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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Randomised trial of anal- gesic effects of sucrose, glucose, and pacifiers in termneonates 显示文摘 | Carbajal R Chauvet X Couderc S | 1999 | BMJ1999，319，1： | 1 |
| 3 | Randomi,sed trial of anagesic effects of sucrose, glucose,and pacifiers in term neonates 显示文摘 | CARBAJAL R CHAUVET X COUDERC S | 1999 | BMJ1999，319，7222： | 1 |
| 4 | Adenovirus-mediated suicide gene transduction: feasibility in lens epithelium and in prevention of posterior capsule opacification in rabbits显示文摘 | Malecaze F Couderc B de-Neuville S | 1999 | Hum Gene Ther1999，10，14： | 1 |
| 5 | Pulmonary toxicity of chemotherapy and G/GM-CSF: a report of five cases 显示文摘 | COUDERC LJ ANIDES S FRACHON I | 1999 | Respir Med1999，93，1： | 1 |
| 6 | Randomized Trial of Analgesic Effects of Sucrose,Glucose,and Pacifiers in Term Neonates显示文摘 | Carbajal R Chauvet X Couderc S | 1999 | BMJ1999，319，27： | 1 |
| 7 | Prevalence of apolipoprotein E phenotypes in ischemic cerebrovascuIar disease:A case-control study显示文摘 | Couderc R Mahieuk F Bailleul S | 1993 | Stroke1993，24，： | 1 |
| 8 | Adenovirus-mediated suicide gene transduc- tion: feasibility in lens epithelium and in prevention of posterior capsule opacification in rabbits显示文摘 | Malecaze F Couderc B de Neuville S Serres B Mallet J Douin- Echinard V | 1999 | Hum Gene Ther1999，10，14： | 1 |
| 9 | Pulmonary toxicity of chemotherapy and G/GM-CSF:a report of five cases显示文摘 | Stelianides S Frachon I | 1999 | Respir Med1999，93，1： | 1 |
| 10 | Retrovirus-mediated transfer of a suicide gene into lens epithelial Cells in vitro and in an expenental model of posterior capsule opacification 显示文摘 | Couderc BC de NeuviUe S Douin-Echinard V Serres B Manenti S Darbon JM | 1999 | Curt Eye Res1999，19，5： | 1 |
| 11 | Prevalence of apoliprotein E phenotypes in ischem ic cerebrovascular disease: a case-control study显示文摘 | Couderc R Machieux F Bailleul S | 1993 | Stroke1993，24，： | 1 |
| 12 | Randomized Trial of Analgesic Effects of Sucrose, Glucose and Pacifiers in Term Neonates显示文摘 | Carbajal R Chauvet X Couderc S | 1999 | BMJ1999，319，7222： | 1 |
| 13 | Prevalence of apolipoprotein E Phenotypes in ischemic cerebrovascular disease:A case-control study 显示文摘 | Couderc R Mahieul F Bailleul S | 1993 | Stroke1993，24，5： | 1 |
| 14 | Randomized trial of analgesic effects of surose,glucose,and pacifiers in term neonates显示文摘 | Carbajal R Chauvet X Couderc S | 1999 | BMJ1999，319，7222： | 1 |
| 15 | Interaction between the Nonionic Surfactant Hexaethylene Glycol Mono-n-dodecyl Ether (C12EO6) and the Surface Active Nonionic ABA Block Copolymer Pluronic F127 (EO97PO69EO97)-Formation of Mixed Micelles Studied Using Isothermal Titration Calorimetry and Differential Scanning Calorimetry显示文摘 | Couderc S Li Y Bloor D M | 2001 | Langmuir2001，17，16： | 1 |
| 16 | Randomized trial of analgesiceffects of sucrose,glucose and pacifiers in term neonates显示文摘 | Carbajal R Chauvet X Couderc S | 1999 | BMJ1999，319，： | 1 |
| 17 | Analgesic effect of breast feeding in term neonates:randomized controlled trial显示文摘 | Carbajal R Veerapen S Couderc S | 2003 | BMJ2003，326，7379： | 1 |
| 18 | Randomised trial of analgesic effects of sucrose,glucose,and pacifiers in term neonates显示文摘 | CARBAJAL R CHAUVET X COUDERC S | 1999 | Bmj1999，319，7222： | 1 |
| 19 | Adenovirus-mediated suicide gene transduction:feasibility in lens epithelium and in prevention of posterior capsule opacification in rabbits显示文摘 | Malecaze F Couderc B de Neuville S Serres B Mallet J Douin-Echinard V | 1999 | Hum Gene Ther1999，10，14： | 1 |
| 20 | Randomised trial of analgesic effects of sucrose,glucose,and pacifiers in term neonates显示文摘 | Carbajal R Chauvet X Couderc S | 1999 | BMJ1999，319，： | 1 |
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