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| 1 | The cornerstone of translational research-selection of appropriate animal models显示文摘The appropriate use of animal models is one of the most important steps for a successful translational research project.For scientists working in basic biomaterials research and development,the problem is the uncertainty in selecting the most suitable models for a particular research question.Because of the complexity of translational research,the choice of animal model must be a thorough and clearly-defined process in order to provide relevant,reliable and translatable scientific data,ensure the most beneficial use of the animals,and to be accepted by peers.As stated by Bernard Rollin,1“The most brilliant design,the most elegant procedures,the purest reagents,along with investigator talent,public money,and animal life are all wasted if the choice of animal is incorrect.”To design a successful animal experiment,many questions need to be addressed. | Qian Wang | 2021 | Biomaterials Translational2021，2，2： | 0 |
| 2 | Co-delivery of luteolin and TGF-β1 plasmids with ROS-responsive virus-inspired nanoparticles for microenvironment regulation and chemo-gene therapy of intervertebral disc degeneration显示文摘Intervertebral disc degeneration(IDD)is closely related to inflammation and imbalance of synthesis/catabolism of extracellular matrix(ECM)in intervertebral disc(IVD).Considering this,luteolin(LUT),a kind of natural flavonoid with good anti-inflammatory effect and TGF-β1(a gene that promotes the regeneration of ECM)plasmid was co-loaded and co-delivered to nucleus pulposus cells(NPCs).Reactive oxygen species(ROS)responsive cationic copolymer,poly(β-amino ester)-poly(ε-caprolactone)(PBC),with high plasmid DNA(pDNA)compression affinity was synthesized.It can self-assemble into nano-sized polyplexes(pDNA@PBC)with virus-inspired structure and function through which it can transfect pDNA into NPCs with very high efficiency and negligible cytotoxicity.LUT was encapsulated in the hydrophobic core of pDNA@PBC.The co-delivery system,LUT-pTGFβ1@PBC,could enhance the cellular uptake of NPCs and manifest excellent sustained drug release in IVD.Real time quantitative polymerase chain reaction(RT-qPCR)and Western blot experiments reveal that the co-delivery system could inhibit inflammation in NPCs and restore the balance of anabolism and catabolism in vitro by activating TGF/SMAD3 and inhibiting NFkB/p65.Moreover,LUT-pTGF-β1@PBC retards IDD in vivo as detected by radiological and histological methods with good biosafety in rats.LUT-pTGF-β1@PBC may be a promising option for the treatment of IDD. | Yifan Ding Huan Wang Yunyun Wang Long Li Jiahui Ding Caiyan Yuan Tao Xu Haoran Xu Hui Xie Ning Zhu Xin Hu Huang Fang Songwei Tan | 2022 | Nano Research2022，15，9： | 0 |
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