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		题名	作者	年代	出处	被引量
	1	Collective migrations in an epithelial-cancerous cell monolayer显示文摘Collective cell migration is extensively observed in embryo development and cancer invasion.During these processes,the interactions between cells with distinct identities and fates are of importance for boundary formation and host defense against cancer.In this paper,we explore the collective dynamics of a two-dimensional cell mixing monolayer consisting of non-tumorigenic mammary epithelial cells and breast cancer cells.We show that the epithelial-cancerous cell mixing system displays unique sorting behaviors.The epithelial cells aggregate to form scattered clusters,which perform random motion with simultaneous translation and rotation,strikingly distinct from the classical persistent random walk of individual migratory cells.The motility of cancer cells is markedly promoted by the epithelial clusters,exhibiting remarkable contact enhancement of locomotion.A discrete model based on the Johnson-Kendall-Roberts contact mechanics is proposed to identify the influence of intercellular interactions,active migration forces and cell-substrate friction forces on the collective cell dynamics.These findings could advance our understanding of many biological processes,such as cancer metastasis and tissue morphogenesis.	Jian‑Qing Lv Peng‑Cheng Chen Liu‑Yuan Guan Wojciech T.Góźdź Xi‑Qiao Feng Bo Li	2021	Acta Mechanica Sinica2021，37，5：	0

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