|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 2 | Navigated liver surgery:State of the art and future perspectives显示文摘Background:In recent years,the development of digital imaging technology has had a significant influence in liver surgery.The ability to obtain a 3-dimensional(3D)visualization of the liver anatomy has provided surgery with virtual reality of simulation 3D computer models,3D printing models and more recently holograms and augmented reality(when virtual reality knowledge is superimposed onto reality).In addition,the utilization of real-time fluorescent imaging techniques based on indocyanine green(ICG)uptake allows clinicians to precisely delineate the liver anatomy and/or tumors within the parenchyma,applying the knowledge obtained preoperatively through digital imaging.The combination of both has transformed the abstract thinking until now based on 2D imaging into a 3D preoperative conception(virtual reality),enhanced with real-time visualization of the fluorescent liver structures,effectively facilitating intraoperative navigated liver surgery(augmented reality).Data sources:A literature search was performed from inception until January 2021 in MEDLINE(Pub Med),Embase,Cochrane library and database for systematic reviews(CDSR),Google Scholar,and National Institute for Health and Clinical Excellence(NICE)databases.Results:Fifty-one pertinent articles were retrieved and included.The different types of digital imaging technologies and the real-time navigated liver surgery were estimated and compared.Conclusions:ICG fluorescent imaging techniques can contribute essentially to the real-time definition of liver segments;as a result,precise hepatic resection can be guided by the presence of fluorescence.Furthermore,3D models can help essentially to further advancing of precision in hepatic surgery by permitting estimation of liver volume and functional liver remnant,delineation of resection lines along the liver segments and evaluation of tumor margins.In liver transplantation and especially in living donor liver transplantation(LDLT),3D printed models of the donor’s liver and models of the recipient’s hilar anatomy can contribute further to improving the results.In particular,pediatric LDLT abdominal cavity models can help to manage the largest challenge of this procedure,namely large-for-size syndrome. | Paschalis Gavriilidis Bjørn Edwin Egidijus Pelanis Ernest Hidalgo Nicola de’Angelis Riccardo Memeo Luca Aldrighetti Robert P Sutcliffe | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，3： | 6 |
| 3 | Recurrence and survival following microwave, radiofrequency ablation, and hepatic resection of colorectal liver metastases: A systematic review and network meta-analysis显示文摘Background: Gold standard for colorectal liver metastases(CRLM) remains hepatic resection(HR). However, patients with severe comorbidities, unresectable or deep-situated resectable CRLM are candidates for ablation. The aim of the study was to compare recurrence rate and survival benefit of the microwave ablation(MWA), radiofrequency ablation(RFA) and HR by conducting the first network meta-analysis. Data sources: Systematic search of the literature was conducted in the electronic databases. Both updated traditional and network meta-analyses were conducted and the results were compared between them. Results: HR cohort demonstrated significantly less local recurrence rate and better 3-and 5-year diseasefree(DFS) and overall survival(OS) compared to MWA and RFA cohorts. HR cohort included significantly younger patients and with significantly lower preoperative carcinoembryonic antigen(CEA) by 10.28 ng/m L compared to RFA cohort. Subgroup analysis of local recurrence and OS of solitary and ≤3 cm CRLMs did not demonstrate any discrepancies when compared with the whole sample. Conclusions: For resectable CRLM the treatment of choice still remains HR. MWA and RFA can be used as a single or adjunct treatment in patients with unresectable CRLM and/or prohibitive comorbidities. | Paschalis Gavriilidis Keith J Roberts Nicola de’Angelis Luca Aldrighetti Robert P Sutcliffe | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，4： | 4 |
| 4 | Class A helix-loop-helix proteins are positive regulators of several cyclin-dependent kinase inhibitors' promoter activity and negatively affect cell growth 显示文摘 | Pagliuca A Gallo P De Luca P | 2000 | Cancer Res2000，60，5： | 1 |
| 5 | Prevention of nosocomial infections in neonatal intensive care units 显示文摘 | Manzoni P De Luca D Stronati M | 2013 | AmJPerinatol2013，30，2： | 1 |
| 6 | Laparoscopic ventral rectopexy for internal rectal prolapse using biological mesh: postoperative and short-term functional results显示文摘 | Sileri P Franceschilli L De Luca E | 2012 | J Gastrointest Surg2012，16，3： | 1 |
| 7 | Selective and integrated rehabilitation programs for disturbances of visual/spatial attention and executive function after brain damage: a neuropsychological evidence-based review 显示文摘 | Zoccolotti P Caatagallo & De Luca M | 2011 | Ear J Phys Rehabil Med2011，47，1： | 1 |
| 8 | Time delay to treatment and mortality in primary an-gioplasty for acute myocardial infarction 显示文摘 | DE LUCA G SURYAPRANATA H OTTERVANGERJ P | 2004 | Circulation2004，109，： | 1 |
| 9 | Value of helical computed tomography in the management of upper esophageal foreign bodies显示文摘 | Marco De Lucas E Sádaba P Lastra García-Barón P | | 0，，04： | 1 |
| 10 | Risk profile and benefits from Gp Ⅱ b Ⅲ a inhibitors among patients with ST-segment elevation myocardial infarction treated with primary angioplasty: a meta-regression analysis of randomized trials 显示文摘 | de Luca G Navarese E Marino P | 2009 | Eur Heart J2009，30，22： | 1 |
| 11 | Detachable snare versus epinephrine injection in the prevention of postpolypectomy bleeding: arendomized and controlled study 显示文摘 | Di Giorgio P De Luca L Calcagno G | 2004 | Endoscopy2004，56，10： | 1 |
| 12 | IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance显示文摘 | Zelante T De Luca A Bonifazi P | 2007 | Eur J Immunol2007，37，10： | 1 |
| 13 | Vision from the right stem显示文摘 | Pellegrini G Rama P De Luca M | 2011 | Trends Mol Med2011，17，1： | 1 |
| 14 | Time delay to treatment and mortality in primary angioplasty for acut myocardial infarction every minute of delay counts显示文摘 | De Luca G Suryapranata H Ottervanger J P | 2006 | Circulation2006，109，2： | 1 |
| 15 | n-Butane hydroisomerization over Pd/HZSM-5 catalysts:palladium loaded by ion exchange 显示文摘 | Canizares P De Lucas A Dorado F | 2001 | Microporous and Mesoporous Materials2001，42，： | 1 |
| 16 | Levosimendan improves hemody- namics and coronary flow reserve after percutaneous coronary interven- tion in patients with acute myocardial infarctionand left ventricular dys- function显示文摘 | De Luca L Proietti P Celotto A | 2005 | Am Heart J2005，150，3： | 1 |
| 17 | Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major 显示文摘 | Darrah PA Patel D T De Luca P M | 2007 | Nat Med2007，13，7： | 1 |
| 18 | Transcriptional autoregulation by BRCA1 显示文摘 | De Siervi A De Luca P Byun JS | 2010 | Cancer Res2010，70，2： | 1 |
| 19 | Reperfusion strate- gies in acute ST-elevation myocardial infarction:an overview of current status显示文摘 | De Luca G Suryapranata H Marino P | 2008 | Prog Cardiovasc Dis2008，50，5： | 1 |
| 20 | Value of helical computed tomography in the management of upper esophageal foreign bodies显示文摘 | De Lucas EM Sadaba P Lastra GP | 2004 | Acta Radiol2004，45，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员