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| 1 | Chemotherapy of glioblastoma in rats using doxorubicin - loaded nanoparticles显示文摘Glioblastomas belong to the most aggressive human cancers with short survival times.Due to the blood-brainbarrier,they are mostly inaccessible to traditional chemotherapy.We have recently shown that doxorubicin boundto polysorbate-coated nanoparticles crossed the intact blood-brain barrier,thus reaching therapeutic concentra-tions in the brain.Here,we investigated the therapeutic potential of this formulation of doxorubicin in vivo using ananimal model created by implantation of 101/8 glioblastoma tumor in rat brains.Groups of 5-8 glioblastoma- | Steiniger SC Kreuter J Khalansky AS Skidan IN Bobruskin I Smirnova ZS Severin SE Uhl R Kock M Geiger KD Gelperina SE | 2004 | 中国神经肿瘤杂志2004，2，1： | 13 |
| 2 | Relevance of α-defensins(HNP1-3) and defensin β-1 in diabetes显示文摘AIM: To investigate the genetic background of human defensin expression in type 1 and 2 diabetes.METHODS: Associations between DEFA1/DEFA3 gene copy number polymorphism and diabetes as well as between the promoter polymorphisms of DEFB1 and diabetes were studied. The copy number variation of the DEFA1/DEFA3 genes was determined in 257 diabetic patients(117 patients with type 1 and 140 with type 2 diabetes). The control group consisted of 221 age- and gender-matched healthy blood donors. The cumulative copy numbers of the DEFA1/DEFA3 genes were detected by using quantitative PCR analysis. To evaluate the HNP 1-3(human neutrophil peptide 1-3 or α-defensin) levels in the circulation, plasma HNP 1-3 concentrations were measured by ELISA. The expression of DEFA1/A3 in peripheral leukocytes of the diabetic patients was measured by quantitative RT PCR analysis. Three SNPs of the human DEFB1(human defensin β-1) gene: DEFB1 G-20A(rs11362), DEFB1 C-44G(rs1800972) and DEFB1 G-52A(rs1799946) were genotyped by Custom TaqMan? Real Time PCR assay.RESULTS: Significant differences were observed in HNP1-3 levels between the healthy subjects and both groups of diabetic patients. The mean ± SE was 28.78 ± 4.2 ng/mL in type 1 diabetes, and 29.82 ± 5.36 ng/mL in type 2 diabetes, vs 11.94 ± 2.96 ng/mL in controls; P < 0.01 respectively. There was no significant difference between patients with type 1 and type 2 diabetes in the high plasma concentrations of HNP1-3. The highest concentrations of α-defensin were found in diabetic patients with nephropathy(49.4 ± 4.8 ng/mL), neuropathy(38.7 ± 4.8 ng/mL) or cardiovascular complications(45.6 ± 1.45 ng/L). There was no significant difference in the cumulative copy numbers of DEFA1/DEFA3 genes between controls and patients, or between patients with the two types of diabetes. Comparisons of HNP 1-3 plasma level and DEFA1/A3 copy number of the same patient did not reveal significant relationship between defensin-α levels and the gene copy numbers(r2 = 0.01). Similarly, no positive correlation was observed between the copy numbers and the mRNA expression levels of DEFA1/A3. Regarding the C-44G polymorphism of DEFB1, the GG 'protective' genotype was much less frequent(1%-2%) among both groups of patients than among controls(9%).CONCLUSION: Elevated HNP1-3 levels in diabetes are independent of DEFA1/DEFA3 copy numbers, but GG genotype of C-44G SNP in DEFB1 gene may result in decreased defensin β-1 production. | Balázs Csaba Németh Tamás Várkonyi Ferenc Somogyvári Csaba Lengyel Katalin Fehértemplomi Szabolcs Nyiraty Péter Kempler Yvette Mándi | 2014 | World Journal of Gastroenterology2014，20，27： | 4 |
| 3 | In vitro and in vivo release of vas~:ular endothelial growth factor from gelatin microparticles and biodegradable composite scaffolds 显示文摘 | Patel ZS Ueda H Yamamoto M | 2008 | Pharm Res2008，25，10： | 1 |
| 4 | Enhanced expression of vascular matrix metalloproteinases induced in vitro by cytokines and in regions of human atherosclerotic lesions显示文摘 | Galis ZS Muszynski M Sukhova GK | 1995 | Ann N Y Acad Sci1995，748，： | 1 |
| 5 | Proteomics of a new esophageal cancer cell line established from Persian patient 显示文摘 | Moghanibashi M Jazii FR Soheili ZS | 2012 | Gene2012，500，1： | 1 |
| 6 | Theoretical study on 3-hydroxykynurenine transaminase by homology modeling and molecular dynamics 显示文摘 | Zheng QC Li ZS Sun M | 2005 | Polymer2005，46，8： | 1 |
| 7 | Biodegradable gelatin microparticles as delivery systems for the controlled release of bone morphogenetic protein-2 显示文摘 | Patel ZS Yamamoto M Ueda H | 2008 | Acta Biomater2008，4，5： | 1 |
| 8 | Study of pulsed electric field treated citrus juices显示文摘 | Cserhalmi Zs Sass-Kiss A Toth-Markus M | 2006 | Innovative Food Science and Emerging Technolgies2006，7，1： | 1 |
| 9 | Evidence for the partial dopamine-receptor agonist aripiprazole as a first-line treatment of psychosis in patients with iatrogenic or tumorogenic hyperprolactinemia显示文摘 | Hoffer ZS Roth RL Mathews M | 2009 | Psychosomatics2009，50，4： | 1 |
| 10 | Long-term prognostic role of coronary flow velocity reserve in patients with aortic valve stenosisinsights from the SZEGED Study显示文摘 | Nemes A Balázs E Csanády M | 2009 | Clin Physiol Funct Imaging2009，29，6： | 1 |
| 11 | Widespread iron limitation of phy- toplankton in the south pacific ocean 显示文摘 | Behrenfeld M J Kolber ZS | 1999 | Science1999，283，： | 1 |
| 12 | Erythroderma:a clinical study of 97 eases显示文摘 | Akhyani M Ghodsi ZS Toosi S | | 0，，： | 1 |
| 13 | Pyrolysis and debromination of flame retarded polymers of electronic scrap studied by analytical pyrolysis显示文摘 | Blazso M Czegeny Zs Csoma Cs | 2002 | Journal of Analytical and Applied Pyrolysis2002，64，2： | 1 |
| 14 | Cytokine2stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extra2celluar matrix digestion显示文摘 | Galas ZS Muszynski M Sukhova GK | 1994 | Circ Res1994，75，4： | 1 |
| 15 | Comparison of the effi- cacy of different types of lasers for the treatment of peri-implanti- tis: a systematic review 显示文摘 | Natto ZS Aladmawy M Levi PA Jr | 2015 | Int J Oral Maxillofac Implants2015，30，2： | 1 |
| 16 | Effects of endodontic post surface treatment,dentin conditioning,and artificial aging on the retention of glass fiber-reinforced composite resin posts显示文摘 | Alhashaireh ZS Ghazal M Kern M | 2010 | J Prosthet Dent2010，103，1： | 1 |
| 17 | Neonatal screening for congenital toxoplasmosis in the Poznan region of Poland by analysis of Toxoplasma gondii-specific IgM antibodies eluted from filter paper blood spots显示文摘 | Paul M Petersen E Pawlowski ZS Szczapa J | 2000 | Pediatr Infect Dis J2000，19，： | 1 |
| 18 | Structure and drug release of lamellar liquid crystals containing glycerol显示文摘 | Mkai M Csanyi E Nemeth Zs | 2003 | Int J Pharm2003，256，： | 1 |
| 19 | Cytokine---stimalated human vascular smooth musele cells synthesize a complement of enzymes required for extracellular matrixdigestion 显示文摘 | Gadis ZS Muszynski M Sukhova GK | 1994 | Circ Res1994，75，： | 1 |
| 20 | The connection between absence-like seizures and hypothermia induced by penicillin:possible implication on other animal models of peril mal epitepsy显示文摘 | Ostojic ZS Ruzdijic S Car M | 1997 | Brain research1997，777，： | 1 |
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