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| 1 | Video capsule endoscopy vs double-balloon enteroscopy in the diagnosis of small bowel bleeding:A systematic review and metaanalysis显示文摘AIM To compare the diagnostic accuracy of video capsule endoscopy(VCE) and double-balloon enteroscopy(DBE) in cases of obscure gastrointestinal bleeding(OGIB) of vascular origin.METHODS MEDLINE(via PubMed), LILACS(via BVS) and Cochrane/CENTRAL virtual databases were searched for studies dated before 2017. We identified prospective and retrospective studies, including observational, cohort, single-blinded and multicenter studies, comparing VCE and DBE for the diagnosis of OGIB, and data of all the vascular sources of bleeding were collected. All patients were subjected to the same gold standard method. Relevant data were then extracted from each included study using a standardized extraction form. We calculated study variables(sensitivity, specificity, prevalence, positive and negative predictive values and accuracy) and performed a meta-analysis using Meta-Disc software.RESULTS In the per-patient analysis, 17 studies(1477 lesions) were included. We identified3150 exams(1722 VCE and 1428 DBE) in 2043 patients and identified 2248 sources of bleeding, 1467 of which were from vascular lesions. Of these lesions, 864(58.5%) were diagnosed by VCE, and 613(41.5%) were diagnosed by DBE. The pretest probability for bleeding of vascular origin was 54.34%. The sensitivity of DBE was 84%(95%CI: 0.82-0.86; heterogeneity: 78.00%), and the specificity was92%(95%CI: 0.89-0.94; heterogeneity: 92.0%). For DBE, the positive likelihood ratio was 11.29(95%CI: 4.83-26.40; heterogeneity: 91.6%), and the negative likelihood ratio was 0.20(95%CI: 0.15-0.27; heterogeneity: 67.3%). Performing DBE after CE increased the diagnostic yield of vascular lesion by 7%, from 83% to90%.CONCLUSION The diagnostic accuracy of detecting small bowel bleeding from a vascular source is increased with the use of an isolated video capsule endoscope compared with isolated DBE. However, concomitant use increases the detection rate of the bleeding source. | Hélcio Pedrosa Brito Igor Braga Ribeiro Diogo Turiani Hourneaux de Moura Wanderley Marques Bernardo Dalton Marques Chaves Rogério Kuga Ethan Dwane Maahs Robson Kiyoshi Ishida Eduardo Turiani Hourneaux de Moura Eduardo Guimaraes Hourneaux de Moura | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，12： | 10 |
| 2 | Neither maitiple tumors nor portalhypertension are surgical contrain dications for hepatocellular carcinoma显示文摘 | Takeaki L Kiyoshi H Taku A | 2008 | Gastroenterology2008，134，7： | 1 |
| 3 | Development of a database of low energy homes around the world and analyses of their trends显示文摘 | Yasuhiro H Makoto N Kiyoshi O | 2006 | Renewable Energy2006，28，2： | 1 |
| 4 | Liquid chromatography-Mass spectrometry analysis of propolis显示文摘 | KIYOSHI M ARJUN H B YASUHIRO T | 2001 | Phyrochem Anal2001，12，： | 1 |
| 5 | Mechanical and electrical properties of B 4C-CrB 2 ceramics fabricated by liquid phases intering显示文摘 | Suzuya Y Kiyoshi H | 2003 | CeramicsInternational2003，29，3： | 1 |
| 6 | Debittering of protein hydrolyzates显示文摘 | Badal C Saha Kiyoshi H | 2001 | Biotechnol Adv2001，19，5： | 1 |
| 7 | Inhibition ofangiogenesis and HIF-1αactivity by antimycin A1显示文摘 | Masayuki M Yuki H Kiyoshi E | 2006 | Biol Pharm Bull2006，29，： | 1 |
| 8 | Angiogenic activity of osteopontin-derived peptide SVVYGLR显示文摘 | Yoshinosuke H Kiyoshi N Masayuki O | 2003 | Biochem Biophys Res Commun2003，310，： | 1 |
| 9 | J Polym Sci Part A:Polym Chem显示文摘 | Kaoru K Kiyoshi H | 1969 | 7(12):3 3631969，7，12： | 1 |
| 10 | A study on characteristics of pressure reduction of compressed air in a long pipe installing branch pipes显示文摘 | Izumi H Kiyoshi K Hiroshi T | 1987 | Nippon Kikai Gakkai Ronbunshu: B Hen1987，54，3： | 1 |
| 11 | Cytotoxic, hepatoprotective and free radical scavenging effects of propolis from Brazil, Peru, the Netherlands and China显示文摘 | Arjun H Banskota Yasuhiro Tezuka I Ketut Adnyana Kiyoshi Midorikawa Katsumichi Matsushige Dejair Message Alfredo A.G Huertas Shigetoshi Kadota | 2000 | Journal of Ethnopharmacology2000，，1： | 1 |
| 12 | 显示文摘 | Kiyoshi A John W H | 2004 | Am Ceram Soc2004，87，10： | 1 |
| 13 | Neither multiple tumors nor portal hypertension are surgical contraindieations forhepatocellular carcinoma 显示文摘 | TAKEAKI I KIYOSHI H TAKU A | 2008 | Gastroenterology2008，134，7： | 1 |
| 14 | Porous ceramic bodies with interconnected pore channels by a novel freeze casting techniques显示文摘 | John W H | 2005 | J Am Ceram Soc2005，88，3： | 1 |
| 15 | Clinical evaluation of severe asthma attacks requiring tracheal intubation and mechanical ventilation显示文摘 | Kiyoshi S Keishi S Takako H | 2009 | Allergoglogy International2009，58，： | 1 |
| 16 | On-line monitoring of trace copper( II ) in steam condensate and boiler feed- water by flaw injection based on its catalytic effect on the oxidation of hydroquinone by hydrogen peroxide 显示文摘 | CAO S A ZHONG J C KIYOSHI H | 1996 | Analytica Chimica Acta1996，331，3： | 1 |
| 17 | Li~ ion diffusion in Li4Ti~Olz thin film electrode prepared by PVP sol-gel method显示文摘 | YOUNG H R KIYOSHI K | 2004 | J Solid State Chem2004，177，： | 1 |
| 18 | Adsorption of bisphenol A by cross-linked β-cyclodextrin polymer显示文摘 | Motomitsu K Kiyoshi H | 2002 | Journal of Inclusion Phenomena and Macrocyclic Chemistry2002，44，： | 1 |
| 19 | Separation and Concentration of Trace Lead by Coprecipitation with Yttrium Phosphate 显示文摘 | Shigehiro K Yasuko A Kiyoshi H | 2000 | Chemistry Letters2000，19，： | 1 |
| 20 | New freeze-casting technique for ceramics with sublimable vehicles显示文摘 | Kiyoshi A John W H | 2004 | Journal of the American Ceramic Society2004，87，10： | 1 |
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