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| 1 | Deep structure beneath the southwestern section of the Longmenshan fault zone and seimogenetic context of the 4.20 Lushan M_S7.0 earthquake显示文摘Magnetotelluric measurements were carried out along two profiles across the middle and southwestern sections of the Longmenshan fault zone(LMSf)from 2009 to 2011,after the 2008 Wenchuan MW7.9 earthquake.The former profile crosses the Wenchuan event epicenter and the latter one crosses 2013 Lushan MS7.0 event epicenter.The data were analyzed using advanced processing techniques,including phase tensor and two-dimensional inversion methods,in order to obtain reliable 2-D profiles of the electrical structure in the vicinity of the two earthquakes.A comparison of the two profiles indicates both similarities and differences in the deep crustal structure of the LMSf.West of the southwestern section,a crustal high conductivity layer(HCL)is present at about 10 km depth below the Songpan-Garzêblock;this is about 10 km shallower than that under the middle section of the LMSf.A high resistivity body(HRB)is observed beneath the southwestern section,extending from the near surface to the top of upper mantle.It has a smaller size than the HRB observed below the middle section.In the middle section,there is a local area of decreased resistivity within the HRB but there is absence of this area.The 2013 Lushan earthquake occurred close to the eastern boundary of HRB and the Shuangshi-Dachuan fault,of which the seismogenic context has both common and different features in comparison with the 2008 Wenchuan event.On a large scale,the 2013 Lushan earthquake is associated with the HCL and deformation in the crust including HCL of the eastern Tibetan Plateau.In order to assess seismic risk,it is important to consider both the stress state and the detailed crustal structure in different parts of the LMSf. | ZHAN Yan ZHAO GuoZe UNSWORTH Martyn WANG LiFeng CHEN XiaoBin LI Tao XIAO QiBin WANG JiJun TANG Ji CAI JunTao WANG YanZhao | 2013 | Chinese Science Bulletin2013，58，28： | 39 |
| 2 | (-)-Epigallocatechin-3-gallate inhibits growth of gastric cancer by reducing VEGF production and angiogenesis显示文摘AIM: To investigate the effect of (-)-epigallocatechin- 3-gallate (EGCG) on growth of gastric cancer and its possible mechanism. METHODS: Heterotopic tumors were induced by subcutaneously injection of SGC-7901 cells in nude mice. Tumor growth was measured by calipers in two dimensions. Tumor angiogenesis was determined with tumor microvessel density (MVD) by immunohistology. Vascular endothelial growth factor (VEGF) protein level and activation of signal transducer and activator of transcription 3 (Stat3) were examined by Western blotting. VEGF mRNA expression was determined by RT-PCR and VEGF release in tumor culture medium by ELISA. VEGF-induced cell proliferation was studied by MTT assay, cell migration by gelatin modified Boyden chamber (Transwell) and in vitro angiogenesis by endothelial tube formation in Matrigel. RESULTS: Intraperitoneal injection of EGCG inhibited the growth of gastric cancer by 60.4%. MVD in tumor tissues treated with EGCG was markedly reduced. EGCG treatment reduced VEGF protein level in vitro and in vivo. Secretion and mRNA expression of VEGF in tumor cells were also suppressed by EGCG in a dose-dependent manner. This inhibitory effect was associated with reduced activation of Stat3, but EGCG treatment did not change the total Stat3 expression. EGCG also inhibited VEGF-induced endothelial cell proliferation, migration and tube formation. CONCLUSION: EGCG inhibits the growth of gastriccancer by reducing VEGF production and angiogenesis, and is a promising candidate for anti-angiogenic treatment of gastric cancer. | Bao-He Zhu, Wen-Hua Zhan, Zheng-Rong Li, Zhao Wang, Yu-Long He, Jun-Sheng Peng, Shi-Rong Cai, Jin-Ping Ma, Chang-Hua Zhang, Department of Gastrointestinal & Pancreatic Surgery, First Affiliated Hospital, Sun Yat-Sen University Gastric Center of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China | 2007 | World Journal of Gastroenterology2007，13，8： | 30 |
| 3 | Telomerase activity in gastric cancer and its clinical implications显示文摘INTRODUCTIONThedevelopmentofcarcinomaresultsfrommultipleindependentgeneticchangesthatactivateprotooncogenesorinactivatetheac... | ZHAN Wen Hua, MA Jin Ping, PENG Jun Sheng, GAO Jing Song, CAI Shi Rong, WANG Jian Ping, ZHENG Zhang Qing and WANG Lei | 1999 | World Journal of Gastroenterology1999，5，4： | 25 |
| 4 | (-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric cancer显示文摘AIM: To demonstrate that (-)-Epigallocatechin-3-gallate (EGCG) inhibits vascular endothelial growth factor (VEGF) expression and angiogenesis induced by interleukin-6 (IL-6) via suppressing signal transducer and activator of transcription 3 (Stat3) activity in gastric cancer. METHODS: Human gastric cancer (AGS) cells were treated with IL-6 (50 ng/mL) and EGCG at different concentrations. VEGF, total Stat3 and activated Stat3 protein levels in the cell lyses were examined by Western blotting, VEGF protein level in the conditionedmedium was measured by enzyme-linked immunosorbent assay, and the level of VEGF mRNA was evaluated by reverse transcription polymerase chain reaction (RTPCR). Stat3 nuclear translocation was determined by Western blotting with nuclear extract, and Stat3-DNA binding activity was examined with Chromatin immunoprecipitation (ChIP) assay. IL-6 induced endothelial cell proliferation was measured with 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyl tetrazoliumbromide assay, in vitro angiogenesis was determined with endothelial cell tube formation assay in Matrigel, and IL-6-induced angiogenesis in vitro was measured with Matrigel plug assay. RESULTS: There was a basal expression and secretion of VEGF in AGS cells. After stimulation with IL-6, VEGF expression was apparently up-regulated and a 2.4-fold increase was observed. VEGF secretion in the conditioned medium was also increased by 2.8 folds. When treated with EGCG, VEGF expression and secretion were dose-dependently decreased. IL-6 also increased VEGF mRNA expression by 3.1 folds. EGCG treatment suppressed VEGF mRNA expression in a dose-dependent manner. EGCG dose-dependently inhibited Stat3 activation induced by IL-6, but did not change the total Stat3 expression. When treated with EGCG or AG490, VEGF expressions were reduced to the level or an even lower level in the tumor cells not stimulated with IL-6. However, PD98059 and LY294002 did not change VEGF expression induced by IL-6. EGCG inhibited Stat3 nucleus translocation, and Stat3-DNA binding activity was also markedly decreased by EGCG. Furthermore, EGCG inhibited IL-6 induced vascular endothelial cell proliferation and tube formation in vitro and angiogenesis in vitro . CONCLUSION: EGCG inhibits IL-6-induced VEGF expression and angiogenesis via suppressing Stat3 activity in gastric cancer, which has provided a novel mechanistic insight into the anti-angiogenic activity of EGCG. | Bao-He Zhu Hua-Yun Chen Wen-Hua Zhan Cheng-You Wang Shi-Rong Cai Zhao Wang Chang-Hua Zhang Yu-Long He | 2011 | World Journal of Gastroenterology2011，17，18： | 21 |
| 5 | Efficacy and Safety of Niaoduqing Particles for Delaying Moderate-to-severe Renal Dysfunction: A Randomized, Double-blind, Placebo-controlled, Multicenter Clinical Study显示文摘 | Ying Zheng Guang-Yan Cai Li-Qun He Hong-Li Lin Xiao-Hong Cheng Nian-Song Wang Gui-Hua Jian Xu-Sheng Liu Yu-Ning Liu Zhao-Hui Ni Jing-Ai Fang Han-Lu Ding Wang Guo Ya-Ni He Li-Hua Wang Ya-Ping Wang Hong-Tao Yang Zhi-Ming Ye Ren-Huan YU Li-Juan Zhao Wen-Hua Zhou Wen-Ge Li Hui-Juan Mao Yong-Li Zhan Zhao Hu Chen Yao Ri-Bao Wei Xiang-Mei Chen | 2017 | Chinese Medical Journal2017，，20： | 21 |
| 6 | Clinicopathologic features and survival of patients with colorectal mucinous, signet-ring cell or non-mucinous adenocarcinoma:experience at an institution in southern China显示文摘以前的研究显示出冲突的背景与 colorectal mucinous,图章戒指房间,或 non-mucinous 腺癌在在 clinicopathologic 特征和病人的预后之间的关系上结果;仅仅这学习的很少在中国被执行了。这回顾的研究从我们的部门分析了数据调查 clinicopathologic 特征,预后和三种 histologic 类型的可能的关联-- colorectal mucinous ,图章戒指房间,和 non-mucinous 腺癌,到为可以导致 2079 个病人的指向的治疗方法的开发的观察差别的库与在 1994 和 2007 之间的 colorectal 癌症诊断了的清澈, 144 有 mucinous , 25 有的图章戒指房间,和 1837 有的 non-mucinous 腺癌。他们的 clinicopathologic 参数和幸存用确定的统计 methodologies.Results Mucinous 被分析,图章戒指房间腺癌在更年轻的病人是普通的(P < 0.001 ) 。地点,尺寸和疾病舞台在三种类型之中显著地不同。图章戒指房间肿瘤更通常比 mucinous 和 non-mucinous 腺癌在直肠被发现(P < 0.001 ) 。Mucinous 和图章戒指房间肿瘤比 non-mucinous 腺癌更经常在生活在一个以后的阶段介绍了,与淋巴节点参与, serosal 渗入,腹传播,和邻近的机关侵略(P < 0.01 ) 。激进的切除术,肝的转移和本地复发的率没在类型(P 0.05 ) 之中不同。与有 non-mucinous 腺癌的病人相比,潜在地经历了药品切除术或阶段 / 疾病的有 mucinous 和图章戒指房间肿瘤的病人有更差的长期的全面幸存。幸存没与舞台或疾病(P 0.05 ) 为病人由类型不同。结论 Mucinous 和图章戒指房间腺癌让唯一的 carcinogenesis 和类似的生物学的 behavior.Our 学习证实两 histologic 打字,特别图章戒指房间肿瘤,为有 colorectal 癌症的病人的独立、否定预示的因素。当疾病是任何一个舞台时,类型不看起来在幸存上有重要效果或在表示。 | SONG Wu WU Sui-jing HE Yu-long CAI Shi-rong ZHANG Chang-hua ZHANG Xin-hua ZHAN Wen-hua | 2009 | Chinese Medical Journal2009，，13： | 20 |
| 7 | Early operation for fulminant acute pancreatitis: a possible way to decrease mortality显示文摘背景尽管指示并且在暴发性的尖锐胰腺炎(FAP ) 为外科预定仍然是争论的,我们为暴发性的尖锐 pancreaUtis 的外科的治疗的经验可以帮助为 patients.Methods 改进结果有到 10 月 1,2005 日的从 2001 年 1 月 1 日的 FAP 的 26 个病人的临床的数据被分析。诊断标准由有 FAP 的 26 个病人收到了的中国医药 Association.Results 为严重尖锐胰腺炎的管理适合 2007 个指南外科的清创术,与 42.3% 的死亡率(11/26 ) 。在 72 小时操作的手术后的死亡组织并且 < 72 小时操作组是高度显著地不同(7/8 对 22.2%(4/18 ) ,分别地) 早外科可以减少的 .Conclusions intraabdominal 迫使并且阻止 FAP 的恶化。在从症状的发作的 72 个小时以内的操作可能减少疾病的死亡。 | YANG Dong-jie HE Yu-long CAI Shi-rong PENG Jian-jun ZHANG Chang-hua ZHAN Wen-hua | 2009 | Chinese Medical Journal2009，，13： | 19 |
| 8 | Methane and Nitrous Oxide Emissions from Rice-Duck and Rice-Fish Complex Ecosystems and the Evaluation of Their Economic Significance显示文摘Rice-duck (RD) and rice-fish (RF) ecological systems are major complex planting and breeding models of rice paddy fields in southern China. Studying the methane (CH4) and nitrous oxide (N2O) emissions and their economic value from these two ecosystems can provide theoretical and practical basis for further development and utilization of these classical agricultural techniques. CH4 and N2O emissions from RD and RF ecological systems were measured in situ by using static chambers technique. Using global warming potentials (GWPs), we assessed the greenhouse effect of CH4 and N2O and their economic value. Results showed that the peaks of CH4 emission fluxes from RD and RF appeared at full tillering stage and at heading stage, and the average emission fluxes were significantly (P < 0.05) lower than that from CK. N2O fluxes remained low when the field is flooded and high after draining the water. Compared with CK, the total amount of N2O emissions was significantly (P < 0.05) higher and slightly lower than those from RD and RF, respectively. In 2006 and 2007, the total greenhouse effect of CH4 and N2O from RD and RF were 4 728.3 and 4 611 kg CO2 ha-1, 4 545 and 4 754.3 kg CO2 ha-1, respectively. The costs of greenhouse effect were 970.89 and 946.81 RMB yuan ha-1, and 933.25 and 976.23 RMB yuan ha-1, respectively, which were significant lower than those from CK (5 997.6 and 5 391.5 RMB yuan ha-1). Except for the environment cost of CH4 and N2O, the economic benefits from RD and RF were 2 210.64 and 4 881.92 RMB yuan ha-1; 3 798.37 and 5 310.64 RMB yuan ha-1, respectively, higher than those from CK. Therefore, RD and RF complex ecological planting and breeding models can effectively decrease and control CH4 and N2O emissions, and they are two of the effective strategies to reduce greenhouse gases from rice paddy fields and contribute in alleviating global warming. Thus, their adoption is important to the environment together with their economy benefits. | YUAN Wei-ling CAO Cou-gui LI Cheng-fang ZHAN Ming CAI Ming-li WANG Jin-ping | 2009 | Agricultural Sciences in China2009，8，10： | 13 |
| 9 | Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers on lymphangiogenesis of gastric cancer in a nude mouse model显示文摘背景变换血管收缩素的酶禁止者( ACEI )和 1 受体 blockers ( ARB )能禁止的血管收缩素 II 类型由 angiogenesis.This 学习的抑制的肿瘤生长被设计在植入的胃的癌症老鼠 model.Methods 在肿瘤生长和 lymphangiogenesis 上学习 ACEI 和 ARB 的 anticancer 效果胃的癌症的一个模特儿被建立由以后皮下地接种人的胃的癌症房间线 SGC-7901 直到 60 裸体 mice.One 星期,所有老鼠随机被划分成 5 | WANG Liang CAI Shi-rong ZHANG Chang-hua HE Yu-long ZHAN Wen-hua WU Hui PENG Jian-jun | 2008 | Chinese Medical Journal2008，，21： | 12 |
| 10 | Role of silencing phosphatase of regenerationg liver-3 expression by microRNA interference in the growth of gastric cancer显示文摘积累的证据表明的背景新生 liver-3 (PRL-3 ) 的那磷酸酶与多重肿瘤类型的转移被联系,并且为转移作为一个潜在的治疗学的目标被验证了。PRL-3 的高表示在胃的癌症的淋巴节点转移被含有。在现在的学习,我们由 microRNA (miRNA ) 调查了 silencing PRL-3 表示的角色在胃的癌症生长的干扰。方法 RNA 干扰,由表示人工的 PRL-3 miRNA 的 recombinant lentivirus 调停了,在人的 SGC7901 胃的癌症房间被采用到击倒的 PRL-3 表示。MTT 试金和肿瘤培植实验被进行在 SGC7901 细胞和肿瘤生长的增长决定 PRL-3 的角色。显著地表示人工的 PRL-3 miRNA 的 recombinant lentivirus 的结果 Transfection 在 vitro 压制了 SGC7901 房间的增长。PRL-3 transfection 组的植入的肿瘤尺寸是(1.92 ?????????? 呈 ?? ??? 吗?? | CAI Shi-rong WANG Zhao CHEN Chuang-qi WU Wen-hui HE Yu-long ZHAN Wen-hua ZHANG Chang-hua CUI Ji WU Hui | 2008 | Chinese Medical Journal2008，，24： | 12 |
| 11 | Effects of diabetes mellitus on prognosis of the patients with colorectal cancer undergoing resection: a cohort study with 945 patients显示文摘背景糖尿病 mellitus 在癌症流行和结果起一个重要作用。这研究的目的是与学习注册了的 colorectal cancer.Methods 在病人之中在舞台和结果上评估 DM 的影响作为从 1994 年 8 月有 colorectal 癌到 2002 年 12 月被诊断的 945 个病人。在队, 26 个病人作为有 DM 被诊断。与 45.8 个月的中部的后续,在在糖尿病和非糖尿病组之间的全面幸存和没有疾病的幸存的差别是 analyzed.Results Kaplan, Meier 分析证明处于在 3 年或 5 年的全面幸存率的二个组之间没有重要差别。在 5 年,与没有糖尿病的病人相比,有 DM 的病人经历了显著地更低的没有疾病的幸存率(34.2% 糖尿病患者对 55.1% 非糖尿病患者;P=0.025 ).Conclusions DM 与 colorectal 癌症在病人与复发的增加的风险被联系。 | CHEN Chuang-qi FANG Le-kun CAI Shi-rong MA Jin-ping YANG Guang-xin YANG Wan ZHAN Wen-hua HE Yu-long | 2010 | Chinese Medical Journal2010，，21： | 9 |
| 12 | Effects of N Management on Yield and N Uptake of Rice in Central China显示文摘Efficient N fertilizer management is critical for the economic production of rice and the long-term protection of environmental quality. A field experiment was designed to study the effects of N fertilizer management practices on grain yield and N uptake of rice. The experiment was laid out in the randomized complete block design with four replications in Central China during 2008 and 2009. Five N treatments denoted as N0, N150A, N150B, N240A, and N240B, respectively, were studied. N0 represented no N application and served as a control, N150A and N150B indicated the total N application of 150 kg N ha-1 but with two different application schedules (A and B) across the early stage of rice growth. Schedule A was applied as follows: 40% basal, 30% at 10 d after transplanting (DAT) and 30% at 36 DAT (nearly at the panicle initiation stage), while schedule B was as follows: 30% at basal, 20% at 10 DAT, and 50% at 36 DAT. Similarly, N240A and N240B indicated the total N application of 240 kg N ha-1 with schedules A and B as described above. To quantify N uptake from fertilizer and soil, a 15N experiment was also conducted within the main experimental field, with micro-plots. Grain yields were significantly increased as N rates increased from 0 to 240 kg N ha-1. At the same rate, splitting N application as schedule B significantly increased the grain yield, spikelets per panicle, percentage of ripened grain, and 1 000-grain weight, compared with the N application according to schedule A. Mean rice recovery of N fertilizer by 15N tracing method ranged from 25.39% at N240A to 34.89% at N150B, however, N fertilizer residual rate in the soil ranged from 12.40% at N240A to 16.61% at N150B. About 31.5 and 28.5% of total uptake of 15N derived from basal fertilizer was absorbed at panicle initiation and heading stages, respectively. However, 65.6-92.5% of total uptake of 15N derived from topdressing fertilizer was absorbed at the heading stage. Based on yield and nitrogen recovery efficiency, splitting N application according to schedule B at the rate of 240 kg N ha-1 will be more profitable among the tested five N treatments in Central China. | PAN Sheng-gang HUANG Sheng-qi ZHAI Jing WANG Jing-ping CAO Cou-gui CAI Ming-li ZHAN Ming TANG Xiang-ru | 2012 | Journal of Integrative Agriculture2012，11，12： | 9 |
| 13 | Direct generation of an ultrafast vortex beam in a CVD-graphene-based passively mode-locked Pr:LiYF4 visible laser显示文摘We report on the direct generation of passively mode-locked vortex lasers in the visible spectral region, for the first time to the best of our knowledge, using a Pr :Li YF4(Pr:YLF) crystal as the gain medium. A stable mode-locked TEM00 mode has been achieved with a maximum average output power of 75 m W using a graphene saturable absorber mirror. The mode-locked pulse width is measured to be as short as about 73.4 ps at a repetition rate of about 140 MHz, and the laser wavelength is at about 721 nm with spectral width of about 0.5 nm. By slightly misaligning the laser resonator, a first-order Laguerre-Gaussian mode(LG0,1) has also been obtained with output power reduced to about 22 m W. The achieved LG0,1 mode has been verified via a home made improved Fizeau interferometer. This work provides a simple and universal method for direct generation of an ultrafast vortex laser,which can be readily extended to other spectral regions by using different laser gain mediums. | Nan Li Junjie Huang Bin Xu Yaqi Cai Jie Lu Linjie Zhan Zhengqian Luo Huiying Xu Zhiping Cai Weiwei Cai | 2019 | Photonics Research2019，7，11： | 9 |
| 14 | Genomic landscape and genetic manipulation of the black soldier fly Hermetia illucens,a natural waste recycler显示文摘The black soldier fly(BSF),Hermetia illucens(Diptera:Stratiomyidae),is renowned for its bioconversion of organic waste into a sustainable source of animal feed.We report a high-quality genome of 1.1 Gb and a consensus set of 16,770 gene models for this beneficial species.Compared to those of other dipteran species,the BSF genome has undergone a substantial expansion in functional modules related to septic adaptation,including immune system factors,olfactory receptors,and cytochrome P450s.We further profiled midgut transcriptomes and associated microbiomes of BSF larvae fed with representative types of organic waste.We find that the pathways related to digestive system and fighting infection are commonly enriched and that Firmicutes bacteria dominate the microbial community in BSF across all diets.To extend its potential practical applications,we further developed an efficient CRISPR/Cas9-based gene editing approach and implemented this to yield flightless and enhanced feeding capacity phenotypes,both of which could expand BSF production capabilities.Our study provides valuable genomic and technical resources for optimizing BSF lines for industrialization. | Shuai Zhan Gangqi Fang Minmin Cai Zongqing Kou Jun Xu Yanghui Cao Liang Bai Yixiang Zhang Yongmao Jiang Xingyu Luo Jian Xu Xia Xu Longyu Zheng Ziniu Yu Hong Yang Zhijian Zhang Sibao Wang Jeffery K.Tomberlin Jibin Zhang Yongping Huang | 2020 | Cell Research2020，30，1： | 9 |
| 15 | Shape-Controlled Synthesis of Mn_(3)O_(4) Nanocrystals and Their Catalysis of the Degradation of Methylene Blue显示文摘Various sizes and shapes of Mn_(3)O_(4) nanocrystals have been prepared in a one-pot synthesis in extremely dilute solution by soft template self-assembly. To better control size and shape, the effects of varying the growth time, reaction temperature, surfactant, and manganese source were examined. The average size of octahedral Mn_(3)O_(4) crystallites was found to be related to the reaction time, while higher reaction temperature (150 °C) and the use of a cetyltrimethylammonium bromide/poly(vinylpyrrolidone) (CTAB/PVP) mixture allowed construction of a better-defined octahedral morphologies. When PVP or poly(ethylene oxide)-poly(propylene oxide) (P123) was used as template, large-scale agglomeration resulting in loss of the octahedral morphology occurred and crystallites with a quasi-spherical shape were obtained. The nano-octahedral crystallites were shown to be an efficient catalyst for the oxidation of methylene blue. | Pengqu Zhang Yonggong Zhan Bingxin Cai Chenchun Hao Jun Wang Chunxiao Liu Zhoujun Meng Zhoulan Yin Qiyuan Chen | 2010 | Nano Research2010，3，4： | 9 |
| 16 | A Spatially Weighted Degree Model for Network Vulnerability Analysis显示文摘Using degree distribution to assess network vulnerability represents a promising direction of network analysis.However,the traditional degree distribution model is inadequate for analyzing the vulnerability of spatial networks because it does not take into consideration the geographical aspects of spatial networks.This paper proposes a spatially weighted degree model in which both the functional class and the length of network links are considered to be important factors for determining the node degrees of spatial networks.A weight coefficient is used in this new model to account for the contribution of each factor to the node degree.The proposed model is compared with the traditional degree model and an accessibility-based vulnerability model in the vulnerabil-ity analysis of a highway network.Experiment results indicate that,although node degrees of spatial networks derived from the tra-ditional degree model follow a random distribution,node degrees determined by the spatially weighted model exhibit a scale-free distribution,which is a common characteristic of robust networks.Compared to the accessibility-based model,the proposed model has similar performance in identifying critical nodes but with higher computational efficiency and better ability to reveal the overall vulnerability of a spatial network. | WAN Neng1,ZHAN F.Benjamin1,2,CAI Zhongliang2 1.School Texas Center for Geographic Information Science,Department of Geography,Texas State University,San Marcos,TX 78666,USA 2.School of Resource and Environmental Science,Wuhan University,129 Luoyu Road,Wuhan 430079,China | 2011 | Geo-Spatial Information Science2011，14，4： | 9 |
| 17 | Identification and characterization of a novel isoform of hepatopoietin显示文摘AIM: To isolate a novel isoform of human HPO (HPO-205)human fetal liver Marathon-reedy cDNA andcharacterize its primary biological function.METHODS: 5'-RACE (rapid amplification of cDNA 5' ends)was used to isolate a novel isoform of hHPO in this paperThe constructed pcDNAHPO-205, pcDNAHPO and pcDNA eukaryotic expression vectors were respectively transfectedby lipofectamine method and the stimulation of DNAsynthesis was observed by 3H-TdR incorporation assay.Proteins extracted from different cells were analyzed byWestern blot.RESULTS: A novel isoform of hHPO (HPO-205) encoding a205 amino acid ORF corresponding to a translatedproduction of 23 kDa was isolated and distinguished fromthe previous HPO that lacked the N-terminal 80 amino acids.The dnse-dspendent stimulation of DNA synthesis of HepG2hepatoma cells by HPO-205 demonstrated its similarbiological activity with HPO in vitro. The level of MAPK(Mitogen-activated protein kinase) phnsphorylarion byWestern blot analysis revealed that HPO-205 might have thestronger activity of stimulating hepatic cell proliferation thanthat of HPO.CONCLUSION: A novel isoform of hHPO (HPO-205) wasisolated from hepatic-derived cells. The comparison of HPO-205 and HPO will lead to a new insight into the structure andfunction of hHPO, and provide the new way of thinking todeeply elucidate the biological roles of HPO/ALR. | Jun Lu Wei-Min Cai,Institute of Infectious Disease,First Affiliated Hospital,Medical SchooI,Zhejiang University,Hangzhou 310003 China Wang-Xiang Xu Yi-Qun Zhan Xiao-Lin Cui Fu-Chu He Xiao-Ming Yang,Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing 100850,China | 2002 | World Journal of Gastroenterology2002，8，2： | 8 |
| 18 | Evaluation system for CO_2 emission of hot asphalt mixture显示文摘The highway construction industry plays an important role in economic and development,but is also a primary source of carbon emission. Accordingly, with the global climate change, energy conservation and reduction of carbon emissions have become critical issues in the highway construction industry. However, to date, a model for the highway construction industry has not been established. Hence, to implement a low-carbon construction model for highways, this study divided asphalt pavement construction into aggregate stacking, aggregate supply, and other stages, and compiled a list of energy consumption investigation. An appropriate calculation model of CO_2 emission was then built. Based on the carbon emission calculation model, the proportion of carbon emissions in each stage was analyzed. The analytic hierarchy process was used to establish the system of asphalt pavement construction with a judgment matrix, thereby enabling calculation of the weight coefficient of each link. In addition, the stages of aggregate heating, asphalt heating, and asphalt mixture mixing were defined as key stages of asphalt pavement construction. Carbon emissions at these stages accounted for approximately 90% of the total carbon emissions. Carbon emissions at each stage and their impact on the environment were quantified and compared. The energy saving construction schemes as well as the environmental and socioeconomic benefits were then proposed. Through these schemes, significant reductions in carbon emissions and costs can be achieved. The results indicate that carbon emissions reduce by 32.30% and 35.93%, whereas costs reduce by 18.58% and 6.03%. The proposed energy-saving and emission reduction scheme can provide a theoretical basis and technical support for the development of low-carbon highway construction. | Bo Peng Chunli Cai Guangkai Yin Wenying Li Yaowen Zhan | 2015 | Journal of Traffic and Transportation Engineering(English Edition)2015，2，2： | 8 |
| 19 | Efficacy and safety of Shenyankangfu Tablet,a Chinese patent medicine,for primary glomerulonephritis:A multicenter randomized controlled trial显示文摘Background:Shenyankangfu Tablet(SYKFT)is a Chinese patent medicine that has been used widely to decrease proteinuria and the progression of chronic kidney disease.Objective:This trial compared the efficacy and safety of SYKFT,for the control of proteinuria in primary glomerulonephritis patients,against the standard drug,losartan potassium.Design,setting,participants and intervention:This was a multicenter,double-blind,randomized,controlled clinical trial.Primary glomerulonephritis patients,aged 18-70 years,with blood pressure≤140/90 mmHg,estimated glomerular filtration rate(eGFR)>45 mL/min per 1.73 ㎡,and 24-hour proteinuria level of 0.5-3.0 g,were recruited in 41 hospitals across 19 provinces in China and were randomly divided into five groups:SYKFT,losartan potassium 50 mg or 100 mg,SYKFT plus losartan potassium 50 mg or 100 mg.Main outcome measu res:The primary outcome was change in the 24-hour proteinuria level,after 48 weeks of treatment.Results:A total of 735 participants were enrolled.The percent decline of urine protein quantification in the SYKFT group after 48 weeks was 8.78%±2.56%(P=0.006)more than that in the losartan 50 mg group,which was 0.51%±2.54%(P=1.000)less than that in the losartan 100 mg group.Compared with the losartan potassium 50 mg group,the SYKFT plus losartan potassium 50 mg group had a 13.39%±2.49%(P<0.001)greater reduction in urine protein level.Compared with the losartan potassium 100 mg group,the SYKFT plus losartan potassium 100 mg group had a 9.77%±2.52%(P=0.001)greater reduction in urine protein.With a superiority threshold of 15%,neither was statistically significant.eGFR,serum creatinine and serum albumin from the baseline did not change statistically significant.The average change in TCM syndrome score between the patients who took SYKFT(-3.00[-6.00,-2.00])and who did not take SYKFT(-2.00[-5.00,0])was statistically significant(P=0.003).No obvious adverse reactions were observed in any group.Conclusion:SYKFT decreased the proteinuria and improved the TCM syndrome scores of primary glomerulonephritis patients,with no change in the rate of decrease in the eGFR.SYKFT plus losartan potassium therapy decreased proteinuria more than losartan potassium therapy alone.Trial registration number:NCT02063100 on ClinicalTrials.gov. | Jie Wu Shu-wei Duan Hong-tao Yang Yue-yi Deng Wei Li Ya-ni He Zhao-hui Ni Yong-li Zhan Shan Lin Zhi-yong Guo Jun Zhu Jing-ai Fang Xu-sheng Liu Li-hua Wang Rong Wang Nian-song Wang Xiao-hong Cheng Li-qun He Ping Luo Shi-ren Sun Ji-feng Sun Ai-ping Yin Geng-ru Jiang Hong-yu Chen Wen-hu Liu Hong-li Lin Meng Liang Lu Ma Ming Chen Li-qun Song Jian Chen Qing Zhu Chang-ying Xing Yun Li Ji-ning Gao Rong-shan Li Ying Li Hao Zhang Ying Lu Qiao-ling Zhou Jun-zhou Fu Qiang He Guang-yan Cai Xiang-mei Chen | 2021 | Journal of Integrative Medicine2021，19，2： | 8 |
| 20 | Acquired immunodeficiency syndrome associated disseminated Penicillium Marneffei infection: report of 8 cases显示文摘 | LU Pu-xuan ZHU Wen-ke LIU Yan CHEN Xin-chun ZHAN Neng-yong LIU Jin-qing ZANG Jian YANG Gen-dong YE Ru-xin CAI Li-sheng | 2005 | Chinese Medical Journal2005，，16： | 7 |
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