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| 1 | Dual-stimuli responsive near-infrared emissive carbon dots/hollow mesoporous silica-based integrated theranostics platform for real-time visualized drug delivery显示文摘Due to better penetrating abilities of near-infrared (NIR) light and lower autofluorescence of biological tissue at NIR region, the combination of NIR fluorescent imaging with therapeutic abilities has gradually emerged as a promising strategy for cancer therapy. Herein, tumor microenvironment (TME) sensitive nanocarriers based on doxorubicin hydrochloride (DOX), NIR emitting carbon dots (C-dots), hollow mesoporous silica nanoparticles (HMSN) and anionic polymer citraconic anhydride-modified polylysine (PLL(cit)) are fabricated for imaging guided drug delivery. The NIR emitting C-dots were conjugated onto the surface of HMSN via disulfide bonds which can be reduced by intracellular glutathione (GSH) and result in the release of DOX into cells. And then the PLL(cit) was grafted on the surface of the nanocarriers to endow the nanocarriers with charge convertible property in mildly acidic TME (pH = 6.50) which results in prolonged blood circulation time and enhanced cellular internalization. The in vitro and in vivo experiments confirmed that the dual pH/GSH responsive features of nanocarriers can eliminate the tumor tissues effectively and elicit much slighter side effects. Moreover, since the fluorescence of C-dots can be recovered after the reduction of disulfide bonds and selectively accumulation of nanocarriers around tumor tissue, the DOX@HMSN-SS-C-dots-PLL(cit) can be served as a promising NIR fluorescence probe for targeted imaging of tumor tissue. As a kind of multifunctional nanocarrier with NIR fluorescent imaging and therapeutic functions, the theranostic nanocarriers hold great potential for tumor therapy and in vivo imaging of tumor tissue. | Zhongyin Chen Tao Liao Lihui Wan Ying Kuang Chang Liu Junlin Duan Xiangyu Xu Ziqiang Xu Bingbing Jiang Cao Li | 2021 | Nano Research2021，14，11： | 1 |
| 2 | 烧结温度对碳聚合物点/铜复合材料显微组织与性能的影响显示文摘以碳聚合物点(carbonized polymer dot,CPD)作为铜的增强体,采用粉末冶金法制备碳聚合物点/铜复合材料,分析和测试不同烧结温度(350~750℃)下CPD/Cu复合材料的致密度、硬度、拉伸性能与耐磨性能。结果表明:CPD在铜基体中均匀分散,并且CPD壳体网络中的非晶碳有利于CPD与铜基体形成良好的界面结合,CPD/Cu复合材料的致密化程度高,相对密度达到95%以上。CPD/Cu复合材料的力学性能和摩擦磨损性能均明显高于纯Cu。随烧结温度升高,CPD/Cu复合材料的致密度、硬度、抗拉强度先升高后降低,在550℃烧结的复合材料具有最佳的综合性能,硬度(HV)比Cu提高49.4、抗拉强度(334.0 MPa)比纯Cu提高约25.6%,体积磨损率为17.67×10^(−12) m^(3)/m。 | 杨亚杰 李兆杰 赵文敏 鲍瑞 易健宏 | 2021 | 粉末冶金材料科学与工程2021，26，6： | 0 |
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