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| 1 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 2 | Strategies of heavy metal uptake by three plant species growing near a metal smelter显示文摘 | H Dahmani-Muller F van Oort B Gélie M Balabane | 2000 | Environmental Pollution2000，，2： | 2 |
| 3 | Method to calculate the fire resistance of cir- cular reinforced concrete columns 显示文摘 | Lie T T Celikkol B | 1991 | Material Journal1991，88，1： | 1 |
| 4 | A Practical Simple Geometry and Gain/Phase Calibration Technique for An- tenna Array Processing显示文摘 | Ng B P Lie J P Er M H Feng A | 2009 | IEEE Transactions on Anten- nas and Propagation2009，57，7： | 1 |
| 5 | Anterior cervical discectomy with fusion in patients with cervical disc degeneration: a prospective outcome study of 258 patients ( 181 fused with autologous bone graft and 77 fused with a PEEK cage) 显示文摘 | Lied B Roenning PA Sundseth J | 2010 | BMC Surg2010，0，1： | 1 |
| 6 | Transgenic human fetal fibroblasts as feeder layer for human embryonic stem cell lineage selection显示文摘 | Sidhu K S Lie K H Tuch B E | 2006 | Stem Cells Dev2006，15，5： | 1 |
| 7 | Parametric equations of stress intensity factor for K-joint under balanced axial loads显示文摘 | SHAO Y B LIE S T | 2005 | International Journal of Fatigue2005，27，6： | 1 |
| 8 | Anterior cervical discectomy with fusion in patients with cervical disc degeneration:a prospective outcome study of 258 patients (181 fused with autologous bone graft and 77 fused with a PEEK cage)显示文摘 | Lied B Roenning PA Sundseth J | | 0，，： | 1 |
| 9 | Ultra wideband direction finding using digital channelization receiver architecture显示文摘 | Lie J P See C M Ng B P | 2006 | IEEE Communications letters2006，10，2： | 1 |
| 10 | VSC transmission operating under unbalanced AC conditions 显示文摘 | Xu Lie Andersen B R Phillip C | 2005 | IEEE Trans on Power Delivery2005，20，1： | 1 |
| 11 | Enzymatic hydrolysis of by-product from the fish-filleting industry; chemical characterization and nutritional evaluation显示文摘 | LIASET B LIED E ESPE M | 2000 | J Sci Food Agfic2000，80，5： | 1 |
| 12 | In fluence of sleep apnea on 24 hourblood pressure显示文摘 | Pankow W Natie B Lies A | 1997 | Chest1997，112，5： | 1 |
| 13 | A novel antisense oligonucleotide targeting survival expression induces apoptosis and sensiteizes lung cancer cells to chemotherapy显示文摘 | O lie RA Simoes Wust AP Baumann B | 2000 | Cabcer Res2000，60，1： | 1 |
| 14 | Optimization of a membrane process for CO2 capture in the steelmaking industry显示文摘 | LIE J A VASSBOTN T HhGG M B | 2007 | International Journal of Greenhouse Gas Control2007，1，3： | 1 |
| 15 | Static strength of tubular TJoints with reinforced chord under axial compression显示文摘 | Shao Y B Lie S T Chiew S P | 2010 | Journal of Advances in Structural Engineering2010，13，2： | 1 |
| 16 | Anterior cervical discectomy with fusion in patients with cervical disc degeneration: a prospective outcome study of 258 patients ( 181 fused with autologous bone graft and 77 fused with a PEEK cage) 显示文摘 | Lied B Roenning PA Sundseth J | 2010 | BMC Surg2010，10，： | 1 |
| 17 | influence of sleep apnea on 24-hour blood pressure显示文摘 | Pankow W Nabe B Lies A | 1997 | Chest1997，112，5： | 1 |
| 18 | Aberrant expression of the cell cycle associated proteins TP53,MDM2,p21,p27,cdk4,cyclinD1,RB,and EGRF in cervical carcinomas显示文摘 | SKOMEDAL H KRISTENSEN G B LIE S K | 1999 | Gynecol Oncol1999，73，： | 1 |
| 19 | Method to calculate the fire resistance of circular reinforced concrete columns显示文摘 | Lie T T Celikkol B | 1991 | ACI Materials Journal1991，88，1： | 1 |
| 20 | Method to calculate the fire resistance of circular reinforced concrete columns显示文摘 | Lie T T and Celikkol B | 1991 | ACI Materials Journal1991，88，1： | 1 |
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