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1原发性免疫性血小板减少症的研究和诊治:国际共识报告显示文摘1 前言 原发性免疫性血小板减少症(Primary immune thrombocytopenia,ITP)是一种以血小板减少为特点的获得性免疫紊乱.其定义为外周血血小板数量<100×10^9/L,起病隐匿并缺乏明确的病因.一直以来,ITP的缩写表示特发性血小板减少性紫癜(idiopathic thrombocytopenic purpura),但目前认识到该病具有免疫介导的特点,并且大部分病例无出血或仅有少量出血,因此对该术语进行了修正.Provan D Stasi R Nezoland AC(et al.) 陈飞燕(节译) 梁妤婷(节译) 吴倩倩(节译) 王舒茵(节译) 魏晓星(节译) 叶铁真(审校) 2010国际输血及血液学杂志2010,33,5:4
2Pandemic influenza 2009: Impact of vaccination coverage on critical illness in children, a Canada and France observational study显示文摘AIM To study the impact of vaccination critical illness due to H1N1pdm09, we compared the incidence and severity of H1N1pdm09 infection in Canada and France.METHODS We studied two national cohorts that included children with documented H1N1pdm09 infection, admitted to a pediatric intensive care unit(PICU) in Canada and in France between October 1, 2009 and January 31, 2010.RESULTS Vaccination coverage prior to admission to PICUs was higher in Canada than in France(21% vs 2% of children respectively, P < 0.001), and in both countries, vaccination coverage prior to admission of these critically ill patients was substantially lower than in the general pediatric population(P < 0.001). In Canada, 160 children(incidence = 2.6/100000 children) were hospitalized in PICU compared to 125 children(incidence = 1.1/100000) in France(P < 0.001). Mortality rates were similar in Canada and France(4.4% vs 6.5%, P = 0.45, respectively), median invasive mechanical ventilation duration and mean PICU length of stay were shorter in Canada(4 d vs 6 d, P = 0.02 and 5.7 d vs 8.2 d, P = 0.03, respectively). H1N1pdm09 vaccination prior to PICU admission was associated with a decreased risk of requiring invasive mechanical ventilation(OR = 0.30, 95%CI: 0.11-0.83, P = 0.02).CONCLUSION The critical illness due to H1N1pdm09 had a higher incidence in Canada than in France. Critically ill children were less likely to have received vaccination prior to hospitalization in comparison to general population and children vaccinated had lower risk of ventilation.Olivier Fléchelles Olivier Brissaud Robert Fowler Thierry Ducruet Philippe Jouvet the Pediatric Canadian Critical Care Trials Group H1N1 Collaborative and Groupe Francophone de Réanimation et Urgences Pédiatriques 2016World Journal of Clinical Pediatrics2016,5,4:2
3Association between syndecan-1 expression and clinical outcome in squamous cell carcinoma of the head and neck显示文摘Inki P Joensuu H Grenman R et ol 1994Br J Cancer1994,70,2:1
4QTLs conditioning early growth in a soybean population segregation for growth habit 显示文摘Mian M A R Ashley D A Vencill WK et at 1998Theoretical and Applied Genetics1998,97,8:1
5Minimizing adverse sideeffects of oral bexarotene in cutaneous T - cell lymphoma : an expert opinion 显示文摘Assaf C Bagol M Dummer R et al 2006BrJ Dermatol2006,155,2:1
6Peroxynitfite activates glucose uptake in 3T3-L1 adipocytes through a P13-K-dependent mechanism显示文摘Guzman-Grenfell AM Garcia-Macedo R Gonzalez-Martinez MT et al 2005Front Biosci2005,10,1:1
7Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study 显示文摘Levy D Garrison R J Savage DD et at 1990N Engl J Med1990,322,22:1
8Menopausal estrogen and estrogen- progestin replacement therapy and breast cancer risk 显示文摘 Lubin J Troisi R ET AL 2000JAMA2000,283,4:1
9Revised classification scheme of phytoplasmas based on RFL panalyses of 16S rRNA and ribosomal protein gene sequences 显示文摘Lee I M Gundersen R D E Davis R E et at 1998Int J Syst Acteriology1998,48,:1
10Modulation of inflammatory response by hippocampus of rats exposed to cerebral ischemia/reperfusion显示文摘Coll the PPAR ino M Aragno M Ma oxidative stress -gamma agonists in stro and the cola R et a7 2006Eur J Pharmacol2006,530,:1
11Chartcteristics of heavy metal in contaminated soils显示文摘YALAGADDA P Y MATSUMOTO M R VANBENSCHOTEN J E Et al 1995J Environ Eng1995,,121:1
12Protective role of urinarytrypsin inhibitor in acutlung injury induced by lipopolysaccharide显示文摘Inoue K Takano H Yanagisawa R et a1 2005Exp Biol Med2005,230,:1
13Molecular epidemiology of sequential outbreaks of Acinetobacter baumannii in an intensive care unit shows the emergence of carbapenem resistance 显示文摘Zarruili R Crispino M Bagattini M et ai 2004J Clin Microbiol2004,42,3:1
14Family and psychosocial risk factors in a longitudinal epidemiological study of adolescents显示文摘Cuffe S P Mckeown R E Addyc L et a1 2005J Am Acad Child Adolesc Psy-chiatry2005,44,2:1
15A Semiconducting Metal-Oxide Array for Monitoring Fish Freshness显示文摘Hammond J Marquis B B Michaels R et a1 2002Sensors and Actuators B2002,,84:1
16Aquatic toxicity of triclosan 显示文摘Orvos D R Versteeg D J Inauen J et at 2002Environmental Toxicology and Chemistry2002,21,7:1
17Role of Ki-67 proliferation index and p53 expression in predicting progression of pituitary adenomas显示文摘Gejman R Swearingen B Hedley-Whyte ET 2008Hum Pathol2008,39,5:1
18200 mW at 488 nm from a ppMgO:LNRidge waveguide by frequency doubling of a laser diode module显示文摘Jedrzejczyk D Güther R Paschke K et a1 2010IEEE Photonics Technology Letters2010,22,17:1
19A simple tech- nique for quantitation of low levels of DNA damage in indi-vidual cells 显示文摘Singh N P McCoy M T Tice R R et d 1988Experimental Cell Research1988,175,1:1
20Mutations of the BRAF gene in human cancer显示文摘Davies H Bignell G R Cox C Stephens P Edkins S Clegg S et al 2002Nature2002,417,:1
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