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| 1 | Prognostic significance of tumor immune microenvironment and immunotherapy:Novel insights and future perspectives in gastric cancer显示文摘Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with differentclinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects. | Daniela Cornelia Lazǎr Mihaela Flavia Avram Ioan Romosan Mǎrioara Cornianu Sorina Tǎan Adrian Goldis | 2018 | World Journal of Gastroenterology2018，24，32： | 24 |
| 2 | 干扰素调节因子5通过损伤胞葬作用控制动脉粥样硬化病变中的坏死核心形成显示文摘髓系细胞是动脉粥样硬化病变发展和易损斑块形成的核心。动脉吞噬细胞吸收凋亡细胞(胞葬作用)的能力受损,可促进病变生长并建立坏死核心。干扰素调节因子(interferon regulatory factor,IRF)5是髓系细胞功能的重要调节因子。该研究试图确定IRF5是否影响动脉粥样硬化病变的形成和表型。方法:通过两种互补模型,研究IRF5在动脉粥样硬化中的作用: | Seneviratne AN Edsfeldt AO Cole JE Kassiteridi C Swart M Park I Green P Khoyratty TE Saliba DG Goddard ME Sansom SN Goncalves I Krams R Udalova IA Monaco C 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，8： | 9 |
| 3 | Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanism显示文摘 | An H Xu H Zhang M Zhou J Feng T Qian C Qi R Cao X | 2006 | 第二军医大学学报2006，27，1： | 6 |
| 4 | EGFP expres sion in goat mammary epithelial cells显示文摘 | Zheng Y M An Z X Peng X R | 2006 | Chin J Agri Biotechnol2006，3，1： | 1 |
| 5 | Locking plate technology and its applications in upper ex trem ity fracture care显示文摘 | Larson AN R izzo M | 2007 | Hand Clin2007，23，2： | 1 |
| 6 | Characteriza- tion of phosphorus fractions in the sediments of a tropical in- tertidal mangrove ecosystem显示文摘 | BALA K PRASAD M R AM AN ATH AN A L | 2010 | Wetland Ecology and Man- agement2010，18，2： | 1 |
| 7 | Evaluation of water stress control with po- lyethylene glycols by analysis of guttation 显示文摘 | Kaufmann M R An E | 1971 | Plant Physiol1971，47，4： | 1 |
| 8 | T-DNA tagged knockout mutation of rice OsGSK1, an orthologue of Arabidopsis BIN2, with enhanced tolerance to various abiotic stresses 显示文摘 | Koh S Lee S C Kim M K Koh J H Lee S An G Choe S Kim S R | 2007 | Plant Molecular Biology2007，65，4： | 1 |
| 9 | Rupture of the laparotomy incision and its suture using Ventrofilm 显示文摘 | Salapa M Vandriakova R | 2001 | Rozhl Chir2001，80，3： | 1 |
| 10 | Genetic and genomie analysis in model legumes bring Nodfactor signaling to center stage显示文摘 | Riely B K Ané J M Penmetsa R V | 2004 | Current Opinion in Plant Biology2004，，7： | 1 |
| 11 | Systematic parameter study for ultra-fine fiber fabrication via electrospinning process 显示文摘 | An S H Inai R Kotaki M | 2005 | Polymer2005，46，16： | 1 |
| 12 | Mathematical modelling of residue allelopathy:the effects of intrinsic and extrinsic factors显示文摘 | M An I R Johnson J V Lovett | 2002 | Plant and Soil2002，，246： | 1 |
| 13 | Relaxin-like factor expression as a marker of differentiation in the mouse testis and ovary显示文摘 | Balvers M Spiess AN Domagalski R | 1998 | Endocrinology1998，139，6： | 1 |
| 14 | Strong, constitutive expression of the Arabidopsis ACT2/ACT8 actin subclass in vegetative tissues 显示文摘 | An Y Q Mcdowell J M Huang S R | 1996 | Plant Journal1996，10，1： | 1 |
| 15 | Ectopic expression of Tsil in transgenic hot pepper plants enhances host resistance to viral, bacterial, and oomycete pathogens 显示文摘 | Shin R Park J M An J M | 2002 | Mol Plant Microbe Inter-act2002，15，10： | 1 |
| 16 | Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disorders显示文摘 | HE~r'FEMA J M AN S S OORD E J C G | 2008 | Am J Med Genet B Neuropsychiatr Genet2008，147，5： | 1 |
| 17 | 1993 Biological Mathematical response to allelochemicals and its interpretation显示文摘 | An M Johnson I R Lovett modeling of allelopathy J V | 1993 | Journal of Chemical Ecology1993，19，： | 1 |
| 18 | NADK2,an Arabidopsis chlomplasfic NAD kinase,plays a vital role in both chlorophyll synthesis and chloroplast protection 显示文摘 | CHAI M F CHEN Q J AN R | 2005 | Plant Molecular Biology2005，59，： | 1 |
| 19 | The Prevalence of Limited Health Literacy 显示文摘 | PAASCHE- ORLOW M K PARKER R M GAZMARARI- AN J A | 2005 | Journal of General Internal Medicine2005，20，2： | 1 |
| 20 | A high- resolution, absolute-dated Holocene and deglacial Asian monsoon record from Dongge Cave, China显示文摘 | DYKOSKI C A EDWARDS R L CHENG H YUAN D X CAI Y J ZHANG M L LIN Y S QIN J M AN Z S REVENAUGH J | 2005 | Earth & Planetary Science Letters2005，233，12： | 1 |
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