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| 1 | Burden of onchocerciasis-associated epilepsy:first estimates and research priorities显示文摘Background:Since the 1990s,evidence has accumulated of an increased prevalence of epilepsy in onchocerciasisendemic areas in Africa as compared to onchocerciasis-free areas.Although the causal relationship between onchocerciasis and epilepsy has yet to be proven,there is likely an association.Here we discuss the need for disease burden estimates of onchocerciasis-associated epilepsy(OAE),provide them,detail how such estimates should be refined,and discuss the socioeconomic impact of OAE,including a cost-estimate for anti-epileptic drugs.Main body:Providing OAE burden estimates may aid prevention of epilepsy in onchocerciasis-endemic areas by inciting and informing collaboration between onchocerciasis control programmes and mental health services.Epilepsy not only massively impacts the health of those affected,but it also carries a high socioeconomic burden for the households and communities involved.We used previously published geospatial estimates of onchocerciasis in Africa and a separately published logistic regression model quantifying the association between onchocerciasis and epilepsy to estimate the number of OAE cases.We then applied disability weights for epilepsy to quantify the burden in terms of years of life lived with disability(YLD)and estimate the cost of treatment.We estimate that in 2015 roughly 117000 people were affected by OAE across onchocerciasis-endemic areas previously under the African Programme for Onchocerciases control(APOC)mandate where OAE has ever been reported or suspected,and another 264000 persons in onchocerciasis-endemic areas where OAE has never been investigated before.The total number of YLDs due to OAE was 39300 and 88700 in these areas respectively,based on a weighted mean disability weight of 0.336.The burden of OAE is approximately 13%of the total YLDs attributable to onchocerciasis and 10%of total YLDs attributable to epilepsy.We estimated that by 2015 the total costs of treatment with antiepileptic drug for OAE cases would have been a minimum of 12.4 million US$.Conclusions:These estimates suggest a considerable health,social and economic burden of OAE in Africa.The treatment and care for people with epilepsy,especially in hyperendemic onchocerciasis areas with high epilepsy prevalence thus requires more financial and human resources. | Natalie V.S.Vinkeles Melchers Sarah Mollenkopf Robert Colebunders Michael Edlinger Luc E.Coffeng Julia Irani Tresor Zola Joseph N.Siewe Sake Jde Vlas Andrea S.Winkler Wilma A.Stolk | 2018 | Infectious Diseases of Poverty2018，7，1： | 3 |
| 2 | The human leucocyte differentiation antigens (HLDA) workshops: the evolv-ing role of antibodies in research, diagnosis and therapy显示文摘The 8th International Workshop on Human Leucocyte Differentiation Antigens (chaired by Zola H and managed by Swart B) was run over a 4-year period and culminated in a conference in December 2004. Here we review the achieve- ments of the HLDA Workshops and provide links to information on CD molecules and antibodies against them, including the 93 new CDs assigned in the 8th Workshop. We consider what remains to be achieved (including an estimate of the number of leucocyte surface molecules still to be discovered), and how the field can best move forward. | Heddy ZOLA Bernadette SWART | 2005 | Cell Research2005，15，9： | 2 |
| 3 | An analysis of ap- proaches to the treatment of endometrial cancer in western Europe: a CTF study显示文摘 | Maggino T Romagnolo C Zola P | 1995 | EurJ Cancer1995，31，12： | 1 |
| 4 | Serum half- life of CA125 during early chemotherapy as an iudependent prognostic variable for patients with advanced epithelial ovarian cancer: results of a multieentric Italian study 显示文摘 | GADDUCCI A ZOLA P LANDONI F | 1995 | Gynecol Oncol1995，58，1： | 1 |
| 5 | Impaired recognition memory in rats after damage to the hippocampus显示文摘 | Clark R E Zola S M Squire L R | 2000 | J Neurosci2000，20，： | 1 |
| 6 | The clinical outcome of epithelial ovarian cancer patients with apparently isolated lymph node recurrence; a multicenter retrospective Italian study显示文摘 | Gadducci A Cosio S Zola P | 2010 | Gynecol Oncol2010，116，3： | 1 |
| 7 | Effect of ionic impurities on the crystallization of gypsum in wet-process phosphoric acid显示文摘 | Annalize Kruger Walter W Focke Zola Kwela | 2001 | Ind Eng Chem Res2001，40，5： | 1 |
| 8 | Structure and function of declarative and nondeclarative memory systems显示文摘 | Squire LR Zola SM | | 0，，： | 1 |
| 9 | Immune activation inirritable bowel syndrome: can neuroimmune interactionsexplain symptoms? 显示文摘 | Hughes PA Zola H Penttila IA | 2013 | Am J Gastroenterol2013，108，7： | 1 |
| 10 | Simple model of metal oxide varistor for pspice simulation显示文摘 | Julio Guillermo Zola | 2004 | IEEE Trans on Computer aided Design of Intearated Circuits and Systems2004，23，10： | 1 |
| 11 | Interleukin 2 receptor regulation and IL-2 function in the human infant显示文摘 | Zola H Ridings J Elliott S | 1998 | Hum Immunol1998，59，： | 1 |
| 12 | The Taper Effect in KI-I2PO4 Type Crystals显示文摘 | Loiacono G M Zola J J Kostecky G | 1982 | Journal of Crystal Growth1982，58，： | 1 |
| 13 | Minimally invasive radical prostatectomy:Transition from pure la- paroscopic to robotic-assisted radical prostatectomy 显示文摘 | Trabulsi E J Zola JC Colon-Herdman A | 2011 | Arch Esp Urol2011，64，8： | 1 |
| 14 | Haema- tococcus astaxanthin:applications for human health and nutrition 显示文摘 | GUER~N M HUNTLEY M E OLA~ZOLA M | 2003 | Trends in Biotechnology2003，21，5： | 1 |
| 15 | Constrasting effects on discrimination learning after hippocampal lesions and conjoint hippocampal can duate lesions in monkeys显示文摘 | Teng E Stefanacci L Squire LR Zola SM | 2000 | J Neurosci2000，20，10： | 1 |
| 16 | The Fas antigen(CD95) on human lymphoidcells:epitope analysis with ten antibodies显示文摘 | Zola H Fusco M Ridings J | 1996 | Tissue Antigens1996，48，3： | 1 |
| 17 | Structure and function of declarative and nondeclarative memory systems显示文摘 | Squire LR Zola SM | 1996 | Proc Natl Acad Sci USA1996，93，13： | 1 |
| 18 | CD molecules 2005: human cell differentiation molecules显示文摘 | Zola H Swart B Nicholson I | 2005 | Blood2005，106，9： | 1 |
| 19 | Expression of eytokine receptors by human cord blood lymphocytes : comparison with adult blood lymphocytes显示文摘 | Zola H Fuseo M Maeardle PJ | 1995 | Pediatr Res1995，38，： | 1 |
| 20 | Analysis of the cord blood T lymphocyte response to superantigen显示文摘 | Macardle P I Wheatland L Zola H | 1999 | Hum Immunol1999，60，： | 1 |
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