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| 1 | Personalizing therapies for gastric cancer: Molecular mechanisms and novel targeted therapies显示文摘Globally,gastric cancer is the 4thmost frequently diagnosed cancer and the 2ndleading cause of death from cancer,with an estimated 990000 new cases and738000 deaths registered in 2008.In the advanced setting,standard chemotherapies protocols acquired an important role since last decades in prolong survival.Moreover,recent advances in molecular therapies provided a new interesting weapon to treat advanced gastric cancer through anti-human epidermal growth factor receptor 2(HER2)therapies.Trastuzumab,an anti-HER2 monoclonal antibody,was the first target drug in the metastatic setting that showed benefit in overall survival when in association with platinum-5-fluorouracil based chemotherapy.Further,HER2 overexpression analysis acquired a main role in predict response for trastuzumab in this field.Thus,we conducted a review that will discuss the main points concerning trastuzumab and HER2 in gastric cancer,providing a comprehensive overview of molecular mechanisms and novel trials involved. | Michael Luis Ana Tavares Liliana S Carvalho Lúcio Lara-Santos António Araújo Ramon Andrade de Mello | 2013 | World Journal of Gastroenterology2013，19，38： | 6 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 4 | Comparison of two clinical scales for causality assessment in hepatotoxicity显示文摘 | Ma Isabel Lucena Raquel Camargo Raúl J. Andrade Carlos J. Perez-Sanchez Felipe Sanchez De La Cuesta | 2001 | Hepatology2001，，1： | 2 |
| 5 | Renal effects of N - acetylcysteinc in patients at risk for contrast nephropathy : decrease in oxidant stress - mediated renal tubular injury 显示文摘 | Dragcr LF Andrade L Barros de Toledo JF | 2004 | Nephrol Dial Transplant2004，19，7： | 1 |
| 6 | The life cycle of Hebella furax (Cnidaria, Hydrozoa) :a link between a lafoeid hydroid and a laodiceid medusa显示文摘 | Migotto A E De Andrade L P | 2000 | J Nat Hist2000，34，： | 1 |
| 7 | An improved har- mony search algorithm for synchronization of discrete-time chaotic systems 显示文摘 | Santos Coelho L d de Andrade Bernert D L | 2009 | Chaos Solitons and Fractals2009，41，15： | 1 |
| 8 | Review of procedures involving sep- aration and preeoncentration for the determination of cadmium using spectrometric techniques 显示文摘 | Ferreira Srgio L C de Andrade Jailson B Korn Maria das Gracas A | 2007 | Journal of Hazardous Materials2007，145，3： | 1 |
| 9 | Electrically, chemically, and photonically powered torsional and tensile actuation of hybrid carbon nanotube yam muscles显示文摘 | Marcio D L Li Na Monica Jung de Andrade | 2012 | Science2012，338，6116： | 1 |
| 10 | Evaluation of passive confinement in CFT columns显示文摘 | Walter Luiz Andrade de Oliveira Silvana De Nardin Ana Lúcia H. de Cresce El Debs Mounir Khalil El Debs | 2009 | Journal of Constructional Steel Research2009，，4： | 1 |
| 11 | Gravitational Energy-momentum Densityin Teleparallel Gravity显示文摘 | GUILLEN L C T PEREIRA J G | 2000 | Phys Rev Lett2000，84，： | 1 |
| 12 | Experimental and mechanical model for predicting the behaviour of minor axis beam-to-column semi-rigid joints 显示文摘 | de Lima L R O de Andrade S A L da S Vellasco P C G | 2002 | International Journal of Mechanical Science2002，44，6： | 1 |
| 13 | Levonorgestrel-releasing intrauterine system (Mirena) as a therapy for endometrial hyperplasia and carcinoma 显示文摘 | Bahamondes L Ribeiro-Huguet P de Andrade KC | 2003 | Acta Obstet Gynecol Scand2003，82，6： | 1 |
| 14 | Leptospiral nephropathy显示文摘 | Andrade L de Francesco Daher E Seguro AC | | 0，，4： | 1 |
| 15 | An im- proved harmony search algorithm for synchronization of discrete-time chaotic systems显示文摘 | dos Santos Coelho L de Andrade Bemert D L | 2009 | Chaos Solitons and Frac- tals2009，41，5： | 1 |
| 16 | Hydroxyapatite deposition by electrophoresis on titanium sheets with different surface finishing显示文摘 | Lídia de Sena Mica Calixto de Andrade Alexandre Matta Rossi | 2002 | Journal of Biomedical Materials Research2002，60，1： | 1 |
| 17 | Complex high-frequency magnetization dynamics and magnetoimpedance in thin films显示文摘 | DA SILVA R B VIEGAS A D C CORREA M A DE ANDRADE A M H SOMMER R L | 2006 | Physica B: Condensed Matter2006，384，12： | 1 |
| 18 | Electrochemical degradation of sulfamethoxazole and trimethoprim at boron-doped diamond electrode:Performance,kinetics and reaction pathway显示文摘 | De Amorim K P Romualdo L L Andrade L S | 2013 | Separation and Purification Technology2013，120，： | 1 |
| 19 | Structural assessment of current steel design models for transmission and telecommunication towers显示文摘 | Da Silva J G S Vellasco P C G S De Andrade S A L | 2005 | Journal of Constructional Steel Research2005，61，8： | 1 |
| 20 | Semi-rigid composite frames with perfobond and T-rib connectors Part 1: Full scale tests 显示文摘 | da S Vellasco P C G de Andrade S A L Ferreira L T S | 2007 | Journal of Constructional Steel Research2007，63，2： | 1 |
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