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| 1 | TME术前短程放疗后化疗对比术前放化疗联合术后辅助化疗治疗局部晚期直肠癌(RAPIDO研究)—一项随机、开放的Ⅲ期临床试验显示文摘背景:全身复发仍然是局部晚期直肠癌患者需要面临的难题。该研究是采用短程放疗后行化疗和延迟手术对比术前诱导治疗后直接手术疗效的临床试验(the Rectal cancer And Preoperative Induction therapy followed by Dedicated Operation,RAPIDO),旨在不影响局部控制效果的前提下减少远处转移。方法:在这项多中心、随机、开放的Ⅲ期试验中,参与者来自于荷兰、瑞典、西班牙、斯洛文尼亚、丹麦、挪威和美国的共54个医学中心。纳入患者年龄在18岁及以上,ECOG评分为0~1分,且为经活检确诊局部晚期原发直肠腺癌的初诊患者,盆腔MRI评估为高危(至少符合一项标准:cT4a或cT4b,壁外血管侵犯,cN2,直肠系膜筋膜受累,或侧方淋巴结增大)。患者具备化疗适应证,并可在随机分组前5周内完成分期评估。 | 李来元 张维胜 BAHADOER R R DIJKSTRA E A VAN ETTEN B | 2021 | 结直肠肛门外科2021，27，1： | 72 |
| 2 | 焦炭特性及其在高炉下部的变化过程显示文摘气化、石墨化和溶解是影响焦炭从高炉软熔带至炉缸间行为的三个主要过程。过去几年在一些专题项目中对这些过程进行了研究。简要叙述并讨论了这些过程的相互作用及其与焦炭特性的关系。对焦炭的气化反应进行了实验室测试研究,用以评价高炉条件下焦炭的特性。用高炉条件下的气化测试装置测试了几种焦炭试样,考查的质量指标包括反应性、结构变化和强度等。用实际尺寸的焦炭块对块状焦炭试样的高温行为进行了评估,将不同种类的焦炭试样加热到2 000℃,以鉴别其在高温下的行为。高温下焦炭将发生石墨化,对高温反应后的强度进行了评定,并作了显微观察,发现了一些现象和组织结构的变化。焦炭与液态渣铁相互作用的研究结果对焦炭在高炉下部的行为有了更好的理解。通过试验研究了焦炭抗液态铁水溶解的性能,对入炉前的焦炭和经高温反应的焦炭分别进行了试验。分析讨论了焦炭的抗气化、抗石墨化和抗铁水溶解性能与其结构、化学成分和强度的关系。 | B van der Velden C J Atkinson T Bakker J R H Stuurwold G J Tijhuis 徐万仁 | 2014 | 世界钢铁2014，，2： | 11 |
| 3 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 4 | 比索洛尔治疗后给予依那普利对慢性心力衰竭患者生存率和住院率的影响:CIBISⅢ期随机临床试验结果显示文摘 | Willenheimer R van Veldhuisen DJ Silke B 任美峰 | 2006 | 中国处方药2006，5，1： | 4 |
| 5 | Experimental and theoretical study of the swirling flow in centrifugal compressor volute显示文摘 | Van den Braembussche R A Hand B M | 1990 | ASME Journal of Turbornachinery1990，112，3： | 2 |
| 6 | Inhi- bition of Denitrification Activity but not of mRNA Induction in Paracoccus denitrificans by Nitrite at a Suboptimal pH 显示文摘 | BAUMANN B VAN DER MEER J R SNOZZI M | 1997 | Antonie van Leeuwenhoek1997，72，： | 1 |
| 7 | A contin uous-flow crushing device for on-line δ^2 H analysis of fluid inclusion water in speleothems显示文摘 | Vonhof H B van Breukelen M R Postma O | 2006 | Rapid Communications in Mass Spectrometry2006，20，17： | 1 |
| 8 | Rapid on-farm analysis of manure nutrients using quick tests显示文摘 | Van Kessel Thompson J S R B Reeves J B III | 1999 | Journal of Production Agriculture1999，12，： | 1 |
| 9 | Pulmonary embolism:valiclition of spiral CT angiography in 149 patients显示文摘 | Van Rossum A B Pattynama P M Ton E R | 1996 | Radiology1996，201，2： | 1 |
| 10 | Increased risk of grade IV neutropenia after administration of 5 fluorouracil due to a dihydropyrimidine dehydrogenase deficiency: high prevalence of the IVS14 + 1 g > a mutation 显示文摘 | VAN KUILENBURG A B MEINSMA R ZOETEKOUW L | 2002 | Int J Cancer2002，101，3： | 1 |
| 11 | Seismic tomography with P and S data reveals lateral variations in the rigidity of deep slabs显示文摘 | Widiyantoro S Kennett B L N van der Hilst R D | 1999 | Earth and Planetary Science Letters1999，173，： | 1 |
| 12 | The Proterozoic supercontinent Rodinia:Paleomagnetically derived reconstructions for 1100 to 800Ma显示文摘 | Weil A B Van der Voo R MaCniocail C | 1998 | Earth and Planetary Science Letters1998，154，： | 1 |
| 13 | Visualization of differential gene expression using a novel method of RNA fingerprinting based on AFLP: Analysis of gene expression during potato tuber development显示文摘 | Bachem C W B Van der Hoeven R S de Bruijn S M | 1996 | Plant J1996，9，： | 1 |
| 14 | L-shaped linear programs with application to optimal control and stochastic program- ming显示文摘 | Van Slyke R Wets R B | 1969 | SlAM Journal on Applied Mathematics1969，17，： | 1 |
| 15 | Enhanced peroxynitrite formation is associated with vascular aging显示文摘 | van der Loo B Labugger R Skepper JN | | 0，，12： | 1 |
| 16 | Imaging the impact of genes on Parkinson's disease显示文摘 | van der Vegt J P van Nuenen B F Bloem B R | 2009 | Neuroscience2009，164，19： | 1 |
| 17 | Three-dimensional vortex organization in a high-Reynolds-number supersonic turbulent boundary layer显示文摘 | Elsinga G E Adrian R J Van Oudheusden B W | 2010 | J Fluid Mech2010，644，： | 1 |
| 18 | SF6/N2mix- tures basic and HV insulation properties显示文摘 | CHRISTOPHOROU L G VAN B R J | 1995 | IEEE Transactions on Dielectrics and Electrical Insula- tion1995，2，5： | 1 |
| 19 | Signaling molecules in overcirculation-induced pulmonary hypertension in piglets:effects of sildenafil therapy显示文摘 | Rondelet B Kerbaul F van Beneden R | 2004 | Circulation2004，110，15： | 1 |
| 20 | Towards a pan-European consensus on the treatment of patients with colorectal liver metastases 显示文摘 | Van Cutsem E Nordlinger B Adam R | 2006 | Eur J Cancer2006，42，14： | 1 |
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