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| 1 | 酸损伤所致的兔食管缩短和功能改变显示文摘目的观察酸灌注损伤对兔食管长度及功能的影响。方法采用食管腔内灌注方法,用0.1mol·L^1HCl以1mL·min^1的速度,行兔(n=10)食管灌注,每天30min连续4d,测定食管下括约肌(LES)的压力及食管长度的变化,结合食管灌注后病理改变进行分析。结果酸灌注后LES粘膜产生明显的炎症改变,光镜下可见,实验组家兔食管粘膜基底细胞层明显增生,固有层中性粒细胞增生,粘膜下层内血管扩张,充血,电镜下可见平滑肌细胞内线粒体肿大,嵴溶解,周围肌浆网明显扩张,肌丝部分溶解减少。LES的压力在0.1mol·L^1HCl灌注4d时明显下降。灌注前后LES的平均压力分别为:1.40kPa±0.14kPa及0.71kPa±0.12kPa(P<0.001)。对照组压力未见显著改变。生理盐水灌注组灌注前后LES的平均压力分别为:1.25kPa±0.14kPa及1.36kPa±0.12kPa(P>0.05)。食管长度明显缩短d2及d4缩短分别为0.41cm±0.12cm及0.69cm±0.22cm(P<0.05),其中d2实验组于灌注后30min食管长度可恢复正常,而于d430min后仍不能恢复正常。对照组均无明显变化(P>0.05)。结论酸灌注可以影响食管LES压力及平滑肌细胞的结构功能,同时导致食管长度缩短,这可能是导致食管裂孔疝形成的原因。 | 韩勇 王云杰 刘锟 | 2001 | 世界华人消化杂志2001，9，4： | 1 |
| 2 | Study on the preventive effects of different drugs on reflux esophagitis in rats显示文摘Objective: To observe the damage of mixed reflux to the rat esophageal mucosa, and investigate the preventive effects of cisapride, nabumetone and hydrotalcite on the damaged esophageal mucosa. Methods: Three hundred sixty-eight Sprague-Dawley rats were treated as esophagoduodenostomy and divided into four groups in random. Group Y: operation + saline as positive controls; Group P: operation + cisapride; Group R: operation + nabumetone; Group D: operation + hydrotalcite. Different drugs were perfused in the 1 st week after operation. The lesions of esophageal mucosa were observed in the 5th, 9th, 13th, 17th, 22nd, 28th, 35th and 40th week respectively, and evaluated the preventive effects of these drugs. Results: The lesions of esophageal mucosa in group Y were more severe than other three groups in different time (P < 0.05), and the incidence of Barrett's esophagus(BE), severe atypical hyperplasia and esophageal adenocarcinoma (EAC) in group Y were higher than others. After 22 weeks, the lesions in group P were more severe than group R and D, and there were obvious differences in different time ( P < 0.05); but the incidence of BE, severe atypical hyperplasia and EAC in group P had no significant difference with group R and group D( P > 0.05). Conclusion: BE, severe atypical hyperplasia and EAC could occur because of severe reflux esophagitis for a long term. Cisapride, nabumetone and hydrotalcite could reduce mucosa injury in reflux esophagitis and resist the development of BE, severe atypical hyperplasia and EAC.In addition, the curative effects of nabumetone and hydrotalcite were better than cisapride. | 汪涛 龚均 陈杰 程鹏 常英 王进海 汪涛 | 2004 | Journal of Medical Colleges of PLA(China)2004，19，5： | 1 |
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