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| 1 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 2 | Six-minute walking test performance is associated with survival in cirrhotic patients显示文摘BACKGROUND Patients with cirrhosis are at risk of cirrhotic cardiomyopathy,with resulting cardiac dysfunction and exercise limitations.Six minute walking test(6MWT)assesses functional status and predicts morbidity and mortality in cardiopulmonary diseases.AIM To determine if it associates with mortality by analyzing 6MWT performance in patients with liver cirrhosis.METHODS A cohort of 106 cirrhotic patients was evaluated in the outpatient setting with echocardiogram and 6MWT and follow up for one year to document hepatic decompensation and mortality.The distance in meters was recorded at the end of 6 min(6MWD).RESULTS This cohort had a mean age of 51 years and 56%male;patients were staged as Child A in 21.7%,B 66%and C 12.3%.Walk distance inversely correlated with Child scores,and was significantly reduced as Child stages progresses.Patients who died(10.4%)showed shorter mean 6MWD(P=0.006).Low 6MWD was an independent predictor of mortality(P=0.01).CONCLUSION 6MWT is a noninvasive inexpensive test whose result is related to Child scores and mortality.It is useful to identify patients with liver cirrhosis at high risk of mortality for closer monitoring and potential early intervention. | Carolina Frade M G Pimentel Ana Cristina de Castro Amaral Adriano Miziara Gonzalez Michelle Lai Danielde Oliveira Mota Maria Lucia Gomes Ferraz Wilson Mathias Junior Mario Kondo | 2021 | World Journal of Hepatology2021，13，11： | 2 |
| 3 | Hypercoaguiable state in patients with advanced gastrointestinal cancer: evidence for an acquired resistance to activated protein C显示文摘 | De lucia D De Vita F Orditura M | 1997 | Tumor1997，83，6： | 1 |
| 4 | Acid-promoted reaction of the stilbene antioxidant resveratrol with nitrite ions : mild phenolic oxidation at the 4' -hydroxystiryl sector triggering nitration, dimerization, and aldehyde-forming routes显示文摘 | Panzella L De Lucia M Amalfitano C | 2006 | J Org Chem2006，71，11： | 1 |
| 5 | Analysis of continuous glucose monitoring data from non-diabetic and diabetic children: A tale of two algorithms 显示文摘 | WEINZIMER S A DE Lucia M C BOLAND E A | 2003 | Diabetes Technology & Therapeutics2003，5，3： | 1 |
| 6 | Intranasal flunisolide treatment in patients with non-allergic rhinitis 显示文摘 | Varricchio A Capasso M De Lucia A | 2011 | Int J Immunopathol Pharmacol2011，24，2： | 1 |
| 7 | A vision-based particle tracking velocimetry显示文摘 | Lucia M De Nesi P | 2001 | Real-Time Imaging2001，7，2： | 1 |
| 8 | Inherited thrombophilic risk factors and venous throraboembolism: distinct role in peripheral deep venous thrombosis and pulmonary embolism显示文摘 | Margaglione M Brancaccio V De Lucia D | 2000 | Chest2000，118，5： | 1 |
| 9 | A 3-D finite ele- ment study of the influence of crown implant ratio on stress distribution 显示文摘 | Lucia M S de Verri D Ramos F | 2013 | Brazilian Dental Journal2013，24，： | 1 |
| 10 | A vision-based particle tracking velocimetry 显示文摘 | Baldassarre A De Lucia M Nesi P | 2001 | Real-Time Imaging2001，7，2： | 1 |
| 11 | Transesterification reaction of vegetable oils, using superacid sulfated TiOEbase catalysts 显示文摘 | Rusiene M de Almeida Lucia K Noda | 2008 | Applied Catalysis A : General2008，347，1： | 1 |
| 12 | Transesterication reaction of vegetable ils, using superacid sulfated TiO2-base catalysts显示文摘 | Rusiene M de Almeida Lucia K Noda Norberto S Goncalves | 2008 | Applied Catalysis A: General2008，347，： | 1 |
| 13 | Evaluation of the influence of the column axial load on the behavior of monotonically loaded R/C exterior beam-column joints through nu- merical simulations 显示文摘 | Haach V G LUcia Homce De Cresce E1 Debs Ana Khalil E1 Debs M | 2008 | Engineering Structures2008，30，4： | 1 |
| 14 | Inherited thrombophilic risk factors and venous thromboembolism:distinct role in peripheral deep venous thrombosis and pulmomary embolism显示文摘 | Margaglione M Brancaccio V De Lucia D | 2000 | Chest2000，118，： | 1 |
| 15 | Cormlet planting density and gladiolus corm productin显示文摘 | Cocozza Talia M A Lucia B De | 1994 | Culture Protect1994，23，5： | 1 |
| 16 | Hypercoagulable state in patients with advanced gastrointestinal cancer: evidence for an acquired resistance to activated protein C 显示文摘 | De Lucia D De Vita F Orditura M | 1997 | Turnori1997，83，6： | 1 |
| 17 | Clinical usefulness of D-dimer testing in cancer patients with suspected pulmonary embolism显示文摘 | Righini M Le Gal G De Lucia S Roy PM Meyer G Aujesky D | 2006 | Thromb Haemost2006，95，： | 1 |
| 18 | Evolution of X - ray machine quality controlaccep- tance indices显示文摘 | Maria Lucia Nana Maria de Fatima A Magon Yvone M Mas- carenhas | 2009 | Journal of Applied Clinical Medical Phys- ics2009，10，4： | 1 |
| 19 | Diagnostic accuracy and clinical relevance of brain natriuretic peptide assay in pediatric patients with congenital heart diseases显示文摘 | Cantinotti M Vittorini S Storti S Prontera C Murzi M De Lucia V | 2009 | J Cardiovasc Med (Hagerstown)2009，13，1： | 1 |
| 20 | Inheri-ted thrombophilic risk factors and venous thromboembolism:distinct role in peripheral deep venous thrombosis and pulmonary embolism显示文摘 | Margaglione M Brancaccio V De Lucia D | 2000 | Chest2000，118，： | 1 |
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