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| 1 | Global secretome analysis identifies novel mediators of bone metastasis显示文摘骨头是稳固的肿瘤的远转移的一个最普通的地点。分泌蛋白质被知道影响在变形癌症房间和骨头基质之间的病理学的相互作用。为了包括地介绍,分泌了与骨头转移联系的蛋白质,我们使用了量、非量的集体 spectrometry 全球性分析改变从多重种类和癌症的变形能力打的骨头的九根细胞线的 secretomes。由比较父母房间和他们的骨头的 secretomes 变形衍生物,我们识别了特别地在这些房间线与骨头转移被联系的分泌蛋白质。我们然后合并了大临床的转移数据集的生物信息的分析获得强烈与临床、试验性的骨头转移被联系的几个功能的班的候选人小说骨头转移蛋白质的一张表。选择蛋白质的功能的确认显示在 vivo,骨头转移能被高表示支持(1 ) 唾液的 cystatins CST1, CST2,和 CST4;(2 ) plasminogen 使活跃之物小块地和 PLAU;或(3 ) 骨胶原功能蛋白质 PLOD2 和 COL6A1。总的来说,我们的学习揭开了骨头转移并且因此的几个新分泌调停人证明 secretome 分析是为新奇 biomarkers 和候选人的鉴定的一个强大的方法治疗学的目标。 | Maria Andres Blanco Gary LeRoy Zia Khan Ma a Ale kovi Barry M Zee Benjamin A Garcia Yibin Kang | 2012 | Cell Research2012，22，9： | 12 |
| 2 | Assessing crop water stress of winter wheat by thermography under different irrigation regimes in North China Plain显示文摘Thermal imaging can be used as an indicator of water stress due to the closure of stomatal aperture.In this paper,we analyzed the robustness and sensitivity of thermography of winter wheat in the North China Plain.The seasonal and diurnal variations of Crop Water Stress Index(CWSI)were evaluated.Five treatments were applied by means of irrigation,with plots receiving 100%of ETo(DI),50%(D50),16%(D16)and no irrigation(NI).A high correlation was found between stomatal conductance(gs)and CWSI,depending on the phenological stage of the crop with R2=0.44 at pre-heading stage and R2=0.77 at post-heading stage.In addition,a high correlation between yield and CWSI at different growth stages indicates that thermography can predict yield.Hourly measurements of canopy temperature were taken to study the effect of the time of day on image acquisition and it was found that midday was the most appropriate time.These results should assist in designing precision irrigation scheduling for setting the threshold values. | Shamaila Zia Du Wenyong Wolfram Spreer Klaus Spohrer He Xiongkui Joachim Müller | 2012 | International Journal of Agricultural and Biological Engineering2012，5，3： | 4 |
| 3 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 4 | Non-invasive water status detection in grapevine(Vitis vinifera L.)by thermography显示文摘Grapevines are preferentially grown under mild to moderate water stress conditions to achieve the best compromise between wine quality and quantity.Water status detection for advanced irrigation scheduling is frequently done by predawn leaf water potential(ΨPD)or leaf stomata conductance(gL)measurements.However,these measurements are time and labor consuming.Therefore,the use of infrared thermography(IRT)opens up the possibility to study large population of leaves and to give an overview on the stomatal variation and their dynamics.In the present study IRT was used to identify water stress of potted grapevines.In order to define the sensitivity of IRT measurements to water stress,the IRT-based water status information were compared with simultaneously measuredΨPD and gL data.Correlations between IRT-based CWSI data on the one hand and gL andΨPD on the other showed the potential of IRT for water stress detection.However,the CWSI calculation procedure is laborious and the sensitivity of CWSI for water stress detection still needs to be improved.Therefore,further improvements are necessary in order to apply remote IRT-based systems for irrigation scheduling in the field. | Shamaila Zia Klaus Spohrer Nikolaus Merkt Du Wenyong Xiongkui He Joachim Müller | 2009 | International Journal of Agricultural and Biological Engineering2009，2，4： | 3 |
| 5 | Monitoring physiological responses to water stress in two maize varieties by infrared thermography显示文摘Water stress is one of the main causes of yield reductions in crops,especially in arid and semi-arid regions where the water supply is limited.Plant water status is frequently assessed by pre-dawn leaf water potential(ΨPD)or leaf stomata conductance(gL)measurements,in support of advanced irrigation scheduling.However,both methods are time and labour consuming.A non-invasive approach to water status detection is the use of infrared thermography(IRT).This experiment was conducted in a greenhouse on two potted maize varieties under irrigated and non-irrigated conditions,and the measurements began when the crop had reached its twelve leaf stage.In order to establish the IRT measurements for detecting the water status of maize,an IRT-based crop water stress index(CWSI)was calculated and compared with simultaneously measuredΨPD and gL data.Good correlations were found between CWSI and gL data(r2=0.71&0.81),as well between CWSI andΨPD data(r2=0.53&0.81).These results highlight the appropriateness of infrared thermal imagery to detect and differentiate between the crop water statuses of different genotypes. | Shamaila Zia Klaus Sophrer Du Wenyong Wolfram Spreer Giuseppe Romano He Xiongkui Joachim Müller | 2011 | International Journal of Agricultural and Biological Engineering2011，4，3： | 3 |
| 6 | Aripiprazole-induced hiccups:a case report显示文摘 | Ray P Zia Ul Haq M Nizamie SH | 2009 | General Hospital Psychiatry2009，，： | 1 |
| 7 | Thymosin alpha 1 down regulates the growth of human non-small celllung cancer cells in vitro and in vivo 显示文摘 | MOODY T FAGARASAN M ZIA F | 1993 | Cancer Res1993，53，21： | 1 |
| 8 | Chloride penetration and AC impedance of high performance concrete显示文摘 | LEMING M L ZIA P | 1995 | ACI SP-1401995，，： | 1 |
| 9 | Copper uptake and regulation in a copper-tolerant decapod Cambarusbartoni(Fabricius)(Decapoda,Crustacea)显示文摘 | Zia S Alikhan M A | 1989 | Bulletin of Environmental Contamination and Toxicology1989，42，1： | 1 |
| 10 | Frontal brain lobe impairment in obstructive sleep apnea:a proton MR spectroscopy study显示文摘 | Alchanatis M Deligiorgis N Zias N | 2004 | Eur Respir J2004，24，6： | 1 |
| 11 | Frontal brain lobe impairment in obstructive sleep apnoea: a proton MR spectroscopy study显示文摘 | Alchanatis M Deligiorgis N Zias N | 2004 | Eur Respir J2004，24，6： | 1 |
| 12 | Modification of cellulosic fabric using polyvinyl alcohol,Part?Ⅱ:colorfastness properties显示文摘 | ZUBER M ZIA KM BHATTI I A | 2012 | Carbohyd Polym2012，87，4： | 1 |
| 13 | XRD studies of polyurethane elastomers based on chitin/1,4-butane diol blends 显示文摘 | Zia K M Bhatti I A | 2009 | Carbohydrate Polymers2009，76，： | 1 |
| 14 | Percutaneous locking plates for fractures of the distal tibia: our experience and a review of the litera- ture显示文摘 | Ahmad M A Sivaraman A Zia A | 2012 | J Trauma Acute Care Surg2012，72，2： | 1 |
| 15 | The influence of the enhancer dimyristoylphosphatidylglycerol and formulation factors on the nasal absorption of salmon calcitonim显示文摘 | Dua R Duncan M Zia H | 1998 | Drug Deliv J Deliv Targeting Ther Agents1998，5，2： | 1 |
| 16 | Biochemical profiling of mucilage extracted from seeds of different citrus rootstocks显示文摘 | Naqvi SA Khan MM Shahid M Jaskani MJ Khan IA Zuber M Zia KM | 2011 | Carbohyd Polym2011，83，2： | 1 |
| 17 | Duplications and defects in the CYP2A6 gene:identification,genotyping,and in vivo effects on smoking显示文摘 | Hoffmann E Zia M | 2000 | Mol Pharmacol2000，58，4： | 1 |
| 18 | Sleep apnea-related cognitive deficits and intelligence:an implication of cognitive reserve theory显示文摘 | Alchanatis M Zias N Deligiorgis N | 2005 | J Sleep Res2005，14，1： | 1 |
| 19 | Contribution of routine joint aspiration to the diagnosis of infection before hip revision surgery显示文摘 | Somme D Zia J M Displaces N | 2003 | Joint Bone Spine2003，70，6： | 1 |
| 20 | Rabies molecular virology,diagno- sis,prevention and treatment显示文摘 | Yousaf MZ Qasim M Zia S | 2012 | Virol J2012，9，1： | 1 |
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