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| 1 | Rational Daily Administration Times of Yinchenhao Decoctionin Rats with Jaundice Based on PD/PK显示文摘Objective To study the rational daily administration times of Yinchenhao Decoction(YCHD)when it was used to treat experimental jaundice in rats based on pharmacodynamics/pharmacokinetics model.Methods Rats were modeled by 4%1-naphthylisothiocyanate(75 mg/kg)for 48 h,then YCHD was drenched with doses of 0.324 g/kg (extract,calculated with the clinical dosage)once,0.162 g/kg twice,and 0.108 g/kg thrice a day,respectively.The total bile and the flow rate of bile were observed after the first administration;Blood samples collected from the orbital sinus at different intervals were used to investigate the levels of liver enzymes(ALT and AST)and bilirubins (TBIL and DBIL),and determine the concentration of 6,7-dimethoxycoumarin(DME)in the plasma using UPLC at the same time,then we obtained the time-effect and time-dose curves.The rational daily administration times of YCHD when treating experimental jaundice were determined based on the comprehensive analysis of time-effect and time-concentration relationships.Results Within 10 h the total bile of rats which were administered once daily(G1) was 1.65 and 1.33 times higher than that of twice and thrice(G2 and G3)a day,respectively,and the four biochemical indexes(TBIL,ALT,DBIL,and AST)of G1 decreased faster than those of G2 and G3(P<0.05).On the other hand, the blood drug level of DME when administrated once daily could maintain at a higher level for a longer time,and its Cmax and AUC0→t were higher than those of G2 and G3,which might be the main reason why its effect was the most significant.Conclusion It is more appropriate to administrate once daily when YCHD is used to treat jaundice. | LV Jun-lan JIN Shi-ying YUAN Hai-long HAN Jin FU Shan-shan JIN Shi-xiao GUO Jing-jing XIAO Xiao-he | 2012 | Chinese Herbal Medicines2012，4，2： | 7 |
| 2 | 扎托布洛芬缓释微丸的制备及释放特性显示文摘目的以不同处方制备扎托布洛芬缓释微丸,考察包衣层处方对药物释放的影响及其释药特性。方法采用空白丸芯流化床混悬液上药法制备扎托布洛芬载药微丸,以HPMC为隔离材料包隔离衣、以乙基纤维素水分散体为缓释材料,考察不同种类、用量的致孔剂以及包衣增重对药物释放行为的影响。结果以10%HPMC为致孔剂、缓释衣层包衣增重为4.5%时,制得的微丸具明显的缓释效果,其释放曲线符合一级动力学,且批内及批间重复性良好。结论制得的扎托布洛芬缓释微丸具有较理想的体外缓释效果。 | 余凤玮 龚涛 刘福 | 2013 | 华西药学杂志2013，28，1： | 5 |
| 3 | 高效液相色谱法测定人血浆中扎托布洛芬的浓度显示文摘目的建立高效液相色谱法测定人血浆中扎托布洛芬浓度的方法。方法采用沉淀法,将待测血浆样品经乙腈沉淀后,以双氯芬酸钠为内标,用高效液相色谱法进行检测。采用Platisil ODS C18色谱柱(250 mm×4.6 mm,5μm),流动相:0.05 mol.L-1磷酸二氢钠(三乙胺调pH=5.1)-乙腈(58∶42);流速:1.2 mL.min-1;检测波长:330 nm。结果本方法扎托布洛芬标准曲线范围为0.05~30.00μg.mL-1(n=7),r>0.99,最低定量浓度0.05μg.mL-1。日内和日间RSD均<7.9%。提取回收率为74.13%~78.64%,内标提取回收率为80.32%~86.13%。结论该方法简便、快速,灵敏度高,专属性强,适用于人血浆中扎托布洛芬浓度的测定。 | 孙喜东 高颖 刘婷立 刘洋 宋冬梅 张煊 | 2013 | 中南药学2013，11，2： | 4 |
| 4 | HPLC测定扎托布洛芬缓释胶囊的含量显示文摘目的采用HPLC法测定扎托布洛芬缓释胶囊的含量。方法采用Kromasil C18(150 mm×4.6 mm,5μm)色谱柱,流动相为乙腈-水-冰醋酸(300∶200∶1),流速1.0 mL·min-1,检测波长240 nm。结果 5~35μg·mL-1扎托布洛芬与峰面积呈良好的线性关系(r=0.9999),平均回收率为99.03%,RSD=0.52%。结论所用方法准确可靠,简便,快速,适用于扎托布洛芬缓释胶囊的质量控制。 | 余凤玮 孙逊 张彦 刘福 龚涛 张志荣 | 2012 | 华西药学杂志2012，27，3： | 2 |
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