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| 1 | Electrocatalytic determination of L-cysteine using a modified carbon nanotube paste electrode:Application to the analysis of some real samples显示文摘The electrooxidation of L-cysteine(L-Cys) was studied using a benzoylferrocene(BF) modified multi-wall carbon nanotube paste electrode(BFCNPE) using cyclic voltammetry(CV),square wave voltammetry(SWV) and chronoamperometry(CHA).Under optimum pH in CV the oxidation of L-Cys occurs at a potential about 215 mV less positive than that at the surface of unmodified carbon paste electrode.The catalytic oxidation peak currents were dependent on the L-Cys concentration and a linear calibration curve was obtained in the range 0.7-350.0 mmol/L of L-Cys with SWV method.The detection limit(3s) was determined as 0.1 mmol/L.This method was also used for the determination of L-Cys in some real samples. | Malihe Ahmadipour Mohammad Ali Taher Hadi Beitollahi Rahman Hosseinzadeh | 2012 | Chinese Chemical Letters2012，23，8： | 5 |
| 2 | Voltammetric determination of cysteamine at multiwalled carbon nanotubes paste electrode in the presence of isoproterenol as a mediator显示文摘A sensitive electrochemical sensor for the determination of cysteamine(CA) was developed using a modified multiwall carbon nanotube paste electrode(MWCNTPE) with isoproterenol(ISPT) as a mediator.This modified electrode showed very high electrocatalytic activity for the anodic oxidation of CA.Under the optimized conditions,the electrocatalytic peak current showed a linear relationship with CA concentration in the range of 0.3–450.0 mmol/L with a detection limit of 0.09 mmol/L CA.The modified electrode was used for the determination of CA in real samples such as urine and drug samples. | Mohsen Keyvanfard Maryam Ahmadi Fatemeh Karimi Khadijeh Alizad | 2014 | Chinese Chemical Letters2014，25，9： | 4 |
| 3 | Low generational polyamidoamine dendrimers to enhance the solubility of folic acid:A‘‘dendritic effect’’investigation显示文摘Low generational(G0–G2,G for generation) polyamidoamine(PAMAM) dendrimers were investigated as enhancers to improve the aqueous solubility of folic acid at pH 11 and pH 5.In these two cases,the solubility of folic acid increases with both the dendrimer concentration and generation.However,the solubilization mechanism is different.The electrostatic interaction between the primary amines of dendrimers and the ionized carboxylic groups of folic acid dominates the dissolution process at pH 11 while the increase of the solubility of folic acid at pH 5 is attributed to the hydrophobic encapsulation inside the dendrimer molecules.In addition,for comparison ethylenediamine was used as a small molecule control to examine the ‘‘dendritic effect'' in the dendrimer-related solubilization process.Interestingly,PAMAM dendrimers exhibit,at pH 5,a significant superiority over ethylenediamine in enhancing solubility,whereas this ‘‘dendritic effect'' cannot be observed under the basic condition. | Yong Zhang Mei-Ying Xu Tie-Kun Jiang Wei-Zhe Huang Jiang-Yu Wu | 2014 | Chinese Chemical Letters2014，25，5： | 3 |
| 4 | (4-Ferrocenylethyne) phenylamine on Graphene as the Signal Amplificator to Determinate Dopamine and Acetaminophen Simultaneously显示文摘A 小说(4-ferrocenylethyne ) phenylamine functionalized graphene 表(FEPA-GR ) ,结合 chitosan (CS ) 为多巴胺(DA ) 和 acetaminophen (交流) 的同时、敏感的决心被用作一个信号扩大平台。在这个工作,当电子转移调停人能在 GR 表面上被使不能调动经由, FEPA 使用了强壮 - 叠在 FEPA 和 GR 的 conjugate 链之间的相互作用,它有效地阻止 FEPA 电子调停人漏电极表面并且放大了信号。传播电子显微镜学,英尺红外光谱学,紫外力的光谱学和电气化学的实验结果都被表明强壮 - 叠在 FEPA 和 GR 之间的相互作用。结果的生物传感器为 DA 和交流的同时的察觉展出了快回答,显著 electrocatalytic 活动,完美的反干扰能力和好稳定性。在最佳条件下面, DA 和交流的氧化山峰电流线性地在 2.0135.0 的范围被相关到他们的集中吗? | Linping Wang Meiling Liu Yue Meng Haitao Li Youyu Zhang Shouzhuo Yao | 2013 | Chinese Journal of Chemistry2013，31，6： | 0 |
| 5 | Challenges for cysteamine stabilization,quantification,and biological effects improvement显示文摘The aminothiol cysteamine,derived from coenzyme A degradation in mammalian cells,presents several biological applications.However,the bitter taste and sickening odor,chemical instability,hygroscopicity,and poor pharmacokinetic profile of cysteamine limit its efficacy.The use of encapsulation systems is a good methodology to overcome these undesirable properties and improve the pharmacokinetic behavior of cysteamine.Besides,the conjugation of cysteamine to the surface of nanoparticles is generally proposed to improve the intra-oral delivery of cyclodextrin-drug inclusion complexes,as well as to enhance the colorimetric detection of compounds by a gold nanoparticle aggregation method.On the other hand,the detection and quantification of cysteamine is a challenging mission due to the lack of a chromophore in its structure and its susceptibility to oxidation before or during the analysis.Derivatization agents are therefore applied for the quantification of this molecule.To our knowledge,the derivatization techniques and the encapsulation systems used for cysteamine delivery were not reviewed previously.Thus,this review aims to compile all the data on these methods as well as to provide an overview of the various biological applications of cysteamine focusing on its skin application. | Carla Atallah Catherine Charcosset Helene Greige-Gerges | 2020 | Journal of Pharmaceutical Analysis2020，10，6： | 0 |
| 6 | Highly sensitive determination of promazine in pharmaceutical and biological samples using a ZnO nanoparticle-modified ionic liquid carbon paste electrode显示文摘In this work we describe the first report for the determination of promazine using a nanostructuremodified ionic liquid carbon paste electrode in aqueous solutions. To achieve this goal, a novel modified carbon paste electrode using ZnO nanoparticles and 1-methyl-3-butylimidazolium bromide as a binder(ZnO/NPs/ILs/CPE) was fabricated. The oxidation peak potential of promazine at the surface of the ZnO/NPs/ILs/CPE appeared at 685 m V, which was about 65 m V lower than the oxidation potential at the surface of CPE under similar conditions. Also, the peak current was increased to about 4.0 times higher at the surface of ZnO/NPs/ILs/CPE compared to that of CPE. The linear response range and detection limit were found to be 0.08–450 and 0.04 mmol/L, respectively. The modified electrode was successfully used for the determination of promazine in real samples with satisfactory results. | Vahid Arabali Mahmoud Ebrahimi Hassan Karimi-Maleh | 2016 | Chinese Chemical Letters2016，27，5： | 0 |
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