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| 1 | 多孔聚乳酸/醋酸纤维素电纺支架的制备与生物相容性研究显示文摘以聚乳酸(PLA)和醋酸纤维素(CA)为溶质,选择二氯甲烷(DCM)和丙酮作为溶剂,通过静电纺丝技术制备多孔PLA/CA纤维。使用SEM对纤维形貌及表面结构进行观察,对纤维膜采用PDL进行表面修饰,并通过XPS分析纤维支架表面元素,将PC12细胞接种在纤维支架上,培养48 h后利用MTT法测定细胞在支架上的增殖水平。该文对无孔PLA/CA纤维、多孔PLA/CA纤维及改性后的纤维进行体外细胞增殖实验,探究多孔结构对组织工程支架的影响。结果表明,以DCM/丙酮为溶剂成功制备多孔PLA/CA纤维,这是因为这2种溶液沸点较低,在纺丝过程中由于热致相分离形成相互贯通的三维孔。多孔纤维对PDL的吸收能力强于无孔纤维,所以能够更好地促进PC12细胞的增殖。该研究表明具有多孔结构的纤维支架更适合组织工程应用。 | 夏宏燕 陈雪六 谢康 | 2022 | 科技创新与应用2022,12,23: | 1 |
| 2 | 3D生物打印在组织缺损修复应用中的研究进展显示文摘3D生物打印作为组织工程领域中最先进的工具之一,能够实现人造复杂组织结构制造的高精度和准确性,并能制造出更符合天然组织和生物学功能的移植物。在组织缺损治疗中,生物3D打印不仅可以克服供体来源不足的问题,还能解决传统组织工程无法实现个性化匹配及生物活性低的问题。基于此,本综述概述了几种常用3D生物打印技术及最新进展,并对参与打印的生物墨水和种子细胞进行了总结,还回顾了3D生物打印技术在皮肤、心脏、骨及软骨和神经组织的重要研究,并讨论了未来临床转化的方向和生物打印技术未来的发展前景。 | 郭宇昕 王浩 周青 | 2023 | 中华生物医学工程杂志2023,29,4: | 0 |
| 3 | Advancing Wound Filling Extraction on 3D Faces:An Auto-Segmentation and Wound Face Regeneration Approach显示文摘Facial wound segmentation plays a crucial role in preoperative planning and optimizing patient outcomes in various medical applications.In this paper,we propose an efficient approach for automating 3D facial wound segmentation using a two-stream graph convolutional network.Our method leverages the Cir3D-FaIR dataset and addresses the challenge of data imbalance through extensive experimentation with different loss functions.To achieve accurate segmentation,we conducted thorough experiments and selected a high-performing model from the trainedmodels.The selectedmodel demonstrates exceptional segmentation performance for complex 3D facial wounds.Furthermore,based on the segmentation model,we propose an improved approach for extracting 3D facial wound fillers and compare it to the results of the previous study.Our method achieved a remarkable accuracy of 0.9999993% on the test suite,surpassing the performance of the previous method.From this result,we use 3D printing technology to illustrate the shape of the wound filling.The outcomes of this study have significant implications for physicians involved in preoperative planning and intervention design.By automating facial wound segmentation and improving the accuracy ofwound-filling extraction,our approach can assist in carefully assessing and optimizing interventions,leading to enhanced patient outcomes.Additionally,it contributes to advancing facial reconstruction techniques by utilizing machine learning and 3D bioprinting for printing skin tissue implants.Our source code is available at http://gffzz188fe103f8f1460asko9k5xcq0wqp695o.ffgz.tsg.suse.edu.cn/SIMOGroup/WoundFilling3D. | Duong Q.Nguyen Thinh D.Le Phuong D.Nguyen Nga T.K.Le H.Nguyen-Xuan | 2024 | Computer Modeling in Engineering & Sciences2024,139,5: | 0 |
| 4 | 微纳增材制造微圆柱结构的形貌分析与工艺优化研究显示文摘针对目前亚像素微扫描的LCD式光固化3D打印技术在微纳结构增材制造中存在的典型打印瑕疵,通过优化打印工艺和分析打印结构,以提高打印成型质量和生产效率。首先,通过对打印材料后处理工艺研究,设计单因素试验并打印平板模型,分析后固化时长对零件硬度、粗糙度及形貌影响规律。其次,结合打印工艺参数,设计正交试验并打印圆柱阵列模型,分析打印层厚、曝光时间、振动次数对微圆柱成型的影响规律。结果表明:后固化时间在5~10 min时,后固化效果最优,此时表面粗糙度Ra值约为29 nm,邵氏硬度在88 HD左右。打印工艺参数对微圆柱直径尺寸影响大小排序为:曝光时间>打印层厚>振动次数。在均衡打印质量和打印效率的前提下,打印参数优化后,打印直径50μm,高度210μm的微圆柱结构应采用打印层厚10μm,曝光时间2500 ms,振动次数64 x的打印工艺参数。 | 陈玉田 吴重军 魏馨怡 孟宪凯 刘杰 王琪冰 | 2023 | 机械工程学报2023,59,1: | 0 |