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| 1 | Palaeozoic tectonic evolution of the Tianshan belt,NW China显示文摘The Chinese Tianshan belt is a major part of the southern Central Asian Orogenic Belt,extending westward to Kyrgyzstan and Kazakhstan.Its Paleozoic tectonic evolution,crucial for understanding the amalgamation of Central Asia,comprises two stages of subduction-collision.The first collisional stage built the Eo-Tianshan Mountains,before a Visean unconformity,in which all structures are verging north.It implied a southward subduction of the Central Tianshan Ocean beneath the Tarim active margin,that induced the Ordovician-Early Devonian Central Tianshan arc,to the south of which the South Tianshan back-arc basin opened.During the Late Devonian,the closure of this ocean led to a collision between Central Tianshan arc and the Kazakhstan-Yili-North Tianshan Block,and subsequently closure of the South Tianhan back-arc basin,producing two suture zones,namely the Central Tianshan and South Tianshan suture zones where ophiolitic mélanges and HP metamorphic rocks were emplaced northward.The second stage included the Late Devonian-Carboniferous southward subduction of North Tianshan Ocean beneath the Eo-Tianshan active margin,underlined by the Yili-North Tianshan arc,leading to the collision between the Kazakhstan-Yili-NTS plate and an inferred Junggar Block at Late Carboniferous-Early Permian time.The North Tianshan Suture Zone underlines likely the last oceanic closure of Central Asia Orogenic Belt;all the oceanic domains were consumed before the Middle Permian.The amalgamated units were affected by a Permian major wrenching,dextral in the Tianshan.The correlation with the Kazakh and Kyrgyz Tianshan is clarified.The Kyrgyz South Tianshan is equivalent to the whole part of Chinese Tianshan(CTS and STS) located to the south of Narat Fault and Main Tianshan Shear Zone;the so-called Middle Tianshan thins out toward the east.The South Tianshan Suture of Kyrgyzstan correlates with the Central Tianshan Suture of Chinese Tianshan.The evolution of this southern domain remains similar from east(Gangou area) to west until the Talas-Ferghana Fault,which reflects the convergence history between the Kazakhstan and Tarim blocks. | Jacques CHARVET SHU LiangShu Sebastien LAURENT-CHARVET WANG Bo Michel FAURE Dominique CLUZEL CHEN Yan Koen De JONG | 2011 | Science China Earth Sciences2011，54，2： | 57 |
| 2 | 限制热量摄入6个月对超重者寿命指标、代谢调节及氧化应激的影响——随机对照试验AuthorAffiliations:PenningtonBiomedicalResearchCenter.LouisianaStateUniversity.BatonRouge;andGarvan.InstituteforMedicalResearch.Dadinghurst,AustraIia(DrHeilbronn).显示文摘背景:长期限制热量摄入可延长啮齿类动物的寿命。但是,尚未有研究观测长期限制人体热量是否会影响其寿命及氧化应激指标,降低代谢率。
目的:在超重但不肥胖(体重指数为25—30)的人群中研究限制热量6个月伴/不伴运动对其产生的影响。
设计、地点及参试者:于2002年3月至2004年8月在位于路易斯安娜州首府巴顿鲁治的研究中心对48名不好动的健康人进行随机对照研究。
干预:参试者在6个月内随机分为4个组:对照组(饮食可维持体重);限制热量组(限制基线所需能量的25%);限制热量+运动组(限制12.5%的热量+运动增加12.5%的能耗);极低热量饮食组(每日摄入890keal,直至体重减少15%,随后采用维持体重的饮食)。
主要观测指标:机体组成;硫酸脱氢表雄酮(dehydroepiandrostemne sulfate,DHEAS)、葡萄糖及胰岛素水平;蛋白羰基化合物;DNA损伤;24小时能耗;核心体温。
结果:6个月时各组体重变化的均值(标准误)为:对照组-1.0%(1.1%);限制热量组-10.4%(0.9%);限制热量+运动组-10.0%(0.8%);极低热量饮食组-13.9%(0.7%)。6个月时,各干预组空腹血糖水平较基线明显降低(P均〈0.01),而DHEAS和葡萄糖水平没有改变。限制热量组及限制热量+运动组核心体温有所下降(P均〈0.05)。对机体组成进行校正后发现,对照组24小时静息能耗无变化,但限制热量组(-135kcal/d[42kcal/d])、限制热量+运动组(-117kcal/d[52kcal/d])和极低热量饮食组(-125kcal/d[35kcal/d])24小时静息能耗有所下降(P均〈0.008)。上述“代谢调节”(超出预计值的-6%)与对照组相比存在显著差异(P〈0.05)。6个月时,各组蛋白羰基化合物的浓度较基线时无变化,而各干预组DNA损伤有所减少(P〈0.005)。
结论:我们的研究结果显示,长期限制热量可降低人类寿命的2种指标(即空腹胰岛素水平和体温)。此外,我们的研究结果还支持下述理论,即限制热量能降低代谢率,且超过缩小代谢面积产生的相应效应。我们尚需开展远期研究来评价限制热量能否延缓人类衰老过程。 | Leonie K. Heibronn Lilian de Jonge Madlyn I. Frisard James P. DeLany D. Enette Larson-Meyer Jennifer Rood Tuong Nguyen Corby K. Martin Julia Volaufova Marlene M. Most Frank L. Greenway Steven R. Smith Walter A. Deutsch Donald A. Williamson Eric Ravussin 顾佳(译) | 2006 | 美国医学会杂志(中文版)2006，25，5： | 18 |
| 3 | 马铃薯块茎形状基因CAPS标记的开发与验证显示文摘马铃薯块茎形状(薯形)是选育马铃薯品种尤其是加工品种最重要的性状之一。前人研究表明薯形是由位于第10染色体的单基因Ro控制的,并且圆形对长形为显性。本研究以二倍体马铃薯长薯形基因型10618-01和圆薯形基因型320-02及其213个F1代薯形分离群体为材料,基于马铃薯基因组相关序列信息结合分离群体分组分析法开发标记,获得了一个CAPS标记1137-CAPSVI。利用该标记对53份不同薯形的四倍体马铃薯高代品系进行验证,结果表明该标记的选择准确率达83.02%,进一步的Pearson双侧相关分析显示其相关性达极显著水平,且该标记对圆薯形材料的选择准确率更高,达91.42%。该CAPS标记的获得对于四倍体马铃薯分子标记辅助育种,加速马铃薯品种尤其是加工专用型品种的选育具有重要意义。 | 朱文文 徐建飞 李广存 段绍光 刘杰 卞春松 庞万福 Walter De Jong 金黎平 | 2015 | 作物学报2015，41，10： | 11 |
| 4 | Glutamate reduces experimental intestinal hyperpermeability and facilitates glutamine support of gut integrity显示文摘AIM:To assess whether glutamate plays a similar role to glutamine in preserving gut wall integrity.METHODS:The effects of glutamine and glutamate on induced hyperpermeability in intestinal cell lines were studied.Paracellular hyperpermeability was induced in Caco2.BBE and HT-29CL.19A cell lines by adding phorbol-12,13-dibutyrate(PDB) apically,after which the effects of glutamine and glutamate on horseradish peroxidase(HRP) diffusion were studied.An inhibitor of glutamate transport(L-trans-pyrrolidine-2,4-dicarboxylic acid:trans-PDC) and an irreversible blocker(acivicin) of the extracellular glutamine to glutamate converting enzyme,γ-glutamyltransferase,were used.RESULTS:Apical to basolateral HRP flux increased significantly compared to controls not exposed to PDB (n=30,P<0.001).Glutamine application reduced hyperpermeability by 19%and 39%in the respective cell lines.Glutamate application reduced hyperpermeability by 30%and 20%,respectively.Incubation of HT29CL.19A cells with acivicin and subsequent PDB and glutamine addition increased permeability levels.Incubation of Caco2.BBE cells with trans-PDC followed by PDB and glutamate addition also resulted in high permeability levels.CONCLUSION:Apical glutamate-similar to glutaminecan decrease induced paracellular hyperpermeability.Extracellular conversion of glutamine to glutamate and subsequent uptake of glutamate could be a pivotal step in the mechanism underlying the protective effect of glutamine. | Mechteld AR Vermeulen Jeffrey de Jong Mathijs J Vaessen Paul AM van Leeuwen Alexander PJ Houdijk | 2011 | World Journal of Gastroenterology2011，17，12： | 9 |
| 5 | 基础设施网络整合与跨区域治理——“哈大齐”工业走廊与松花江水污染案例分析显示文摘在全球化和信息化背景下,区域管理正在从传统的都市区(Metropolitan)管理过渡到巨型都市区(Megapolitan)或者城市走廊(City Corridor)的管理。从社会技术系统(Societal-techno System)视角,将区域管理作为一个涉众系统(Multi-actor System)考虑,研究物理系统与社会网络之间的交互作用,通过研究基础设施网络和跨区域治理关系,探索涉众系统情境下的政策制定模型。采用理论分析和案例研究相结合的方法,利用哈大齐工业走廊案例和松花江水污染案例进行了研究。结果发现,基础设施整合具有嵌入性特征;基础设施整合和专业化分工网络的形成,是跨区域治理的基础,所形成的城市网络,其核心功能体现在'分散的集中化'上,以保证有效的基础设施整合、分工网络的形成和提供高级生产者服务;在跨区域治理政策制定中,应该采用自上而下和自下而上组合的基于规则和过程的涉众情境下的政策制定过程,以实现社会、政府和市场之间的均衡。 | 西宝 Martin de Jong | 2007 | 公共管理学报2007，4，4： | 6 |
| 6 | m TOR signaling in liver regeneration: Rapamycin combined with growth factor treatment显示文摘AIM: To investigate the effects of mammalian target of rapamycin(mT OR) inhibition on liver regeneration and autophagy in a surgical resection model.METHODS: C57BL/6 mice were subjected to a 70% partial hepatectomy(PH) and treated intraperitoneally every 24 h with a combination of the m TOR inhibitor rapamycin(2.5 mg/kg per day) and the steroid dexamethasone(2.0 mg/kg per day) in phosphate bufferedsaline(PBS) or with PBS alone as vehicle control. In the immunosuppressant group, part of the group was treated subcutaneously 4 h prior to and 24 h after PH with a combination of human recombinant interleukin 6(IL-6; 500 μg/kg per day) and hepatocyte growth factor(HGF; 100 μg/kg per day) in PBS. Animals were sacrificed 2, 3 or 5 d after PH and liver tissue and blood were collected for further analysis. Immunohistochemical staining for 5-Bromo-2'-deoxyuridine(Brd U) was used to quantify hepatocyte proliferation. Western blotting was used to detect hepatic microtubule-associated protein 1 light chain 3(LC3)-Ⅱ protein expression as a marker for autophagy. Hepatic gene expression levels of proliferation-, inflammation- and angiogenesisrelated genes were examined by real-time reverse transcription-polymerase chain reaction and serum bilirubin and transaminase levels were analyzed at the clinical chemical core facility of the Erasmus MC-University Medical Center.RESULTS: m TOR inhibition significantly suppressed regeneration, shown by decreased hepatocyte proliferation(2% vs 12% Brd U positive hepatocyte nuclei at day 2, P < 0.01; 0.8% vs 1.4% at day 5, P = 0.02) and liver weight reconstitution(63% vs 76% of initial total liver weight at day 3, P = 0.04), and furthermore increased serum transaminase levels(aspartate aminotransferase 641 U/L vs 185 U/L at day 2, P = 0.02). Expression of the autophagy marker LC3-Ⅱ, which was reduced during normal liver regeneration, increased after mT OR inhibition(46% increase at day 2, P = 0.04). Hepatic gene expression showed an increased inflammation-related response [tumor necrosis factor(TNF)-α 3.2-fold upregulation at day 2, P = 0.03; IL-1Ra 6.0-fold upregulation at day 2 and 42.3-fold upregulation at day 5, P < 0.01] and a reduced expression of cell cycle progression and angiogenesis-related factors(HGF 40% reduction at day 2; vascular endothelial growth factor receptor 2 50% reduction at days 2 and 5; angiopoietin 1 60% reduction at day 2, all P ≤ 0.01). Treatmentwith the regeneration stimulating cytokine IL-6 and growth factor HGF could overcome the inhibitory effect on liver weight(75% of initial total liver weight at day 3, P = 0.02 vs immunosuppression alone and P = 0.90 vs controls) and partially reversed gene expression changes caused by rapamycin(TNF-α and IL-1Ra levels at day 2 were restored to control levels). However, no significant changes in hepatocyte proliferation, serum injury markers or autophagy were found.CONCLUSION: mT OR inhibition severely impairs liver regeneration and increases autophagy after PH. These effects are partly reversed by stimulation of the IL-6 and HGF pathways. | Suomi MG Fouraschen Petra E de Ruiter Jaap Kwekkeboom Ron WF de Bruin Geert Kazemier Herold J Metselaar Hugo W Tilanus Luc JW van der Laan Jeroen de Jonge | 2013 | World Journal of Transplantation2013，3，3： | 6 |
| 7 | 成人型梭行细胞横纹肌肉瘤高频发生MYOD1基因反式激活突变显示文摘习惯上将横纹肌肉瘤(RMS)分为以下3型,即腺泡状横纹肌肉瘤(ARMS)、胚胎型横纹肌肉瘤(ERMS)及多形性横纹肌肉瘤(PRMS),而ERMS中包括了梭形细胞RMS。在2013版的WHO软组织及骨肿瘤分类中,梭形细胞RMS已从ERMS中分离出来,其梭形细胞/硬化性RMS被列为一种独立的类型。迄今为止,成人梭形细胞RMS并未被检测到高频发生的基因突变。 | Szuhai K de Jong D Leung A Y 杨文婷(摘译) 余英豪(审校) | 2014 | 临床与实验病理学杂志2014，30，5： | 6 |
| 8 | 国际视野下的数字人文教育--基础设施视角的社区驱动型数字人文课程登记中心显示文摘数字人文以其新实践、新途径和新方法丰富了传统的人文学科领域。进入21世纪以来,暑期学校、研讨会和其他类似形式的教育活动普及了一系列与之相关的必备技能,以保证学生、学者们能够把握数字时代的新机会,同时世界各地推出了越来越多相关的学士和硕士项目。本文论述的焦点--数字人文课程登记中心(Digital Humanities Course Registry,DHCR)的创建就是为了展现全球日益兴盛的数字人文教育状况,其使命是广泛收集同类课程的资料,提供数字人文领域教学和培训的最新动态。文章探讨了数字人文这一新兴领域,并对CLARIN和DARIAH这两个欧洲基础设施进行介绍--它们是DHCR的共同运营者。文中还具体描述了DHCR的数据模型和数据管护流程,简要介绍其历史。利用DHCR实时数据,以定量方式描绘了数字人文教学的国际格局。 | Tanja Wissik Jennifer Edmond Frank Fischer Franciska de Jong Stefania Scagliola Andrea Scharnhorst Hendrik Schmeer Walter Scholger Leon Wessels 郑炜楠(译) 肖鹏(译) 林佩倩(校) | 2020 | 图书馆论坛2020，40，6： | 6 |
| 9 | An efficient and accurate framework for calculating lattice thermal conductivity of solids:AFLOW-AAPL Automatic Anharmonic Phonon Library显示文摘One of the most accurate approaches for calculating lattice thermal conductivity,κ_(l),is solving the Boltzmann transport equation starting from third-order anharmonic force constants.In addition to the underlying approximations of ab-initio parameterization,two main challenges are associated with this path:high computational costs and lack of automation in the frameworks using this methodology,which affect the discovery rate of novel materials with ad-hoc properties.Here,the Automatic Anharmonic Phonon Library(AAPL)is presented.It efficiently computes interatomic force constants by making effective use of crystal symmetry analysis,it solves the Boltzmann transport equation to obtain κ_(l),and allows a fully integrated operation with minimum user intervention,a rational addition to the current high-throughput accelerated materials development framework AFLOW.An“experiment vs.theory”study of the approach is shown,comparing accuracy and speed with respect to other available packages,and for materials characterized by strong electron localization and correlation.Combining AAPL with the pseudo-hybrid functional ACBN0 is possible to improve accuracy without increasing computational requirements. | Jose J.Plata Pinku Nath Demet Usanmaz Jesus Carrete Cormac Toher Maarten de Jong Mark Asta Marco Fornari Marco Buongiorno Nardelli Stefano Curtarolo | 2017 | npj Computational Materials2017，，1： | 5 |
| 10 | CT筛查降低肺癌死亡率的随机试验显示文摘目前在曾经和现在吸烟的男性中,基于容积的低剂量计算机断层扫描(CT)筛查能否降低肺癌死亡率的随机试验证据有限。2020年初新英格兰医学杂志报道了一项来自欧洲的CT筛查对降低肺癌死亡率的临床试验结果。该研究招募了50~74岁的13195名男性(主要分析)和2594名女性(亚组分析),并将其随机分配至不筛查对照组和干预组,后者分别在基线、第1年、第3年和第5.5年进行CT筛查。通过荷兰和比利时国家登记处获得癌症诊断、死亡日期和死因。 | 王红(译) 唐威(译) 石菊芳(译) De Koning HJ Van der Aalst CM De Jong PA | 2020 | 中华预防医学杂志2020，54，7： | 5 |
| 11 | 阿尔茨海默病患者脑血流的动态调节显示文摘脑自动调节和压力反射敏感性是维持脑血流量的关键机制。该研究评估了这些调控机制在阿尔茨海默病导致的痴呆和轻度认知障碍患者中是否受到影响,因为这会增加降压治疗的风险。 | 刘青 叶鹏 de Heus RAA de Jong DLK Sanders ML van Spijker GJ Oudegeest-Sander MH Hopman MT Lawlor BA Olde Rikkert MGM Claassen JAHR | 2018 | 中华高血压杂志2018，26，8： | 4 |
| 12 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 13 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 14 | 视网膜血管直径与卒中风险的关系:鹿特丹研究显示文摘Background: Retinal vessels may provide information on cerebral vascular pathology, because they share many features with cerebral vessels. A smaller ratio of the retinal arteriolar-to-venular diameters reportedly predicts the risk of stroke. It is unclear if this is due to arteriolar narrowing or venular dilation. Objective: To investigate whether smaller arteriolar or larger venular diameters are related to the risk of stroke and cerebral infarction. Methods: This study was based on the prospective population-based Rotterdam Study and included 5,540 participants of 55 years or over, who had gradable fundus transparencies and were free of stroke at baseline (1990 to 1993). For each participant, retinal arteriolar and venular diameters were measured on digitized images of one eye. Follow-up for first-ever stroke was complete until January 1, 2002. Results: After a mean follow-up of 8.5 years, 411 participants had a stroke, of whom 259 had cerebral infarction. Larger venular diameters were associated with an increased risk of stroke (hazard ratio [HR] adjusted for age and sex per SD increase: 1.12 [95%CI: 1.02 to 1.24]) and cerebral infarction (HR: 1.15 [95%CI: 1.02 to 1.29]). Smaller arteriolar diameters were neither related to the risk of stroke (HR per SD decrease: 1.02 [95%CI: 0.93 to 1.13]) nor to the risk of cerebral infarction (HR: 1.02 [95%CI: 0.90 to 1.15]). After additional adjustment for other cardiovascular risk factors, the results did not change. Conclusions: Larger retinal venular diameters are associated with an increased risk of stroke and cerebral infarction. The role of venules in cerebrovascular disease warrants further exploration. | Ikram M.K. De Jong F.J. Bos M.J. P.T.V.M. De Jong 邱伟庆 | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，9： | 4 |
| 15 | 感染人类的禽流感病毒A(H5N1)研究进展显示文摘 | Abdel-Nasser Abdel-Ghafar Tawee Chotpitayasunondh Zhancheng Gao Frederick G. Hayden Nguyen Duc Hien Menno D. de Jong Azim Naghdaliyev J.S. Malik Peiris Nahoko Shindo Santoso Soeroso Timothy M. Uyeki 钟晓琴(译) 王关嵩(校) | 2009 | 中华肺部疾病杂志(电子版)2009，2，1： | 4 |
| 16 | Stability and activity of carbon nanofiber-supported catalysts in the aqueous phase reforming of ethylene glycol显示文摘Nickel, cobalt, copper and platinum nanoparticles supported on carbon nano-fibers were evaluated with respect to their stability, catalytic activity and selectivity in the aqueous phase reforming of ethylene glycol (230 C, autogenous pressure, batch reactor). The initial surface-specific activities for ethylene glycol reforming were in a similar range but decreased in the order of Pt (15.5 h1 ) >Co(13.0 h1 ) >Ni(5.2 h1 ) while the Cu catalyst only showed low dehydrogenation activity. The hydrogen molar selectivity decreased in the order of Pt (53%)>Co(21%)>Ni (15%) as a result of the production of methane over the latter two catalysts. Over the Co catalyst acids were formed in the liquid phase while alcohols were formed over Ni and Pt. Due to the low pH of the reaction mixture, especially in the case of Co (as a result of the formed acids), significant cobalt leaching occurs which resulted in a rapid deactivation of this catalyst. Investigations of the spent catalysts with various techniques showed that metal particle growth is responsible for the deactivation of the Pt and Ni catalysts. In addition, coking might also contribute to the deactivation of the Ni catalyst. | T. van Haasterecht C. C. I. Ludding K. P. de Jong J. H. Bitter | 2013 | Journal of Energy Chemistry2013，22，2： | 3 |
| 17 | The Soil-Borne Identity and Microbiome-Assisted Agriculture:Looking Back to the Future显示文摘Looking forward includes looking back every now and then.In 2007,David Weller looked back at 30 years of biocontrol of soil-borne pathogens by Pseudomonas and signified that the progress made over decades of research has provided a firm foundation to formulate current and future research questions.It has been recognized for more than a century that soil-borne microbes play a significant role in plant growth and health.The recent application of high-throughput omics technologies has enabled detailed dissection of the microbial players and molecular mechanisms involved in the complex interactions in plant-associated microbiomes.Here,we highlight old and emerging plant microbiome concepts related to plant disease control,and address perspectives that modern and emerging microbiomics technologies can bring to functionally characterize and exploit plant-associated microbiomes for the benefit of plant health in future microbiome-assisted agriculture. | Peter A.H.M.Bakker Roeland L.Berendsen Johan A.Van Pelt Gilles Vismans Ke Yu Erqin Li Sietske Van Bentum Sanne W.M.Poppeliers Juan J.Sanchez Gil Hao Zhang Pim Goossens Ioannis A.Stringlis Yang Song Ronnie de Jonge CornéM.J.Pieterse | 2020 | Molecular Plant2020，13，10： | 3 |
| 18 | Prevention of overuse: A view on upper gastrointestinal endoscopy显示文摘Many upper gastrointestinal(GI) endoscopies worldwide are performed for inappropriate indications. This overuse of healthcare negatively affects healthcare quality and puts pressure on endoscopy services. Dyspepsia is one of the most common inappropriate indications for upper GI endoscopy as diagnostic yield is low. Reasons for untimely referral are: unfamiliarity with dyspepsia guidelines,uncertainty about etiology of symptoms, and therapy failure. Unfiltered openaccess referrals feed upper GI endoscopy overuse. This review highlights strategies applied to diminish use of upper GI endoscopies for dyspepsia. First,we describe the impact of active guideline implementation. We found improved guideline adherence, but resistance was encountered in the process. Secondly, we show several forms of clinical assessment. While algorithm use reduced upper GI endoscopy volume, effects of referral assessment of individual patients were minor. A third strategy proposed Helicobacter pylori test and treat for all dyspeptic patients. Many upper GI endoscopies can be avoided using this strategy, but outcomes may be prevalence dependent. Lastly, empirical treatment with Proton pump inhibitors achieved symptom relief for dyspepsia and avoided upper GI endoscopies in about two thirds of patients. Changing referral behavior is complex as contributing factors are manifold. A collaboration of multiple strategies is most likely to succeed. | Judith J de Jong Marten A Lantinga Joost PH Drenth | 2019 | World Journal of Gastroenterology2019，25，2： | 3 |
| 19 | 心肌梗死后抑郁的预测:来自心肌梗死和抑郁干预试验(MIND-IT)的数据显示文摘Background: Depression following myocardial infarction(MI) is associated with complicated cardiac rehabilitation, noncompliance and poor prognosis. Whether de pression following MI can be predicted from variables routinely assessed during hospitalization for MI is unknown. Methods: Using data from the Myocardial INfar ction and Depression-Intervention Trial(MIND-IT),we identified 2177 MI patient s(mean age 63 years; 23%female). Patients were randomly divided into a derivati on and a validation sample. In the derivation sample, we analyzed variables pote ntially associated with the development of post-MI depressive disorder, which w ere tested in the validation sample. Results: In the year following MI, 18.5%su ffered from depressive disorder(ICD-10 criteria). In a multivariate model, fact ors associated with depression were younger age(OR 1.94; CI 1.38-2.74), hyperch olesterolemia(OR 1.68; CI 1.08-2.61), the use of calcium channel blockers at di scharge(OR 1.80; CI 1.20-2.71), and left ventricular ejection fraction(LVEF)(OR 4.14 for patients with LVEF< 30%; CI 2.42-7.10). The derived predictors were tested in the validation sample. The final model yielded two clinical predictors , i.e., younger age and severe LV-dysfunction, which correctly predicted post- discharge depression status in 82.9%of the MI patients. The model yielded a hig h negative predictive value(89%). A positive depression questionnaire(BDI) duri ng hospitalization increased the positive predictive value of 23%to 52%. Concl usions: During hospitalization for MI and using a two-step strategy with common clinical variables, i.e., younger age, severe LV-dysfunction and BDI score dur ing hospitalization, it is possible to identify MI patients with a high risk for subsequent development of depression. | Van Melle J.P. De Jonge P. Kuyper A.M.G. 孙凯 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，9： | 3 |
| 20 | Anxiety and Risk of Incident Coronary Heart Disease显示文摘 | Annelieke M. Roest Elisabeth J. Martens Peter de Jonge Johan Denollet | 2010 | Journal of the American College of Cardiology2010，，1： | 3 |
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