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| 1 | Calcium signaling and T-type calcium channels in cancer cell cycling显示文摘Regulation of intracellular calcium is an important signaling mechanism for cell proliferation in both normal and cancerous cells. In normal epithelial cells, free calcium concentration is essential for cells to enter and accomplish the S phase and the M phase of the cell cycle. In contrast, cancerous cells can pass these phases of the cell cycle with much lower cytoplasmic free calcium concentrations, indicating an alternative mechanism has developed for fulfilling the intracellular calcium requirement for an increased rate of DNA synthesis and mitosis of fast replicating cancerous cells. The detailed mechanism underlying the altered calcium loading pathway remains unclear; however, there is a growing body of evidence that suggests the T-type Ca2+ channel is abnormally expressed in cancerous cells and that blockade of these channels may reduce cell proliferation in addition to inducing apoptosis. Recent studies also show that the expression of T-type Ca2+ channels in breast cancer cells is proliferation state dependent, i.e. the channels are expressed at higher levels during the fast-replication period, and once the cells are in a non-proliferation state, expression of this channel isminimal. Therefore, selectively blocking calcium entry into cancerous cells may be a valuable approach for preventing tumor growth. Since T-type Ca2+ channels are not expressed in epithelial cells, selective T-type Ca2+ channel blockers may be useful in the treatment of certain types of cancers. | James T Taylor Xiang-Bin Zeng Jonathan E Pottle Kevin Lee Alun R Wang Stephenie G Yi lennifer A S Scruggs Suresh S Sikka Ming Li | 2008 | World Journal of Gastroenterology2008，14，32： | 12 |
| 2 | Identification and comparison of aerobic and denitrifying polyphosphateaccumulating organisms显示文摘 | Zeng R J Saunders A M Yuan Z G | 2003 | Biotechnol Bioeng2003，83，2： | 1 |
| 3 | Anaerobic metabolism of propionate by polyphosphate-aeeumulating organisms in enhanced biological phosphorus removal systems 显示文摘 | OEHMEN A ZENG R J YUAN Z | 2005 | Biotechnology and Bioengineering2005，91，1： | 1 |
| 4 | Optimisation of poly-beta-hydroxyalkanoate analysis using gas chromatography for enhanced biological phosphorus removal systems 显示文摘 | Oehmen A Keller-Lehmann B Zeng R J | 2005 | Journal of Chromatography A2005，1070，12： | 1 |
| 5 | Anaerobic and aerobic metabolism of glycogen-accumulating organisms selected with propionate as the sole carbon source显示文摘 | Oehmen A Zeng R J Yuan Z G | 2006 | Microbiol-Sg2006，152，： | 1 |
| 6 | Identification of associations between SSR markers and fiber traits in an exotic germplasm derived from multiple crosses among Gossypium tetraploid species显示文摘 | Zeng L H Meredith W R Jr Gutiérrez O A | 2009 | Theor Appl Genet2009，119，： | 1 |
| 7 | Information reduction in credit risk models显示文摘 | Guo X Jarrow R A Zeng Y | 2009 | Mathematical Finance2009，19，2： | 1 |
| 8 | Silent information regulator,Sirtuin 1, and age-related diseases显示文摘 | Zeng L Chen R Liang F et a/ | 2009 | Geriatr Gerontol Int2009，9，1： | 1 |
| 9 | Identification and comparison of aerobic and denitrifyingpolyphosphate-accumulating organisms显示文摘 | ZENG R J SAUNDERS A M YUAN Z G | 2003 | Biotechnologyand Bioengineering2003，83，2： | 1 |
| 10 | The influence of pH and organic matter content in paddy soil on heavy metal availability and their uptake by rice plants 显示文摘 | Zeng F R Shafaqat A Zhaug H T | 2011 | Environment Pollution2011，159，1： | 1 |
| 11 | The application ofbiotechnology to orchids显示文摘 | Hossain M M Kant R Van P T Winarto B Zeng S J Teixeira da Silva J A | | 0，，02： | 1 |
| 12 | Distri- bution of trace elements in selected pulverized coals as a function of particle size and density 显示文摘 | Senior C L Zeng T Che J Ames M R Sarofim A F Olmez I | 2000 | Fuel Process Technology2000，63，23： | 1 |
| 13 | Development of Microsatellite Markers Derived from Expressed Sequence Tags of Polyporales for Genetic Diversity Analysis of Endangered Polyporusumbellatus显示文摘 | Zhang Y Chen Y Wang R Zeng A Deyholos M K | 2015 | Biomed Res Int2015，，： | 1 |
| 14 | Comparison of planetary boundary layer model winds with dropsonde observations in tropical cyclones 显示文摘 | BROWN R A ZENG L | 2001 | Journal of Applied Meteor2001，，40： | 1 |
| 15 | Characterization of replication and conjugation of Streptomyces circular plasmids pFP1 and pFPll and their ability to propagate in linear mode with artificially attached telomeres显示文摘 | Zhang R Zeng A Fang P | 2008 | Applied and Environmental Microbiology2008，74，11： | 1 |
| 16 | Identification and comparison of aerobic and denitrifying polyphosphateaccumulating organisms 显示文摘 | Zeng R J Saunders A M Yuan Z G | 2003 | Biotechnol Bioeng2003，83，2： | 1 |
| 17 | Anaerobic metabolism of propionate by polyphosphate accumulating organisms in enhanced biological phosphorus removal systems显示文摘 | OEHMEN A ZENG R J YUAN Z | 2005 | Biotechnology and Bioengineering2005，91，1： | 1 |
| 18 | Identification and Comparison of Aerobic and Denitrifying Polyphosphate-Accumulating Organisms显示文摘 | Zeng R J Saunders A M Yuan Z G | 2003 | Biotechnol Bioeng2003，83，2： | 1 |
| 19 | Identification and comparison of aerobic and denitrifying polyphosphate accumulating organisms 显示文摘 | Zeng R J Saunders A M Yuan Z G | 2003 | Biotechnology and Bioengineering2003，83，2： | 1 |
| 20 | Systematic search for low-enthalpy sp3 carbon allotropes using evolutionary metadynamics 显示文摘 | Zhu Q Zeng Q Oganov A R | 2012 | Phys Rev B2012，85，20： | 1 |
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