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| 1 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 2 | Sensor-based demand-cont -rolled ventilation: a review 显示文摘 | William J Fisk Anibal T De Almeida | 1998 | Energy and Buildings1998，29，： | 1 |
| 3 | Immune function in young children with previous pulmonary or miliary/meningeal tuberculosis and impact of BCG vaccination 显示文摘 | Terling TR Martire T de Almeida AS | 2007 | Pediatrics2007，120，4： | 1 |
| 4 | Particle swarm-based olfactory guided search 显示文摘 | L Marques U Nunes A T de Almeida | 2006 | Autonomous Robotics (S0929-5593)2006，20，： | 1 |
| 5 | A new method for rapidly generating gene-targeting vectors by engi- neering BACs through homologous recombination in bacteria显示文摘 | Cotta de Almeida V Schonhoff S Shibata T | 2003 | Genome Res2003，13，9： | 1 |
| 6 | Indexing the trajectories of moving objects in networks显示文摘 | de Almeida V T Guting R H | 2005 | Geolnformatica2005，9，1： | 1 |
| 7 | Learning Sensor-Based Navigation of a Real Mobile Robot in Unknown Worlds 显示文摘 | Rui Araujo Anibal T de Almeida | 1999 | IEEE Transactions on System Man and Cybernetics-Part B: Cybernetics1999，29，2： | 1 |
| 8 | Modeling and Querying Moving Objects in Networks显示文摘 | Guting R H de Almeida V T | 2006 | The Interna tional Journal on Very Large DataBases2006，15，2： | 1 |
| 9 | Olfaction-based mobile robot navigation显示文摘 | Marques L Nunes U De Almeida A T | 2002 | Thin Solid Films2002，418，1： | 1 |
| 10 | Stereotactic disconnection of hypothalamic hamartoma to control seizure and behavior disturbance:case report and literature review显示文摘 | de Almeida AN Fonoff E T Ballester G | | 0，，： | 1 |
| 11 | Supercapacitor-based Optimum Switched Reluctance Drive for Advanced Electric Vehicles显示文摘 | GE Bao-ming AHIBAL T de Almeida FERNANDO J T E Ferreira | 2003 | IEEE2003，，： | 1 |
| 12 | Zona pellucida birefringence score and meiotic spindle visualization in relation to embryo development and ICSI outcomes显示文摘 | Madaschi C Aoki T de Almeida Ferreira Braga DP | 2009 | Re-prod Biomed Online2009，18，5： | 1 |
| 13 | Safety and effi- cacy of gemcitabine plus cisplatin combination in pretreated meta- static breast cancer patients 显示文摘 | Brito LG De Andrade JM Lins - Almeida T | 2012 | Med Oncol2012，29，1： | 1 |
| 14 | Group decision-making for leakage management strategy of water network显示文摘 | Morais D C de Almeida A T | 2007 | Resour Conserva Recycl2007，52，2： | 1 |
| 15 | Circalating levels of maeroph again igrati on in hiitorg factor are associated with mild palnonarg dys function after cardiopulnonarg bypass显示文摘 | de Mendonca-Filho H T Gomes R V de Almeida campos L A | 2004 | Shock2004，22，6： | 1 |
| 16 | Technical and economical considerations on super hlgh-efficiency three-phase motors 显示文摘 | de Almeida A T Ferreira F J T E Quintino D A | 2014 | IEEE Transactions on Industry Applications2014，50，2： | 1 |
| 17 | When stress and development go hand in hand:main hormonal controls of adventitious rooting in cuttings显示文摘 | da Costa C T de Almeida M R Ruedell C M | 2013 | Frontiersin Plant Science2013，4，： | 1 |
| 18 | Cognitive dysfunction in children with sleep-disordered breathing 显示文摘 | Carvalho LB Prado LF Silva L de Almeida MM Almeida e Silva T Lora MI | 2005 | J Child Neurol2005，20，5： | 1 |
| 19 | Marine paints:The particular case of antifouling paints显示文摘 | Almeida E Diamantino T C De Sousa O | 2007 | Progress in Organic Coatings2007，59，： | 1 |
| 20 | Olfaction-based mobile robot navigation显示文摘 | MARQUES L NUNES U de ALMEIDA A T | 2002 | Thin Solid Films2002，418，1： | 1 |
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