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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Beneficial effects of adenosine triphosphate-sensitive K^+ channel opener on liver ischemia/reperfusion injury显示文摘AIM:To investigate the effect of diazoxide administration on liver ischemia/reperfusion injury.METHODS:Wistar male rats underwent partial liver ischemia performed by clamping the pedicle from the medium and left anterior lateral segments for 1 h under mechanical ventilation.They were divided into 3 groups:Control Group,rats submitted to liver manipulation,Saline Group,rats received saline,and Diazoxide Group,rats received intravenous injection diazoxide(3.5 mg/kg) 15 min before liver reperfusion.4 h and 24 h after reperfusion,blood was collected for determination of aspartate transaminase(AST),alanine transaminase(ALT),tumor necrosis factor(TNF-α),interleukin-6(IL-6),interleukin-10(IL-10),nitrite/nitrate,creatinine and tumor growth factor-β1(TGF-β1).Liver tissues were assembled for mitochondrial oxidation and phosphorylation,malondialdehyde(MDA) content,and histologic analysis.Pulmonary vascular permeability and myeloperoxidase(MPO) were also determined.RESULTS:Four hours after reperfusion the diazoxide group presented with significant reduction of AST(2009 ± 257 U/L vs 3523 ± 424 U/L,P = 0.005); ALT(1794 ± 295 U/L vs 3316 ± 413 U/L,P = 0.005); TNF-α(17 ± 9 pg/mL vs 152 ± 43 pg/mL,P = 0.013; IL-6(62 ± 18 pg/mL vs 281 ± 92 pg/mL); IL-10(40 ± 9 pg/mL vs 78 ± 10 pg/mL P = 0.03),and nitrite/nitrate(3.8 ± 0.9 μmol/L vs 10.2 ± 2.4 μmol/L,P = 0.025) when compared to the saline group.A significant reduction in liver mitochondrial dysfunction was observed in the diazoxide group compared to the saline group(P < 0.05).No differences in liver MDA content,serum creatinine,pulmonary vascular permeability and MPO activity were observed between groups.Twenty four hours after reperfusion the diazoxide group showed a reduction of AST(495 ± 78 U/L vs 978 ± 192 U/L,P = 0.032); ALT(335 ± 59 U/L vs 742 ± 182 U/L,P = 0.048),and TGF-β1(11 ± 1 ng/mL vs 17 ± 0.5 ng/mL,P = 0.004) serum levels when compared to the saline group.The control group did not present alterations when compared to the diazoxide and saline groups.CONCLUSION:Diazoxide maintains liver mitochondrial function,increases liver tolerance to ischemia/reperfusion injury,and reduces the systemic inflammatory response.These effects require further evaluation for using in a clinical setting. | Mateus Antunes Nogueira Ana Maria Mendona Coelho Sandra Nassa Sampietre Rosely Antunes Patzina Fabiano Pinheiro da Silva Luiz Augusto Carneiro D'Albuquerque Marcel Cerqueira Cesar Machado | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 3 | Determination of Lead in Biological Samples by High-resolution Continuum Source Graphite Furnace Atomic Absorption Spectrometry with Direct Solid Sampling显示文摘 | BORGES D G DA SILVA A F WELZ B | 2006 | JAnal at Spectrom2006，21，： | 1 |
| 4 | Parametric Study of Adhesive Joints with Composites 显示文摘 | NETO J A B P CAMPILHO R D S G DA SILVA L F M | 2012 | International Journal of Adhesion and Adhesives2012，，： | 1 |
| 5 | Inhibitory action of aqueous coffee ground extracts on the corrosion of carbon steel in HC1 solution 显示文摘 | TORRESS V V AMADO R S de sAC F FERNANDEZ T L da SILVA RIEHI C A TORRES A G D'ELIA E | 2011 | Corrosion Science2011，53，： | 1 |
| 6 | Small strain viscoelastic behaviour of wheat gluten-pentosan mixtures 显示文摘 | Santos D M J Monteiro S R Da Silva J A L | 2005 | Eur Food Res Technol2005，，221： | 1 |
| 7 | Blending PSO and ANN for optimal design of FSS filters with Koch Island patch elements 显示文摘 | Da F Silva P H Cruz R M S D' Assuncao A G | 2010 | IEEE Trans on Magnetics2010，46，8： | 1 |
| 8 | Parameterized fast deeoupled power flow methods for obtaining the maximum loading point of power systems Part Ⅰ and Part Ⅱ显示文摘 | Alves D A Da Silva L C P Castro C A | 2004 | Electric Power Systems Research2004，69，： | 1 |
| 9 | Genome-wide comparative diversity uncovers multiple targets of selection for improvement in hexaploid wheat landraces and cultivars 显示文摘 | Cavanagh CS Chao S Wang BE Huang BE Stephen S Kiani S Forrest K Saintenac C Brown-Guedira GL Akhunova A See D Bai G Pumphrey M Tomar L Wong D Kong S Reynolds M da Silva ML Bockelman H Talbert L Anderson JA Dreisigacker S Baenziger S Carter A Korzun V Morrell PL Dubcovsky J Morell MK Sorrells ME Hayden MJ Akhunov E | 2013 | PNAS2013，110，： | 1 |
| 10 | A successive approximation vector quantizer for wavelet transform image coding显示文摘 | da Silva E A B Sampson D G Ghanbari M | 1997 | IEEE Trans on Image Processing1997，5，2： | 1 |
| 11 | Identification of pumpkin populations as resistance sources against the Zucchini yellow virus (ZYMV)显示文摘 | Moura M da C C L Zerbini E M da Silva D J H de Queiroz M A | 2005 | Horticultura Brasileira2005，23，： | 1 |
| 12 | Assessment of aroma impact compounds in a cashew apple-based alcoholic beverage by GC-MS and GC-olfactometry显示文摘 | GARRUTI D S FRANCO M R B da SILVA M A | 2006 | LWT-Food Science and Technology2006，39，4： | 1 |
| 13 | Study of ethylic Babassu biodiesel properties at low temperatures显示文摘 | Silva M C D Da Silva L M Santos N A | 2011 | J Therm Anal Calorim2011，106，2： | 1 |
| 14 | Production performance and milk composition of dairy cows fed whole or ground flaxseed with or without monensin显示文摘 | Da Silva D C Santos G T Branco A F | 2007 | J Dairy Sci2007，90，： | 1 |
| 15 | The use of headspace solid phase microextraction for the characterization of volatile compounds in olive oil matrices显示文摘 | Ribeiro L H Freitas A M C Gomes da Silva M D R | 2008 | Talanta2008，77，1： | 1 |
| 16 | 显示文摘 | COROPCEANU V CORNIL J DA SILVA FILHO D A | 2007 | Chem Rev2007，107，： | 1 |
| 17 | 黄粉虫替代蛋白质饲料对太平洋白虾(凡纳滨对虾)消化性能的影响显示文摘试验旨在评估黄粉虫粉(MM)作为凡纳滨对虾养殖中蛋白质来源的可行性。饲料分为正常饲料和试验饲粮,试验饲料中包含正常饲料85%和MM 15%,两种饲料中均含有氧化铬0.5%作为惰性标记,试验采用表观消化率系数(ADC)对两种饲料进行检测。为评估MM消化价值,对虾饲料中采用鱼粉替代MM,替代比例分别为0%、25%、50%、75%和100%,在清水中饲养6周后,对生长参数和整个虾体成分进行评估。干物质ADC为45.9%,能量ADC为66.5%,粗蛋白质ADC为76.1%,必须氨基酸ADC为72%~86%。MM中蛋氨酸为第一限制性氨基酸。饲料中添加MM后,各组间对虾的体增重、特定生长率、采食量、饲料转化率、存活率和蛋白质合成率均无显著变化(P>0.05),虾体蛋白质含量无显著差异(P>0.05)。而随着鱼粉替代比例上升,虾体脂含量从1.13%升至1.88%。结果表明,黄粉虫粉可作为凡纳滨对虾饲料中的替代蛋白质饲料,但添加时应注意补充蛋氨酸。 | Panini R L Freitas L E L Guimarǎes A M Rios C da Silva M F O Vieira F N Fracalossi D M Samuels R I | 2017 | 饲料博览2017，0，7： | 1 |
| 18 | Genetic deletion of the angiotensin (1 7) receptor Mas leads to glomerular hyperfiltration and microalbu minuria显示文摘 | Pinheiro S V Ferreira A J Kitten G T da Silveira K D da Silva D A Santos S H | 2009 | Kidney Int2009，75，： | 1 |
| 19 | The sensitivity of shoot growth of corn to theleast limiting water range of soils显示文摘 | DA SILVA A P KAY B D | 1996 | Plant and Soil1996，184，： | 1 |
| 20 | 显示文摘 | da Silva A L D Martin-Martinez J M Bordado J C M | 2006 | International Journal of Adhesion and Adhesives2006，26，5： | 1 |
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