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| 1 | Feasibility of allogeneic mesenchymal stem cells in pediatric hypoxic-ischemic encephalopathy: Phase I study显示文摘BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is one of the leading causes of death and long-term neurological impairment in the pediatric population.Despite a limited number of treatments to cure HIE,stem cell therapies appear to be a potential treatment option for brain injury resulting from HIE.AIM To investigate the efficacy and safety of stem cell-based therapies in pediatric patients with HIE.METHODS The study inclusion criteria were determined as the presence of substantial deficit and disability caused by HIE.Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)were intrathecally(IT),intramuscularly(IM),and intravenously administered to participants at a dose of 1×10^(6)/kg for each administration route twice monthly for 2 mo.In different follow-up durations,the effect of WJ-MSCs administration on HIE,the quality of life,prognosis of patients,and side effects were investigated,and patients were evaluated for neurological,cognitive functions,and spasticity using the Wee Functional Independence Measure(Wee FIM)Scale and Modified Ashworth(MA)Scale.RESULTS For all participants(n=6),the mean duration of exposure to hypoxia was 39.17+18.82 min,the mean time interval after HIE was 21.83±26.60 mo,the mean baseline Wee FIM scale score was 13.5±0.55,and the mean baseline MA scale score was 35±9.08.Three patients developed only early complications such as low-grade fever,mild headache associated with IT injection,and muscle pain associated with IM injection,all of which were transient and disappeared within 24 h.The treatment was evaluated to be safe and effective as demonstrated by magnetic resonance imaging examinations,electroencephalographies,laboratory tests,and neurological and functional scores of patients.Patients exhibited significant improvements in all neurological functions through a 12-mo follow-up.The mean Wee FIM scale score of participants increased from 13.5±0.55 to 15.17±1.6 points(mean±SD)at 1 mo(z=-1.826,P=0.068)and to 23.5±3.39 points at 12 mo(z=-2.207,P=0.027)post-treatment.The percentage of patients who achieved an excellent functional improvement(Wee FIM scale total score=126)increased from 10.71%(at baseline)to 12.03%at 1 mo and to 18.65%at 12 mo posttreatment.CONCLUSION Both the triple-route and multiple WJ-MSC implantations were safe and effective in pediatric patients with HIE with significant neurological and functional improvements.The results of this study support conducting further randomized,placebo-controlled studies on this treatment in the pediatric population. | Serdar Kabatas Erdinç Civelek Eyüp Can Savrunlu Necati Kaplan Osman Boyalı Furkan Diren Halil Can Ali Genç Tunç Akkoç Erdal Karaöz | 2021 | World Journal of Stem Cells2021，13，5： | 2 |
| 2 | In-situ Ti-TiB metal-matrlx composite prepared by a reactive pressing process 显示文摘 | Ma Z Y Tjong S C Gen L | 2000 | Scripta Mater2000，42，4： | 1 |
| 3 | Daphneticin, a coumarinolignoid from Daphne tangutica 显示文摘 | Gen Z L Seligmann O Wagner H | 1983 | Phytochemistry1983，22，2： | 1 |
| 4 | An application of fuzzy set theory to inventory control models 显示文摘 | Gen M Tsujimura Y Zheng D Z | 1997 | Computers and Industrial Engineering1997，33，34： | 1 |
| 5 | Solving multiobjective solid transportation problem by genetic algorithm显示文摘 | Gen M Da K Liy Z | 1995 | Journal of Japan Indus Manage Associ1995，46，： | 1 |
| 6 | Solving bicriteria solid transportation problem with fuzzy numbers by a genetic algorithm显示文摘 | Gen M Da K Liy Z | 1995 | Computera Ind Engng1995，29，： | 1 |
| 7 | Nonlinear fixed charge transportation problem by spanning tree-based genetic algorithm显示文摘 | Jo J B Li Y Z Gen M | 2007 | Computers & Industrial Engineering2007，53，： | 1 |
| 8 | Study on the application of DME / diesel blends in a diesel engine显示文摘 | YING W GEN B L WEI Z | 2008 | Fuel Process Technol2008，89，12： | 1 |
| 9 | Magnetic noise in MgO-based magnetic tunnel junction rings 显示文摘 | Feng J F Diao Z Feng Gen | 2010 | Appl Phys Lett2010，96，05： | 1 |
| 10 | Clinical and prognostic implica- tions of serum uric acid levels on IgA nephropathy:a cohort study of 348 eases with a mean 5-year follow-up显示文摘 | Gen YC Dong WL Na Z | 2013 | Clin Nephrol2013，80，1： | 1 |
| 11 | Solving bi-criteria solid transportation problem with fuzzy numbers by genetic algorithm显示文摘 | GEN M IDA K LI Y Z | 1995 | Computers and Industrial Engineering1995，29，14： | 1 |
| 12 | An Application of Fuzzy Set Theory to Inventory Control Models 显示文摘 | Gen M Tsujimura Y Dazhong Z | 1997 | Computers Industrial Engineering (S0360-8352)1997，33，34： | 1 |
| 13 | Monitoring coal fires using multi- temporal night-time thermal images in a eoal field in north-west China显示文摘 | Prakash A Gens R Vekerdy Z | 1999 | International Journal of Remote Sensing1999，20，14： | 1 |
| 14 | Outcome and long term follow-up after corpus callosotomy in childhood onset intractable epilepsy显示文摘 | Güzide Turanl? Dilek Yaln?zo?lu Demet Gen?-A??kg?z Nejat Akalan Meral Top?u | 2006 | Child’s Nervous System2006，，10： | 1 |
| 15 | Blood pressure of rats lowered by sulfur dioxide and its derivatives 显示文摘 | Meng Z Q Gen H Bai J L | 2003 | Inhal Toxical2003，15，9： | 1 |
| 16 | Solving Multiobjective Solid Transportation Problem by Genetic Algorithm显示文摘 | GEN M IDA K LI Y Z | 1995 | Jour of Japan Indus Manag Associ1995，46，5： | 1 |
| 17 | The algorithm of interpolating windowed FFT for harmonic analysis of electric power system 显示文摘 | ZHAN G F GEN G Z YUAN W | 2001 | IEEE Transactions on Power Delivery2001，16，2： | 1 |
| 18 | Improved Genetic Algorithm for Solving Multi-objective Solid Transportation Problem with Fuzzy Number显示文摘 | Li Y Z Gen M Ida K | 1998 | International Journal of Fuzzy Theory Systems1998，4，22： | 1 |
| 19 | The grouper Plectropomus complete mitochondrial genome of red leopardus and its applications in species显示文摘 | Ze Y Z Gen H Y | 2008 | Aquaculture2008，276，14： | 1 |
| 20 | Formation of nanocrystalline TiN films by ion -beam -enhanced deposition 显示文摘 | Gen Q Y Da Z W Xiang H L | 1994 | Surface and Coatings Technology1994，65，1： | 1 |
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