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| 1 | 汽车用铝合金开发近况(英文)显示文摘介绍了汽车车身用轻质材料铝合金的研究近况,包括材料选择和车体设计新概念等方面。为满足经济和环境保护等方面不断增长的要求,对乘用车在使用已成熟的和最新研究开发的铝合金方面的进展进行了讨论。介绍了一些改进的具有更高的强度和更好的成形性能的5系和6系铝合金,使用这些合金能减轻汽车质量和提高防撞性能。以铝合金在'多材料超轻汽车'概念中的应用到达显著的减重效果为例,介绍了多材料轻质设计方面的研究进展。 | Jürgen HIRSCH | 2014 | Transactions of Nonferrous Metals Society of China2014，24，7： | 84 |
| 2 | Gastroenteric tube feeding: Techniques, problems and solutions显示文摘Gastroenteric tube feeding plays a major role in the management of patients with poor voluntary intake,chronic neurological or mechanical dysphagia or gut dysfunction,and patients who are critically ill.However,despite the benefits and widespread use of enteral tube feeding,some patients experience complications.This review aims to discuss and compare current knowledge regarding the clinical application of enteral tube feeding,together with associated complications and special aspects.We conducted an extensive literature search on PubMed,Embase and Medline using index terms relating to enteral access,enteral feeding/nutrition,tube feeding,percutaneous endoscopic gastrostomy/jejunostomy,endoscopic nasoenteric tube,nasogastric tube,and refeeding syndrome.The literature showed common routes of enteral access to include nasoenteral tube,gastrostomy and jejunostomy,while complications fall into four major categories:mechanical,e.g.,tube blockage or removal;gastrointestinal,e.g.,diarrhea;infectious e.g.,aspiration pneumonia,tube site infection;and metabolic,e.g.,refeeding syndrome,hyperglycemia.Although the type and frequency of complications arising from tube feeding vary considerably according to the chosen access route,gastrointestinal complications are without doubt the most common.Complications associated with enteral tube feeding can be reduced by careful observance of guidelines,including those related to food composition,administration rate,portion size,food temperature and patient supervision. | Irina Blumenstein Yogesh M Shastri Jürgen Stein | 2014 | World Journal of Gastroenterology2014，20，26： | 63 |
| 3 | 美国临床生化科学院检验医学实践指南:睾丸、前列腺、结直肠、乳腺及卵巢癌肿瘤标志物的应用显示文摘经美国临床生化科学院(NCAB)授权,由鄢盛恺教授组织学者、专家翻译审定2009年NCAB检验医学实践指南:睾丸、前列腺、结直肠、乳腺及卵巢癌中肿瘤标志物的应用单行本(Catharine M.Sturgeon教授和Eleftherios P.Diaman-dis教授编辑)。该指南包含第1至6章共6部分内容,参加指南制订的专家阵容强大,分别从临床及检验角度对睾丸、前列腺、结直肠、乳腺及卵巢癌中肿瘤标志物的检测与临床应用方面的问题进行了详细阐述与说明,是目前国内外在肿瘤实验诊断方面的纲领性应用文件。不仅适合广大检验人员、临床医护人员学习使用,也非常适合相关仪器试剂生产厂商研发应用。本指南由刘洋、薛丽、林文涛、李江、梁红艳、顾兵、潘世扬、郑磊等翻译,姜晓峰、沈文梅、田亚平、鄢盛恺审校,最后由鄢盛恺统稿审定。本指南的翻译出版,不仅有助于我国检验人员和医护人员合理的检测和应用睾丸、前列腺、结直肠、乳腺及卵巢癌肿瘤标志物,对我国检验医学指南的编写与应用也有一定的借鉴作用。本刊特在本期刊发,以飨广大读者。 | 鄢盛恺 Ulf-Hkan Stenman Rolf Lamerz Leendert H.Looijenga Nils Brünner Michael J.Duffy Caj Haglund Mads Holten-Andersen Hans JФrgen Nielsen Francisco J.Esteva Nadia Harbeck Daniel F.Hayes Rafael Molina Daniel W.Chan Robert C.Bast Jr Ie-Ming Shih Lori J.Sokoll Gyrgy Slétormos 刘洋 梁红艳 姜晓峰 田亚平 薛丽 林文涛 顾兵 潘世扬 沈文梅 郑磊 李江 | 2012 | 临床检验杂志2012，30，2： | 32 |
| 4 | 选区激光熔化成形颗粒增强铝基复合材料综述显示文摘选区激光熔化(SLM)是一种新兴逐层增材制造技术,能够生成具有三维复杂结构的高性能构件。颗粒增强铝基复合材料(PAMCs)由于结合铝基体和增强相的优异特性在很多领域被认为是一种重要材料。基于SLM和PAMCs的综合优势,新型SLMPAMCs在近年来被陆续开发和研究。因而,本文总结当前有关SLMPAMCs的研究进展。首先,着重分析SLM PAMCs的凝固行为。其次,对高性能SLM PAMCs设计和制造中涉及的重要问题进行全面的讨论,其中包括增强相的选择、工艺参数对成形和微观结构的影响以及缺陷演变和相调控。第三,对SLM PAMCs的性能和增强机制进行系统讨论。最后,对高性能SLM PAMCs未来发展方向提出建设性的观点。 | 王沛 Jürgen ECKERT Konda-gokuldoss PRASHANTH 吴明伟 Ivan KABAN 席丽霞 Sergio SCUDINO | 2020 | Transactions of Nonferrous Metals Society of China2020，30，8： | 29 |
| 5 | 鄂尔多斯盆地志留-泥盆纪和侏罗纪热事件——伊利石K-Ar年龄证据显示文摘利用伊利石K-Ar测年法,结合伊利石结晶度分析,首次在鄂尔多斯盆地确定出两期不同时代热事件。晚三叠世和晚二叠世<0.2μm粒级的岩石样品的K-Ar年龄(159-173Ma)反映了与燕山运动有关的伊利石化年龄,指示有一期中侏罗世的热事件;其<2μm粒级的K-Ar年龄(210-308Ma)则被解释为碎屑物和自生伊利石的混合年龄。中寒武世<0.2μm和<2μm粒级的岩石样品K-Ar年龄(368Ma与419Ma)对应于北秦岭加里东褶皱带变质作用与最早期花岗岩侵入的时代(380-420Ma),表明在志留-泥盆纪发生了一期热事件。 | 赵孟为 Hans Ahrendt Klaus Wemmer Hans-Jürgen Behr | 1996 | 地质学报1996，70，2： | 22 |
| 6 | On the combined effect of soil fertility and topography on tree growth in subtropical forest ecosystems—a study from SE China显示文摘Aims The aim of our research was to understand small-scale effects of topography and soil fertility on tree growth in a forest biodiversity and ecosystem functioning(BEF)experiment in subtropical SE China.Methods Geomorphometric terrain analyses were carried out at a spatial resolution of 5×5 m.Soil samples of different depth increments and data on tree height were collected from a total of 566 plots(667 m2 each).The soils were analyzed for carbon(soil organic carbon[SOC]),nitrogen,acidity,cation exchange capacity(CEC),exchangeable cations and base saturation as soil fertility attributes.All plots were classified into geomorphological units.Analyses of variance and linear regressions were applied to all terrain,soil fertility and tree growth attributes.Important Findings In general,young and shallow soils and relatively small differences in stable soil properties suggest that soil erosion has truncated the soils to a large extent over the whole area of the experiment.This explains the concurrently increasing CEC and SOC stocks downslope,in hollows and in valleys.However,colluvial,carbon-rich sediments are missing widely due to the convexity of the footslopes caused by uplift and removal of eroded sediments by adjacent waterways.The results showed that soil fertility is mainly influenced by topography.Monte-Carlo flow accumulation(MCCA),curvature,slope and aspect significantly affected soil fertility.Furthermore,soil fertility was affected by the different geomorphological positions on the experimental sites with ridge and spur positions showing lower exchangeable base cation contents,especially potassium(K),due to leaching.This geomorphological effect of soil fertility is most pronounced in the topsoil and decreases when considering the subsoil down to 50 cm depth.Few soil fertility attributes affect tree height after 1-2 years of growth,among which C stocks proved to be most important while pH_(KCl)and CEC only played minor roles.Nevertheless,soil acidity and a high proportion of Al on the exchange complex affected tree height even after only 1-2 years growth.Hence,our study showed that forest nutrition is coupled to a recycling of litter nutrients,and does not only depend on subsequent supply of nutrients from the mineral soil.Besides soil fertility,topography affected tree height.We found that especially MCCA as indicator of water availability affected tree growth at small-scale,as well as aspect.Overall,our synthesis on the interrelation between fertility,topography and tree growth in a subtropical forest ecosystem in SE China showed that topographic heterogeneity lead to ecological gradients across geomorphological positions.In this respect,small-scale soil-plant interactions in a young forest can serve as a driver for the future development of vegetation and biodiversity control on soil fertility.In addition,it shows that terrain attributes should be accounted for in ecological research. | Thomas Scholten Philipp Goebes Peter Kühn Steffen Seitz Thorsten Assmann Jürgen Bauhus Helge Bruelheide Francois Buscot Alexandra Erfmeier Markus Fischer Werner Härdtle Jin-Sheng He Keping Ma Pascal A.Niklaus Michael Scherer-Lorenzen Bernhard Schmid Xuezheng Shi Zhengshan Song Goddert von Oheimb Christian Wirth Tesfaye Wubet Karsten Schmidt | 2017 | Journal of Plant Ecology2017，10，1： | 22 |
| 7 | 整体壁板成形评述显示文摘介绍了整体壁板的概念和分类,总结了传统和现代的整体壁板成形工艺方法,如滚弯成形,增量压弯成形,蠕变时效成形,喷丸成形和激光弯曲成形,比较了它们之间的优、缺点及适应范围,简述了各成形工艺目前的应用状态及发展前景。提出针对不同外形形状和筋条高度的整体壁板的成形,可以采用不同的成形方法,必要时还可将几种成形方法进行复合。 | 王秀凤 郭晓丽 陈光南 Jürgen Silvanus | 2008 | 现代制造技术与装备2008，44，3： | 20 |
| 8 | Liver fat content determined by magnetic resonance imaging and spectroscopy显示文摘Hepatic steatosis as the most prevalent liver disorder can either be related to alcoholic liver disease (ALD) or non-alcoholic fatty liver disease (NAFLD). In both conditions, hepatocytes excessively accumulate fatcontaining vacuoles within their cytoplasm, which is the key histological feature. In contrast to ALD, NAFLD is commonly associated with metabolic syndrome, obesity and insulin resistance. To determine increased liver fat content, liver biopsy is currently considered the gold standard. Besides the invasive technique, various other non-invasive techniques have been developed, such as ultrasound, computed tomography (CT), magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) based methods. Among these techniques, ultrasound and CT provide only qualitative information about hepatic steatosis, whereas MRS-or MRI-based methods are able to determine even small amounts of fat accurately. These non-invasive magnetic resonance techniques have already proven their great potential, especially in longitudinal and cross-sectional studies regarding various metabolic conditions and medical treatment regimens. In this review, the most common, non-invasive MRS/MRI techniques for assessment of intrahepatic lipid content are described with their inherent advantages and limitations. | Fabian Springer Jürgen Machann Claus D Claussen Fritz Schick Nina F Schwenzer | 2010 | World Journal of Gastroenterology2010，16，13： | 19 |
| 9 | miR-20b, miR-98, miR-125b-1*, and let-7e* as new potential diagnostic biomarkers in ulcerative colitis显示文摘AIM:To use microarray-based miRNA profiling of colonic mucosal biopsies from patients with ulcerative colitis (UC), Crohn's disease (CD), and controls in order to identify new potential miRNA biomarkers in inflammatory bowel disease. METHODS:Colonic mucosal pinch biopsies from the descending part were obtained endoscopically from patients with active UC or CD, quiescent UC or CD, as well as healthy controls. Total RNA was isolated and miRNA expression assessed using the miRNA microarray Geniom Biochip miRNA Homo sapiens (Febit GmbH, Heidelberg, Germany). Data analysis was carried out by principal component analysis and projection to latent structure-discriminant analysis using the SIMCA-P+12 software package (Umetrics, Umea, Sweden). The microarray data were subsequently validated by quantitative real-time polymerase chain reaction (qPCR) performed on colonic tissue samples from active UC patients (n = 20), patients with quiescent UC (n = 19), and healthy controls (n = 20). The qPCR results were analyzed with Mann-WhitneyU test.In silico prediction analysis were performed to identify potential miRNA target genes and the predicted miRNA targets were then compared with all UC associated susceptibility genes reported in the literature. RESULTS:The colonic mucosal miRNA transcriptome differs significantly between UC and controls, UC and CD, as well as between UC patients with mucosal inflammation and those without. However, no clear differences in the transcriptome of patients with CD and controls were found. The miRNAs with the strongest differential power were identified (miR-20b, miR-99a, miR-203, miR-26b, and miR-98) and found to be upregulated more than a 10-fold in active UC as compared to quiescent UC, CD, and controls. Two miRNAs, miR-125b-1* and let-7e*, were up-regulated more than 5-fold in quiescent UC compared to active UC, CD, and controls. Four of the seven miRNAs (miR-20b, miR-98, miR-125b-1*, and let-7e*) were validated by qPCR and found to be specifically upregulated in patients with UC. Usingin silico analysis we found several predicted pro-inflammatory target genes involved in various pathways, such as mitogen-activated protein kinase and cytokine signaling, which are both key signaling pathways in UC.CONCLUSION:The present study provides the first evidence that miR-20b, miR-98, miR-125b-1*, and let7e* are deregulated in patients with UC. The level of these miRNAs may serve as new potential biomarkers for this chronic disease. | Mehmet Coskun Jacob Tveiten Bjerrum Jakob Benedict Seidelin Jesper Thorvald Troelsen JΦrgen Olsen Ole Haagen Nielsen | 2013 | World Journal of Gastroenterology2013，19，27： | 19 |
| 10 | Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology显示文摘AIM: To examine the vitamin D status in patients with alcoholic cirrhosis compared to those with primary biliary cirrhosis. METHODS: Our retrospective case series comprised 89 patients with alcoholic cirrhosis and 34 patients with primary biliary cirrhosis who visited our outpatient clinic in 2005 and underwent a serum vitamin D status assessment. RESULTS: Among the patients with alcoholic cirrhosis, 85% had serum vitamin D levels below 50 nmol/L and 55% had levels below 25 nmol/L, as compared to 60% and 16% of the patients with primary biliary cirrhosis, respectively (P < 0.001). In both groups, serum vitamin D levels decreased with increasing liver disease severity, as determined by the Child-Pugh score. CONCLUSION: Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology, with lower levels of vitamin D in alcoholic cirrhosis than in primary biliary cirrhosis. | Mikkel Malham SΦren Peter JΦrgensen Peter Ott JΦrgen Agnholt Hendrik Vilstrup Mette Borre Jens F Dahlerup | 2011 | World Journal of Gastroenterology2011，17，7： | 15 |
| 11 | 呈现科研数据知识库:re3data.org注册机制显示文摘科研人员在钻研科研问题与分享科研数据的过程中,需要某种基础设施来确保数据最大程度的获取性、稳定性和可用性。这类基础设施可以统称为科研数据知识库(Research Data Repository,RDR)。自2012年启动的re3data.org项目,主要从事科研数据知识库的登记注册,以及为科研人员、科研资助组织、图书馆和出版商等提供有关异构科研数据知识库的全景概述。截至2013年7月,已有400个科研数据知识库向re3data.org登记,其中288个采用re3data.org的信息图标,以协助科研人员遴选合适的知识库,并且存储与重用他们的数据。这篇论文描绘异构RDR的全景,表述机构的、学科的、跨学科的以及项目专业的RDR类型。深入描述re3data.org的特性,以及这套注册系统如何协助科研人员分辨适合存储和搜索科研数据的知识库。 | Heinz Pampel Paul Vierkant Frank Scholze Roland Bertelmann Maxi Kindling Jens Klump Hans-Jürgen Goebelbecker Jens Gundlach Peter Schirmbacher Uwe Dierolf 顾立平 | 2014 | 现代图书情报技术2014，，3： | 15 |
| 12 | The herbal compound geniposide rescues formaldehyde-induced apoptosis in N2a neuroblastoma cells显示文摘The herbal medicine Tong Luo Jiu Nao(TLJN)contains geniposide(GP)and ginsenoside Rg1 at a molar ratio of 10:1.Rg1 is the major component of another herbal medicine,panax notoginseng saponin(PNS).TLJN has been shown to strengthen brain function in humans,and in animals it improves learning and memory.We have previously shown that TLJN reduces amyloidogenic processing in Alzheimer’s disease(AD)mouse models.Together this suggests TLJN may be a potential treatment for patients with dementia.Because chronic damage of the central nervous system by formaldehyde(FA)has been presented as a risk factor for age-associated cognitive dysfunction,in the present study we investigated the protective effect of both TLJN and GP in neuron-like cells exposed to FA.FA-exposed murine N2a neuroblastoma cells were incubated with TLJN,its main ingredient GP,as well as PNS,to measure cell viability and morphology,the rate of apoptosis and expression of genes encoding Akt,FOXO3,Bcl2 and p53.The CCK-8 assay,cytoskeletal staining and flow cytometry were used to test cell viability,morphology and apoptosis,respectively.Fluorescent quantitative real-time PCR(qRT-PCR)was used to monitor changes in gene expression,and HPLC to determine the rate of FA clearance.Treatment of N2a cells with 0.09 mmol L?1 FA for 24 h significantly reduced cell viability,changed cell morphology and promoted apoptosis.Both TLJN and GP conferred neuroprotection to FA-treated N2a cells,whereas PNS,which had to be used at lower concentrations because of its toxicity,did not.Our data demonstrate that TLJN can rescue neuronal damage caused by FA and that its main ingredient,GP,has a major role in this efficacy.This presents purified GP as a drug or lead compound for the treatment of AD. | CHEN JinYan SUN MengRu WANG XingHua LU Jing WEI Yan TAN Yan LIU Ying GTZ Jürgen HE RongQiao HUA Qian | 2014 | Science China(Life Sciences)2014，57，4： | 15 |
| 13 | Requirements for the transfer of lead-free piezoceramics into application显示文摘The recent review for the Restriction of Hazardous Substances Directive(RoHS)by the expert committee,appointed by the European Union,stated that the replacement of PZT“…may be scientifically and technologically practical to a certain degree…”,although replacement“…is scientifically and technically still impractical in the majority of applications.”Thus,two decades of sustained research and development may be approaching fruition,at first limited to a minority of applications.Therefore,it is of paramount importance to assess the viability of lead-free piezoceramics over a broad range of application-relevant properties.These are identified and discussed in turn:1.Cost,2.Reproducibility,3.Mechanical and Thermal Properties,4.Electrical Conductivity,and 5.Lifetime.It is suggested that the worldwide efforts into the development of lead-free piezoceramics now require a broader perspective to bring the work to the next stage of development by supporting implementation into real devices.Guidelines about pertinent research requirements into a wide range of secondary properties,measurement techniques,and salient literature are provided. | Jurij Koruza Andrew J.Bell Till Fromling Kyle G.Webber Ke Wang Jürgen Rodel | 2018 | Journal of Materiomics2018，4，1： | 14 |
| 14 | 真实溶剂似导体屏蔽模型(COSMO-RS)显示文摘真实溶剂似导体屏蔽模型(COSMO-RS,Conductor-likescreening model for real solvents)是Klamt等在连续介质溶剂化模式COSMO的基础上,结合统计力学方法发展起来的定量计算溶剂化现象的新方法。本文简单介绍了COSMO-RS的基本原理、概念,以及应用该模式的基本步骤。综述了COSMO-RS应用于离子性化合物、聚合物溶液体系、高温高压体系以及预测复杂生物体系的分配系数和药物设计的进展。评述了简化分子表面屏蔽电荷分布计算的COSMOfrag和GC-COSMO(group contribution COSMO)方法,对不同版本的COSMO-RS之间以及其与基团贡献方法的对比研究也作了详细的讨论,并指出了COSMO-RS的不足之处和进一步发展该模式的建议。 | 牟天成 Jürgen Gmehling | 2008 | 化学进展2008，20，10： | 14 |
| 15 | 活性炭C40/4吸附甲苯和丙酮吸附性能研究显示文摘为探讨活性炭吸附C40/4有机蒸汽的性能曲线规律,在不同温度288.15K,293.15K和298.15K下实验测试了活性炭C40/4吸附有机气体甲苯和丙酮的吸附性能,基于langmuir等温吸附理论,从吸附动态平衡的角度,理论分析了吸附性能曲线中参数与温度之间的关系,提出一个经验的langmuir等温吸附曲线模型,它能很好地描述不同温度下的有机蒸汽在活性炭上的吸附性能曲线.模型计算值与实验测试值之间的误差小于6%.为确定活性炭吸附有机蒸汽的吸附量提供了有效的计算模式,从而为有机蒸汽吸附过程的设计、预测和优化提供有益的支持. | 李立清 HANGS-Jürgen Rhm Wolf-Dieter.Suβebach | 2003 | 湖南大学学报(自然科学版)2003，30，5： | 14 |
| 16 | 西那卡塞降低血液透析患者钙性尿毒症小动脉病变的发生显示文摘终末期肾病(ESRD)患者未控制的继发性甲状旁腺功能亢进(secondary hyperparathyroidism,SHPT),是钙性尿毒症小动脉病变(calcific uremic arteriolopathy,CUA,即钙化防御)的危险因素。CUA是相对罕见的综合症,1年生存率仅为45%;其主要病变是皮肤和脂肪组织小动脉和中动脉壁的中层钙化,导致进行性和极其痛苦的皮肤溃疡、感染,是CUA高死亡率的主要原因。CUA很少见于肾功能正常的患者,大多数CUA都局限于晚期CKD尤其是ESRD患者。在所有ESRD患者中CUA的患病率估计为1%到4%。 | Jürgen Floege Yumi Kubo Anna Floege 王建中 | 2015 | 中华肾病研究电子杂志2015，4，3： | 13 |
| 17 | 中文文本关键词自动抽取方法研究显示文摘随着信息技术的发展,中文电子文本信息资源正以惊人的速度急剧增长。文本自动处理技术,通过自动组织海量文献信息资源,能够为用户提供简易有效的信息检索服务。关键词自动抽取是文本自动处理的基础和核心。汉语的特殊性加剧了中文文本关键词自动抽取的难度。本文提出了一种基于N-gram权重计算和关键词筛选算法的中文文本关键词自动抽取方法。该方法不依赖特定的数据集和中文分词技术,可以有效地抽取出任意单篇文本的关键词,而且通过参数调整,应用系统可以灵活地控制标引深度和标引专指度。实验表明,该方法简单、快速、断词错误率低,标引性能明显优于基于中文分词和TF/IDF的方法,可以满足大规模文本的在线处理要求。 | 张雪英 Jǔrgen Krause | 2008 | 情报学报2008，27，4： | 13 |
| 18 | 关闭煤炭矿区资源利用与可持续发展的几点思考显示文摘随着中国能源结构的调整,煤炭开采从原来的分散式开采向精细化、集中化和精准化发展,矿井数量大幅度减少,大量资源枯竭及落后产能矿井面临关闭或废弃。这一转变将使中国现阶段及未来很长一段时间都将面临与德国相似的“后采矿”时代。从中国能源结构发展的大趋势以及煤炭资源开发的宏观战略来看,已经关闭和即将关闭的大量矿井或者矿区重新恢复开采的可能性不大。矿井的关闭或废弃不仅会带来水、大气等环境污染问题,还会带来企业职工难以安置、固定资产难以处理等社会经济问题。因此,本文针对矿区关闭或废弃后出现的问题,借鉴德国应对后采矿的处理方案、后采矿工业区资源可持续发展战略,对比中国对关闭矿区的处理案例,提出了应把矿区关闭后资源的利用纳入整个矿山开发的顶层设计中的理念,以及煤炭地下空间、矿井水等资源综合利用的思路。国内外虽提出了形式多样的废弃矿井利用方案,但总体利用率不高,仍需继续深入探究关闭矿区资源利用基础理论和手段方法,以及应对关闭矿区后发展需要的教育与技术人才培养措施。 | 王家臣 Jürgen Kretschmann 李杨 | 2021 | 矿业科学学报2021，6，6： | 12 |
| 19 | Transforming growth factor-β1 induces intestinal myofibroblast differentiation and modulates their migration显示文摘AIM:To investigate the effects of transforming growth factorβ1(TGF-β1)on the differentiation of colonic lamina propria fibroblasts(CLPF)into myofibroblasts in vitro. METHODS:Primary CLPF cultures were incubated with TGF-β1 and analyzed for production ofα-smooth muscle actin(α-SMA),fibronectin(FN)and FN isoforms.Migration assays were performed in a modified 48-well Boyden chamber.Levels of total and phosphorylated focal adhesion kinase(FAK)in CLPF were analyzed after induction of migration.RESULTS:Incubation of CLPF with TGF-β1 for 2 d did not changeα-SMA levels,while TGF-β1 treatment for 6 d significantly increasedα-SMA production. Short term incubation(6 h)with TGF-β1 enhanced CLPF migration,while long term treatment(6 d)of CLPF with TGF-β1 reduced migration to 15%-37% compared to untreated cells.FN and FN isoform mRNA expression were increased after short term incubation with TGF-β1(2 d)in contrast to long term incubation with TGF-β1 for 6 d.After induction of migration, TGF-β1-preincubated CLPF showed higher amounts of FN and its isoforms and lower levels of total and phosphorylated FAK than untreated cells. CONCLUSION:Long term incubation of CLPF with TGF-β1 induced differentiation into myofibroblasts with enhancedα-SMA,reduced migratory potential and FAK phosphorylation,and increased FN production.In contrast,short term contact(6 h)of fibroblasts with TGF-β1 induced a dose-dependent increase of cell migration and FAK phosphorylation without induction ofα-SMA production. | Julia Brenmoehl Sandra Nicole Miller Claudia Hofmann Daniela Vogl Werner Falk Jrgen Schlmerich Gerhard Rogler | 2009 | World Journal of Gastroenterology2009，15，12： | 12 |
| 20 | Effect of Powder Particle Shape on the Properties of In Situ Ti–TiB Composite Materials Produced by Selective Laser Melting显示文摘This work studied the preparation of starting powder mixture influenced by milling time and its effect on the particle morphology(especially the shape) and, consequently, density and compression properties of in situ Ti–Ti B composite materials produced by selective laser melting(SLM) technology. Starting powder composite system was prepared by mixing 95 wt% commercially pure titanium(CP-Ti) and 5wt% titanium diboride(TiB 2) powders and subsequently milled for two different times(i.e. 2 h and 4 h).The milled powder mixtures after 2 h and 4 h show nearly spherical and irregular shape, respectively.Subsequently, the resultant Ti–5 wt% TiB 2 powder mixtures were used for SLM processing. Scanning electron microscopy image of the SLM-processed Ti–Ti B composite samples show needle-shape TiB phase distributed across the Ti matrix, which is the product of an in-situ chemical reaction between Ti and TiB 2during SLM. The Ti–Ti B composite samples prepared from 2 h and 4 h milled Ti–TiB 2 powders show different relative densities of 99.5% and 95.1%, respectively. Also, the compression properties such as ultimate strength and compression strain for the 99.5% dense composite samples is 1421 MPa and 17.8%, respectively, which are superior to those(883 MPa and 5.5%, respectively) for the 95.1% dense sample. The results indicate that once Ti and TiB 2 powders are connected firmly to each other and powder mixture of nearly spherical shape is obtained, there is no additional benefit in increasing the milling time and, instead, it has a negative effect on the density(i.e. increasing porosity level) of the Ti–Ti B composite materials and their mechanical properties. | Hooyar Attar Konda G.Prashanth Lai-Chang Zhang Mariana Calin Ilya V.Okulov Sergio Scudino Chao Yang Jürgen Eckert | 2015 | Journal of Materials Science & Technology2015，31，10： | 12 |
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