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| 1 | GDNF-Enhanced Axonal Regeneration and Myelination Following Spinal Cord Injury is Mediated by Primary Effects on Neurons显示文摘我们先前研究表明胶质细胞源性神经营养因子(GDNF)联合施万细胞移植能促进脊髓损伤后轴突再生和髓鞘形成。然而,GDNF介导这一过程的细胞靶点尚不清楚。在此,我们报道了GDNF可增加在体再生轴突的数目和直径,并促进体外背根神经节神经元的轴突向外生长,提示GDNF对神经元有直接作用。在施万细胞-背根神经节神经元共培养下,GDNF显著增加施万细胞生成的髓鞘数目;GDNF处理对孤立培养的施万细胞增殖无作用,但可促进已与神经轴突有突触联系的施万细胞增殖;GDNF可增加孤立施万细胞中分子量为140kDa的神经细胞黏附分子(NCAM)的表达,但对黏附分子L1表达或神经营养因子NGF、NT3及BDNF分泌没有影响。总之,这些结果支持假设:GDNF提高轴突再生和施万细胞髓鞘形成主要是通过GDNF对神经元的直接作用介导的,并且提示GDNF联合施万细胞移植可能是促进脊髓损伤后轴突再生和髓鞘形成的有效策略之一。 | LIQUN ZHANG ZHENGWEN MA GEORGE M. SMITH XUEJUN WEN YELENA PRESSMAN PATRICK M. WOOD AND XIAO-MING XU | 2009 | 神经损伤与功能重建2009，4，4： | 25 |
| 2 | Grass height and transmission ecology of Echinococcus multilocularis in Tibetan communities, China显示文摘背景牙槽的包虫病是在西方的中国的公共健康意义的主要动物病。过度放牧最近为牙槽的包虫病的传播作为一个潜在的风险因素被假定。研究被设计进一步由调查过度放牧怎么影响了中间的主人的洞穴密度测试过度放牧的假设小哺乳动物并且小哺乳动物的洞穴密度怎么与狗包虫 multilocularis infection.Methods 被联系学习地点被发现了牙槽的包虫病是流行的区域的以前的研究选择。数据包括草高度,挖中间的主人的密度烘便的样品以及全球放系统(GPS ) 放的小哺乳动物,狗和狐狸,在 Shiqu 县从领域调查被收集,四川省,中国。烘便的样品用 copro-PCR 被分析。在烘便的样品的蠕虫,牙齿,骨头和头发视觉上被检验。包括 chi 平方和概括线性模型的单个因素和 multifactor 分析工具被把草高度用作在同质的牧场擦伤压力的一个代理用于这些 data.Results ,在导致的牧场发现那棵更高的草的这研究降低小哺乳动物的洞穴密度 X^2=A.67O , P=0.031 , coefficient=-1.570 )。在狗的包虫 multilocularis 蠕虫负担是显著地统计上与中介的最大的密度有关招待 Ochotona spp。(X^2=5.250, P=0.022, coefficient=0.028 ) 。在拥有的狗的流行断然被相关到在 200 米半径以内看见的迷路的狗的数字(Wald X^2=8.375, P=0.004,机会 ratio=1.198 ) 。结论我们的调查结果支持过度放牧支持的假设牙槽的包虫病的传播并且在牙槽的包虫病的传播证实迷路的狗的角色。 | WANG Qian Francis Raoul Christine Budke Philip S. Craig XIAO Yong-fu, Dominique A. Vuitton,Maiza Campos-Ponce, QIU Dong-chuan, David Pleydell and Patrick Giraudoux XIAO Yong-fu Dominique A. Vuitton Maiza Campos-Ponce QIU Dong-chuan David Pleydell Patrick Giraudoux | 2010 | Chinese Medical Journal2010，，1： | 12 |
| 3 | 直接评估吗啡刺激糖尿病人隐静脉内皮一氧化氮释放减少显示文摘to directly measure in real time basal and stimulated levels of NO released from human saphenous vein endothelium and to quantify the expression of the μopiate receptor, which has been linked with NO release. METHODS: Saphenous vein segments from patients with type 2 diabetes ( n = 12) and patients without diabetes (n =8) were obtained. The release of NO was measured directly from the endothelium using a NO-specific amperometric probe. NΩ-nitro-L-arginine methyl ester (L-NAME, 0.1 mmol/L), a NO synthase (NOS) inhibitor, or morphine (1 μmol/L), a stimulant, was administered and the measurements were repeated. Values were reported relative to the mean initial measurement of NO release from diabetic endothelium, which was defined as the relative zero level of NO release. A RT-PCR was then performed on the endothelium to measureμ opiate receptor expression. RESULTS: Diabetic patients (n = 12) showed a relative and significantly diminished basal level of released NO, (0.049± 0.012) nmol/L, compared | Thomas V BILHNGER, James A VOSSWINKEL, Patrick CADET, Christos M RIALAS, Harold I MAGAZINE, George B STEFANO(Division of Cardiothoracic Surgery, Department of Surgery, University Hospital and Medical Center, HSC, T19-080, Stony Brook, New York 11794-8191 Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York , USA) | 2002 | Acta Pharmacologica Sinica2002，23，2： | 3 |
| 4 | Brain MRI of hippocampal volumetry in patients with refractory temporal lobe epilepsy显示文摘Objective To detect for hippocampal sclerosis presurgically in a group of patients with refractory temporal lobe epilepsy Methods Eighty four consecutive patients with refractory temporal lobe epilepsy were subjected to brain MRI of hippocampal volumetry A ratio of smaller to larger hippocampal volume was determined and unilateral hippocampal atrophy (HA) was diagnosed if the ratio is less than 0 91 Results Unilateral HA was diagnosed in 42 patients (50%) and bilateral HA in 1 patient Other MRI abnormalities were detected in 18 patients with or without coexisting HA Conclusions Hippocampal sclerosis can be detected presurgically in many patients by brain MRI Additional abnormalities not detected by brain CT can also be | Ka Kui Philip Ng, Kwok Wing Tang, Yuk Ling James Cheung and Patrick Chung Ki Li | 2000 | Chinese Medical Journal2000，，3： | 3 |
| 5 | Gap filling strategies for long term energy flux data sets显示文摘 | Eva Falge Dennis Baldocchi Richard Olson Peter Anthoni Marc Aubinet Christian Bernhofer George Burba Reinhart Ceulemans Robert Clement Han Dolman André Granier Patrick Gross Thomas Grünwald David Hollinger Niels-Otto Jensen Gabriel Katul Petri Keronen And | 2001 | Agricultural and Forest Meteorology2001，，1： | 2 |
| 6 | An Incomplete Contracts Approach to Financial Contracting显示文摘 | Aghion Philippe and Bolton Patrick | 1992 | Review of Economic Studies1992，，57： | 1 |
| 7 | Equidistant Fish-Eye Calibration and Rectification by Vanishing Point Extraction 显示文摘 | Ciara'n Hughes Patrick Denny Martin Glavin and Edward Jones | 2010 | IEEE Transactions on Pattern Analysis and Machine Intelligence2010，32，12： | 1 |
| 8 | Schlievert Exotoxins of Staphylococcus ameus显示文摘 | Martin M Dinges Paul M Orwin and Patrick M | 2000 | Clinical microbiology reviews2000，13，1： | 1 |
| 9 | The Impact of Channel Leadership Behavior on Intrachannel Conflict 显示文摘 | Patrick L Schul William M Pride and Taylor L Little | 1983 | Journal of Marketing1983，47，3： | 1 |
| 10 | Rural resident tourism perceptions and attitudes 显示文摘 | Perdue Richard Long Patrick and Allen Lawrence | 1987 | Annals of Tourism Research1987，14，： | 1 |
| 11 | kehoe Modeling and Measuring Organization Capital 显示文摘 | Andrew Atkeson and Patrick J | 2005 | Journal of Political Economy2005，，： | 1 |
| 12 | A Trickle-Down Theory of Growth and Development with Debt Overhang显示文摘 | Aghion Philippe and Bohon Patrick (1997) | 1997 | Review of Economic1997，64，： | 1 |
| 13 | An Incomplete Contracts Approach to Financial Contracting显示文摘 | Aghion Philippe and Patrick Bolton | 1992 | Review of Economic Studies1992，59，3： | 1 |
| 14 | Agriculture, Ecosystems and Environment 显示文摘 | Jjemba Patrick K The Potential Impact of Veterinary and Human Therapeutic Agents in Manure and Bisolids on Plants Grown on Arable land: A Review | 2002 | 93:267--2782002，93，： | 1 |
| 15 | Transformation of manganese in a water- logged soll as affected by redox potential and pH显示文摘 | Gotoch S and W H Patrick | 1972 | PSSSA1972，36，： | 1 |
| 16 | A theory of trickle-down growth and development显示文摘 | Aghion Philippe and Patrick Bolton | 1997 | Review of Economic Studies1997，64，2： | 1 |
| 17 | The causal relationship between real estate and stock markets显示文摘 | John Okuney Patrick Wilson and Ralf Zurbruegg | 2000 | Journal of RealEstate Finance and Economics2000，21，3： | 1 |
| 18 | Phase Analysis in Zorconia Systems显示文摘 | Ronald C Garvie and Patrick S Nicholson | 1972 | Journal of The American Ceramic Society1972，55，6： | 1 |
| 19 | Liedtke, On insurability, its limits and extensions 显示文摘 | Christophe Courbage and Patrick M | 2002 | The Geneva Papers on Risk and Insurance-Issues and Practice2002，，： | 1 |
| 20 | Physical modeling of spiral inductors on silicon 显示文摘 | Yue C Patrick and S Simon Wong | 2000 | IEEE Transactions on Electron Devices2000，47，3： | 1 |
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