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| 1 | 基于免疫相关性疾病的艾灸镇痛与抗炎免疫研究显示文摘艾灸治疗痛症从古有之,抗炎免疫是现代针灸临床研究的热点。艾灸镇痛及其抗炎免疫作用已被中医针灸临床实践所证实,对其效应机制的研究多从温热刺激穴位(区)启动着手,研究发现皮肤穴位(区)中嘌呤受体(P2受体)和瞬时感受器电位香草酸受体(TRP)在艾灸效应的启动环节发挥了重要作用,参与机体疼痛、炎性反应的发生和发展,这种调节效应发生在'神经-内分泌-免疫'网络的各个环节,对诸多介导的疼痛的镇痛/致痛因子、炎性细胞因子具有调节作用,'艾灸嘌呤'这一概念可以概括目前研究发现的艾灸镇痛与抗炎效应,实验研究已发现艾灸能够对腹痛大鼠脊髓背角广动力神经元的异常兴奋性具有调节作用;临床中通过脑功能成像(f MRI)技术研究发现,艾灸和针刺在调控缓解期CD腹痛患者异常的脑灰质密度以及静息状态下异常的脑功能活动方面,镇痛效应的发挥存在着'共同响应脑区'和'差异响应脑区';温热刺激能够在丘脑内侧和腹内侧核绕开对低阈值的下行易化系统的激活而实现对高阈值激活的下行抑制系统选择性激活,这种艾灸的内源性的调节作用可能在CD痛觉及炎性反应的治疗中发挥了重要的作用,今后将围绕'艾灸嘌呤'这一机制方向来展开更为深入的艾灸镇痛与抗炎研究。艾灸抗炎免疫研究发现,艾灸能通过HPA轴提高肾上腺素皮质激素的水平调节炎性细胞因子的合成,艾灸镇痛与抗炎免疫效应大多数情况下是同时存在,艾灸通过外周穴位(区)和中枢响应,激活抗炎通路,调节免疫应答,在实现抗炎作用的同时实现了镇痛效应。文章围绕'穴位(区)启动-中枢响应-靶器官效应'对艾灸镇痛与抗炎免疫机制进行回顾研究。 | 吴焕淦 翁志军 刘慧荣 张建斌 余曙光 常小荣 马晓芃 沈雪勇 王晓梅 吴璐一 黄艳 | 2016 | 世界中医药2016，11，12： | 72 |
| 2 | 灸法研究的战略思考显示文摘在中医针灸学现代化和国际化进程中,灸法的应用日益受到关注。灸法作用机理研究已成为针灸医学研究领域亟待解决的关键科学问题。该文在总结前期灸法研究成果的基础上,对灸法下一步深入研究进行了思考和展望,认为亟需开展多学科交叉研究,阐明灸法的内源性调节机制,揭示艾灸得气、灸温、灸材等因素的作用特点、规律和机制,明确艾灸热、光、烟与灸效的关系,并确证艾灸与针刺作用的异同,以推动灸法研究新一轮的发展和创新;并展望灸法在'治未病'及防治疾病中的作用与贡献。 | 吴焕淦 马晓芃 刘慧荣 余曙光 吴璐一 孙艳红 田甜 施茵 张建斌 赵百孝 胡玲 常小荣 | 2016 | 世界科学技术-中医药现代化2016，18，3： | 44 |
| 3 | 艾灸疗法:在调节肠易激综合征肠道菌群与黏膜免疫中的展望显示文摘背景:肠道菌群在宿主肠道内寄生,与肠黏膜免疫屏障相互作用,相互影响,在机体内肠道内环境稳态的调解中起着重要作用。目的:从肠道菌群失调和黏膜免疫激活角度,探讨肠道菌群在肠易激综合征发病环节中的作用及其艾灸治疗肠易激综合征的作用机制。方法:以'肠易激综合征,肠道菌群,肠道黏膜免疫,艾灸'为中文检索词,以'irritable bowel syndrome,intestinal flora,intestinal immune,moxibustion'为英文检索词,应用计算机在中国知网、维普和Pub Med数据库检索2001年10月至2014年10月的相关文献,并进行筛选、归纳和总结。结果与结论:共纳入37篇符合标准文献,其中中文文献15篇,英文文献22篇。文章阐述了肠道菌群失调和肠黏膜免疫在肠易激综合征发病的病理生理过程中发挥的重要作用,肠道菌群失调可影响机体对直肠扩张刺激的感觉阈值、内脏敏感性等。艾灸可从多环节、多靶点调节机体生理平衡,在改善肠易激综合征各项症状,尤其是内脏高敏感性腹痛方面凸显优势。 | 赵继梦 黄艳 窦传字 王硕硕 王晓梅 李垠和 包春辉 周次利 翁志军 陆嫄 吴焕淦 | 2015 | 中国组织工程研究2015，19，2： | 19 |
| 4 | 艾灸抑制肠腑病内脏痛的效应及机制研究显示文摘本课题组对艾灸疗法在肠腑病内脏痛中镇痛实践进行了探索,开展了艾灸治疗溃疡性结肠炎、克罗恩病、肠易激综合征的临床实践,结果显示艾灸对溃疡性结肠炎、克罗恩病、肠易激综合征患者腹痛症状具有良好的镇痛效应;并从抑制肠道炎性反应、促进病变局部组织修复和/或功能改善、提高痛阈及调节中枢/病变局部神经介质等疼痛相关物质水平等方面分别阐释了艾灸在不同类型的肠腑病内脏痛中镇痛的作用机制,并对今后艾灸镇痛在肠腑病中的应用与研究发展趋势进行思考和展望。 | 包春辉 吴璐一 吴焕淦 徐斌 陆嫄 刘慧荣 余曙光 赵天平 赵继梦 赵百孝 胡玲 常小荣 | 2014 | 中华中医药杂志2014，29，2： | 14 |
| 5 | Electroacupuncture at He-Mu points reduces P2X_4 receptor expression in visceral hypersensitivity显示文摘Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) was reported to improve visceral hypersensitivity in rats.Colorectal distension was utilized to generate a rat model of chronic visceral hypersensitivity in irritable bowel syndrome.Results showed that abdominal withdrawal reflex scores noticeably increased after model establishment.Simultaneously,P2X 4 receptor immunoreactivity significantly increased in the colon and spinal cord.Electroacupuncture and pinaverium bromide therapy both markedly decreased abdominal withdrawal reflex scores in rats with visceral hypersensitivity,and significantly decreased P2X 4 receptor immunoreactivity in the colon and spinal cord.These data suggest that electroacupuncture treatment can improve visceral hypersensitivity in rats with irritable bowel syndrome by diminishing P2X 4 receptor immunoreactivity in the colon and spinal cord. | Xinxin Guo Jifei Chen Yuan Lu Luyi Wu Zhijun Weng Ling Yang Yuhu Xin Xianming Lin Yi Liang Jianqiao Fang | 2013 | Neural Regeneration Research2013，8，22： | 9 |
| 6 | Effect of Acupoints on Acupuncture-Moxibustion and its Therapeutic Mechanism显示文摘The clinical efficacy of acupuncture-moxibustion(AM)mainly depends on acupoints,but the relationship between the acupoints and AM remains unclear.Improving clinical efficacy and clarifying the mechanisms of AM is critical.We found that the specificity and sensitivity of acupoints,the skill of operation,and reasonable amount of stimulation can significantly improve the efficacy of AM.In addition,some studies have shown that Neural-Endocrine-Immune network and metabolites are involved in this process,clarifying the therapeutic mechanism of acupoints.Therefore,how to effectively use acupoints to improve the clinical efficacy of AM is one of the key issues in need of an urgent solution.In summary,this article reviewed the Chinese and English databases on the clinical efficacy and underlying mechanisms of acupoints to clarify the relationship between acupoints and AM efficacy and ultimately improve clinical efficacy through effective and rational use of acupoints. | Han-Dan Zheng Zhao-Qin Wang Shan-Shan Li Yuan Lu Yan Huang Ci-Li Zhou Yu-Qing Lu Hui-Rong Liu Ya-Nan Liu Huan-Gan Wu | 2020 | World Journal of Traditional Chinese Medicine2020，6，3： | 5 |
| 7 | Factorial study of moxibustion in treatment of diarrhea-predominant irritable bowel syndrome显示文摘AIM: To identify an appropriate therapeutic regimen for using aconite cake-separated moxibustion to treat diarrhea-predominant irritable bowel syndrome(D-IBS).METHODS: A factorial design was employed to examine the two factors of moxibustion frequency and number of cones. The two tested frequencies were three or six moxibustion sessions per week, and the two tested doses were one or two cones per treatment. A total of 166 D-IBS patients were randomly divided into four treatment groups, which included each combination of the examined frequencies and doses. The bilateral Tianshu acupoints(ST25) and the Qihai acupoint(RN6) were selected for aconite cake-separated moxibustion. Each patient received two courses of treatment, and each course had a duration of 2 wk. For each group, the scores on the Birmingham irritable bowel syndrome(IBS) symptom questionnaire, the IBS Quality of Life scale, the Self-Rating Depression Scale(SDS), the Self-Rating Anxiety Scale(SAS), the Hamilton Depression(HAMD) scale, and the Hamilton Anxiety(HAMA) scale were determined before treatment, after the first course of treatment, and after the second course of treatment. RESULTS: The symptom, quality of life, SDS, SAS, HAMD, and HAMA scores of the patients in all 4 aconite cake-separated moxibustion groups were significantly lower after the first and second courses of treatment than before treatment(P < 0.001 for all). The symptom, quality of life, SDS, SAS, HAMD, and HAMA scores of the patients in all four aconite cake-separated moxibustion groups were significantly lower after the second course of treatment than after the first course of treatment(P < 0.001 for all). Between-group comparisons after the second course of treatment revealed that the symptom scores for group 1(1 cone, 3 treatments/wk) and group 3(2 cones, 3 treatments/wk) were significantly lower than that for group 2(1 cone, 6 treatments/wk)(5.55 ± 5.05 vs 10.45 ± 6.61, P < 0.001; 5.65 ± 4.00 vs 10.45 ± 6.61, P < 0.001). Regarding the two levels of the two examined factors for aconite cake-separated moxibustion, after the first course of treatment, the changes in HAMA scores weresignificantly different for the two tested moxibustion frequencies(P = 0.011), with greater changes for the '6 treatments/wk' groups than for the '3 treatments/wk' groups; in addition, there were interaction effects between the number of cones and moxibustion frequency(P = 0.028). After the second course of treatment, changes in symptom scores for the 2 tested moxibustion frequencies were significantly different(P = 0.002), with greater changes for the '3 treatments/wk' groups than for the '6 treatments/wk' groups.CONCLUSION: An aconite cake-separated moxibustion treatment regimen of 3 treatments/wk and 1 cone/treatment appears to produce better therapeutic effects for D-IBS compared with the other tested regimens. | Ji-Meng Zhao Lu-Yi Wu Hui-Rong Liu Hong-Yi Hu Jia-Ying Wang Ren-Jia Huang Yin Shi Shan-Ping Tao Qiang Gao Ci-Li Zhou Li Qi Xiao-Peng Ma Huan-Gan Wu | 2014 | World Journal of Gastroenterology2014，20，37： | 4 |
| 8 | 艾灸治疗内脏痛的研究进展显示文摘研究艾灸直接或间接治疗内脏痛的机制,发现艾灸可通过调节抗炎因子、干预信号传导通路、增强人体免疫力等途径缓解内脏痛症状,为临床诊治内脏痛提供新的思路和参考。 | 李艳丽 王迎斌 武芳 张雪逸 | 2021 | 西部中医药2021，34，2： | 2 |
| 9 | 《制革及毛皮加工工业水污染物排放标准》解读显示文摘新发布的《制革及毛皮加工工业水污染物排放标准》(GB30486—2013)对于我国加强重金属等有毒有害污染物排放控制具有重要意义,环境保护部科技标准司负责人接受了记者采访,就如何理解、实施该标准,回答了记者的提问。 | | 2014 | 皮革科学与工程2014，24，1： | 1 |
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