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	题名	作者	年代	出处	被引量
1	Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation.	Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon	2012	World Journal of Gastrointestinal Oncology2012，4，5：	5
2	Mechanisms of acetaldehyde mediated growth inhibition: delayed cell cycle progression and induction of apoptosis显示文摘	Zimmerman BT Crawford GD Dahl R	1995	Alcohol-clin-exp-res1995，19，2：	2
3	Removal of arsenic by magnetic biochar prepared from pinewood and natural hematite显示文摘	Shengsen Wang Bin Gao Andrew R Zimmerman Yuncong Li Lena Ma Willie Harris Kati Migliaccio	2014	Bioresource Technology2014，，：	2
4	Quantitative apparent diffusion coefficient measurements in term neonates for early detection of hypoxic-ischemic brain injury: initial experience 显示文摘	Wolf R Zimmerman RA Clancy R	2001	Radiology2001，218，3：	1
5	Impact of carbadox on rate,efficiency,and composition of growth in pigs with a low or high level of immune system activation显示文摘	STAHLY T S WILLIAMS N H ZIMMERMAN D R	1994	J Anim Sci1994，72，1：	1
6	Positive AccountingTheory : A ten Years Perspective 显示文摘	Watts R Zimmerman J	1990	Accounting Review1990，，65：	1
7	Quantitative ap- parent diffusion coefficient measurements in term neonates for early detection of hypoxic-ischemic brain injury: initial expe- rience显示文摘	Wolf RL Zimmerman RA Clancy R	2001	Radiology2001，218，：	1
8	Nursing, nursing education, and anxiety显示文摘	Bigegers T Zimmerman R S Alpert G	1988	J Nurs Educ1988，27，9：	1
9	Advances in treatment of lupus nephritis显示文摘	Zimmerman R Radhakrishnan J Valeri A	2001	Annu Rev Med2001，52，：	1
10	Diagnostic marker coop- erative study for the diagnosis of myocardial infarction显示文摘	Zimmerman J Fromm R Meyer D	1999	Circu- lation1999，99，13：	1
11	Lymphangiogenesis concurrent with haemangiogenesis in the human cornea显示文摘	Regina M Zimmerman R Malik G		0，，6：	1
12	Comparison of three types of pulse tube refrigerators: new methods for reaching 60K 显示文摘	Radebaugh R Zimmerman J	1986	Advances in Cryo- genic Engineering1986，31，：	1
13	MATPOWER: Steady-state operations, planning and analysis tools for power systems research and education显示文摘	Zimmerman R Murillo-Sanchez C Thomas R	2011	1EEE Transactions on Power Systems2011，26，1：	1
14	Mat- power: steady- state operations, planning and analysis tools for power systems research and education 显示文摘	Zimmerman R D Murillo - Samchez C E Thomas R J	2011	IEEE Transac- tions on Power Systems2011，26，1：	1
15	Encephalomyocarditis virus infection in raccoons (procyonlotor) 显示文摘	Zimmerman J J Hill R E Smith K	1994	Journal of Zoo and Wildlife Medicine1994，25，：	1
16	A ring-like nucleoid is not necessary for radioresistance in the Deinococcaceae显示文摘	Zimmerman J M Battista J R	2005	BMC Microbiol2005，5，：	1
17	Effects of chronic immune system activation on the rate,efficiency,and composition of growth and lysine ceeds of pigs fed from 6 to 7 kg显示文摘	WILLIAMS N H STAHLY T S ZIMMERMAN D R	1997	J Anim Sci1997，75，：	1
18	Quantitative apparent diffusion coefficient measurements in term neonates for early detection of hypoxic-ischemic brain injury:initial experience显示文摘	Wolf RL Zimmerman RA Clancy R	2001	Radiology2001，218，3：	1
19	Stability- constrained optimal power flow 显示文摘	GAN D THOMAS R J ZIMMERMAN R D	2000	IEEE Trans on Power Systems2000，15，2：	1
20	Towards a positive theory of the determination of accounting standards显示文摘	WATTS R L ZIMMERMAN J L	1978	Accounting Review1978，，1：	1

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