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| 1 | Liver biochemistry profile,significance and endoscopic management of biliary tract complications post orthotopic liver transplantation显示文摘AIM: To correlate the significance of liver biochemical tests in diagnosing post orthotopic liver transplantation (OLT) biliary complications and to study their profile before and after endoscopic therapy. METHODS: Patients who developed biliary complications were analysed in detail for the clinical information,laboratory tests,treatment offered,response to it,follow up and outcomes. The profile of liver enzymes was determined. The safety,efficacy and outcomes of endoscopic retrograde cholangiography (ERC) were also analysed. RESULTS: 40 patients required ERC for 70 biliary complications. GGT was found to be > 3 times (388.1 ± 70.9 U/mL vs 168.5 ± 34.2 U/L,P = 0.007) and SAP > 2 times (345.1 ± 59.1 U/L vs 152.7 ± 21.4 U/L,P = 0.003) the immediate post OLT values. Most frequent complication was isolated anastomotic strictures in 28 (40%). Sustained success was achieved in 26 (81%) patients. CONCLUSION: Biliary complications still remain an important problem post OLT. SAP and GGT can be used as early,non-invasive markers for diagnosis and also to assess the adequacy of therapy. Endoscopic management is usually effective in treating the majority of these biliary complications. | Yogesh M Shastri Nicolas M Hoepffner Bora Akoglu Christina Zapletal Wolf O Bechstein Wolfgang F Caspary Dominik Faust | 2007 | World Journal of Gastroenterology2007，13，20： | 6 |
| 2 | Identification of differentially expressed genes after partial rat liver ischemia/reperfusion by suppression subtractive hybridization显示文摘AIM: To identify potential diagnostic target genes in early reperfusion periods following warm liver ischemia before irreversible liver damage occurs.METHODS: We used two strategies (SSH suppression subtractive hybridization and hybridization of cDNA arrays)to determine early changes in gene expression profiles in a rat model of partial WI/R, comparing postischemic and adjacent nonischemic liver lobes. Differential gene expression was verified (WT/R; 1 h/2 h) and analyzed in more detail after warm ischemia (1 h) in a reperfusion time kinetics (0, 1, 2 and 6 h) and compared to untreated livers by Northern blot hybridizations. Protein expression was examined on Western blots and by immunohistochemistry for four differentially expressed target genes (Hsp70,Hsp27, Gadd45a and IL-1rl).RESULTS: Thirty-two individual WI/R target genes showing altered RNA levels after confirmation by Northern blot analyzes were identified. Among them, six functionally uncharacteristic expressed sequences and 26 known genes (12 induced in postischemic liver lobes, 14 with higher transcriptional expression in adjacent nonischemic liver lobes). Functional categories of the verified marker genes indicate on the one hand cellular stress and tissue damage but otherwise activation of protective cellular reactions (AP-1 transcription factors, apoptosis related genes, heat shock genes). In order to assign the transcriptional status to the biological relevant protein level we demonstrated that Hsp70, Hsp27, Gadd45a and IL-1rI were clearly up-regulated comparing postischemic and untreated rat livers, suggesting their involvement in the WI/R context.CONCLUSION: This study unveils a WI/R response gene set that will help to explore molecular pathways involved in the tissue damage after WI/R. In addition, these genes especially Hsp70and Gadd45a might represent promising new candidates indicating WI/R liver damage. | Christine Fallsehr Christina Zapletal Michael Kremer Resit Demir Magnus von Knebel Doeberitz Ernst Klar | 2005 | World Journal of Gastroenterology2005，11，9： | 4 |
| 3 | Atlantoodontoid osteoarthritis: comparison of lateral cervical projection and CT 显示文摘 | Zapletal J Hekster RE Wilmink JT | 1995 | Eur Spine1995，4，4： | 1 |
| 4 | Chest physiotherapy and airway obstruction in patients with cystic fibrosis-a nega- tive report 显示文摘 | Zapletal A Stefanova J Horak J | 1983 | European journal of respiratory diseases1983，64，6： | 1 |
| 5 | Normal values of static pulmonary volumes and ventilation in children and adolescents显示文摘 | Zapletal A Paul T Samanek M | 1976 | Cesk Pediatr1976，31，10： | 1 |
| 6 | Atlanto - odontoid osteoarthritis: appearance and prevalance at CT显示文摘 | Zapletal J Hekster REM Straver JS | 1995 | Spine1995，20，1： | 1 |
| 7 | Chemicalcharacterization of rain and fog water in theCervenohorske Sedlo ( Hruby Jesenik mountains, CzechRepublic) 显示文摘 | Zapletal M Kunak D Chroust P | 2007 | Water Air and Soil Pollution2007，186，14： | 1 |
| 8 | Vacuum phenomenon in osteoarthritis of the atlanto-odontoid joint: CT findings 显示文摘 | Zapletal J Hekster RE Wilmink JT | 1995 | Skeletal Radiol1995，24，2： | 1 |
| 9 | Radiologic prevalance of advanced lateral C1 - C2 osteoarthritis显示文摘 | Zapletal J Valois JC | 1997 | Spine1997，22，21： | 1 |
| 10 | N-acetylcysteine induces shedding of selectins from liver and intestine during orthotopic liver transplantation显示文摘 | Taut FJ Schmidt H Zapletal CM | | 0，，： | 1 |
| 11 | Radiologic prevalence of advanced lateral C1 ~C2 osteoarthritis显示文摘 | Zapletal J Valois JC | 1997 | Spine1997，22，21： | 1 |
| 12 | Atlanto-odontoid osteoarthritis:appearance and prevalance at CT显示文摘 | zapletal J Hekster REM Straver J S | 1995 | Spine1995，20，1： | 1 |
| 13 | Correlation between magnetic parameters and chemical composition of lake sediments from Northern Bohemia-preliminary study 显示文摘 | Petrovsky E Kapicka A Zapletal K | 1998 | Phys Chem Earth1998，23，： | 1 |
| 14 | The number of removed axillary sentinel lymph nodes and its impact on the diagnostic accuracy of sentinel lymph node biopsy in breast cancer显示文摘 | Zapletal O Coufal O SelingerováI | 2013 | Rozhl Chir2013，92，1： | 1 |
| 15 | Simultaneous,pancreaskidney transplantation in patients with antiphospholipid syndrome 显示文摘 | Woeste G Zapletal C | 2003 | Transplantation2003，75，4： | 1 |
| 16 | assessment of hepatic perfusion in pigs by pharmacokinetic analysis of dynamic MR images 显示文摘 | SCHARF J ZAPLETAL C HESS T | 1999 | J Magn Reson Imaging1999，，4： | 1 |
| 17 | 查看详情显示文摘 | Zapletal Ch Faust D Wullstein C | | 0，，： | 1 |
| 18 | Acute hyponatremia af- ter cardioplegia by histidine-tryptophan-ketoglutarate - a retro- spective study 显示文摘 | Lindner G Zapletal B Schwarz C | 2012 | J Cardiothorac Surg2012，7，： | 1 |
| 19 | Definition of maximum cold ischemia time without reduction of graft quality in clinical liver transplantation显示文摘 | Klar E Angelescu M Zapletal C | 1998 | Transplant Proc1998，30，7： | 1 |
| 20 | Quantication of liver perfusion by dynamic magnetic resonance imaging:experimental evaluation and clinical pilot study显示文摘 | Zapletal C Jahnke C Mehrabi A | 2009 | Liver Transplantatoon2009，15，： | 1 |
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