 中国生物学文摘2006，20，4： | 2 |
| 5 | Mutational analysis of the transforming growth factor beta receptor type I gene in primary non-small cell lung cancer显示文摘 | Zhang HT Fei QY Chen F | 2003 | Lung Cancer2003，40，3： | 1 |
| 6 | Trends in prevalence of HIV, syphilis, hepatitis C, hepatitis B and sexual risk behav- ior among men who have sex with ruen 显示文摘 | Ma XY Zhang QY He X | 2007 | J Acquit Immune Defic Syndr2007，45，5： | 1 |
| 7 | Insertion of an extra amino acid is the main cause of the low affinity of penicillin-binding protein 2 in penicillin-resistant strains of Neisseria gonorrhoeae 显示文摘 | Brannigan JA Tirodimos IA Zhang QY | 1990 | Mol Microbiol1990，4，： | 1 |
| 8 | Hypnotic effect of jujubosides from Semen Ziziphi Spinosae 显示文摘 | Cao JX Zhang QY Cui SY | 2010 | J Ethnopharmacol2010，130，1： | 1 |
| 9 | Thoracoumbilical flap: experience with 33 eases显示文摘 | Zhang XQ Wang SD Fan QY | 2004 | J Reeonstr Mierosurg2004，20，2： | 1 |
| 10 | Baicalein induces apoptosis in e- sophageal squamous cell carcinoma cells through modulation of the PI3K/Akt pathway显示文摘 | HB Zhang P Lu QY Guo | 2013 | Oncol Lett2013，5，2： | 1 |
| 11 | Cloning and characterization of a blood coagulation factor Ⅸ - binding protein from the venom of Trimeresurus stejnegeri 显示文摘 | Lee WH Zhuang QY Zhang Y | 2003 | Toxicon2003，41，7： | 1 |
| 12 | Expression of E-cadherin and nm23 is associated with the clinicopathological factors of human non-small cell lung cancer in China 显示文摘 | Chen XF Zhang HT Qi QY | 2005 | Lung Cancer2005，48，1： | 1 |
| 13 | Block of mouse Slol and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine显示文摘 | Tang QY Zhang Z Xia XM | 2010 | Channels2010，4，1： | 1 |
| 14 | Modulation of intracellular calcium transient in response to beta-adrenoceptor stimulation in the hearts of 4-wk-old rats during simulated weightlessness显示文摘 | Cui Y Zhang SM Zhang QY | 2010 | J Appl Physiol (1985)2010，108，4： | 1 |
| 15 | Estrogen - like activities in Vitex species from China determined by a cell based proliferation assay 显示文摘 | Hu Y Zhang QY Hou TT | 2007 | Pharmazie2007，62，11： | 1 |
| 16 | The beneficial effect of resveratrol on severe acute panereatitis显示文摘 | Ms QY Zhang M Wang z | 2011 | Ann NY Aead sei2011，1215，： | 1 |
| 17 | Daidzein induces MCF-7breast cancer cell apoptosis via the mitochondrial pathway 显示文摘 | Jin S Zhang QY Kang XM | 2010 | Ann Oncol2010，21，2： | 1 |
| 18 | Induction of CYP1A by Benzo fluoranthene in Human Hepatocytes: CYP1A1 or CYP1A2? 显示文摘 | Ning L Zhang QY Dilip V | 2001 | Arch Biochem Biophys2001，389，1： | 1 |
| 19 | Protective effects of salvianolate on microvascular flow in a porcine model of myocardial ischaemia and reperfusion显示文摘 | Han BB Zhang X Zhang QY | 2011 | Archives of Cardiovascular Diseases2011，104，5： | 1 |
| 20 | Expression and function of aquaporin-1 in hyperoxia exposed alveolar epithelial type II cells 显示文摘 | Zhang QY Fu JH Xue XD | 2014 | Exp Ther Med2014，8，2： | 1 |
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