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| 1 | H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas:Correlation with p53 mutation and c-Myc,Bcl-2 and Bax expression显示文摘AIM: To investigate the interrelationship between H pylori and Epstein-Barr virus (EBV) infection in the gastric carcinogenesis having in focus the p53 mutation and the c-Myc, Bcl-2 and Bax expression. METHODS: seventy-one gastric carcinoma tissues were assessed by polymerase chain reaction (PCR) for H pylori and in situ hybridization for EBV. c-Myc, Bcl-2 and Bax expression were detected by immunohistochemistry and single-stranded conformational polymorphism (SSCP) for p53 mutation. RESULTS: The positivity rates for H pylori and EBV were 94.4% and 8.45%, respectively. The majority of the cases displayed only the H pylori presence. All EBV positive cases were also H pylori positive. None infectious agent was observed in 5.55% of the cases. The intestinal type tumor was more frequent in the co-infected and non-infected groups. The female predominated in the non-infected group showing statistical significance (70.4% vs 29.6%, P=0.039). The Bcl-2 was only detected in the group exclusively infected by H pylori. However, c-Myc and Bax were detected in the three groups but with a low frequency in the co-infected group. Mutation of p53 was present in all groups, with the highest frequencies in the H pylori positive groups. CONCLUSION: The frequency of H pylori infection in gastric carcinomas was high. The presented data indicated that gastric carcinogenesis has different pathways depending of the presence of the two investigated infectious agents, suggesting a possible involvement of H pylori with apoptotic process. The low expression of c-Myc and Bax in the EBV-positive groups suggests that EBV may inhibit the expression of these proteins. Nevertheless, p53 mutation shows to be a relevant alteration, independent of both infectious agents. | Valeska Portela Lima Marcos Antonio Pereira de Lima Angela Rosa André Márcia Valéria Pitombeira Ferreira Marcos Aurélio Pessoa Barros Sílvia Helena Barem Rabenhorst | 2008 | World Journal of Gastroenterology2008，14，6： | 17 |
| 2 | Relationship between vascular endothelium and periodontal disease in atherosclerotic lesions: Review article显示文摘Inflammation and endothelial dysfunction are linked to the pathogenesis of atherosclerotic disease. Recent studies suggest that periodontal infection and the ensuing increase in the levels of inflammatory markers may be associated with myocardial infarction, peripheral vascular disease and cerebrovascular disease. The present article aimed at reviewing contemporary data on the pathophysiology of vascular endothelium and its association with periodontitis in the scenario of cardiovascular disease. | Marco Aurélio Lumertz Saffi Mariana Vargas Furtado Carisi Anne Polanczyk Márlon Munhoz Montenegro Ingrid Webb Josephson Ribeiro Cassio Kampits Alex Nogueira Haas Cassiano Kuchenbecker Rosing Eneida Rejane Rabelo-Silva | 2015 | World Journal of Cardiology2015，7，1： | 9 |
| 3 | How to manage inflammatory bowel disease during the COVID-19 pandemic:A guide for the practicing clinician显示文摘Managing inflammatory bowel disease(IBD)during the coronavirus disease 2019(COVID-19)pandemic has been a challenge faced by clinicians and their patients,especially concerning whether to proceed with biologics and immunosuppressive agents in the background of a global outbreak of a highly contagious new coronavirus(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2).The knowledge about the impact of this virus on patients with IBD,although it is still scarce,is rapidly evolving.In particular,concerns surrounding medications’impact for IBD on the risk of acquiring SARS-CoV-2 infection or developing COVID-19,and potentially exacerbate viral replication and the COVID-19 course,are a current thinking of both practicing clinicians and providers caring for patients with IBD.Managing patients with IBD infected with SARS-CoV-2 depends on both the clinical activity of the IBD and the occasional development and severity of COVID-19.In this review,we summarize the current data regarding gastrointestinal involvement by SARS-CoV-2 and pharmacologic and surgical management for IBD concerning this infection,and the COVID-19 impact on both the patient's psychological functioning and endoscopy services,and we concisely summarize the telemedicine roles during the COVID-19 pandemic. | Júlio Maria Fonseca Chebli Natália Sousa Freitas Queiroz Adérson Omar Mourão Cintra Damião Liliana Andrade Chebli Márcia Henriques de Magalhães Costa Rogério Serafim Parra | 2021 | World Journal of Gastroenterology2021，27，11： | 2 |
| 4 | 迷走神经刺激和意识水平显示文摘研究表明,植物人状态的患者皮质皮质间和丘脑-皮质间远程通路中断.自我恢复的神经特征与丘脑-皮质活动的增加和前额叶功能连接改善有关.本研究通过刺激-位植物状态患者的植物神经评估来评估丘脑-皮质刺激的作用.该案例研究报道了-名35岁的有创伤性脑损伤史的男性,他15年来-直处于植物人状态.基线评估包括行为、脑电图和18F-FDGPET记录.然后患者接受了手术植入迷走神经刺激器,刺激增加至最大强度为1.5mA. | 李建华 Corazzol M Lio G Lefevre A | 2017 | 中国康复2017，32，6： | 2 |
| 5 | The LISA technology package dynamics and control 显示文摘 | Bortoluzzi D Lio M D Dolesi R | 2003 | Classical and Quantum Gravity2003，20，10： | 1 |
| 6 | Single sheet functionalized graphene by oxidation and thermal expansion of graphite显示文摘 | Mcallister M J Lio J L Adamson D H | 2007 | Chem Mater2007，19，18： | 1 |
| 7 | Natriuretic peptides as predictors of non-sudden and sudden cardiac death after acute myo- cardial infarction in the beta-blocking era显示文摘 | TAPANAINEN J M LINDGREN K S MAKIKAL- LIO T H | 2004 | J Am Coll Cardiol2004，43，： | 1 |
| 8 | Selection of regulatory T cells in the thymus 显示文摘 | HSIEH C S LEE H M LIO C W | 2012 | Nat Rev Immunol2012，12，3： | 1 |
| 9 | Governance and Agricultural Productivity: A Cross-na- tional Analysis显示文摘 | Lio M Liu M | 2008 | Food Policy2008，33，6： | 1 |
| 10 | TNFR1 mediates in- creased neuronal membrane EAAT3 expression after in vivo cerebral ischemic preconditioning显示文摘 | Pradi LIo J M Hu Rtado Romera C | 2006 | Neuroscience2006，138，4： | 1 |
| 11 | Degradation of phenol by immobilized mycelium of Fusarium flocciferum in continuous culture显示文摘 | Novais Júlio M | 1992 | Water Science and Technology1992，25，1： | 1 |
| 12 | Angle-splitting ostectomy for reducing the width of the lower face 显示文摘 | Deguchi M Lio Y Kobayashi K | 1997 | J Plast Reconstr Surg1997，99，20： | 1 |
| 13 | A general method for the evaluation of vehicle maneuverability with special emphasis on motorcycles显示文摘 | Cossaher V Da Lio M Lot R | 1999 | Vehicle System Dynamics1999，31，2： | 1 |
| 14 | Angle-splitting ostectomy for reducing the width of the lower face显示文摘 | Deguchi M lio Y Kobayashi K | 1997 | Plast Reconstr Surg1997，99，7： | 1 |
| 15 | A physiological and molecular analysis of the genus Nicotiana显示文摘 | Bogani P Lio P Intfieri M C | 1997 | Molecular Phylogenetics and Evolution1997，7，1： | 1 |
| 16 | Comparison of Superior Gluteal Artery Musculocutaneous and Superior Gluteal Artery Perforator Flaps for Microvascular Breast Reconstruction显示文摘 | Boyd J B Gelfand M Da Lio A | 2009 | Plast Reconstr Surg2009，123，6： | 1 |
| 17 | Pleiotropic effects of statins on the treatment of chronic periodontitis – a systematic review显示文摘 | Ilanna Mara Gomes Estanislau Icrólio Ribeiro Colares Terceiro Mario Roberto Pontes Lisboa Patrícia de Barros Teles Rosimary de Sousa Carvalho Ricardo Souza Martins Maria M?nica Studart Mendes Moreira | 2015 | Br J Clin Pharmacol2015，，： | 1 |
| 18 | Robust design linkages-synthesis by solving non-linear optimization problems显示文摘 | LIO M D | 1997 | Mechanism and Machine Theory1997，32，8： | 1 |
| 19 | Glycolytic flux and hexokinase activities in anoxic maize root tips acclimated by hypoxic pretreatment显示文摘 | Bouny J M Sag lio P H | 1996 | Plant Physiology1996，111，： | 1 |
| 20 | Wavelet change-point prediction of transmembrane proteins显示文摘 | Lio P Vannucci M | 2000 | Bioinformatics2000，16，： | 1 |
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