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| 1 | Role of E3 ubiquitin ligases in lung cancer显示文摘E3 ubiquitin ligases are a large family of proteins that catalyze the ubiquitination of many protein substrates for targeted degradation by the 26S proteasome.Therefore,E3 ubiquitin ligases play an essential role in a variety of biological processes including cell cycle regulation,proliferation and apoptosis.E3 ubiquitin ligases are often found overexpressed in human cancers,including lung cancer,and their deregulation has been shown to contribute to cancer development.However,the lack of specific inhibitors in clinical trials is a major issue in targeting E3 ubiquitin ligases with currently only one E3 ubiquitin ligase inhibitor being tested in the clinical setting.In this review,we focus on E3 ubiquitin ligases that have been found deregulated in lung cancer.Furthermore,we discuss the processes in which they are involved and evaluate them as potential anti-cancer targets.By better understanding the mechanisms by which E3 ubiquitin ligases regulate biological processes and their exact role in carcinogenesis,we can improve the development of specific E3 ubiquitin ligase inhibitors and pave the way for novel treatment strategies for cancer patients. | Barbara C Snoek Leonie HAM de Wilt Gerrit Jansen Godefridus J Peters | 2013 | World Journal of Clinical Oncology2013，4，3： | 5 |
| 2 | Separating pose and expression in face images:a manifold learning approach显示文摘 | Ham J H Daniel D L | 2007 | Neural Information Processing- Letters and Reviews2007，11，46： | 1 |
| 3 | Serotonin receptor 2A gene polymorphism ( - 1438A/G) and short - term treatment response to citalopram 显示文摘 | Choi M J Kang RH Ham B J | 2005 | Neuropsychobiology2005，52，3： | 1 |
| 4 | Right lobe living donor liver transplantation显示文摘 | Marcos A Fisher R A Ham J M | 1999 | Transplantation1999，68，6： | 1 |
| 5 | Preparation of noble metal nanowires using hexagonal mesoporous silica SBA- 15 显示文摘 | Ham Y J Kim J M Stucky G D | 2000 | Chem Mater2000，12，： | 1 |
| 6 | Prevalence,Capsular Type and Antimicrobial Susceptibility of Streptococcus suis Isolated from Slaughter Pigs in Korea显示文摘 | Han D U Choi C Ham H J | 2001 | Can J Vet Res2001，65，3： | 1 |
| 7 | Error analysis of the heat pulse method for measuring soil volumetric heat capacity显示文摘 | Kluitenberg G J Ham J M Bristow K L | 1993 | Soil Sci Soc Am J1993，57，6： | 1 |
| 8 | Endoerinological response to soy protein and fiber in mildly hypercholesterolemic men 显示文摘 | HAM J O CHAPMAN K M | 1993 | Nutr Res1993，13，： | 1 |
| 9 | Antitumor activity of novel deoxoartemisinin monomers,dimers,and trimer显示文摘 | Jung M Lee S Ham J | 2003 | J Med Chem2003，46，6： | 1 |
| 10 | Ku autoantigen af-fects the susceptibility to anticancer druge显示文摘 | Kim S H Kim D Ham J S | 1999 | CancerRes1999，59，16： | 1 |
| 11 | Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins,neuronal activity,and cAMP in neurons显示文摘 | Cavanaugh J E Ham J Hetman M | 2001 | J Neurosci2001，21，2： | 1 |
| 12 | Genomic cloning of mud loach Misgurnus mizolepis (Cypriniformes,Cobitidae)beta-actin gene and usefulness of its promoter region for fish transgenesis显示文摘 | Noh J K Cho K N Ham E H | 2003 | Mar Biotechnol (NY)2003，5，3： | 1 |
| 13 | Emission of volatile organic compounds during composting of municipal solid wastes显示文摘 | Komilis D P Ham R K Park J K | | 0，，07： | 1 |
| 14 | Dimensional accuracy of single point incremental formin 显示文摘 | HAM M JESWIET J | 2008 | Int J Mater Form2008，3，1： | 1 |
| 15 | Emission of volatile organic compounds during composting of municipal solid wastes 显示文摘 | Komilis D P Ham R K Park J K | 2004 | Water Research2004，38，7： | 1 |
| 16 | Isolation and characterization of cellulose secreting bacterium from cattle manure application to corn- posting显示文摘 | Kim T I Eong K H Ham J S | 2004 | Compost Science and Utilization2004，12，3： | 1 |
| 17 | CD99 (MIC2) regulates the LFA-I/ICAM-7-mediated adhesion of lymphocytes, and its gene encodes both positive and negative regulators of cellular adhesion显示文摘 | Hahn J H Kim M K Choi E Y Kim S H Sohn H W Ham D I | 1997 | J Immunol1997，159，22： | 1 |
| 18 | Limb salvage surgery for primary bone sarcoma of the lower extremities: long - term consequences of endoprosthetic reconstructions 显示文摘 | HAM S J SCHRAFFORDT KOOPS H VETH R P | 1988 | Ann Surg Oncol1988，5，5： | 1 |
| 19 | The adenosine a2b receptor:its role in inflammation显示文摘 | Ham J Rees DA | 2008 | Endocr Metab Immune Disord Drug Targets2008，8，4： | 1 |
| 20 | Feasibility of a constructed wetland and wastewater stabilisation pond system as a sewage reclamation system for agricultural reuse in a decentralised rural area 显示文摘 | Ham J H Yoon C G Jeon J H | 2007 | Water Science & Technology2007，55，12： | 1 |
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