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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Efficient recovery of envi- ronmental DNA for expression cloning by indirect extraction meth- ods显示文摘 | Gabor E M de Vries E J Janssen D B | 2003 | FEMS Microbiol Ecol2003，44，2： | 1 |
| 3 | Measles vaccination of nonhuman primates provides partial protection against infection with canine distemper vi- rus显示文摘 | de Vries R D Ludlow M Verburgh R J | 2014 | J Virol2014，88，8： | 1 |
| 4 | The ther -mal and electrical yield of a PV-thermal collector 显示文摘 | Zondag H A De Vries D W D Van Helden W G J | 2002 | Solar energy2002，72，2： | 1 |
| 5 | Rigging the lobbying process: An application of the all-pay auction显示文摘 | Baye M R Kovenock D de Vries C G | 1993 | The American Economic Review1993，83，1： | 1 |
| 6 | Cobalt-catalysed growth of carbon nanotubes with single-atomic-layer walls显示文摘 | Kiang C H de Vries M S | 1993 | Nature1993，363，6430： | 1 |
| 7 | Preoperative treatment with capeeitabine, bevacizumab and radiotherapy for primary loeally ad- vanced rectal caneer-a two stage phase II clinical trial显示文摘 | Resch G De Vries A Ofner D | 2012 | Radiother- apy Oneol2012，102，1： | 1 |
| 8 | Moisture movement in porous materials under temperature gradients显示文摘 | PHILIP J R DE VRIES D A | 1957 | Transactions American Geophysical Union1957，38，2： | 1 |
| 9 | The all-pay auction with complete information 显示文摘 | Baye M R Kovenock D de Vries C G | 1996 | Economic Theory1996，8，： | 1 |
| 10 | Cobalt-catalysed growth of carbon nanotubes with single-atomiclayer walls 显示文摘 | Bethune D S Kiang C H De Vries M S | 1993 | Nature1993，363，6430： | 1 |
| 11 | Repair of large midline incisional hernias with polypropyl-ene mesh:comparison of three operative techniques 显示文摘 | de Vries Reilingh Ts van Geldere D Langenhorst B | 2004 | Hernia2004，8，1： | 1 |
| 12 | Moisture movement in porous materials under temperature gradients显示文摘 | Philip J R De Vries D A | 1957 | Trans Am Geophys Union1957，38，： | 1 |
| 13 | Nrf2-induced antioxidant protection:A promising target to counteract ROS-mediateddamage in neurodegenerative disease?显示文摘 | de Vries H E Witte M Hondius D | 2008 | Free Radic Biol Med2008，45，： | 1 |
| 14 | WHISCY:what information does surface conservation yield? Application to data-driven docking显示文摘 | de Vries S J Dijk A D Bonvin A M | 2006 | Proteins2006，63，3： | 1 |
| 15 | Cobalt-catalysed growth of carbon nanotubes with single-atomic-layer walls 显示文摘 | BETHUNE D S KIANG C H DE VRIES M S | 1993 | Nature1993，363，： | 1 |
| 16 | The thermal and electrical yield of a PV-thermal collector显示文摘 | Zondag H A De Vries D W Van Heldan W G J | 2002 | Solar Energy2002，72，2： | 1 |
| 17 | Developments in breeding for horizontal and vertical fungus resistance in roses 显示文摘 | de Vries D P Dubois L A M | 2001 | Acta Horticulturae2001，552，： | 1 |
| 18 | Cobalt- catalysed growth of carbon nanotubes with single-atomic- layer walls 显示文摘 | Bethune D S Kiang C H de Vries M S | 1993 | Nature (London)1993，363，6340： | 1 |
| 19 | Moisture movement in porous materials under temperature gradi- ents显示文摘 | Philip J R De Vries D A | 1957 | Transaction American Geophysical Union1957，38，2： | 1 |
| 20 | Genetic variation of rose cultivars for direct shoot organogenesis显示文摘 | DUBOIS L A M de VRIES D P KOOT A | 1997 | Acta Horticulturae1997，447，： | 1 |
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