|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | An exploitable Achilles heel of MITF?显示文摘Microphthalmia-associated transcription factor(MITF)has been implicated in melanoma development and progression.In a study published in Cell Research,Liu et al.suggest that inhibition of MITF via targeting of its dimer interface may provide a novel therapeutic modality.As the master regulator of melanoma biogenesis,microphthalmia-associated transcription factor(MITF)coordi-nates survival,differentiation,proliferation,invasion,senescence,metabolism,and DNA damage repair in both melanocytes and melanomas. | Carolina Silva Ze’ev A.Ronai | 2023 | Cell Research2023，33，3： | 0 |
| 2 | 前苏联的自然保护政策显示文摘当今,超越一定的国家或地区的社会经济结构范围去分析环境问题是不实际的。没有对自然资源保护的研究。就不重视那些危及各种保护区和物种的“冲击”。前苏联相继进行的一些改革也许比其它国家都更为激进。一切政治的、经济的和社会的变革都极大地影响着资源保护的后果。通过大量的资料与过去进行对比,我们可了解前苏联的环境政策与状况。据官方报告。 | ZE’EV WOLFSON 刘自培 | 1992 | 资源开发与保护1992，8，2： | 0 |
| 3 | Radiofrequency-driven skin microchanneling as a new way for electrically assisted transdermal delivery of hydrophilic drugs显示文摘 | Amnon C Sintov Igor Krymberk Dorit Daniel Talli Hannan Ze’ev Sohn Galit Levin | 2003 | Journal of Controlled Release2003，，2： | 1 |
| 4 | Near infrared spectrometry of milk in its heterogeneous state显示文摘 | Ze’ev Schmilovitch Itzhak Shmulevich Amos Notea Ephraim Maltz | 2000 | Computers and Electronics in Agriculture2000，，3： | 1 |
| 5 | 什么是量子混沌?显示文摘最近,我的基金项目的一位评审人抱怨我的申请书中并没有解释“什么是量子混沌”,而想知道这一问题的答案正是该评审人同意评审该项目的唯一原因.我感到不解,因为那个项目和量子混沌毫无关系.但是这件事使我想试着阐述一下什么是量子混沌. | Ze’ev Rudnick 费少明(译) 郑驻军(校) | 2008 | 数学译林2008，27，4： | 0 |
| 6 | SUMO-1 Modification of Mdm2 Prevents Its Self-Ubiquitination and Increases Mdm2 Ability to Ubiquitinate p53显示文摘 | Thomas Buschmann Serge Y Fuchs Chee-Gun Lee Zhen-Qiang Pan Ze’ev Ronai | 2000 | Cell2000，，7： | 1 |
| 7 | Critical Function for SIP, a Ubiquitin E3 Ligase Component of the β-Catenin Degradation Pathway, for Thymocyte Development and G1 Checkpoint显示文摘 | Toru Fukushima Juan M. Zapata Netai C. Singha Michael Thomas Christina L. Kress Maryla Krajewska Stan Krajewski Ze’ev Ronai John C. Reed Shu-ichi Matsuzawa | 2006 | Immunity2006，，1： | 2 |
| 8 | Siah1/SIP regulates p27kip1 stability and cell migration under metabolic stress显示文摘 | Yoshito Nagano Toru Fukushima Kazuo Okemoto Keiichiro Tanaka David D.L. Bowtell Ze’ev Ronai John C. Reed Shu-ichi Matsuzawa | 2011 | Cell Cycle2011，，15： | 1 |
| 9 | Siah2 Regulates Stability of Prolyl-Hydroxylases, Controls HIF1α Abundance, and Modulates Physiological Responses to Hypoxia显示文摘 | Koh Nakayama Ian J Frew Mette Hagensen Marianne Skals Hasem Habelhah Anindita Bhoumik Takayuki Kadoya Hediye Erdjument-Bromage Paul Tempst Peter B Frappell David D Bowtell Ze’ev Ronai | 2004 | Cell2004，，： | 1 |
| 10 | Alternative Splicing Regulates Biogenesis of miRNAs Located across Exon-Intron Junctions显示文摘 | Ze’ev Melamed Asaf Levy Reut Ashwal-Fluss Galit Lev-Maor Keren Mekahel Nir Atias Shlomit Gilad Roded Sharan Carmit Levy Sebastian Kadener Gil Ast | 2013 | Molecular Cell2013，，6： | 1 |
| 11 | Markers for neural degeneration and regeneration:novel highly sensitive methods for the measurement of thrombin and activated protein C in human cerebrospinal fluid显示文摘Inflammation and coagulation are tightly interconnected in the pathophysiology of neuronal diseases.Thrombin,a pro-coagulant serine protease is associated with neurodegeneration and its indirect inhibitor,activated protein C(aPC),is considered neuroprotective.While levels of thrombin and aPC activity are readily measured in the blood,similar assays in the cerebrospinal fluid(CSF)have not been described.The aim of this study was to establish a specific and sensitive enzymatic assay to measure both thrombin and aPC activity in the CSF.CSF was collected from 14 patients with suspected normal pressure hydrocephalus served as a control group,while seven patients with central nervous system infections served as an acute neuro-inflammatory study group and one sample of CSF following traumatic lumbar puncture served as a positive control.Thrombin and aPC activities were measured by fluorescence released by specific proteolytic cleavage in the presence of endopeptidase and amino-peptidase inhibitors to ensure specificity.Specificity of the method was verified by thrombin and serine-protease inhibitors N-alpha-((2-naphthylsulfinyl)glycyl)-DL-p-amidinophenylalanylpiperidine and phenylmethanesulfonyl fluoride.Inhibition of thrombin activity by CSF samples and levels of specific thrombin inhibitors were also assessed.Thrombin and aPC activities were reliably measured and were significantly higher in the CSF of patients with central nervous system infections compared to normal pressure hydrocephalus controls,suggesting the involvement of these factors in neuro-inflammation.CSF thrombin activity levels in the presence of known thrombin concentration were high in patients with central nervous system infections,and low in normal pressure hydrocephalus patients.Quantification of endogenous thrombin inhibitors protease nexin 1,amyloid precursor protein and anti-thrombin III in CSF by western blot indicated a significant elevation of amyloid precursor protein in infectious CSF.In conclusion,this study describes a novel and sensitive assay aimed at the detection of thrombin and aPC activity in CSF.This method may be useful for measuring these factors that reflect degenerative and protective influences of coagulation on neurological disorders.The study procedure was approved by the Ethics Committee of the Chaim Sheba Medical Center(approval No.4245-17-SMC)on October 18,2018. | Alexandra Gerasimov Valery Golderman Shany Guly Gofrit Shay Anat Aharoni Daniela Noa Zohar Ze’ev Itsekson-Hayosh Tsviya Fay-Karmon Sharon Hassin-Baer Joab Chapman Nicola Maggio Efrat Shavit-Stein | 2021 | Neural Regeneration Research2021，16，10： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员