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| 1 | Effect of sustained virological response on long-term clinical outcome in 113 patients with compensated hepatitis C-related cirrhosis treated by interferon alpha and ribavirin显示文摘AIM:To assess the long-term clinical benefit of sustained virological response(SVR)in patients with hepatitis C virus(HCV)cirrhosis treated by antiviral therapy using mostly ribavirin plus interferon either standard or pegylated.METHODS:One hundred and thirteen patients with uncomplicated HCV biopsy-proven cirrhosis,treated by at least one course of antiviral treatment ≥ 3 mo and followed ≥ 30 mo were included.The occurrence of clinical events hepatocellular carcinoma(HCC),decompensation and death was compared in SVR and non SVR patients.RESULTS:Seventy eight patients received bitherapy and 63 had repeat treatments.SVR was achieved in 37 patients(33%).During a mean follow-up of 7.7 years,clinical events occurred more frequently in non SVR than in SVR patients,with a significant difference for HCC(24/76 vs 1/37,P = 0.01).No SVR patient died while 20/76 non-SVR did(P = 0.002),mainly in relation to HCC(45%).CONCLUSION:In patients with HCV-related cirrhosis,SVR is associated with a significant decrease in the incidence of HCC and mortality during a follow-up period of 7.7 years.This result is a strong argument to perform and repeat antiviral treatments in patients with compensated cirrhosis. | Roland El Braks Nathalie Ganne-Carrié Hélène Fontaine Jacques Paries Véronique Grando-Lemaire Michel Beaugrand Stanislas Pol Jean-Claude Trinchet | 2007 | World Journal of Gastroenterology2007，13，42： | 3 |
| 2 | Nitrogen and phosphorus removal from urban wastewater by the microalga Scenedesmus obliquus显示文摘 | M.E Mart??nez S Sánchez J.M Jiménez F El Yousfi L Mu?oz | 2000 | Bioresource Technology2000，，3： | 2 |
| 3 | Completeness of malaria notification in Tunisia assessed by capture recapture method显示文摘 | N Ben Alaya-Bouafif MK Chahed H El Bez H Bellali L Ayari N Achour | 2011 | Asian Pacific Journal of Tropical Disease2011，，3： | 2 |
| 4 | Evidence that the lateral septurn is involved in the antidepressant-like effects of the vasopressin Vlb receptor antagonist, SSR149415显示文摘 | Stemmelin J l ukovic L Salome N el al | 2005 | Neuropsychopharmacology2005，30，1： | 1 |
| 5 | Reflective Tomography Images from Range-resolved Laser Radar Measurements 显示文摘 | PARKER J K CRAIG E B KLICK D L el al | 1988 | Applied Optics1988，27，13： | 1 |
| 6 | Chlamydia pneumoniae, herpes simplex virus type 1, and Cytomegalovirus and incident myocardial infarction and coronary heart disease death in older adults: the Cardiovascular Health Study 显示文摘 | Siscovick DS Schwartz SM Corey L el al | 2000 | Circulation2000，102，19： | 1 |
| 7 | Classical conditioning of the electrically elicited blink response in humans:a new method of data analysis显示文摘 | Glocker F X Laukb M Lückinga F el al | 1999 | J Neurosci Method1999，89，2： | 1 |
| 8 | A high performance intermediate temperature fuel cell based on a thick oxide-carbonate electrolyte显示文摘 | ZHANG L LAN R XU X el al | 2009 | Journal of Power Sources2009，194，2： | 1 |
| 9 | Is elfidermal cell prolitbra- tion in psoriatic skin grafts on nude mice driven by T-cell derived cytokines?显示文摘 | Baker BS Brenl L Valdimarsson H el al | 1992 | Br J Dennatol1992，126，： | 1 |
| 10 | A Multilevel Study of Leadership, Empowerment, and Performance in Teams 显示文摘 | Chen G Kirkman B L Kanfer R et el | 2007 | Journal of Applied Psychology2007，92，2： | 1 |
| 11 | Nerve growth factor overexpression and autocrine loop in breast cancer cell 显示文摘 | Dolle L El Yazidi-Belkoura I Adriaenssens E | 2003 | Oncogene2003，22，36： | 1 |
| 12 | Expression of serotonin receptors in allergic contact eczematous human skin 显示文摘 | Lundeberg L El NH Mohabbati S | 2002 | Arch Dermatol Res2002，294，9： | 1 |
| 13 | A randomized, double-blind conparison of lumber epidural and intravenous fentanvl infusion for post-thoracotomy pain relief: analgesic,pharmacokinetic and respiratory effects显示文摘 | Sandler AN Panos L Stringer D el al | 1992 | Anesthesiology1992，77，： | 1 |
| 14 | Apolipoprotein A-I-mediated efflux of sterols fromoxidized LDL-loaded macrophages 显示文摘 | Kritharides L Jessup W Mander EL | 1995 | ArteriosclThromb Vase Biol1995，15，2： | 1 |
| 15 | Vertebral artery embolism after acute cervical spine trauma显示文摘 | VERAS L M PEDRAZA GUTIERREZ S CASTELLANOS J el al | 2000 | Spine2000，25，9： | 1 |
| 16 | A statistical analysis of conditional launch for gigabit ethernet links using multimode fiber显示文摘 | Webster M Raddatz L White I H et el | 1999 | J Lightwave Technol1999，17，9： | 1 |
| 17 | Changes in muscle strength, muscle fibre size and myofibrillar gene expression after immobilization and retraining in humans 显示文摘 | Hortobagyi T Dempsoy L Fraser O et el | 2000 | J Physiol2000，524，1： | 1 |
| 18 | Postmenopausal status, hypertension and obesity as risk factors for malignant transformation in endometrial polyps 显示文摘 | Giordano G Gnetti L Merisio C et el | 2007 | Mamritas2007，56，2： | 1 |
| 19 | On minimal order in-verse of discrete - time descriptor systems显示文摘 | El - Tohami M Lovassnagy V Powers D L | 1985 | Int Journal of Con-trol1985，41，4： | 1 |
| 20 | Anti-HER agents in gastric cancer: from bench to bedside显示文摘 | Fnrnarn L Lucehesi M Caparello C el al | 2011 | Nat Rev Gastrnenlerol Hepalol2011，8，7： | 1 |
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