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| 1 | Clinicopathological significance of FHIT protein expression in gastric adenocarcinoma patients显示文摘AIM: To investigate the expression of fragile histidine triad (FHIT) protein, and the possible relationship between FHIT expression and clinicopathological indices in gastric carcinoma.METHODS: FHIT protein expression was examined in 76 cases of gastric carcinoma, 58 cases of intraepithelial neoplasia, and 76 cases of corresponding normal mucosae by immunohistochemical method to analyze its relationship to histological grade, clinical stage, metastatic status and prognosis.RESULTS: The FHIT protein expression was positive in 28/76 (36.8%) cases of adenocarcinoma tissue, 22/58(37.9%) cases of adjacent dysplastic tissue and 76/76(100%) cases of distal normal gastric mucosa. There was a significant difference in the expression of FHIT protein between cancer or adjacent intraepithelial neoplasia and normal gastric mucosa (P = 0.000). FHIT protein expression was found in 64.3% (18/28) of grades Ⅰ and Ⅱ cancers,and 20.8% (10/48) of grade Ⅲ cancers (P = 0.000), in 56.3% (18/32) of stages Ⅰ and Ⅱ cancers and 22.7%(10/44) of stages Ⅲ and Ⅳ cancers (P = 0.004), and in 63.6% (14/22) of cancers without metastasis but only 25.9% (14/54) of those with metastasis (P = 0.003). The significant difference in the expression of FHIT was found between histological grade, clinical stage and metastatic status of cancer. Follow-up data showed that there was a significant difference in median survival time between cancer patients with expression of FHIT (71 mo) and those without (33 mo, log rank = 20.78, P = 0.000).CONCLUSION: FHIT protein is an important tumor suppressor protein. Loss of FHIT protein expression may be associated with carcinogenesis, invasion, metastasis and prognosis of gastric adenocarcinoma. | Po Zhao Wu Liu Ya-Li Lu | 2005 | World Journal of Gastroenterology2005，11，36： | 30 |
| 2 | Loss of fragile histidine triad protein in human hepatocellular carcinoma显示文摘AIM: To investigate the expression of fragile histidine triad (FHIT) gene protein, Fhit, which is recently thought to be a candidate tumor suppressor. Abnormal expression of fragile histidine triad has been found in a variety of human cancers,but little is known about its expression in human hepatocellular carcinogenesis and evolution.METHODS: Sections of 83 primary human hepatocellular carcionoma with corresponding para-neoplastic liver tissue and 10 normal liver tissue were evaluated immunohistochemically for Fhit protein expression.RESULTS: All normal liver tissue and para-neoplastic liver tissue showed a strong expression of Fhit, whereas 50 of 83(65.0 %) carcinomas showed a marked loss or absence of Fhit expression. The differences of Fhit expression between carcinoma and normal or para-neoplastic liver tissue werehighly significant (P=0.000). The proportion of carcinomas with reduced Fhit expression showed an increasing trend (a) with decreasing differentiation or higher histological grade (P=0.219); (b) in tumors with higher clinical stage Ⅲ and ⅣV (91.3 %, P=0.000), compared with tumors with lower stage Ⅰ and Ⅱ (27.6 %); and (c) in cancers with bigger tumor size (>50 mm) (75.0 %, P=0.017), compared withsmaller tumor size (≤ 50 mm).
CONCLUSION: FHIT inactivation seems to be both an earlyand a later event, associated with carcinogenesis andprogression to more aggressive hepatocellular carcinomas.Thus, evaluation of Fhit expression by immunohistochemistryin hepatocellular carcinoma may provide important diagnosticand prognostic information in clinical application. | Po Zhao Xin Song Yuan-Yuan Nin Ya-Li Lu Xiang-Hong Li Department of Pathology,Chinese PLA General Hospital,Beijing 100853,China | 2003 | World Journal of Gastroenterology2003，9，6： | 28 |
| 3 | Recent advancement on technical requirements for grid integration of wind power显示文摘The installation of wind energy has experienced rapid development during recent years.As a result,the operation of power system can be greatly affected.Therefore,the operators of different countries have formulated the grid codes which reinforce technical requirements for wind power plants.In this paper,recent grid codes published in different countries have been carefully reviewed.The basic requirements of active power control and reactive power compensation,both of which have particular influence on wind power plants operation,are focused on.Based on this review,it is understood that with the increasing integration of wind energy,there is a worldwide trend to regulate the performance of wind power plants so that they can contribute to the stability and reliability of power system. | Xiaoge LIU Zhao XU Kit Po WONG | 2013 | Journal of Modern Power Systems and Clean Energy2013，1，3： | 19 |
| 4 | Histological origin of pseudomyxoma peritonei in Chinese women:Clinicopathology and显示文摘AIM:To investigate the histological origin of pseudomyxoma peritonei(PMP)in Chinese women.METHODS:The clinical and pathological data were reviewed for 35 women with PMP,and specimens of the peritoneal,appendiceal and ovarian lesions of each patient were examined using the PV-6000 immunohistochemistry method.Antibodies included cytokeratin(CK)7,CK20,mucin(MUC)-1,MUC-2,carbohydrate antigen(CA)-125,estrogen receptor(ER),and progesterone receptor(PR).RESULTS:Abundant colloidal mucinous tumors were observed in the peritoneum in all 35 cases.Thirty-one patients had a history of appendectomy,28 of whom had mucinous lesions.There was one patient with appendicitis,one whose appendix showed no apparent pathological changes,and one with unknown surgical pathology.Ovarian mucinous tumors were found in 24 patients.The tumors were bilateral in 13 patients,on the right-side in nine,and on the left side in two.Twenty patients had combined appendiceal and ovarian lesions;16 of whom had undergone initial surgery for appendiceal lesions.Four patients had undergone initial surgery for ovarian lesions,and relapse occurred in these patients at 1,11,32 and 85 mo after initial surgery.Appendi-ceal mucinous tumors were found in each of these four patients.Thirty-three of the 35 patients showed peritoneal lesions that were positive for CK20 and MUC-2,but negative for CK7,MUC-1,CA125,ER and PR.The expression patterns in the appendix and the ovary were similar to those of the peritoneal lesions.In one of the remaining two cases,CK20,CK7 and MUC-2 were positive,and MUC-1,CA125,ER and PR were negative.The ovaries were not resected.The appendix of one patient was removed at another hospital,and no specimen was evaluated.In the other case,the appendix appeared to be normal during surgery,and was not resected.Peritoneal and ovarian lesions were negative for CK20,MUC-2,CK7,MUC-1,CA125,ER and PR.CONCLUSION:Most PMP originated from the appendix.Among women with PMP,the ovarian tumors were implanted rather than primary.For patients with PMP,appendectomy should be performed routinely.The ovaries,especially the right ovaries should be explored. | Ai-Tao Guo Xin Song Li-Xin Wei Po Zhao | 2011 | World Journal of Gastroenterology2011，17，30： | 14 |
| 5 | Clinicopathological significance and prognostic value of LRP16 expression in colorectal carcinoma显示文摘AIM: To explore the expression of leukemia related protein 16 (LRP16) in colorectal carcinoma, and analyze its correlation with clinicopathologic features and prognosis. METHODS: Immunohistochemistry for LRP16 was performed in 201 cases of colorectal carcinoma and 60 cases of distal normal mucosa. Medical records were reviewed and clinicopathological analysis was performed. RESULTS: LRP16 expression was detected in 117 of 201 cases of the colorectal carcinoma and in 21 cases of 60 distal normal mucosa. The expression of LRP16 in carcinoma was significantly higher than that in normal mucosa (χ 2 = 9.999, P = 0.002). LRP16 protein expression was found in 43.3% (52/120) of carcinoma at stage Ⅰ and Ⅱ , and 80.2% (65/81) of carcinoma at stage Ⅲ and Ⅳ (χ 2 =27.088, P = 0.001). Correlation between LRP16 expression and clinicopathological factors was significant in differentiation (P = 0.010), tumor size (P = 0.001), infiltrative depth (P = 0.000) and distant metastasis (P = 0.027). The difference of median survival time between cancer patients with LRP16 expression (38.0 mo) and those without was statistically significant (105.0 mo, Log rank = 41.455, P = 0.001). The multivariate survival analysis revealed that LRP16 expression was correlated significantly (Cox’s regression: P = 0.001, relative risk = 2.082) with shortened survival in the patients with colorectal cancer. CONCLUSION: The expression of LRP16 is related to the degree of differentiation, invasiveness, metastasis and prognosis of colorectal carcinoma. | Xi, Hong-Qing Zhao, Po Han, Wei-Dong | 2010 | World Journal of Gastroenterology2010，16，13： | 10 |
| 6 | A low-carbon oriented probabilistic approach for transmission expansion planning显示文摘Following the deregulation of the power industry,transmission expansion planning(TEP)has become more complicated due to the presence of uncertainties and conflicting objectives in a market environment.Also,the growing concern on global warming highlights the importance of considering carbon pricing policies during TEP.In this paper,a probabilistic TEP approach is proposed with the integration of a chance constrained load curtailment index.The formulated dynamic programming problem is solved by a hybrid solution algorithm in an iterative process.The performance of our approach is demonstrated by case studies on a modified IEEE 14-bus system.Simulation results prove that our approach can provide network planners with comprehensive information regarding effects of uncertainties on TEP schemes,allowing them to adjust planning strategies based on their risk aversion levels or financial constraints. | Jing QIU Zhaoyang DONG Junhua ZHAO Ke MENG Fengji LUO Kit Po WONG Chao LU | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，1： | 8 |
| 7 | Clinicopathological significance of LRP16 protein in 336 gastric carcinoma patients显示文摘AIM:To investigate the expression of leukemia related protein 16 (LRP16), and the possible relationship between LRP16 expression and clinicopathological indices in 336 gastric carcinoma patients.METHODS: Immunohistochemistry was used to detect LRP16 expression in 336 cases of paraffin-embedded gastric carcinoma tissues and 60 cases of distal normal mucosa. The relationships between LRP16 expression and patients' age, tumor size, histological grade, clinical stage, metastatic status and prognosis were analysed.RESULTS: The expression of LRP16 was 58.6% (197/336) in gastric carcinoma and 31.7% (19/60) in distal normal gastric mucosa. The expression of LRP16 in carcinoma was significantly higher than that in normal mucosa tissues (χ2=14.929, P=0.001). LRP16 protein expression was found in 44.1% (63/143) carcinomas at stage and,and 69.4%(134/193) carcinomas at stage and (χ2=21.804,P=0.001),and in 56.9%(182/320)of cancers without metastasis but 93.8%(15/16)of those with metastasis(χ2=8.543,P=0.003).The expression of LRP16 was correlated with tumor size,infiltrative depth,clinical stage,lymphatic invasion and distant metastasis(all P<0.05). Follow-up data showed that there was a significant difference in median survival time between cancer patients with expression of LRP16 (27.0 mo) and those without (48.0 mo, Log rank=31.644, P=0.001).CONCLUSION: The expression of LRP16 may be associated with invasion, metastasis and prognosis of gastric cancer. | Ya-Zhuo Li Po Zhao Wei-Dong Han | 2009 | World Journal of Gastroenterology2009，15，38： | 8 |
| 8 | Learning curve of computer-assisted navigation system in spine surgery显示文摘用帮助计算机的航行(罐头) 的背景脊骨外科被证明了导致低螺丝钉误放率,放射暴露的低发生和看的优秀的起作用的地对常规 intraoperative 图象 intensifier (C) 。不管多么当我们知道,以前的研究描述了的很少二个连续盒子队与不同经验背景, A 和 B 在花梗螺丝钉精确性和二位脊骨外科医生的起作用的时间上学习的在我们执行了的脊骨 surgery.Methods 的罐头的学习曲线,在一个机构在一样的时期期间。外皮的穿孔率和操作使用的一样的类型的起作用的时间装的腰部的花梗螺丝钉被分析并且比较了为二位外科医生使用 C 在起始,当四年的全部的盒子被包括时, 6 个月和 12 月罐头 usage.Results 罐头脊骨外科为外科医生 A 和 B 队与 C 相比有全面更低的外皮的穿孔率和不太吝啬的起作用的时间。它错过了是统计上重要的,与 3.3% 对 4.7%(P=0.191 ) 并且为外科医生 A 的 125.7 对 132.3 分钟(P=0.428 ) 并且 3.6% 对 6.4%(P=0.058 ) ,并且为外科医生 B 的 183.2 对 213.2 分钟(P=0.070 ) 。在一次尝试到表明学习曲线,在 6 月在每位外科医生的队的罐头系统以后的盒子被比较。穿孔率在 2.4% 减少了(P=0.039 ) 并且 4.3%(P=0.003 ) 并且起作用的时间分别地为外科医生 A 和 B 的 CAN 组到 31.8 分钟(P=0.002 ) 和 14.4 分钟(P=0.026 ) 被减少。当仅仅盒子表现在 12 以后时,用 CAN 系统的月被考虑,穿孔率在3.9%减少了( P=0.006 )并且5.6%( P 0.001 )并且起作用的时间为外科医生 A 和 B 的 CAN 组到 20.9 分钟( P 0.001 )和 40.3 分钟( P 0.001 )被减少, respectively.Conclusions 长远来说,罐头脊骨外科减少了腰部的螺丝钉外皮的穿孔率和起作用的时间。在 6 月使用在 12 个月以后装那 plateaued 以后,学习曲线显示出锋利的落下;它被穿孔率和起作用的时间数据表明。数据的小心的分析证明罐头是特别有用的让更少的富有经验的外科医生减少穿孔率和 intraoperative 时间,尽管进一步比较的研究被期望。 | BAI Yu-shu ZHANG Ye CHEN Zi-qiang WANG Chuan-feng ZHAO Ying-chuan SHI Zhi-cai LI Ming LIU Ka Po Gabriel | 2010 | Chinese Medical Journal2010，，21： | 8 |
| 9 | Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)显示文摘There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world situations.In this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May 2021.The primary endpoint was progression-free survival(PFS)according to modified RECIST.The secondary outcomes included overall survival(OS),objective response rate(ORR),and safety.We performed propensity score matching approaches to reduce bias between two groups.After matching,228 pairs were included with a predominantly advanced disease population.Median PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,respectively.Our results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile. | Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 7 |
| 10 | Efficacy and safety of the Qiguiyin formula in severe pneumonia: study protocol for a randomized, double-blind, placebo-controlled clinical trial显示文摘OBJECTIVE: To evaluate the clinical efficacy and safety of Qiguiyin(QGY) formula in patients with severe pneumonia in China compared with a placebo.METHODS: This is a multicenter double-blind, placebo-controlled, randomized clinical trial with two parallel arms. There will be 530 patients enrolled and randomized into either the experimental group(QGY formula) or the control group(placebo). Therapies for patients in the two groups above will be based on the conventional therapy. The primary outcome is 28-day mortality. Secondary outcomes include:(a) duration of hospital stay;(b) duration of time in the intensive care unit(ICU) stays;(c) duration of mechanical ventilation;(d) antibiotic DDD value(which means the doses of antibotics during the treatment period);(e) serum procalcitonin(PCT) level;(f) serum C-reactive protein(CRP)level;(g) Pneumonia severity index(PSI) score;(h)Sequential Organ Failure Assessment(SOFA) score;(i) sputum culture results;(j) blood routine examination results;(k) routine urine test results;(l) stool routine examination results;(m) electrocardiogram results;(n) alanine aminotransferase levels;(o) aspartate amino transferase levels;(p) total bilirubin;(q) creatinine levels;(r) urea nitrogen levels;and(s)adverse events.ETHICS AND DISSEMINATION: The protocol has been approved by the Research Ethics Committee of Beijing Hospital of Traditional Chinese Medicine,Affiliated with Capital Medical University(2018 BL-053-02). This trial aims to provide evidence for QGY formula combined with conventional therapy in treating patients with severe bacterial pneumonia,and to verify the clinical effectiveness and safety of QGY formula in China compared with placebo. Additionally, this trial will reveal the effect of QGY formula on delaying/reversing the characteristics of drug-resistant bacteria.Trial registration number: Chi CTR1800019785. | Huang Po Guo Yuhong Zhao Jingxia Li Bo Wu Yanqing Liu Qingquan | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 6 |
| 11 | Development of gated fiber detectors for laser-induced strong electromagnetic pulse environments显示文摘With the development of laser technologies,nuclear reactions can happen in high-temperature plasma environments induced by lasers and have attracted a lot of attention from different physical disciplines.However,studies on nuclear reactions in plasma are still limited by detecting technologies.This is mainly due to the fact that extremely high electromagnetic pulses(EMPs)can also be induced when high-intensity lasers hit targets to induce plasma,and then cause dysfunction of many types of traditional detectors.Therefore,new particle detecting technologies are highly needed.In this paper,we report a recently developed gated fiber detector which can be used in harsh EMP environments.In this prototype detector,scintillating photons are coupled by fiber and then transferred to a gated photomultiplier tube which is located far away from the EMP source and shielded well.With those measures,the EMPs can be avoided which may result that the device has the capability to identify a single event of nuclear reaction products generated in laser-induced plasma from noise EMP backgrounds.This new type of detector can be widely used as a time-of-flight(TOF)detector in high-intensity laser nuclear physics experiments for detecting neutrons,photons,and other charged particles. | Po Hu Zhi-Guo Ma Kai Zhao Guo-Qiang Zhang De-Qing Fang Bao-Ren Wei Chang-Bo Fu Yu-Gang Ma | 2021 | Nuclear Science and Techniques2021，32，6： | 6 |
| 12 | Aberrant cytological localization of p16 and CDK4 in colorectal epithelia in the normal adenoma carcinoma sequence显示文摘AIM: To study the correlation between the patterns of subcellular expression of p16 and CDK4 in colorectal epithelia in the normal-adenoma-carcinoma sequence. METHODS: Paraffin sections of 43 cases of normal colorectal epithelia and corresponding adenomas as well as carcinomas were analysed immunocytochemically for subcellular expression of p16 and CDK4 proteins. RESULTS: Most carcinomas showed more cytoplasmic overexpression for p16 and CDK4 than the adenomas from which they arised or the adjacent normal mucosa. Most normal or non-neoplastic epithelia showed more p16 and CDK4 expression in the nucleus than their adjacent adenomas and carcinomas. There was a significant difference between the subcellular expression pattern of p16 and CDK4 in normal-adenoma-carcinoma sequence epithelia (P < 0.001). Neither p16 nor CDK4 subcellular patterns correlated with histological grade or Dukes’ stage. CONCLUSION: Interaction of expression of p16 and CDK4 plays an important role in the Rb/p16 pathway. Overexpression of p16 and CDK4 in the cytoplasm, as well as loss expression of p16 in the nucleus might be important in the evolution of colorectal carcinoma from adenoma and, of adenoma from normal epithelia. | PO Zhao Xin Mao Ian C Talbot | 2006 | World Journal of Gastroenterology2006，12，39： | 5 |
| 13 | Overexpression of carbonic anhydrase Ⅱ and Ki-67 proteins in prognosis of gastrointestinal stromal tumors显示文摘AIM: To investigate the expression and prognostic value of carbonic anhydrase Ⅱ (CA Ⅱ) and Ki-67 in gastrointestinal stromal tumors (GISTs). METHODS: One hundred and thirteen GIST patients admitted to Chinese People's Liberation Army General Hospital from January 2004 to December 2010 were retrospectively followed up, and immunohistochemistry was used to detect CA Ⅱ, Ki-67 and CD117 expression in tumor samples. The survival rates of the patients were analyzed using the Kaplan-Meier method. Log-rank test, χ 2 test and Cox proportional hazards model were used to determine the relationships between CA Ⅱ, Ki-67 and CD117 expression and prognostic value in GISTs. RESULTS: The survival rates at 1, 3 and 5 years were 90.0%, 82.0% and 72.0% in all patients. However, in patients with positive CA Ⅱ or Ki-67, the survival rates were 92.0%, 83.0% and 77.0% or 83.0%, 66.6% and 53.0%, respectively. Compared with the negative groups, the survival rates in the positive groups were significantly lower (CA Ⅱ log-rankP = 0.000; Ki-67 logrank P = 0.004). Multivariate Cox analysis revealed that CA Ⅱ, CD117 and Ki-67 were considerable immune factors in prognosis of GIST patients (CA Ⅱ P = 0.043; CD117 P = 0.042; Ki-67 P = 0.007). Besides, tumor diameter, mitotic rate, tumor site, depth of invasion, complete resection, intraoperative rupture, and adjuvant therapy were important prognosis predictive factors. Our study indicated that CA Ⅱ had strong expression in GISTs and the prognosis of GISTs with high CA Ⅱ expression was better than that of GISTs with low or no expression, suggesting that CA Ⅱ is both a diagnostic and prognostic biomarker for GIST. CONCLUSION: CA Ⅱ and Ki-67 are significant prognostic factors for GISTs. CA Ⅱ associated with neovascular endothelia could serve as a potential target for cancer therapy. | Li-Cheng Liu Wen-Tong Xu Xin Wu Po Zhao Ya-Li Lv Lin Chen | 2013 | World Journal of Gastroenterology2013，19，16： | 5 |
| 14 | Distributed Control of Thermostatically Controlled Loads in Distribution Network with High Penetration of Solar PV显示文摘High penetration of solar energy can result in voltage rise in midday,while growth in residential air conditioning is the main contributor of overloading and voltage drop issues during peak demand time.This paper provides a hierarchical control scheme to coordinate multiple groups of aggregated thermostatically controlled loads to regulate network loading and voltage in a distribution network.Considering the limited number of messages that can be exchanged in a realistic communication environment,an event-triggered distributed control strategy is proposed in this paper.Through intermittent on and off toggling of air conditioners,the required active power adjustment is shared among participating aggregators to solve the issue.A case study is conducted and simulation results are presented to demonstrate the performance of the proposed control scheme. | Ke Meng Dongxiao Wang Zhao Yang Dong Xiaodan Gao Yu Zheng Kit Po Wong | 2017 | CSEE Journal of Power and Energy Systems2017，3，1： | 4 |
| 15 | Loss of heterozygosity of Kras2 gene on 12p12-13 in Chinese colon carcinoma patients显示文摘瞄准:在中国冒号癌病人在 12p12-13 上学习杂合现象(LOH ) 的损失。方法:DNA 分别地从癌症组织,邻近的组织的 10 个标本和正常组织的 10 个标本的 10 个标本被提取。Kras2 基因的 LOH 被聚合酶链反应(PCR ) 和使中毒的 polyacrylamide 胶化电气泳动在 12p-12-13 上用 11 个微卫星标记分析。结果:Kras 基因的 LOH 在 30% 至少在 12p-12-13 的一个标记上被检测(3/10 ) 邻近的织物标本。LOH 的高频率在 28.57% 在 D12S1034 上被识别(2/7 ) 邻近的织物标本。LOH 至少在一个上被检测癌织物标本的在 60% 的 12p12-13 (6/10 ) 的标记,最经常的 LOH 在 42.86% 在 D12S1034 和 D12S1591 上被发现(3/7 ) 癌织物标本。LOH 在 30% 被检测(3/10 ) 癌组织标本,(3/10 )30% 在 1% 邻近的组织标本,并且不发信号(1/0 ) 癌组织标本。LOH 的出现没与性别,年龄,肿瘤尺寸和淋巴节点转移相关。结论:Genomic 不稳定性可以在冒号癌的发展和前进发生在 Kras2 基因的 12p-12-13 上。Kras2 基因的高 LOH 可以直接影响野类型 Kras2 基因的抄写和翻译。 | Jun wan Hong Li Yuan Li Mei-Ling Zhu Po Zhao | 2006 | World Journal of Gastroenterology2006，12，7： | 3 |
| 16 | Growth inhibitory effect of wild-type Kras2 gene on a colonic adenocarcinoma cell line显示文摘AIM: To observe the growth inhibitory effect of wild-type Kras2 gene on a colonic adenocarcinoma cell line Caco-2. METHODS: Recombinant plasmid pCI-neo-Kras2 with wild type Kras2 open reading frame was constructed. The Caco-2 cells were transfected with either pCI-neo or pCI-neo-Kras2 using Lipofectamine 2000. The expression of wild type Kras 2 was examined by Northern blot analysis. And the expression of wild type Kras2 protein was examined by Western blot analysis. The effects of wild-type Kras2 on cell proliferation were analyzed by monotetrazolium (MTT) assay, meanwhile analyses of cell cycle and spontaneous apoptosis rate were carried out by flow cytometry (FCM). RESULTS: The plasmid of pCI-neo-Kras 2 was successfully established. The growth rate of cells transfected with pCI-neo-Kras2 was significantly lower than the control cells transfected with the empty pCI-neo vector (P < 0.05). Cell cycle analysis revealed arrest of the pCI-neo-Kras2 transfected cells in G0/G1 phases, decreased DNA synthesis and decreased fractions of cells in S phase. The proliferative index of cells transfected with pCI-neo-Kras2 was decreased compared with the control cells (49.78% vs 64.21%),while the apoptotic rate of Caco-2 cells with stable Kras 2 expression increased (0.30% vs 0.02%). CONCLUSION: The wild-type Kras2 gene effectively inhibits the growth of the colonic adenocarcinoma cell line Caco-2. | Hong Li Hou-Fa Cao Jun Wan Yuan Li Mei-Ling Zhu Po Zhao | 2007 | World Journal of Gastroenterology2007，13，6： | 3 |
| 17 | Effects of Internal Flow on Vortex-Induced Vibration and Fatigue Life of Submarine Pipelines显示文摘- With the rapid development of the offshore oil industries, submarine oil / gas pipelines have been widely used. Under the complicated submarine environmental conditions, the dynamic characteristics of pipelines show some new features due to the existence of both internal and external flows. The paper is intended to investigate the vortex-induced vibration of the suspended pipeline span exposed to submarine steady flow. Especially, the effects of the flow inside the pipeline are taken into account. Its influences on the amplitude of pipeline response, and then on the fatigue life, are given in terms of the velocity of the internal flow. | Shen Zhonghan and Zhao Qiang Professor, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100080Applied and Computation Analysis and Modeling (ACAM) Program, Louisiana Tech University, PO Box 3827, LA 71272, USA | 1996 | China Ocean Engineering1996，11，3： | 3 |
| 18 | Compressional Wave Velocities in Some Volcanic Rocks at Pressure up to 4.5 GPa显示文摘INTRODUCTIONThecompressionalwavevelocity(vp)inrockmeasuredathighpressureandhightemperatureisofsignificantimpor-tancetoelucida... | Zhou Wenge Zhao Zhidan Xie Hongsen Li Yuwen Guo Jie Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002 Xu Ji ’an Institute of Earth Sciences, Academia Sinica, Nankang PO Box1 55, Taipei, Taiwan 115 | 1998 | Journal of Earth Science1998，17，2： | 3 |
| 19 | Multi-objective Distributed Wind Generation Planning in an Unbalanced Distribution System显示文摘In addition to increasing penetration of distributed generation(DG),the distribution system power flow may be significantly impacted by direction and magnitude.This paper proposes a method for optimal placement of wind DG considering the unbalanced operation of distribution systems.The objective function includes static voltage stability index,three-phase unbalance index,system reliability index,and DG investment cost.The untransposed distribution lines and unbalanced load are modelled,and corresponding static voltage stability index and system reliability considering DG penetrations are derived.The expected and stochastic daily distributed generation and demand profiles in four seasons are calculated to improve the accuracy.To solve this multi-objective optimization model,a fuzzy membership function is used to integrate the four individual objectives,and a sensitivity-based method is proposed to solve the model efficiently.Case study on IEEE 13-bus distribution 3-phase networks and 123-node test feeder successfully verifies the performance of the proposed approach. | Yu Zheng Zhao Yang Dong Ke Meng Hongming Yang Mingyong Lai Kit Po Wong | 2017 | CSEE Journal of Power and Energy Systems2017，3，2： | 2 |
| 20 | Relationship between loss of heterozygosity of microsatellite on DCC gene and prognosis of colorectal adenocarcinoma显示文摘RelationshipbetweenlossofheterozygosityofmicrosateliteonDCCgeneandprognosisofcolorectaladenocarcinomaZHAOPo1,HUYingChuan2... | ZHAO Po 1, HU Ying Chuan 2, WANG De Wen 3, WANG Zhi Ping 3, XU Xin Zhao 4, YI Ping Yong 2, GAO Ya Bing 3 and YANG Guang Hua 2 | 1997 | World Journal of Gastroenterology1997，3，2： | 2 |
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