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| 1 | 二烯丙基二硫对人胃癌MGC803细胞生长的影响显示文摘目的:研究二烯丙基二硫(DADS)对人胃癌MGC803细胞生长的抑制作用。方法:采用MTT法、生长曲线分析、细胞活力检测、双层软琼脂集落形成率、及倒置显微镜等方法,观察DADS对体外培养的人胃癌MGC803细胞的影响。结果:DADS对MGC803细胞具有明显的生长抑制效应,且呈剂量-效应依赖关系(P<0.05)。培养96 h,35mg/LDADS的抑制作用呈时间-效应依赖关系(P<0.05)。细胞群体倍增时间由33.8 h处长至DADS处理后的84.0 h(P<0.05);细胞存活率分别为阴性对照组97.4%和DADS处理组80.4%(P>0.05);软琼脂集落形成率由 1.23%下降到0.33%(P<0.05)。阴性对照组细胞多角形、圆形,体积大,多形性明显,核大小不一,见双核及核仁,细胞生长紧密呈堆叠生长,DADS处理后细胞异型性降低,为形态一致的梭形,体积小,境界清楚而分散,胞质丰富,核明显变小。结论:DADS对体外培养的MGC803细胞具有明显的增生抑制作用,且呈现剂量-效应依赖关系。 | 张良运 凌晖 苏琦 宋颖 梁晓秋 | 2003 | 世界华人消化杂志2003，11，9： | 29 |
| 2 | Fish sauce and gastric cancer:an ecological study in Fujian Province,China显示文摘AIM To explore the relationship betweenconsumption of fish sauce and the risk of gastriccancer in Fujian Province.METHODS An ecological study was carriedout.A total of 11000 subjects from 55 townshipswere randomly selected from 10 counties withinFujian Province.All subjects were localresidents who had been living in Fujian Provincefor more than 20 years,within the age group of45-74 years.Trained interviewers conductedface-to-face interviews with a standardizedquestionnaire,which covered the frequency andamount of food intake,dietary habit,tobaccoand alcohol consumption and history of chronicgastric diseases.Univariate and multivariateanalyses were performed using Epi-info and SASstatistical packages,respectively.RESULTS A significant correlation betweenmonthly consumption of fish sauce and mortalityof gastric cancer was found.Pearson’scoefficient of correlation was statisticallysignificant with r=0.7356 for males,r=0.5246for females(P<0.01).In the multivariateanalysis,consumption of fish sauce still showedan association with the risk of gastric cancer.No significant positive correlation betweenesophagus cancer,liver cancer,colon cancerand consumption of fish sauce were observed.CONCLUSION Long-term intake of fish saucemay be related to high mortality of gastriccancer.Consumption of fish sauce might be oneof important and unique etiologic factors ofgastric cancer in Fujian Province.Furtherstudies are needed to confirm this ecologicalstudy. | Lin Cai Shun Zhang Yu Wei Min Ye Ying Nan Yi | 2000 | World Journal of Gastroenterology2000，6，5： | 18 |
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